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1دورية أكاديمية
المؤلفون: Yong Ran, Gabriela Z Ladd, Carolina Ceballos-Diaz, Joo In Jung, Doron Greenbaum, Kevin M Felsenstein, Todd E Golde
المصدر: PLoS ONE, Vol 10, Iss 6, p e0128619 (2015)
وصف الملف: electronic resource
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2دورية أكاديمية
المؤلفون: Joo In Jung, Sasha Premraj, Pedro E Cruz, Thomas B Ladd, Yewon Kwak, Edward H Koo, Kevin M Felsenstein, Todd E Golde, Yong Ran
المصدر: PLoS ONE, Vol 9, Iss 10, p e111553 (2014)
وصف الملف: electronic resource
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3
المصدر: Translational Research. 163:432-438
مصطلحات موضوعية: Pathology, medicine.medical_specialty, Neurogenesis, Cell- and Tissue-Based Therapy, Subventricular zone, Disease, Regenerative Medicine, Regenerative medicine, Article, Alzheimer Disease, Physiology (medical), Intervention (counseling), medicine, Humans, business.industry, Biochemistry (medical), Public Health, Environmental and Occupational Health, General Medicine, medicine.disease, medicine.anatomical_structure, Drug development, Stem cell, Alzheimer's disease, business, Neuroscience
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المؤلفون: Thomas B. Ladd, Todd E. Golde, Joo In Jung, Awilda M. Rosario, Kevin M. Felsenstein, Edward H. Koo, Pedro E. Cruz, Yong Ran, Thomas Kukar
المصدر: Biochemistry
مصطلحات موضوعية: Molecular Sequence Data, Down-Regulation, CHO Cells, Cleavage (embryo), Biochemistry, Article, Presenilin, Substrate Specificity, Cricetulus, Cricetinae, Amyloid precursor protein, Animals, Point Mutation, Amino Acid Sequence, Peptide sequence, Amyloid beta-Peptides, biology, Point mutation, Processivity, Up-Regulation, Cell biology, Transmembrane domain, Mutagenesis, Site-Directed, biology.protein, Amyloid Precursor Protein Secretases, Protein Processing, Post-Translational, Amyloid precursor protein secretase
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5
المصدر: Biochimica et Biophysica Acta (BBA) - Biomembranes. 1828(12):2898-2907
مصطلحات موضوعية: Proteases, medicine.medical_treatment, Biophysics, Plasma protein binding, Pharmacology, Biochemistry, Article, Substrate Specificity, Amyloid beta-Protein Precursor, Structure-Activity Relationship, 03 medical and health sciences, 0302 clinical medicine, Alzheimer Disease, Neoplasms, medicine, Humans, Protease Inhibitors, Cancer, 030304 developmental biology, Clinical Trials as Topic, 0303 health sciences, Binding Sites, γ-Secretase inhibitor, Protease, biology, Mechanism (biology), γ-Secretase modulator, Cell Biology, Alzheimer's disease, medicine.disease, 3. Good health, Protein Subunits, Mechanism of action, Drug Design, Proteolysis, biology.protein, Amyloid Precursor Protein Secretases, medicine.symptom, Signal transduction, Amyloid precursor protein secretase, 030217 neurology & neurosurgery, Protein Binding, Signal Transduction
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6
المؤلفون: Todd E. Golde, Wuyan Chen, Wei Zhang, Lilibeth A. Salvador, Li Li, Kevin M. Felsenstein, Yechun Xu, Yingxia Li, Jianhua He, Thomas B. Ladd, Hendrik Luesch, Tiantian Chen, Ashleigh R. Price, Yanxia Liu
المصدر: Journal of Medicinal Chemistry. 55:10749-10765
مصطلحات موضوعية: Models, Molecular, Spectrometry, Mass, Electrospray Ionization, Aspartic Acid Proteases, Stereochemistry, Cyanobacteria, Structure-Activity Relationship, Stereospecificity, In vivo, mental disorders, Drug Discovery, Structure–activity relationship, Protease Inhibitors, Beta (finance), Cathepsin, biology, Chemistry, In vitro, Ectodomain, Biochemistry, Drug Design, Molecular Probes, biology.protein, Molecular Medicine, Amyloid Precursor Protein Secretases, Peptides, Amyloid precursor protein secretase
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7
المؤلفون: Kevin M. Felsenstein, Douglas E. Brenneman, Donna M. Klein
المصدر: Journal of Pharmacology and Experimental Therapeutics. 328:813-821
مصطلحات موضوعية: Neurons, Pharmacology, Cathepsin, Small interfering RNA, biology, Amyloid beta, Cathepsin L, P3 peptide, Tetrodotoxin, Cathepsins, Hippocampus, Cathepsin B, Amyloid beta-Protein Precursor, Cysteine Endopeptidases, Biochemistry, Synapses, Alternative complement pathway, biology.protein, Amyloid precursor protein, Animals, Humans, Molecular Medicine, RNA, Small Interfering
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a58a0742a3463d6df35001d3a5e6625
https://doi.org/10.1124/jpet.108.147082 -
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المؤلفون: Kevin M. Felsenstein, Joanne J. Bronson, C.V.C. Prasad, Graham Johnson, Donna M. Barten, Michael F. Parker, Jason A. Corsa, Jeremy Mock, Valerie Guss, David W. Smith, Charles P. Sloan, Williams Andrew, Owen Brendan Wallace, Steven Hansel, Craig Polson, Keavy Daniel J, Milind Deshpande, Bergstrom Carl P, Henry H. Wang, Wai Y. Lau, Ming Zheng
المصدر: Bioorganic & Medicinal Chemistry Letters. 17:4432-4436
