المؤلفون: Peterson QP; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA. peterson.quinn@mayo.edu.; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA. peterson.quinn@mayo.edu.; Center for Regenerative Medicine, Mayo Clinic, Rochester, MN, USA. peterson.quinn@mayo.edu., Veres A; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA., Chen L; Cardiovascular, Renal and Metabolism and Early Development, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Slama MQ; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA., Kenty JHR; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA., Hassoun S; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA., Brown MR; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA., Dou H; Department of Physiology, University of Gothenburg, Gothenburg, Sweden., Duffy CD; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA., Zhou Q; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA., Matveyenko AV; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA., Tyrberg B; Cardiovascular, Renal and Metabolism and Early Development, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.; Department of Physiology, University of Gothenburg, Gothenburg, Sweden.; Cardiovascular and Metabolic Diseases, Institut de Recherches Servier, Suresnes, France., Sörhede-Winzell M; Cardiovascular, Renal and Metabolism and Early Development, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Rorsman P; Department of Physiology, University of Gothenburg, Gothenburg, Sweden.; Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Melton DA; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA. dmelton@harvard.edu.

المصدر: Nature communications [Nat Commun] 2020 May 07; Vol. 11 (1), pp. 2241. Date of Electronic Publication: 2020 May 07.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

مواضيع طبية MeSH: Cell Culture Techniques/*methods , Glucagon-Secreting Cells/*cytology , Insulin-Secreting Cells/*drug effects , Pluripotent Stem Cells/*cytology, Blotting, Western ; Cell Differentiation/physiology ; Cell Line ; Electrophysiology ; Fluorescent Antibody Technique ; Humans ; Pancreas/cytology

المؤلفون: Alvarez-Dominguez JR; Department of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA., Donaghey J; Department of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA., Rasouli N; Department of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA., Kenty JHR; Department of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA., Helman A; Department of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA., Charlton J; Department of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA; Department of Genome Regulation, Max Planck Institute for Molecular Genetics, Berlin 14195, Germany., Straubhaar JR; Department of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA., Meissner A; Department of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA; Department of Genome Regulation, Max Planck Institute for Molecular Genetics, Berlin 14195, Germany., Melton DA; Department of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA. Electronic address: dmelton@harvard.edu.

المصدر: Cell stem cell [Cell Stem Cell] 2020 Jan 02; Vol. 26 (1), pp. 108-122.e10. Date of Electronic Publication: 2019 Dec 12.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101311472 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1875-9777 (Electronic) Linking ISSN: 18759777 NLM ISO Abbreviation: Cell Stem Cell Subsets: MEDLINE

مواضيع طبية MeSH: Cell Differentiation* , Circadian Rhythm*, Islets of Langerhans/*cytology , Pluripotent Stem Cells/*cytology, Glucagon/metabolism ; Humans ; Insulin/metabolism ; Insulin Secretion ; Islets of Langerhans/metabolism

المؤلفون: Glieberman AL; Disease Biophysics Group, Wyss Institute for Biologically Inspired Engineering, Harvard John A. Paulson School of Engineering and Applied Sciences, Harvard University, Pierce Hall, 29 Oxford Street, Cambridge, MA 02138, USA. kkparker@seas.harvard.edu., Pope BD, Zimmerman JF, Liu Q, Ferrier JP, Kenty JHR, Schrell AM, Mukhitov N, Shores KL, Tepole AB, Melton DA, Roper MG, Parker KK

المصدر: Lab on a chip [Lab Chip] 2019 Sep 10; Vol. 19 (18), pp. 2993-3010.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101128948 Publication Model: Print Cited Medium: Internet ISSN: 1473-0189 (Electronic) Linking ISSN: 14730189 NLM ISO Abbreviation: Lab Chip Subsets: MEDLINE

مواضيع طبية MeSH: Lab-On-A-Chip Devices* , Microfluidic Analytical Techniques*/instrumentation, Insulin/*analysis , Islets of Langerhans/*chemistry, Electric Stimulation ; Equipment Design ; Humans