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المؤلفون: Philip J. Jewsbury, Rajesh Odedra, Alan Lau, Sylvie Guichard, James W.T. Yates, Kevin Blades, Gary Wilkinson, Kevin Michael Foote, Dan Heathcote, Turner Paul, Christine M. Wood, J. Willem M. Nissink, Zena Wilson, Thomas M. McGuire
المصدر: Journal of Medicinal Chemistry. 61:9889-9907
مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, Indoles, Chemical Phenomena, Morpholines, Molecular Conformation, Regulator, Antineoplastic Agents, Context (language use), Ataxia Telangiectasia Mutated Proteins, Mice, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Pharmacokinetics, Cell Line, Tumor, Drug Discovery, Animals, Humans, Tissue Distribution, Protein Kinase Inhibitors, Clinical Trials as Topic, Sulfonamides, CYP3A4, Kinase, Drug discovery, Pyrimidines, 030104 developmental biology, chemistry, Cell culture, Sulfoxides, 030220 oncology & carcinogenesis, Cancer research, Molecular Medicine, Female, DNA
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المؤلفون: Jon Read, Kevin Michael Foote, Johannes Wilhelmus Maria Nissink, Alan Lau, Louise Goodwin, Lisa Wissler, Jason Breed, Benjamin Taylor, Nichola L. Davies, Husam Alwan, James S. Scott, Jason Grant Kettle, Kay Eckersley, D.R Jones, Michal Bista, Marta Wylot, Graeme Walker, Shaun M. Fillery, Helena Käck
المصدر: Journal of Medicinal Chemistry. 59:2346-2361
مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, Cell Survival, Antineoplastic Agents, Crystallography, X-Ray, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Cell Line, Tumor, Drug Discovery, medicine, Animals, Humans, Cytotoxic T cell, CRISPR, Potency, Nucleotide, RNA, Small Interfering, chemistry.chemical_classification, Cancer, medicine.disease, Phosphoric Monoester Hydrolases, Rats, DNA Repair Enzymes, 030104 developmental biology, Enzyme, chemistry, Biochemistry, 030220 oncology & carcinogenesis, Cancer cell, Molecular Medicine, DNA
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المؤلفون: Kevin Michael Foote, Jason Grant Kettle, Frederick W. Goldberg, D.M. Wilson, Andrew A. Mortlock
مصطلحات موضوعية: 0301 basic medicine, biology, Kinase, Cancer, Imatinib, Pharmacology, medicine.disease, Highly selective, Third generation, First generation, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, 030220 oncology & carcinogenesis, medicine, Cancer research, biology.protein, Epidermal growth factor receptor, Clinical learning, medicine.drug
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::0f07154f40f126dcae45805f6474ce43
https://doi.org/10.1016/b978-0-12-409547-2.12391-1 -
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المؤلفون: Emma J. Williams, Clare Gregson, Kevin Blades, Kevin Michael Foote, Shaun M. Fillery, Julie Demeritt, Ryan Greenwood, Kurt Gordon Pike, Lorraine A. Hassall, Thomas M. McGuire
المصدر: Tetrahedron Letters. 55:3851-3855
مصطلحات موضوعية: chemistry.chemical_compound, Chemistry, Drug discovery, Organic Chemistry, Drug Discovery, Moiety, Biochemistry, Combinatorial chemistry, Sulfone
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المصدر: Chirality. 25:692-700
مصطلحات موضوعية: Pharmacology, Stereochemistry, Organic Chemistry, Intermolecular force, Polyene, Catalysis, Analytical Chemistry, chemistry.chemical_compound, chemistry, Intramolecular force, Drug Discovery, Halonium ion, Organic chemistry, Enantiomer, Chirality (chemistry), Spectroscopy
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المؤلفون: Rajesh Odedra, Sylvie S. Guichard, Philip J. Jewsbury, Abid Suleman, Christine M. Wood, Lorraine A. Hassall, Kevin Blades, Thomas M. McGuire, Pia Thommes, Xavier Jacq, Paula Perkins, Ian Hickson, Ken Page, J. Willem M. Nissink, Kevin Michael Foote, Kin Yip Tam, Shaun M. Fillery, Rebecca Broadhurst, Anna Cronin
المصدر: Journal of Medicinal Chemistry. 56:2125-2138