مصطلحات موضوعية: Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Mice, Transgenic, Biochemistry, Chemical synthesis, Mice, chemistry.chemical_compound, In vivo, Drug Discovery, Animals, Hydroxymethyl, Molecular Biology, Alkyl, chemistry.chemical_classification, Sulfonamides, Amyloid beta-Peptides, Molecular Structure, biology, Chemistry, Organic Chemistry, Brain, Biological activity, Sulfonamide, Enzyme inhibitor, biology.protein, Molecular Medicine, Amyloid Precursor Protein Secretases, Amyloid precursor protein secretase, Protein Binding
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المؤلفون: Yufei Tang, Carolina Ceballos-Diaz, Ashleigh R. Price, Gideon Shapiro, Todd E. Golde, Joo In Jung, Rajender Akula, Kevin M. Felsenstein, Thomas B. Ladd, Hyo-Jin Park, Lisa A. Smithson, Günther Hochhaus, Edward H. Koo, Saritha Ba, Yong Ran
المصدر: Molecular neurodegeneration, vol 10, iss 1
Molecular Neurodegenerationمصطلحات موضوعية: Aging, Metabolite, medicine.medical_treatment, Drug Evaluation, Preclinical, Endogeny, Cytochrome P450, Pharmacology, Neurodegenerative, Alzheimer's Disease, Inbred C57BL, chemistry.chemical_compound, Mice, 0302 clinical medicine, Cricetinae, CYP27A1, γ-secretase modulator (GSM), Cells, Cultured, Mice, Knockout, Neurons, 0303 health sciences, Cultured, Molecular Structure, Brain, Preclinical, 3. Good health, Cholesterol, 5.1 Pharmaceuticals, Blood-Brain Barrier, Neurological, Cholestanetriol 26-Monooxygenase, Development of treatments and therapeutic interventions, Drug, Alzheimer disease, Neuroglia, Research Article, medicine.medical_specialty, Amyloid, CYP7B1, Cells, Knockout, Clinical Sciences, Clinical Neurology, Cytochrome P450 Family 7, CHO Cells, Bile acid, Biology, Steroid, Dose-Response Relationship, 03 medical and health sciences, Cellular and Molecular Neuroscience, Structure-Activity Relationship, Cricetulus, Cholestenoic acid, Internal medicine, medicine, Acquired Cognitive Impairment, Genetics, Animals, Humans, Molecular Biology, 030304 developmental biology, gamma-secretase modulator, Amyloid beta-Peptides, Neurology & Neurosurgery, Dose-Response Relationship, Drug, Cholic acid, Neurosciences, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Cholic Acids, Peptide Fragments, Coculture Techniques, Brain Disorders, Mice, Inbred C57BL, Endocrinology, chemistry, Steroid Hydroxylases, biology.protein, Drug Evaluation, Dementia, Neurology (clinical), Amyloid Precursor Protein Secretases, Amyloid precursor protein secretase, 030217 neurology & neurosurgery
وصف الملف: application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e253b1b15f82428143d224cadb5cdde
https://escholarship.org/uc/item/71t2x8wr -
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المؤلفون: Joo In Jung, Andrey E. Ryabinin, Oliver Holmes, Ashleigh R. Price, Yehia Daaka, Yong Ran, Carolina Ceballos-Diaz, Kevin M. Felsenstein, Michael S. Wolfe, Todd E. Golde, Lisa A. Smithson, Chul Han, Seong-Hun Kim, Hyo-Jin Park, Richard L. Hauger
المصدر: The EMBO journal, vol 34, iss 12
مصطلحات موضوعية: Aging, Corticotropin-Releasing Hormone, Pituitary-Adrenal System, Endogeny, Neurodegenerative, Inbred C57BL, Alzheimer's Disease, Medical and Health Sciences, Corticotropin-releasing hormone, corticotrophin releasing factor, stress, Mice, Models, Receptors, Cyclic AMP, 2.1 Biological and endogenous factors, Aetiology, Internalization, gamma-secretase, media_common, Microscopy, biology, Blotting, General Neuroscience, Articles, Biological Sciences, amyloid-beta, Cell biology, 5.1 Pharmaceuticals, medicine.symptom, Development of treatments and therapeutic interventions, Western, hormones, hormone substitutes, and hormone antagonists, medicine.medical_specialty, Hypothalamo-Hypophyseal System, media_common.quotation_subject, Physiological, Blotting, Western, Neuropeptide, Enzyme-Linked Immunosorbent Assay, Real-Time Polymerase Chain Reaction, Models, Biological, Receptors, Corticotropin-Releasing Hormone, General Biochemistry, Genetics and Molecular Biology, Fluorescence, Mediator, Membrane Microdomains, amyloid‐β, Alzheimer Disease, Stress, Physiological, Internal medicine, Information and Computing Sciences, medicine, Acquired Cognitive Impairment, Animals, Humans, Immunoprecipitation, Molecular Biology, γ‐secretase, beta-arrestin, Analysis of Variance, Amyloid beta-Peptides, General Immunology and Microbiology, HEK 293 cells, Neurosciences, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Biological, Brain Disorders, Mice, Inbred C57BL, Endocrinology, HEK293 Cells, Mechanism of action, Microscopy, Fluorescence, biology.protein, Dementia, Amyloid Precursor Protein Secretases, Amyloid precursor protein secretase, β‐arrestin, Developmental Biology
وصف الملف: application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f89e60ca5b5374ab49c22d222f1a4c89
https://europepmc.org/articles/PMC4475401/
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