المؤلفون: Balmanno K; Signalling Programme, The Babraham Institute, Babraham Research Campus, Cambridge CB22 3AT, U.K., Kidger AM; Signalling Programme, The Babraham Institute, Babraham Research Campus, Cambridge CB22 3AT, U.K., Byrne DP; Department of Biochemistry and Systems Biology, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, U.K., Sale MJ; Signalling Programme, The Babraham Institute, Babraham Research Campus, Cambridge CB22 3AT, U.K., Nassman N; Signalling Programme, The Babraham Institute, Babraham Research Campus, Cambridge CB22 3AT, U.K., Eyers PA; Department of Biochemistry and Systems Biology, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, U.K., Cook SJ; Signalling Programme, The Babraham Institute, Babraham Research Campus, Cambridge CB22 3AT, U.K.

المصدر: The Biochemical journal [Biochem J] 2023 May 15; Vol. 480 (9), pp. 587-605.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Published by Portland Press on behalf of the Biochemical Society Country of Publication: England NLM ID: 2984726R Publication Model: Print Cited Medium: Internet ISSN: 1470-8728 (Electronic) Linking ISSN: 02646021 NLM ISO Abbreviation: Biochem J Subsets: MEDLINE

مواضيع طبية MeSH: MAP Kinase Signaling System*/physiology , Proteasome Endopeptidase Complex*, Phosphorylation ; Protein Processing, Post-Translational ; Ubiquitination

المؤلفون: Kidger AM; Stress Response Laboratory, Jacqui Wood Cancer Centre, Division of Cellular and Systems Medicine, School of Medicine, University of Dundee, Dundee, DD1 9SY, UK., Saville MK; Stress Response Laboratory, Jacqui Wood Cancer Centre, Division of Cellular and Systems Medicine, School of Medicine, University of Dundee, Dundee, DD1 9SY, UK., Rushworth LK; Stress Response Laboratory, Jacqui Wood Cancer Centre, Division of Cellular and Systems Medicine, School of Medicine, University of Dundee, Dundee, DD1 9SY, UK., Davidson J; Stress Response Laboratory, Jacqui Wood Cancer Centre, Division of Cellular and Systems Medicine, School of Medicine, University of Dundee, Dundee, DD1 9SY, UK., Stellzig J; Stress Response Laboratory, Jacqui Wood Cancer Centre, Division of Cellular and Systems Medicine, School of Medicine, University of Dundee, Dundee, DD1 9SY, UK., Ono M; Stress Response Laboratory, Jacqui Wood Cancer Centre, Division of Cellular and Systems Medicine, School of Medicine, University of Dundee, Dundee, DD1 9SY, UK., Kuebelsbeck LA; Department of Surgery, School of Medicine, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany., Janssen KP; Department of Surgery, School of Medicine, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany., Holzmann B; Department of Surgery, School of Medicine, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany., Morton JP; Institute of Cancer Sciences, Garscube Estate, Switchback Road, Glasgow, G61 1QH, UK.; CRUK Beatson Institute, Garscube Estate, Switchback Road, Glasgow, G61 1BD, UK., Sansom OJ; Institute of Cancer Sciences, Garscube Estate, Switchback Road, Glasgow, G61 1QH, UK.; CRUK Beatson Institute, Garscube Estate, Switchback Road, Glasgow, G61 1BD, UK., Caunt CJ; Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath, BA2 7AY, UK., Keyse SM; Stress Response Laboratory, Jacqui Wood Cancer Centre, Division of Cellular and Systems Medicine, School of Medicine, University of Dundee, Dundee, DD1 9SY, UK. s.m.keyse@dundee.ac.uk.

المصدر: Oncogene [Oncogene] 2022 May; Vol. 41 (20), pp. 2811-2823. Date of Electronic Publication: 2022 Apr 13.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8711562 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5594 (Electronic) Linking ISSN: 09509232 NLM ISO Abbreviation: Oncogene Subsets: MEDLINE

مواضيع طبية MeSH: Carcinoma, Pancreatic Ductal*/genetics , Carcinoma, Pancreatic Ductal*/pathology , Dual Specificity Phosphatase 6*/genetics , Dual-Specificity Phosphatases*/genetics , Pancreatic Neoplasms*/genetics , Pancreatic Neoplasms*/pathology, Animals ; Atrophy/pathology ; Carcinogenesis/genetics ; Carcinogenesis/pathology ; Hyperplasia ; Mice ; Pancreas/pathology ; Proto-Oncogene Proteins p21(ras)/genetics ; Weight Loss

المؤلفون: Ferguson BS; Division of Cardiology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado., Wennersten SA; Division of Cardiology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado.; Consortium for Fibrosis Research & Translation, University of Colorado Anschutz Medical Campus, Aurora, Colorado., Demos-Davies KM; Division of Cardiology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado., Rubino M; Division of Cardiology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado.; Consortium for Fibrosis Research & Translation, University of Colorado Anschutz Medical Campus, Aurora, Colorado., Robinson EL; Division of Cardiology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado.; Consortium for Fibrosis Research & Translation, University of Colorado Anschutz Medical Campus, Aurora, Colorado., Cavasin MA; Division of Cardiology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado.; Consortium for Fibrosis Research & Translation, University of Colorado Anschutz Medical Campus, Aurora, Colorado., Stratton MS; Division of Cardiology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado.; Consortium for Fibrosis Research & Translation, University of Colorado Anschutz Medical Campus, Aurora, Colorado., Kidger AM; Stress Response Laboratory, Division of Cellular Medicine, Jacqui Wood Cancer Centre, School of Medicine, University of Dundee, Dundee, United Kingdom., Hu T; Division of Cardiology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado.; Consortium for Fibrosis Research & Translation, University of Colorado Anschutz Medical Campus, Aurora, Colorado., Keyse SM; Stress Response Laboratory, Division of Cellular Medicine, Jacqui Wood Cancer Centre, School of Medicine, University of Dundee, Dundee, United Kingdom., McKnight RA; Department of Pediatrics, University of Utah, Salt Lake City, Utah., Lane RH; Children's Mercy Kansas City, Kansas City, Missouri., Nozik ES; Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, Colorado.; Cardiovascular Pulmonary Research, University of Colorado Anschutz Medical Campus, Aurora, Colorado., Weiser-Evans MCM; Consortium for Fibrosis Research & Translation, University of Colorado Anschutz Medical Campus, Aurora, Colorado.; Division of Renal Diseases and Hypertension, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado., McKinsey TA; Division of Cardiology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado.; Consortium for Fibrosis Research & Translation, University of Colorado Anschutz Medical Campus, Aurora, Colorado.

المصدر: American journal of physiology. Heart and circulatory physiology [Am J Physiol Heart Circ Physiol] 2021 Aug 01; Vol. 321 (2), pp. H382-H389. Date of Electronic Publication: 2021 Jun 18.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Physiological Society Country of Publication: United States NLM ID: 100901228 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1522-1539 (Electronic) Linking ISSN: 03636135 NLM ISO Abbreviation: Am J Physiol Heart Circ Physiol Subsets: MEDLINE

مواضيع طبية MeSH: Cell Proliferation/*genetics , Dual-Specificity Phosphatases/*genetics , Heart Ventricles/*metabolism , Hypertension, Pulmonary/*genetics , Hypertrophy, Right Ventricular/*genetics , Myocytes, Smooth Muscle/*metabolism , Pulmonary Artery/*metabolism , Vascular Remodeling/*genetics, Angiotensin II/pharmacology ; Animals ; Case-Control Studies ; Cells, Cultured ; Heart Ventricles/drug effects ; Heart Ventricles/pathology ; Heart Ventricles/physiopathology ; Humans ; Hypertension, Pulmonary/chemically induced ; Hypertension, Pulmonary/physiopathology ; Hypertrophy, Right Ventricular/chemically induced ; Hypertrophy, Right Ventricular/physiopathology ; MAP Kinase Signaling System ; Mice ; Mice, Knockout ; Muscle, Smooth, Vascular/cytology ; Myocytes, Smooth Muscle/drug effects ; Pulmonary Artery/drug effects ; Pulmonary Artery/pathology ; Pulmonary Artery/physiopathology ; Vasoconstrictor Agents/pharmacology

المؤلفون: Lochhead PA; Signalling Laboratory, The Babraham Institute, Babraham Research Campus, Cambridge, CB22 3AT, UK. pamela.lochhead@babraham.ac.uk., Tucker JA; York Biomedical Research Institute and Department of Biology, University of York, York, YO10 5DD, UK., Tatum NJ; CRUK Newcastle Drug Discovery Unit, Newcastle University Centre for Cancer, Newcastle University, Newcastle, NE2 4HH, UK., Wang J; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, 02215, USA.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, 02115, USA., Oxley D; Signalling Laboratory, The Babraham Institute, Babraham Research Campus, Cambridge, CB22 3AT, UK., Kidger AM; Signalling Laboratory, The Babraham Institute, Babraham Research Campus, Cambridge, CB22 3AT, UK., Johnson VP; Signalling Laboratory, The Babraham Institute, Babraham Research Campus, Cambridge, CB22 3AT, UK.; Institute of Cancer Research, Chester Beatty Laboratories, 237 Fulham Road, London, SW3 6JB, UK., Cassidy MA; Signalling Laboratory, The Babraham Institute, Babraham Research Campus, Cambridge, CB22 3AT, UK., Gray NS; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, 02215, USA.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, 02115, USA., Noble MEM; CRUK Newcastle Drug Discovery Unit, Newcastle University Centre for Cancer, Newcastle University, Newcastle, NE2 4HH, UK., Cook SJ; Signalling Laboratory, The Babraham Institute, Babraham Research Campus, Cambridge, CB22 3AT, UK. simon.cook@babraham.ac.uk.

المصدر: Nature communications [Nat Commun] 2020 Mar 13; Vol. 11 (1), pp. 1383. Date of Electronic Publication: 2020 Mar 13.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

مواضيع طبية MeSH: Mitogen-Activated Protein Kinase 7/*metabolism , Protein Kinase Inhibitors/*metabolism , Transcription Factors/*metabolism, Gene Expression Regulation ; HEK293 Cells ; HeLa Cells ; Humans ; Inflammation/metabolism ; Mitogen-Activated Protein Kinase 7/genetics ; Models, Molecular ; Mutation ; Protein Conformation ; Protein Domains ; Protein Kinase Inhibitors/pharmacology ; Transcription, Genetic

المؤلفون: Kidger AM; Signalling Laboratory, The Babraham Institute, Babraham Research Campus, Cambridge, United Kingdom. simon.cook@babraham.ac.uk andrew.kidger@babraham.ac.uk., Munck JM; Astex Pharmaceuticals, 436 Cambridge Science Park, Cambridge, United Kingdom., Saini HK; Astex Pharmaceuticals, 436 Cambridge Science Park, Cambridge, United Kingdom., Balmanno K; Signalling Laboratory, The Babraham Institute, Babraham Research Campus, Cambridge, United Kingdom., Minihane E; Signalling Laboratory, The Babraham Institute, Babraham Research Campus, Cambridge, United Kingdom., Courtin A; Astex Pharmaceuticals, 436 Cambridge Science Park, Cambridge, United Kingdom., Graham B; Astex Pharmaceuticals, 436 Cambridge Science Park, Cambridge, United Kingdom., O'Reilly M; Astex Pharmaceuticals, 436 Cambridge Science Park, Cambridge, United Kingdom., Odle R; Signalling Laboratory, The Babraham Institute, Babraham Research Campus, Cambridge, United Kingdom., Cook SJ; Signalling Laboratory, The Babraham Institute, Babraham Research Campus, Cambridge, United Kingdom. simon.cook@babraham.ac.uk andrew.kidger@babraham.ac.uk.

المصدر: Molecular cancer therapeutics [Mol Cancer Ther] 2020 Feb; Vol. 19 (2), pp. 525-539. Date of Electronic Publication: 2019 Nov 20.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Association for Cancer Research, Inc Country of Publication: United States NLM ID: 101132535 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1538-8514 (Electronic) Linking ISSN: 15357163 NLM ISO Abbreviation: Mol Cancer Ther Subsets: MEDLINE

مواضيع طبية MeSH: Extracellular Signal-Regulated MAP Kinases/*analysis , MAP Kinase Signaling System/*drug effects, Animals ; Humans ; Male ; Mice ; Mice, Nude ; Phosphorylation

المؤلفون: Odle RI; Signalling Laboratory, The Babraham Institute, Babraham Research Campus, Cambridge CB22 3AT, UK. Electronic address: richard.odle@babraham.ac.uk., Walker SA; Imaging Facility, The Babraham Institute, Babraham Research Campus, Cambridge CB22 3AT, UK., Oxley D; Proteomics Facility, The Babraham Institute, Babraham Research Campus, Cambridge CB22 3AT, UK., Kidger AM; Signalling Laboratory, The Babraham Institute, Babraham Research Campus, Cambridge CB22 3AT, UK., Balmanno K; Signalling Laboratory, The Babraham Institute, Babraham Research Campus, Cambridge CB22 3AT, UK., Gilley R; Signalling Laboratory, The Babraham Institute, Babraham Research Campus, Cambridge CB22 3AT, UK., Okkenhaug H; Imaging Facility, The Babraham Institute, Babraham Research Campus, Cambridge CB22 3AT, UK., Florey O; Signalling Laboratory, The Babraham Institute, Babraham Research Campus, Cambridge CB22 3AT, UK., Ktistakis NT; Signalling Laboratory, The Babraham Institute, Babraham Research Campus, Cambridge CB22 3AT, UK., Cook SJ; Signalling Laboratory, The Babraham Institute, Babraham Research Campus, Cambridge CB22 3AT, UK. Electronic address: simon.cook@babraham.ac.uk.

المصدر: Molecular cell [Mol Cell] 2020 Jan 16; Vol. 77 (2), pp. 228-240.e7. Date of Electronic Publication: 2019 Nov 13.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 9802571 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4164 (Electronic) Linking ISSN: 10972765 NLM ISO Abbreviation: Mol Cell Subsets: MEDLINE

مواضيع طبية MeSH: Autophagy/*physiology , CDC2 Protein Kinase/*metabolism , Mechanistic Target of Rapamycin Complex 1/*metabolism , Mitosis/*physiology, A549 Cells ; Cell Line ; Cell Line, Tumor ; Female ; HCT116 Cells ; HEK293 Cells ; HT29 Cells ; HeLa Cells ; Humans ; Lysosomes/metabolism ; Male ; Phosphorylation/physiology ; Signal Transduction/physiology

المؤلفون: Seternes OM; Department of Pharmacy, UiT The Arctic University of Norway, N-9037 Tromsø, Norway. Electronic address: ole-morten.seternes@uit.no., Kidger AM; Signalling Programme, The Babraham Institute, Babraham Research Campus, Cambridge CB22 3AT, England, UK. Electronic address: andrew.kidger@babraham.ac.uk., Keyse SM; Stress Response Laboratory, Jacqui Wood Cancer Centre, James Arrot Drive, Ninewells Hospital & Medical School, Dundee DD1 9SY, UK. Electronic address: s.m.keyse@dundee.ac.uk.

المصدر: Biochimica et biophysica acta. Molecular cell research [Biochim Biophys Acta Mol Cell Res] 2019 Jan; Vol. 1866 (1), pp. 124-143. Date of Electronic Publication: 2018 Sep 08.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Review

بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101731731 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-2596 (Electronic) Linking ISSN: 01674889 NLM ISO Abbreviation: Biochim Biophys Acta Mol Cell Res Subsets: MEDLINE

مواضيع طبية MeSH: Dual-Specificity Phosphatases/*metabolism , Mitogen-Activated Protein Kinase Phosphatases/*metabolism , Mitogen-Activated Protein Kinase Phosphatases/*physiology, Animals ; Catalysis ; Cell Nucleus/metabolism ; Cytoplasm/metabolism ; Diabetes Mellitus/metabolism ; Dual-Specificity Phosphatases/physiology ; Humans ; MAP Kinase Signaling System ; Mice ; Mitogen-Activated Protein Kinases/metabolism ; Mitogen-Activated Protein Kinases/physiology ; Neuropathology ; Obesity/metabolism ; Phosphoprotein Phosphatases/physiology ; Phosphorylation ; Protein Tyrosine Phosphatases/physiology ; Signal Transduction/physiology ; Substrate Specificity/physiology

المؤلفون: Kidger AM; Signalling Programme, The Babraham Institute, Babraham Research Campus, Cambridge CB22 3AT, England, United Kingdom. Electronic address: andrew.kidger@babraham.ac.uk., Sipthorp J; Signalling Programme, The Babraham Institute, Babraham Research Campus, Cambridge CB22 3AT, England, United Kingdom., Cook SJ; Signalling Programme, The Babraham Institute, Babraham Research Campus, Cambridge CB22 3AT, England, United Kingdom. Electronic address: simon.cook@babraham.ac.uk.

المصدر: Pharmacology & therapeutics [Pharmacol Ther] 2018 Jul; Vol. 187, pp. 45-60. Date of Electronic Publication: 2018 Feb 16.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Review

بيانات الدورية: Publisher: Pergamon Press Country of Publication: England NLM ID: 7905840 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-016X (Electronic) Linking ISSN: 01637258 NLM ISO Abbreviation: Pharmacol Ther Subsets: MEDLINE

مواضيع طبية MeSH: Neoplasms/*drug therapy , Protein Kinase Inhibitors/*pharmacology , Protein Kinase Inhibitors/*therapeutic use , Protein Kinases/*metabolism, Animals ; Humans ; Neoplasms/metabolism ; Signal Transduction/drug effects

المؤلفون: Kidger AM; Signalling Programme, The Babraham Institute, Cambridge, UK., Cook SJ; Signalling Programme, The Babraham Institute, Cambridge, UK.

المصدر: The FEBS journal [FEBS J] 2018 Jan; Vol. 285 (1), pp. 42-45.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Comment

بيانات الدورية: Publisher: Published by Blackwell Pub. on behalf of the Federation of European Biochemical Societies Country of Publication: England NLM ID: 101229646 Publication Model: Print Cited Medium: Internet ISSN: 1742-4658 (Electronic) Linking ISSN: 1742464X NLM ISO Abbreviation: FEBS J Subsets: MEDLINE

مواضيع طبية MeSH: MAP Kinase Signaling System* , Mitogen-Activated Protein Kinases*, Mitogen-Activated Protein Kinase 3 ; Phosphorylation

المؤلفون: Sipthorp J; Signalling Laboratory, The Babraham Institute , Babraham Research Campus, Cambridge CB22 3AT, U.K., Lebraud H; Astex Pharmaceuticals , 436 Cambridge Science Park, Cambridge CB4 0QA, U.K., Gilley R; Signalling Laboratory, The Babraham Institute , Babraham Research Campus, Cambridge CB22 3AT, U.K., Kidger AM; Signalling Laboratory, The Babraham Institute , Babraham Research Campus, Cambridge CB22 3AT, U.K., Okkenhaug H; Signalling Laboratory, The Babraham Institute , Babraham Research Campus, Cambridge CB22 3AT, U.K., Saba-El-Leil M; Institute of Research in Immunology and Cancer and Department of Pharmacology, Université de Montréal , Montréal, Québec, Canada H3C 3J7., Meloche S; Institute of Research in Immunology and Cancer and Department of Pharmacology, Université de Montréal , Montréal, Québec, Canada H3C 3J7., Caunt CJ; Department of Biology and Biochemistry, University of Bath , Claverton Down, Bath BA2 7AY, U.K., Cook SJ; Signalling Laboratory, The Babraham Institute , Babraham Research Campus, Cambridge CB22 3AT, U.K., Heightman TD; Astex Pharmaceuticals , 436 Cambridge Science Park, Cambridge CB4 0QA, U.K.

المصدر: Bioconjugate chemistry [Bioconjug Chem] 2017 Jun 21; Vol. 28 (6), pp. 1677-1683. Date of Electronic Publication: 2017 May 12.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9010319 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4812 (Electronic) Linking ISSN: 10431802 NLM ISO Abbreviation: Bioconjug Chem Subsets: MEDLINE

مواضيع طبية MeSH: MAP Kinase Signaling System*, Mitogen-Activated Protein Kinase 1/*analysis , Molecular Probes/*chemistry, Cell Line ; Cycloaddition Reaction ; Dual-Specificity Phosphatases/analysis ; Fluorescent Dyes ; Humans ; Protein Kinase Inhibitors