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1
المؤلفون: Stephen E. Webber, Amit M. Shah, Kevin R. Steffy, James R. Appleman, Alan X. Xiang, Robert M. Aust, Thomas Doundoulakis, Richard E. Showalter, Klaus B. Simonsen, William T. Biller, Virginia N. Banh, Wes Sisson, Ricardo Lira, Konstantinos A. Agrios
المصدر: Bioorganic & Medicinal Chemistry Letters. 17:6797-6800
مصطلحات موضوعية: Staphylococcus aureus, Clinical Biochemistry, Pharmaceutical Science, medicine.disease_cause, Methylation, Biochemistry, Microbiology, Inhibitory Concentration 50, Lactones, chemistry.chemical_compound, RNA polymerase, Drug Discovery, Escherichia coli, medicine, Enzyme Inhibitors, Molecular Biology, Polymerase, Antibacterial agent, chemistry.chemical_classification, Molecular Structure, biology, Organic Chemistry, DNA-Directed RNA Polymerases, Anti-Bacterial Agents, Enzyme, chemistry, Myxopyronin, biology.protein, Molecular Medicine, Antibacterial activity
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2Isatoribine, an agonist of TLR7, reduces plasma virus concentration in chronic hepatitis C infection
المؤلفون: Lisa A Bauman, Eckart Schott, Bradley M. Kerr, Yves Horsmans, Tobias Mueller, Kevin R. Steffy, Averett Devron R, Simon P. Fletcher, Jean-Pierre Desager, Thomas Berg
المصدر: Hepatology. 42:724-731
مصطلحات موضوعية: Agonist, medicine.drug_class, Hepacivirus, Hepatitis C virus, Receptors, Cell Surface, medicine.disease_cause, Antiviral Agents, Virus, Immune system, medicine, Humans, Membrane Glycoproteins, Dose-Response Relationship, Drug, Guanosine, Hepatology, biology, Toll-Like Receptors, Hepatitis C, Hepatitis C, Chronic, Viral Load, biology.organism_classification, medicine.disease, Gene Expression Regulation, Toll-Like Receptor 7, Immunology, RNA, Viral, Viral disease, Viral load
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3
المؤلفون: Chih-Ming Chen, Sharon E. Schoen, Kevin R. Steffy
المصدر: Journal of General Virology. 76:1069-1072
مصطلحات موضوعية: Genes, Viral, Herpesvirus 2, Human, viruses, medicine.medical_treatment, Molecular Sequence Data, Biology, medicine.disease_cause, Viral Proteins, Virology, Endopeptidases, medicine, Humans, Amino Acid Sequence, Gene, Genetics, chemistry.chemical_classification, Protease, Base Sequence, Sequence Homology, Amino Acid, Nucleic acid sequence, Amino acid, Open reading frame, Herpes simplex virus, Capsid, chemistry, DNA, Viral, Nucleic acid
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::874c57d1df611c8328c053a9882d11d5
https://doi.org/10.1099/0022-1317-76-4-1069 -
4
المؤلفون: Stephen E. Webber, Virginia N. Banh, Erik J. Rueden, Wei Li, Gregory J. Haley, Darian M. Bartkowski, Clark David Louis, Tingmin Wang, John S Ng, Mark R Herbert, Bradley M. Kerr, Leonid I Kirkovsky, Joseph R. Lennox, Alan X. Xiang, Averett Devron R, Simon P. Fletcher, Kevin R. Steffy, Lisa A Bauman
المصدر: Nucleosides, nucleotidesnucleic acids. 26(6-7)
مصطلحات موضوعية: Agonist, medicine.drug_class, Hepatitis C virus, Administration, Oral, Pyrimidinones, Pharmacology, medicine.disease_cause, Biochemistry, Antiviral Agents, Genetics, medicine, Humans, Prodrugs, Receptor, Toll-like receptor, Guanosine, Chemistry, General Medicine, Hepatitis C, Prodrug, medicine.disease, Small molecule, Toll-Like Receptor 7, Drug Design, Molecular Medicine, Nucleoside
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5