مصطلحات موضوعية: Models, Molecular, Radiosensitizer, Morpholines, Antineoplastic Agents, Cell Cycle Proteins, Ataxia Telangiectasia Mutated Proteins, Protein Serine-Threonine Kinases, Pharmacology, Crystallography, X-Ray, HeLa, Mice, Structure-Activity Relationship, chemistry.chemical_compound, In vivo, Drug Discovery, Animals, Humans, Structure–activity relationship, Protein Kinase Inhibitors, IC50, biology, Chemistry, Drug discovery, biology.organism_classification, Xenograft Model Antitumor Assays, In vitro, Pyrimidines, Molecular Medicine, Female, Growth inhibition, HeLa Cells
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المؤلفون: Kurt Gordon Pike, Christopher J. Lynch, Robert te Poele, Stephen Green, Carl S. Rye, Emmanuel de Billy, Keith Jones, Julie Demeritt, Paul D. Kemmitt, Nicola E. A. Chessum, Kevin Michael Foote, Louise Goodwin, Paul Workman, Florence I. Raynaud, Alan T. Henley, Swee Y. Sharp, Angela Hayes, Rosie Isaac, Lisa O’ Fee, Joanna Boros, Lorenzo Zani, Julie A. Tucker, Matthew D. Cheeseman, Scott G. Lamont, Paul Faulder
المصدر: Medchemcomm
MedChemComm (Online) 7 (2016): 1580–1586. doi:10.1039/C6MD00159A
info:cnr-pdr/source/autori:Carl S. Rye, Nicola E. A. Chessum, Scott Lamont, Kurt G. Pike, Paul Faulder, Julie Demeritt,Paul Kemmitt, Julie Tucker, Lorenzo Zani, Matthew D. Cheeseman, Rosie Isaac, Louise Goodwin, Joanna Boros, Florence Raynaud, Angela Hayes, Alan T. Henley, Emmanuel de Billy, Christopher J. Lynch, Swee Y. Sharp, Robert te Poele, Lisa O' Fee, Kevin M. Foote, Stephen Green, Paul Workman, Keith Jones/titolo:Discovery of 4,6-disubstituted pyrimidines as potent inhibitors of the heat shock factor 1 (HSF1) stress pathway and CDK9/doi:10.1039%2FC6MD00159A/rivista:MedChemComm (Online)/anno:2016/pagina_da:1580/pagina_a:1586/intervallo_pagine:1580–1586/volume:7مصطلحات موضوعية: 0301 basic medicine, Phenotypic screening, Pharmaceutical Science, Pharmacology, Biology, Biochemistry, 03 medical and health sciences, HSF1, kinase inhibitor, cancer, pyrimidine, phenotypic screening, Drug Discovery, medicine, Potency, Transcription factor, Cell survival, chemistry.chemical_classification, Organic Chemistry, fungi, Cancer, medicine.disease, Cell biology, Chemistry, 030104 developmental biology, Enzyme, chemistry, Molecular Medicine, Cyclin-dependent kinase 9
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca6ce0847e97e3ad58a24d19ca03ebf9
https://pubmed.ncbi.nlm.nih.gov/27746890 -
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المؤلفون: Andrew Peter Thomas, Anne-Kathrin Schott, Jennifer H. Pink, Jason Breed, Karen Roberts, David M. Andrews, Andrew G. Leach, Richard A. Norman, Derek Ogg, Andrew P. Garner, Jonathon P. Orme, David Alan Rudge, Kevin Michael Foote
المصدر: Journal of Medicinal Chemistry. 55:5003-5012
مصطلحات موضوعية: Models, Molecular, Stereochemistry, Crystallography, X-Ray, Ligands, Mice, Structure-Activity Relationship, Drug Discovery, Animals, Humans, Structure–activity relationship, Receptor, Fibroblast Growth Factor, Type 1, Phosphorylation, Binding site, Mice, Knockout, chemistry.chemical_classification, Binding Sites, Molecular Structure, Kinase, Pyrimidines, Enzyme, chemistry, Fibroblast growth factor receptor, Drug Design, Pyrazoles, Molecular Medicine, Dimerization, Tyrosine kinase, Protein ligand
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المؤلفون: Patrick Ple, Antoine Le Griffon, Janet Hawkins, Barlaam Bernard Christophe, Rémy Morgentin, Lorraine A. Hassall, Kevin Michael Foote, Clifford David Jones, Aurélien Péru
المصدر: Synthetic Communications. 42:8-24
مصطلحات موضوعية: chemistry.chemical_compound, chemistry, Nucleophilic aromatic substitution, Organic Chemistry, Pyridine, Nucleophilic substitution, chemistry.chemical_element, Regioselectivity, Organic chemistry, Coupling reaction, Palladium
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المؤلفون: Zbegniew M. Matusiak, Benedicte Delouvrie, Craig S. Harris, Christine Lambert-van der Brempt, Maryannick Lamorlette, Jean-Claude Arnould, Kevin Michael Foote, Christian Delvare, David M. Andrews, Annie Hamon, Pascal Boutron
المصدر: Tetrahedron. 65:5805-5816
مصطلحات موضوعية: chemistry.chemical_compound, Chemistry, Stereochemistry, Organic Chemistry, Drug Discovery, Thienopyrrole, Biochemistry, Thiophene derivatives, Pyrrole
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