المؤلفون: Nereida Jiménez de Oya, William P. Esler, Kim Huard, Ayman F. El-Kattan, Georgios Karamanlidis, Ana-Belén Blázquez, Priscila Ramos-Ibeas, Estela Escribano-Romero, Andrés Louloudes-Lázaro, Josefina Casas, Francisco Sobrino, Kyle Hoehn, David E. James, Alfonso Gutiérrez-Adán, Juan-Carlos Saiz, Miguel A. Martín-Acebes

المصدر: Emerging Microbes and Infections, Vol 8, Iss 1, Pp 624-636 (2019)

مصطلحات موضوعية: Flavivirus, West Nile virus, dengue virus, Zika virus, antivirals, Infectious and parasitic diseases, RC109-216, Microbiology, QR1-502

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2222-1751

URL الوصول: https://doaj.org/article/d350776893df432399bdb06605ae985f

المؤلفون: Yoana N. Dimitrova, Jemy A. Gutierrez, Kim Huard

المصدر: RSC Medicinal Chemistry. 14:22-46

مصطلحات موضوعية: Pharmacology, Organic Chemistry, Drug Discovery, Pharmaceutical Science, Molecular Medicine, Biochemistry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::5f0d0bbec23df4c48ef7f7b5635e54b7
https://doi.org/10.1039/d2md00212d

المؤلفون: Kentaro Futatsugi, Shawn Cabral, Daniel W. Kung, Kim Huard, Esther Lee, Markus Boehm, Jonathan Bauman, Ronald W. