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1دورية أكاديمية
المؤلفون: Warfield, Kelly L, Plummer, Emily M, Sayce, Andrew C, Alonzi, Dominic S, Tang, William, Tyrrell, Beatrice E, Hill, Michelle L, Caputo, Alessandro T, Killingbeck, Sarah S, Beatty, P Robert, Harris, Eva, Iwaki, Ren, Kinami, Kyoko, Ide, Daisuke, Kiappes, JL, Kato, Atsushi, Buck, Michael D, King, Kevin, Eddy, William, Khaliq, Mansoora, Sampath, Aruna, Treston, Anthony M, Dwek, Raymond A, Enterlein, Sven G, Miller, Joanna L, Zitzmann, Nicole, Ramstedt, Urban, Shresta, Sujan
مصطلحات موضوعية: Rare Diseases, Vaccine Related, Infectious Diseases, Prevention, Biodefense, Emerging Infectious Diseases, Biotechnology, Vector-Borne Diseases, Orphan Drug, Infection, Good Health and Well Being, 1-Deoxynojirimycin, Animals, Antibodies, Viral, Antibody-Dependent Enhancement, Antiviral Agents, Cells, Cultured, Chlorocebus aethiops, Clinical Trials as Topic, Dengue Virus, Disease Models, Animal, Drugs, Investigational, Endoplasmic Reticulum, Glycoside Hydrolase Inhibitors, Humans, Inhibitory Concentration 50, Mice, Monocytes, Receptors, Interferon, Serogroup, Severe Dengue, Vero Cells, alpha-Glucosidases, Iminosugar, UV-4B, Dengue, Antibody-dependent enhancement, Antiviral, Glucosidase, Microbiology, Medical Microbiology, Pharmacology and Pharmaceutical Sciences, Virology
وصف الملف: application/pdf
URL الوصول: https://escholarship.org/uc/item/03t563th
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المؤلفون: Warfield, K, Alonzi, DS, Hill, JC, Caputo, AT, Roversi, P, Kiappes, JL, Sheets, N, Duchars, M, Dwek, RA, Biggins, J, Barnard, D, Shresta, S, Treston, A, Zitzmann, N
URL الوصول: https://explore.openaire.eu/search/publication?articleId=od______1064::2cf222b961a619947717bdf37704e778
https://doi.org/10.1021/acs.jmedchem.0c00067 -
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المؤلفون: Caputo, AT, Alonzi, DS, Kiappes, JL, Struwe, WB, Cross, A, Basu, S, Darlot, B, Roversi, P, Zitzmann, N, Hilgenfeld, R, Vasudevan, S
المصدر: Advances in Experimental Medicine and Biology ISBN: 9789811087264
مصطلحات موضوعية: 0301 basic medicine, chemistry.chemical_classification, 030102 biochemistry & molecular biology, Endoplasmic reticulum, Iminosugar, 03 medical and health sciences, Broad spectrum, 030104 developmental biology, Enzyme, chemistry, Catalytic cycle, Biochemistry, Glycoprotein, Estrogen receptor alpha, Alpha-glucosidase II
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aae41350564135672a876eafd620ca96
http://ora.ox.ac.uk/objects/uuid: -
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المؤلفون: Sayce, AC, Alonzi, DS, Killingbeck, SS, Tyrrell, BE, Hill, ML, Caputo, AT, Iwaki, R, Kinami, K, Ide, D, Kiappes, JL, Beatty, PR, Kato, A, Harris, E, Dwek, RA, Miller, JL, Zitzmann, N
المصدر: PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Vol 10, Iss 3, p e0004524 (2016)مصطلحات موضوعية: Models, Molecular, lcsh:Arctic medicine. Tropical medicine, lcsh:RC955-962, Glycobiology, Mouse Models, Endoplasmic Reticulum, Research and Analysis Methods, Biochemistry, Microbiology, Antiviral Agents, Model Organisms, Stereochemistry, Animals, Humans, Animal Models of Disease, Enzyme Inhibitors, Cells, Cultured, Virus Release, Glycoproteins, Secretory Pathway, Molecular Structure, lcsh:Public aspects of medicine, Macrophages, Indolizines, Biology and Life Sciences, lcsh:RA1-1270, alpha-Glucosidases, Cell Biology, Animal Models, Cell Cultures, Dengue Virus, Imino Sugars, Animal Models of Infection, Chemistry, Cell Processes, Physical Sciences, Enzymology, Animal Studies, Biological Cultures, Glycolipids, Cellular Structures and Organelles, Research Article
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6دورية أكاديمية
المؤلفون: Boby ML; Pharmacology Graduate Program, Weill Cornell Graduate School of Medical Sciences, New York, NY 10065, USA.; Program in Chemical Biology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.; Program in Computational and Systems Biology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Fearon D; Diamond Light Source Ltd., Harwell Science and Innovation Campus, Didcot, UK.; Research Complex at Harwell, Harwell Science and Innovation Campus, Didcot, UK., Ferla M; Oxford Biomedical Research Centre, National Institute for Health Research, University of Oxford, Oxford, UK., Filep M; Department of Chemical and Structural Biology, The Weizmann Institute of Science, Rehovot, Israel., Koekemoer L; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Structural Genomics Consortium, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Robinson MC; PostEra Inc., Cambridge, MA 02142, USA., Chodera JD; Program in Computational and Systems Biology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Lee AA; PostEra Inc., Cambridge, MA 02142, USA., London N; Department of Chemical and Structural Biology, The Weizmann Institute of Science, Rehovot, Israel., von Delft A; Oxford Biomedical Research Centre, National Institute for Health Research, University of Oxford, Oxford, UK.; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Structural Genomics Consortium, Nuffield Department of Medicine, University of Oxford, Oxford, UK., von Delft F; Diamond Light Source Ltd., Harwell Science and Innovation Campus, Didcot, UK.; Research Complex at Harwell, Harwell Science and Innovation Campus, Didcot, UK.; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Structural Genomics Consortium, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Department of Biochemistry, University of Johannesburg, Auckland Park, Johannesburg 2006, South Africa., Achdout H; Israel Institute for Biological Research, Department of Infectious Diseases, Ness-Ziona, Israel., Aimon A; Diamond Light Source Ltd, Harwell Science and Innovation Campus, Didcot, OX11 0DE, UK.; Research Complex at Harwell, Harwell Science and Innovation Campus, Didcot OX11 0FA, UK., Alonzi DS; University of Oxford, Department of Biochemistry, Oxford Glycobiology Institute, South Parks Road, Oxford OX1 3QU, UK., Arbon R; Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, Computational and Systems Biology Program, New York, NY 10065, USA., Aschenbrenner JC; Diamond Light Source Ltd, Harwell Science and Innovation Campus, Didcot, OX11 0DE, UK.; Research Complex at Harwell, Harwell Science and Innovation Campus, Didcot OX11 0FA, UK., Balcomb BH; Diamond Light Source Ltd, Harwell Science and Innovation Campus, Didcot, OX11 0DE, UK.; Research Complex at Harwell, Harwell Science and Innovation Campus, Didcot OX11 0FA, UK., Bar-David E; Israel Institute for Biological Research, Department of Infectious Diseases, Ness-Ziona, Israel., Barr H; The Weizmann Institute of Science, Wohl Institute for Drug Discovery of the Nancy and Stephen Grand Israel National Center for Personalized Medicine, Rehovot, 7610001, Israel., Ben-Shmuel A; Israel Institute for Biological Research, Department of Infectious Diseases, Ness-Ziona, Israel., Bennett J; University of Oxford, Nuffield Department of Medicine, Centre for Medicines Discovery, Oxford, OX3 7DQ, UK.; University of Oxford, Nuffield Department of Medicine, Target Discovery Institute, Oxford, OX3 7FZ, UK., Bilenko VA; Enamine Ltd, Kyiv, 02094, Ukraine.; Taras Shevchenko National University of Kyiv, Kyiv, 01601, Ukraine., Borden B; Folding@Home Consortium., Boulet P; Drugs for Neglected Diseases Initiative (DNDi), Geneva, 1202, Switzerland., Bowman GR; University of Pennsylvania, Departments of Biochemistry and Biophysics and Bioengineering, Philadelphia, PA 19083, USA., Brewitz L; University of Oxford, Department of Chemistry, Chemistry Research Laboratory, Oxford, OX1 3TA, UK., Brun J; University of Oxford, Department of Biochemistry, Oxford Glycobiology Institute, South Parks Road, Oxford OX1 3QU, UK., Bvnbs S; Sai Life Sciences Limited, ICICI Knowledge Park, Shameerpet, Hyderabad 500 078, Telangana, India., Calmiano M; UCB, Slough, SL1 3WE, UK., Carbery A; Diamond Light Source Ltd, Harwell Science and Innovation Campus, Didcot, OX11 0DE, UK.; University of Oxford, Department of Statistics, Oxford OX1 3LB, UK., Carney DW; Takeda Development Center Americas, Inc., San Diego, CA 92121, USA., Cattermole E; University of Oxford, Department of Biochemistry, Oxford Glycobiology Institute, South Parks Road, Oxford OX1 3QU, UK., Chang E; Takeda Development Center Americas, Inc., San Diego, CA 92121, USA., Chernyshenko E; Enamine Ltd, Kyiv, 02094, Ukraine., Clyde A; Argonne National Lab, Lemont, IL 60439, USA., Coffland JE; Cauldron Development Oy, Helsinki, 00140, Finland., Cohen G; The Weizmann Institute of Science, Wohl Institute for Drug Discovery of the Nancy and Stephen Grand Israel National Center for Personalized Medicine, Rehovot, 7610001, Israel., Cole JC; Cambridge Crystallographic Data Centre, Cambridge, CB2 1EZ, UK., Contini A; University of Milan, Department of General and Organic Chemistry, Milan, 20133, Italy., Cox L; Life Compass Consulting Ltd, Macclesfield, SK10 5UE, UK., Croll TI; The University of Cambridge, Cambridge Institute for Medical Research, Department of Haematology, Cambridge CB2 0XY, UK.; Present address: Altos Labs, BioML group, Great Abington, CB21 6GP., Cvitkovic M; PostEra Inc., Cambridge, MA, 02142, USA., De Jonghe S; KU Leuven, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, Leuven, Belgium., Dias A; Diamond Light Source Ltd, Harwell Science and Innovation Campus, Didcot, OX11 0DE, UK.; Research Complex at Harwell, Harwell Science and Innovation Campus, Didcot OX11 0FA, UK., Donckers K; KU Leuven, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, Leuven, Belgium., Dotson DL; Datryllic LLC, Phoenix AZ, 85003, USA., Douangamath A; Diamond Light Source Ltd, Harwell Science and Innovation Campus, Didcot, OX11 0DE, UK.; Research Complex at Harwell, Harwell Science and Innovation Campus, Didcot OX11 0FA, UK., Duberstein S; The Weizmann Institute of Science, Wohl Institute for Drug Discovery of the Nancy and Stephen Grand Israel National Center for Personalized Medicine, Rehovot, 7610001, Israel., Dudgeon T; Informatics Matters Ltd, Bicester, OX26 6JU, UK., Dunnett LE; Diamond Light Source Ltd, Harwell Science and Innovation Campus, Didcot, OX11 0DE, UK.; Research Complex at Harwell, Harwell Science and Innovation Campus, Didcot OX11 0FA, UK., Eastman P; Stanford University, Department of Chemistry, Stanford, CA 94305, USA., Erez N; Israel Institute for Biological Research, Department of Infectious Diseases, Ness-Ziona, Israel., Eyermann CJ; Northeastern University, Department of Chemistry and Chemical Biology, Boston MA 02115, USA., Fairhead M; University of Oxford, Nuffield Department of Medicine, Centre for Medicines Discovery, Oxford, OX3 7DQ, UK., Fate G; Thames Pharma Partners LLC, Mystic, CT 06355, USA., Fedorov O; University of Oxford, Nuffield Department of Medicine, Centre for Medicines Discovery, Oxford, OX3 7DQ, UK.; University of Oxford, Nuffield Department of Medicine, Target Discovery Institute, Oxford, OX3 7FZ, UK., Fernandes RS; University of Sao Paulo, Sao Carlos Institute of Physics, Sao Carlos, 13563-120, Brazil., Ferrins L; Northeastern University, Department of Chemistry and Chemical Biology, Boston MA 02115, USA., Foster R; University of Leeds, School of Chemistry, Leeds, LS2 9JT, UK., Foster H; University of Leeds, School of Chemistry, Leeds, LS2 9JT, UK.; Present address: Exscientia, Oxford Science Park, Oxford, OX4 4GE, UK., Fraisse L; Drugs for Neglected Diseases Initiative (DNDi), Geneva, 1202, Switzerland., Gabizon R; The Weizmann Institute of Science, Department of Chemical and Structural Biology, Rehovot, 7610001, Israel., García-Sastre A; Icahn School of Medicine at Mount Sinai, Department of Microbiology, New York, NY 10029, USA.; Icahn School of Medicine at Mount Sinai, Global Health and Emerging Pathogens Institute, New York, NY 10029, USA.; Icahn School of Medicine at Mount Sinai, Department of Medicine, Division of Infectious Diseases, New York, NY 10029, USA.; Icahn School of Medicine at Mount Sinai, The Tisch Cancer Institute, New York, NY 10029, USA.; Icahn School of Medicine at Mount Sinai, Department of Pathology, Molecular and Cell-Based Medicine, New York, NY 10029, USA., Gawriljuk VO; University of Sao Paulo, Sao Carlos Institute of Physics, Sao Carlos, 13563-120, Brazil.; Present address: University of Groningen, Groningen Research Institute of Pharmacy, Department of Drug Design, Groningen, 9700 AV, Netherlands., Gehrtz P; The Weizmann Institute of Science, Department of Chemical and Structural Biology, Rehovot, 7610001, Israel.; Present address: Merck Healthcare KGaA, Darmstadt, 64293, Germany., Gileadi C; University of Oxford, Nuffield Department of Medicine, Centre for Medicines Discovery, Oxford, OX3 7DQ, UK., Giroud C; University of Oxford, Nuffield Department of Medicine, Centre for Medicines Discovery, Oxford, OX3 7DQ, UK.; University of Oxford, Nuffield Department of Medicine, Target Discovery Institute, Oxford, OX3 7FZ, UK., Glass WG; Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, Computational and Systems Biology Program, New York, NY 10065, USA.; Present address: Exscientia, Oxford Science Park, Oxford, OX4 4GE, UK., Glen RC; University of Cambridge, Department of Chemistry, Cambridge, CB2 1EW, UK., Glinert I; Israel Institute for Biological Research, Department of Infectious Diseases, Ness-Ziona, Israel., Godoy AS; University of Sao Paulo, Sao Carlos Institute of Physics, Sao Carlos, 13563-120, Brazil., Gorichko M; Taras Shevchenko National University of Kyiv, Kyiv, 01601, Ukraine., Gorrie-Stone T; Diamond Light Source Ltd, Harwell Science and Innovation Campus, Didcot, OX11 0DE, UK.; Research Complex at Harwell, Harwell Science and Innovation Campus, Didcot OX11 0FA, UK., Griffen EJ; MedChemica Ltd, Macclesfield, Cheshire. SK11 6PU UK., Haneef A; Illinois Institute of Technology, Department of Biology, Chicago IL 60616 USA., Hassell Hart S; University of Sussex, Department of Chemistry, School of Life Sciences, Brighton, East Sussex, BN1 9QJ, UK., Heer J; Syngene International Limited, Headington, Oxford, OX3 7BZ, UK., Henry M; Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, Computational and Systems Biology Program, New York, NY 10065, USA., Hill M; University of Oxford, Department of Biochemistry, Oxford Glycobiology Institute, South Parks Road, Oxford OX1 3QU, UK.; Present address: Sir William Dunn School of Pathology, Oxford. OX1 3RE, UK., Horrell S; Diamond Light Source Ltd, Harwell Science and Innovation Campus, Didcot, OX11 0DE, UK.; Research Complex at Harwell, Harwell Science and Innovation Campus, Didcot OX11 0FA, UK., Huang QYJ; University of Massachusetts, Chan Medical School, Department of Biochemistry and Molecular Biotechnology, Worcester MA 01655, USA., Huliak VD; Enamine Ltd, Kyiv, 02094, Ukraine., Hurley MFD; Temple University, Department of Chemistry, Philadelphia, PA 19122, USA., Israely T; Israel Institute for Biological Research, Department of Infectious Diseases, Ness-Ziona, Israel., Jajack A; PostEra Inc., Cambridge, MA, 02142, USA., Jansen J; RWTH Aachen University, Institute of Experimental Medicine and Systems Biology, Aachen, 52074, Germany., Jnoff E; UCB, Chemin du Foriest, 1420 Braine-l'Alleud, Belgium., Jochmans D; KU Leuven, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, Leuven, Belgium., John T; University of Oxford, Department of Chemistry, Chemistry Research Laboratory, Oxford, OX1 3TA, UK.; Present address: AMSilk, Neuried, 82061, Germany., Kaminow B; Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, Computational and Systems Biology Program, New York, NY 10065, USA.; Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, Tri-Institutional Program in Computational Biology and Medicine, New York, NY 10065, USA., Kang L; Illinois Institute of Technology, Department of Applied Mathematics, Chicago IL 60616 USA., Kantsadi AL; University of Oxford, Department of Biochemistry, Oxford Glycobiology Institute, South Parks Road, Oxford OX1 3QU, UK.; University of Thessaly, Department of Biochemistry and Biotechnology, Larissa, 415 00, Greece., Kenny PW; Berwick-on-Sea, North Coast Road, Blanchisseuse, Saint George, Trinidad and Tobago., Kiappes JL; University of Oxford, Department of Biochemistry, Oxford Glycobiology Institute, South Parks Road, Oxford OX1 3QU, UK.; Present address: University College of London, Department of Chemistry, London WC1H 0AJ, UK., Kinakh SO; Enamine Ltd, Kyiv, 02094, Ukraine., Kovar B; M2M solutions s.r.o. Žilina, 010 01, Slovakia., Krojer T; University of Oxford, Nuffield Department of Medicine, Centre for Medicines Discovery, Oxford, OX3 7DQ, UK.; MAX IV Laboratory, Fotongatan 2, 224 84 Lund, Sweden., La VNT; Illinois Institute of Technology, Department of Biology, Chicago IL 60616 USA., Laghnimi-Hahn S; Drugs for Neglected Diseases Initiative (DNDi), Geneva, 1202, Switzerland., Lefker BA; Thames Pharma Partners LLC, Mystic, CT 06355, USA., Levy H; Israel Institute for Biological Research, Department of Infectious Diseases, Ness-Ziona, Israel., Lithgo RM; Diamond Light Source Ltd, Harwell Science and Innovation Campus, Didcot, OX11 0DE, UK.; Research Complex at Harwell, Harwell Science and Innovation Campus, Didcot OX11 0FA, UK., Logvinenko IG; Enamine Ltd, Kyiv, 02094, Ukraine., Lukacik P; Diamond Light Source Ltd, Harwell Science and Innovation Campus, Didcot, OX11 0DE, UK.; Research Complex at Harwell, Harwell Science and Innovation Campus, Didcot OX11 0FA, UK., Macdonald HB; Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, Computational and Systems Biology Program, New York, NY 10065, USA.; Present address: Charm Therapeutics, London, N1C 4AG, UK., MacLean EM; University of Oxford, Nuffield Department of Medicine, Centre for Medicines Discovery, Oxford, OX3 7DQ, UK., Makower LL; University of Oxford, Department of Biochemistry, Oxford Glycobiology Institute, South Parks Road, Oxford OX1 3QU, UK., Malla TR; University of Oxford, Nuffield Department of Medicine, Centre for Medicines Discovery, Oxford, OX3 7DQ, UK., Marples PG; Diamond Light Source Ltd, Harwell Science and Innovation Campus, Didcot, OX11 0DE, UK.; Research Complex at Harwell, Harwell Science and Innovation Campus, Didcot OX11 0FA, UK., Matviiuk T; Enamine Ltd, Kyiv, 02094, Ukraine., McCorkindale W; Present address: Charm Therapeutics, London, N1C 4AG, UK.; University of Cambridge, Cavendish Laboratory, Cambridge, CB3 0HE UK., McGovern BL; Icahn School of Medicine at Mount Sinai, Department of Microbiology, New York, NY 10029, USA.; Icahn School of Medicine at Mount Sinai, Global Health and Emerging Pathogens Institute, New York, NY 10029, USA., Melamed S; Israel Institute for Biological Research, Department of Infectious Diseases, Ness-Ziona, Israel., Melnykov KP; Enamine Ltd, Kyiv, 02094, Ukraine.; Taras Shevchenko National University of Kyiv, Kyiv, 01601, Ukraine., Michurin O; Enamine Ltd, Kyiv, 02094, Ukraine., Miesen P; Radboud University Medical Center, Department of Medical Microbiology, Radboud Institute for Molecular Life Sciences, Nijmegen, 6525 GA, Netherlands., Mikolajek H; Diamond Light Source Ltd, Harwell Science and Innovation Campus, Didcot, OX11 0DE, UK.; Research Complex at Harwell, Harwell Science and Innovation Campus, Didcot OX11 0FA, UK., Milne BF; University of Aberdeen, Department of Chemistry, Old Aberdeen, AB24 3UE Scotland, UK.; University of Coimbra, CFisUC, Department of Physics, Coimbra, 3004-516, Portugal., Minh D; Illinois Institute of Technology, Department of Chemistry, Chicago IL 60616 USA., Morris A; PostEra Inc., Cambridge, MA, 02142, USA., Morris GM; University of Oxford, Department of Statistics, Oxford OX1 3LB, UK., Morwitzer MJ; University of Nebraska Medical Centre, Dept of Pathology and Microbiology, Omaha, NE 68198-5900, USA., Moustakas D; Relay Therapeutics, Cambridge, MA 02139, USA., Mowbray CE; Drugs for Neglected Diseases Initiative (DNDi), Geneva, 1202, Switzerland., Nakamura AM; University of Sao Paulo, Sao Carlos Institute of Physics, Sao Carlos, 13563-120, Brazil.; Present address: Instituto Butantan, Sao Paulo, 05503-900, Brazil., Neto JB; Diamond Light Source Ltd, Harwell Science and Innovation Campus, Didcot, OX11 0DE, UK.; Research Complex at Harwell, Harwell Science and Innovation Campus, Didcot OX11 0FA, UK., Neyts J; KU Leuven, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, Leuven, Belgium., Nguyen L; PostEra Inc., Cambridge, MA, 02142, USA., Noske GD; University of Sao Paulo, Sao Carlos Institute of Physics, Sao Carlos, 13563-120, Brazil., Oleinikovas V; UCB, Slough, SL1 3WE, UK.; Present address: Monte Rosa Therapeutics, Basel, CH 4057, Switzerland., Oliva G; University of Sao Paulo, Sao Carlos Institute of Physics, Sao Carlos, 13563-120, Brazil., Overheul GJ; Radboud University Medical Center, Department of Medical Microbiology, Radboud Institute for Molecular Life Sciences, Nijmegen, 6525 GA, Netherlands., Owen CD; Diamond Light Source Ltd, Harwell Science and Innovation Campus, Didcot, OX11 0DE, UK.; Research Complex at Harwell, Harwell Science and Innovation Campus, Didcot OX11 0FA, UK., Pai R; PostEra Inc., Cambridge, MA, 02142, USA., Pan J; PostEra Inc., Cambridge, MA, 02142, USA., Paran N; Israel Institute for Biological Research, Department of Infectious Diseases, Ness-Ziona, Israel., Payne AM; Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, Computational and Systems Biology Program, New York, NY 10065, USA.; Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, Tri-Institutional Program in Computational Biology and Medicine, New York, NY 10065, USA., Perry B; Drugs for Neglected Diseases Initiative (DNDi), Geneva, 1202, Switzerland.; Present address: Medicxi, Geneva, 1204, Switzerland., Pingle M; Sai Life Sciences Limited, ICICI Knowledge Park, Shameerpet, Hyderabad 500 078, Telangana, India., Pinjari J; Sai Life Sciences Limited, ICICI Knowledge Park, Shameerpet, Hyderabad 500 078, Telangana, India.; Present address: Sun Pharma Advanced Research Company (SPARC), Baroda, India., Politi B; Israel Institute for Biological Research, Department of Infectious Diseases, Ness-Ziona, Israel., Powell A; Diamond Light Source Ltd, Harwell Science and Innovation Campus, Didcot, OX11 0DE, UK.; Research Complex at Harwell, Harwell Science and Innovation Campus, Didcot OX11 0FA, UK., Pšenák V; M2M solutions s.r.o. Žilina, 010 01, Slovakia., Pulido I; Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, Computational and Systems Biology Program, New York, NY 10065, USA., Puni R; Israel Institute for Biological Research, Department of Infectious Diseases, Ness-Ziona, Israel., Rangel VL; University of São Paulo, Ribeirão Preto School of Pharmaceutical Sciences, Ribeirão Preto - SP/CEP 14040-903, Brazil.; Present address: Evotec (UK) Ltd, Milton Park, Abingdon, Oxfordshire, OX14 4RZ, UK., Reddi RN; The Weizmann Institute of Science, Department of Chemical and Structural Biology, Rehovot, 7610001, Israel., Rees P; Compass Bussiness Partners Ltd, Southcliffe, Bucks, SL9 0PD, UK., Reid SP; University of Nebraska Medical Centre, Dept of Pathology and Microbiology, Omaha, NE 68198-5900, USA., Reid L; MedChemica Ltd, Macclesfield, Cheshire. SK11 6PU UK., Resnick E; The Weizmann Institute of Science, Department of Chemical and Structural Biology, Rehovot, 7610001, Israel., Ripka EG; PostEra Inc., Cambridge, MA, 02142, USA., Robinson RP; Thames Pharma Partners LLC, Mystic, CT 06355, USA., Rodriguez-Guerra J; Charité - Universitätsmedizin Berlin, In silico Toxicology and Structural Bioinformatics, Berlin, 10117, Germany., Rosales R; Icahn School of Medicine at Mount Sinai, Department of Microbiology, New York, NY 10029, USA.; Icahn School of Medicine at Mount Sinai, Global Health and Emerging Pathogens Institute, New York, NY 10029, USA., Rufa DA; Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, Computational and Systems Biology Program, New York, NY 10065, USA.; Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, Tri-Institutional Program in Computational Biology and Medicine, New York, NY 10065, USA., Saar K; University of Cambridge, Cavendish Laboratory, Cambridge, CB3 0HE UK., Saikatendu KS; Takeda Development Center Americas, Inc., San Diego, CA 92121, USA., Salah E; University of Oxford, Department of Chemistry, Chemistry Research Laboratory, Oxford, OX1 3TA, UK., Schaller D; Charité - Universitätsmedizin Berlin, In silico Toxicology and Structural Bioinformatics, Berlin, 10117, Germany., Scheen J; Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, Computational and Systems Biology Program, New York, NY 10065, USA., Schiffer CA; University of Massachusetts, Chan Medical School, Department of Biochemistry and Molecular Biotechnology, Worcester MA 01655, USA., Schofield CJ; University of Oxford, Department of Chemistry, Chemistry Research Laboratory, Oxford, OX1 3TA, UK., Shafeev M; Enamine Ltd, Kyiv, 02094, Ukraine., Shaikh A; Sai Life Sciences Limited, ICICI Knowledge Park, Shameerpet, Hyderabad 500 078, Telangana, India., Shaqra AM; University of Massachusetts, Chan Medical School, Department of Biochemistry and Molecular Biotechnology, Worcester MA 01655, USA., Shi J; UCB, Chemin du Foriest, 1420 Braine-l'Alleud, Belgium.; Present address: Eli Lilly and Company, San Diego, CA 92121, USA., Shurrush K; The Weizmann Institute of Science, Wohl Institute for Drug Discovery of the Nancy and Stephen Grand Israel National Center for Personalized Medicine, Rehovot, 7610001, Israel., Singh S; Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, Computational and Systems Biology Program, New York, NY 10065, USA., Sittner A; Israel Institute for Biological Research, Department of Infectious Diseases, Ness-Ziona, Israel., Sjö P; Drugs for Neglected Diseases Initiative (DNDi), Geneva, 1202, Switzerland., Skyner R; Diamond Light Source Ltd, Harwell Science and Innovation Campus, Didcot, OX11 0DE, UK.; Research Complex at Harwell, Harwell Science and Innovation Campus, Didcot OX11 0FA, UK., Smalley A; UCB, Slough, SL1 3WE, UK., Smeets B; Radboud University Medical Center, Department of pathology, Radboud Institute for Molecular Life Sciences, Nijmegen, 6525 GA, Netherlands., Smilova MD; University of Oxford, Nuffield Department of Medicine, Centre for Medicines Discovery, Oxford, OX3 7DQ, UK., Solmesky LJ; The Weizmann Institute of Science, Wohl Institute for Drug Discovery of the Nancy and Stephen Grand Israel National Center for Personalized Medicine, Rehovot, 7610001, Israel., Spencer J; University of Sussex, Department of Chemistry, School of Life Sciences, Brighton, East Sussex, BN1 9QJ, UK., Strain-Damerell C; Diamond Light Source Ltd, Harwell Science and Innovation Campus, Didcot, OX11 0DE, UK.; Research Complex at Harwell, Harwell Science and Innovation Campus, Didcot OX11 0FA, UK., Swamy V; Sai Life Sciences Limited, ICICI Knowledge Park, Shameerpet, Hyderabad 500 078, Telangana, India.; Present address: TCG Life Sciences, Pune, India., Tamir H; Israel Institute for Biological Research, Department of Infectious Diseases, Ness-Ziona, Israel., Taylor JC; University of Oxford, Nuffield Department of Medicine, Wellcome Centre for Human Genetics, Oxford OX3 7BN, UK., Tennant RE; Lhasa Limited, Leeds, LS11 5PS, UK., Thompson W; Diamond Light Source Ltd, Harwell Science and Innovation Campus, Didcot, OX11 0DE, UK.; Research Complex at Harwell, Harwell Science and Innovation Campus, Didcot OX11 0FA, UK., Thompson A; University of Oxford, Nuffield Department of Medicine, Centre for Medicines Discovery, Oxford, OX3 7DQ, UK.; Present address: Walter and Eliza Hall Institute, Parkville 3052, Victoria, Australia., Tomásio S; Collaborative Drug Discovery, Cambridge, CB2 1GE, UK., Tomlinson CWE; Diamond Light Source Ltd, Harwell Science and Innovation Campus, Didcot, OX11 0DE, UK.; Research Complex at Harwell, Harwell Science and Innovation Campus, Didcot OX11 0FA, UK., Tsurupa IS; Enamine Ltd, Kyiv, 02094, Ukraine., Tumber A; University of Oxford, Department of Chemistry, Chemistry Research Laboratory, Oxford, OX1 3TA, UK., Vakonakis I; University of Oxford, Department of Biochemistry, Oxford Glycobiology Institute, South Parks Road, Oxford OX1 3QU, UK.; Present address: Lonza Biologics, Lonza Ltd, Lonzastrasse, CH-3930 Visp, Switzerland., van Rij RP; Radboud University Medical Center, Department of Medical Microbiology, Radboud Institute for Molecular Life Sciences, Nijmegen, 6525 GA, Netherlands., Vangeel L; KU Leuven, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, Leuven, Belgium., Varghese FS; Radboud University Medical Center, Department of Medical Microbiology, Radboud Institute for Molecular Life Sciences, Nijmegen, 6525 GA, Netherlands.; Present address: uniQure Biopharma, Amsterdam, 1105 BP, Netherlands., Vaschetto M; Collaborative Drug Discovery, Cambridge, CB2 1GE, UK., Vitner EB; Israel Institute for Biological Research, Department of Infectious Diseases, Ness-Ziona, Israel., Voelz V; Temple University, Department of Chemistry, Philadelphia, PA 19122, USA., Volkamer A; Charité - Universitätsmedizin Berlin, In silico Toxicology and Structural Bioinformatics, Berlin, 10117, Germany.; Present address: Saarland University, Data Driven Drug Design, Campus - E2.1, 66123 Saarbrücken, Germany., Walsh MA; Diamond Light Source Ltd, Harwell Science and Innovation Campus, Didcot, OX11 0DE, UK.; Research Complex at Harwell, Harwell Science and Innovation Campus, Didcot OX11 0FA, UK., Ward W; Walter Ward Consultancy and Training, Derbyshire, SK22 4AA, UK., Weatherall C; Collaborative Drug Discovery, Burlingame, CA 94010, USA., Weiss S; Israel Institute for Biological Research, Department of Infectious Diseases, Ness-Ziona, Israel., White KM; Icahn School of Medicine at Mount Sinai, Department of Microbiology, New York, NY 10029, USA.; Icahn School of Medicine at Mount Sinai, Global Health and Emerging Pathogens Institute, New York, NY 10029, USA., Wild CF; Diamond Light Source Ltd, Harwell Science and Innovation Campus, Didcot, OX11 0DE, UK.; Research Complex at Harwell, Harwell Science and Innovation Campus, Didcot OX11 0FA, UK., Witt KD; University of Oxford, Nuffield Department of Medicine, Pandemic Sciences Institute, Oxford, Oxon, OX3 7DQ, UK., Wittmann M; Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, Computational and Systems Biology Program, New York, NY 10065, USA., Wright N; University of Oxford, Nuffield Department of Medicine, Centre for Medicines Discovery, Oxford, OX3 7DQ, UK., Yahalom-Ronen Y; Israel Institute for Biological Research, Department of Infectious Diseases, Ness-Ziona, Israel., Yilmaz NK; University of Massachusetts, Chan Medical School, Department of Biochemistry and Molecular Biotechnology, Worcester MA 01655, USA., Zaidmann D; The Weizmann Institute of Science, Department of Chemical and Structural Biology, Rehovot, 7610001, Israel., Zhang I; Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, Computational and Systems Biology Program, New York, NY 10065, USA., Zidane H; The Weizmann Institute of Science, Wohl Institute for Drug Discovery of the Nancy and Stephen Grand Israel National Center for Personalized Medicine, Rehovot, 7610001, Israel., Zitzmann N; University of Oxford, Department of Biochemistry, Oxford Glycobiology Institute, South Parks Road, Oxford OX1 3QU, UK., Zvornicanin SN; University of Massachusetts, Chan Medical School, Department of Biochemistry and Molecular Biotechnology, Worcester MA 01655, USA.
مؤلفون مشاركون: COVID Moonshot Consortium‡
المصدر: Science (New York, N.Y.) [Science] 2023 Nov 10; Vol. 382 (6671), pp. eabo7201. Date of Electronic Publication: 2023 Nov 10.
نوع المنشور: Journal Article
بيانات الدورية: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE
مواضيع طبية MeSH: Coronavirus 3C Proteases*/antagonists & inhibitors , Coronavirus 3C Proteases*/chemistry , SARS-CoV-2* , Drug Discovery* , Coronavirus Protease Inhibitors*/chemical synthesis , Coronavirus Protease Inhibitors*/chemistry , Coronavirus Protease Inhibitors*/pharmacology , COVID-19 Drug Treatment*, Humans ; Molecular Docking Simulation ; Structure-Activity Relationship ; Crystallography, X-Ray
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7دورية أكاديمية
المؤلفون: Guay KP; Department of Biochemistry and Molecular Biology, and Program in Molecular and Cellular Biology, University of Massachusetts, Amherst, MA, USA., Ibba R; Oxford Glycobiology Institute, Department of Biochemistry and Kavli Institute for Nanoscience Discovery, South Parks Road, Oxford OX1 3QU, UK.; Department of Medicine, Surgery and Pharmacy, University of Sassari, Via Muroni 23A, 07100 Sassari, Italy., Kiappes JL; Oxford Glycobiology Institute, Department of Biochemistry and Kavli Institute for Nanoscience Discovery, South Parks Road, Oxford OX1 3QU, UK., Vasiljević S; Oxford Glycobiology Institute, Department of Biochemistry and Kavli Institute for Nanoscience Discovery, South Parks Road, Oxford OX1 3QU, UK., Bonì F; Institute of Biophysics, IBF-CNR Unit of Milano, via Celoria 26, 20133 Milano, Italy., De Benedictis M; Institute of Sciences of Food Production, C.N.R. Unit of Lecce, via Monteroni, 73100 Lecce, Italy., Zeni I; Department of Cellular, Computational and Integrative Biology, University of Trento, Povo, 38123 Trento, Italy., Le Cornu JD; Wellcome Centre for Cell Biology, School of Biological Sciences, University of Edinburgh, Edinburgh, Scotland, United Kingdom., Hensen M; Oxford Glycobiology Institute, Department of Biochemistry and Kavli Institute for Nanoscience Discovery, South Parks Road, Oxford OX1 3QU, UK., Chandran AV; Oxford Glycobiology Institute, Department of Biochemistry and Kavli Institute for Nanoscience Discovery, South Parks Road, Oxford OX1 3QU, UK., Kantsadi AL; Oxford Glycobiology Institute, Department of Biochemistry and Kavli Institute for Nanoscience Discovery, South Parks Road, Oxford OX1 3QU, UK., Caputo AT; Biomedical Manufacturing, Commonwealth Scientific and Industrial Research Organisation, 343 Royal Parade, Parkville, VIC 3052, Australia., Blanco Capurro JI; Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Pab. II (CE1428EHA), Buenos Aires, Argentina.; Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales (IQUIBICEN) CONICET, Ciudad Universitaria, Pab. II (CE1428EHA), Buenos Aires, Argentina., Bayo Y; Department of Biosciences, University of Milano, via Celoria 26, 20133 Milano, Italy., Hill JC; Oxford Glycobiology Institute, Department of Biochemistry and Kavli Institute for Nanoscience Discovery, South Parks Road, Oxford OX1 3QU, UK., Hudson K; Department of Chemistry, University of British Columbia, 2036 Main Mall, Vancouver, BC V6T 1Z1, Canada., Lia A; Oxford Glycobiology Institute, Department of Biochemistry and Kavli Institute for Nanoscience Discovery, South Parks Road, Oxford OX1 3QU, UK.; Institute of Biophysics, IBF-CNR Unit of Milano, via Celoria 26, 20133 Milano, Italy., Brun J; Oxford Glycobiology Institute, Department of Biochemistry and Kavli Institute for Nanoscience Discovery, South Parks Road, Oxford OX1 3QU, UK., Withers SG; Department of Chemistry, University of British Columbia, 2036 Main Mall, Vancouver, BC V6T 1Z1, Canada., Martí M; Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Pab. II (CE1428EHA), Buenos Aires, Argentina.; Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales (IQUIBICEN) CONICET, Ciudad Universitaria, Pab. II (CE1428EHA), Buenos Aires, Argentina., Biasini E; Department of Cellular, Computational and Integrative Biology, University of Trento, Povo, 38123 Trento, Italy.; Dulbecco Telethon Institute, University of Trento, Povo, 38123 Trento, Italy., Santino A; Institute of Sciences of Food Production, C.N.R. Unit of Lecce, via Monteroni, 73100 Lecce, Italy., De Rosa M; Institute of Biophysics, IBF-CNR Unit of Milano, via Celoria 26, 20133 Milano, Italy., Milani M; Institute of Biophysics, IBF-CNR Unit of Milano, via Celoria 26, 20133 Milano, Italy., Modenutti CP; Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Pab. II (CE1428EHA), Buenos Aires, Argentina.; Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales (IQUIBICEN) CONICET, Ciudad Universitaria, Pab. II (CE1428EHA), Buenos Aires, Argentina., Hebert DN; Department of Biochemistry and Molecular Biology, and Program in Molecular and Cellular Biology, University of Massachusetts, Amherst, MA, USA., Zitzmann N; Oxford Glycobiology Institute, Department of Biochemistry and Kavli Institute for Nanoscience Discovery, South Parks Road, Oxford OX1 3QU, UK., Roversi P; Institute of Agricultural Biology and Biotechnology, IBBA-CNR Unit of Milano, via Bassini 15, 20133 Milano, Italy.; Leicester Institute of Chemical and Structural Biology and Department of Molecular and Cell Biology, University of Leicester, Henry Wellcome Building, Lancaster Road, LE1 7HR Leicester, UK.
المصدر: IScience [iScience] 2023 Sep 20; Vol. 26 (10), pp. 107919. Date of Electronic Publication: 2023 Sep 20 (Print Publication: 2023).
نوع المنشور: Journal Article
بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101724038 Publication Model: eCollection Cited Medium: Internet ISSN: 2589-0042 (Electronic) Linking ISSN: 25890042 NLM ISO Abbreviation: iScience Subsets: PubMed not MEDLINE
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8دورية أكاديمية
المؤلفون: Karade SS; University of Maryland Institute for Bioscience and Biotechnology Research, Rockville, Maryland 20850, United States.; Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, Maryland 20742, United States., Hill ML; Oxford Glycobiology Institute, Department of Biochemistry, University of Oxford, Oxford OX1 3QU, U.K., Kiappes JL; Department of Chemistry, University College, London WC1H 0AJ, U.K., Manne R; Sai Life Sciences Ltd., Hyderabad, 500032 Telangana, India., Aakula B; Sai Life Sciences Ltd., Hyderabad, 500032 Telangana, India., Zitzmann N; Oxford Glycobiology Institute, Department of Biochemistry, University of Oxford, Oxford OX1 3QU, U.K., Warfield KL; Emergent BioSolutions, Gaithersburg, Maryland 20879, United States., Treston AM; Emergent BioSolutions, Gaithersburg, Maryland 20879, United States., Mariuzza RA; University of Maryland Institute for Bioscience and Biotechnology Research, Rockville, Maryland 20850, United States.; Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, Maryland 20742, United States.
المصدر: Journal of medicinal chemistry [J Med Chem] 2021 Dec 23; Vol. 64 (24), pp. 18010-18024. Date of Electronic Publication: 2021 Dec 06.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
مواضيع طبية MeSH: Antiviral Agents/*pharmacology , Glycoside Hydrolase Inhibitors/*pharmacology , Imino Sugars/*pharmacology , Inositol/*analogs & derivatives , alpha-Glucosidases/*metabolism, Animals ; Antiviral Agents/chemical synthesis ; Antiviral Agents/metabolism ; Binding Sites ; Chlorocebus aethiops ; Crystallography, X-Ray ; Dengue Virus/drug effects ; Endoplasmic Reticulum/enzymology ; Glycoside Hydrolase Inhibitors/chemical synthesis ; Glycoside Hydrolase Inhibitors/metabolism ; Humans ; Imino Sugars/chemical synthesis ; Imino Sugars/metabolism ; Inositol/chemical synthesis ; Inositol/metabolism ; Inositol/pharmacology ; Mice ; Microbial Sensitivity Tests ; Molecular Docking Simulation ; Protein Binding ; SARS-CoV-2/drug effects ; Vero Cells ; alpha-Glucosidases/chemistry
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9دورية أكاديميةAssessing Antigen Structural Integrity through Glycosylation Analysis of the SARS-CoV-2 Viral Spike.
المؤلفون: Brun J; Oxford Glycobiology Institute, Department of Biochemistry, University of Oxford, Oxford OX1 3QU, United Kingdom., Vasiljevic S; Oxford Glycobiology Institute, Department of Biochemistry, University of Oxford, Oxford OX1 3QU, United Kingdom., Gangadharan B; Oxford Glycobiology Institute, Department of Biochemistry, University of Oxford, Oxford OX1 3QU, United Kingdom., Hensen M; Oxford Glycobiology Institute, Department of Biochemistry, University of Oxford, Oxford OX1 3QU, United Kingdom., V Chandran A; Oxford Glycobiology Institute, Department of Biochemistry, University of Oxford, Oxford OX1 3QU, United Kingdom., Hill ML; Oxford Glycobiology Institute, Department of Biochemistry, University of Oxford, Oxford OX1 3QU, United Kingdom., Kiappes JL; Oxford Glycobiology Institute, Department of Biochemistry, University of Oxford, Oxford OX1 3QU, United Kingdom., Dwek RA; Oxford Glycobiology Institute, Department of Biochemistry, University of Oxford, Oxford OX1 3QU, United Kingdom., Alonzi DS; Oxford Glycobiology Institute, Department of Biochemistry, University of Oxford, Oxford OX1 3QU, United Kingdom., Struwe WB; Physical and Theoretical Chemistry Laboratory, Department of Chemistry, University of Oxford, Oxford OX1 3TA, United Kingdom., Zitzmann N; Oxford Glycobiology Institute, Department of Biochemistry, University of Oxford, Oxford OX1 3QU, United Kingdom.
المصدر: ACS central science [ACS Cent Sci] 2021 Apr 28; Vol. 7 (4), pp. 586-593. Date of Electronic Publication: 2021 Mar 31.
نوع المنشور: Journal Article
بيانات الدورية: Publisher: ACS Publications Country of Publication: United States NLM ID: 101660035 Publication Model: Print-Electronic Cited Medium: Print ISSN: 2374-7943 (Print) Linking ISSN: 23747943 NLM ISO Abbreviation: ACS Cent Sci Subsets: PubMed not MEDLINE
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10دورية أكاديمية
المؤلفون: Warfield KL; Emergent BioSolutions, Gaithersburg, Maryland 20879, United States., Alonzi DS; Oxford Glycobiology Institute, Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, England, U.K., Hill JC; Oxford Glycobiology Institute, Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, England, U.K., Caputo AT; Oxford Glycobiology Institute, Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, England, U.K., Roversi P; Oxford Glycobiology Institute, Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, England, U.K.; Leicester Institute of Structural and Chemical Biology, Department of Molecular and Cell Biology, University of Leicester, Henry Wellcome Building, Lancaster Road, Leicester LE1 7RH, England, U.K., Kiappes JL; Oxford Glycobiology Institute, Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, England, U.K., Sheets N; La Jolla Institute for Allergy and Immunology, La Jolla, California 92037, United States., Duchars M; Emergent BioSolutions, Gaithersburg, Maryland 20879, United States., Dwek RA; Oxford Glycobiology Institute, Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, England, U.K., Biggins J; Integrated Biotherapeutics Inc., Gaithersburg, Maryland 20878, United States., Barnard D; Institute for Antiviral Research, Utah State University, Logan, Utah 84322, United States., Shresta S; La Jolla Institute for Allergy and Immunology, La Jolla, California 92037, United States., Treston AM; Emergent BioSolutions, Gaithersburg, Maryland 20879, United States., Zitzmann N; Oxford Glycobiology Institute, Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, England, U.K.
المصدر: Journal of medicinal chemistry [J Med Chem] 2020 Apr 23; Vol. 63 (8), pp. 4205-4214. Date of Electronic Publication: 2020 Apr 15.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
مواضيع طبية MeSH: alpha-Glucosidases*/metabolism, Dengue/*prevention & control , Endoplasmic Reticulum/*drug effects , Glycoside Hydrolase Inhibitors/*administration & dosage , Influenza, Human/*prevention & control, Animals ; Dengue/drug therapy ; Dengue/enzymology ; Dengue Virus/drug effects ; Dengue Virus/enzymology ; Dose-Response Relationship, Drug ; Endoplasmic Reticulum/enzymology ; Humans ; Influenza, Human/drug therapy ; Influenza, Human/enzymology ; Mice, 129 Strain ; Mice, Inbred BALB C ; Protein Structure, Secondary