المؤلفون: Akhteruzzaman Molla, Robert J Carrick, Minghua Sun, William E Kohlbrenner, Kent D. Stewart, Krueger Allan C, Chen Zhao, Warren M. Kati, K. C. Marsh, Dale J. Kempf, Kevin R. Steffy, Clarence J. Maring, Anita J Kempf-Grote, Yibo Xu, W. Graeme Laver, Vincent S. Stoll, Darold L. Madigan, Debra Montgomery, Yu-Gui Gu, Hing L. Sham
المصدر: Journal of medicinal chemistry. 48(12)
مصطلحات موضوعية: Models, Molecular, Pyrrolidines, Stereochemistry, Biological Availability, Neuraminidase, Stereoisomerism, Crystallography, X-Ray, Chemical synthesis, Pyrrolidine, Hydrophobic effect, chemistry.chemical_compound, Structure-Activity Relationship, Drug Discovery, Structure–activity relationship, Animals, Binding Sites, biology, Hydrogen bond, Active site, Rats, Influenza B virus, chemistry, Influenza A virus, biology.protein, Molecular Medicine, Hydrophobic and Hydrophilic Interactions
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6
المؤلفون: Teresa I. Ng, William E. Kohlbrenner, Akhteruzzaman Molla, Kent D. Stewart, Yan Shi, Debra Montgomery, Kevin R. Steffy, Robert J Carrick, Vincent S. Stoll, Warren M. Kati, Clarence J. Maring, Dale J. Kempf, Nanette Gusick
المصدر: Journal of virology. 76(11)
مصطلحات موضوعية: Oseltamivir, Pyrrolidines, medicine.drug_class, viruses, Immunology, Hemagglutinin (influenza), Neuraminidase, Hemagglutinin Glycoproteins, Influenza Virus, medicine.disease_cause, Microbiology, Antiviral Agents, Guanidines, Virus, Cell Line, chemistry.chemical_compound, Zanamivir, Dogs, Serial passage, Virology, Acetamides, Drug Resistance, Viral, Vaccines and Antiviral Agents, medicine, Influenza A virus, Animals, Humans, Enzyme Inhibitors, Pyrans, biology, Neuraminidase inhibitor, Genetic Variation, Phenotype, chemistry, Mutagenesis, Insect Science, biology.protein, Sialic Acids, medicine.drug
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3c11c6a828d575f1dbc65fecddbc1ef
https://pubmed.ncbi.nlm.nih.gov/11991966 -
7
المؤلفون: Kevin R. Steffy, Dale J. Kempf, Akhteruzzaman Molla, Debra Montgomery, Robert J Carrick, Warren M. Kati, Keith F. McDaniel, Frederick G. Hayden, William E. Kohlbrenner, Clarence J. Maring, Larisa V. Gubareva
مصطلحات موضوعية: Oseltamivir, Pyrrolidines, viruses, Orthomyxoviridae, Neuraminidase, Viral Plaque Assay, medicine.disease_cause, Virus Replication, Antiviral Agents, Virus, Microbiology, Cell Line, chemistry.chemical_compound, Zanamivir, Dogs, Acetamides, medicine, Influenza A virus, Animals, Pharmacology (medical), Enzyme Inhibitors, Pharmacology, biology, virus diseases, biology.organism_classification, Virology, respiratory tract diseases, Influenza B virus, Kinetics, Infectious Diseases, chemistry, Viral replication, Enzyme inhibitor, biology.protein, Algorithms, medicine.drug
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f526c4b36090030e3aaf5593a57375b
https://europepmc.org/articles/PMC127111/ -
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المؤلفون: Kevin R. Steffy, Manjiri Sethna, Jerry P. Weir
المصدر: Gene. 89(2)
مصطلحات موضوعية: viruses, Genetic Vectors, Molecular Sequence Data, Restriction Mapping, Gene Expression, Biology, medicine.disease_cause, Thymidine Kinase, Virus, Plasmid, Genetics, medicine, Multiple cloning site, Simplexvirus, Promoter Regions, Genetic, Gene, Terminator Regions, Genetic, Base Sequence, Promoter, General Medicine, Cell Transformation, Viral, beta-Galactosidase, Virology, Molecular biology, Herpes simplex virus, Thymidine kinase, DNA Transposable Elements, Homologous recombination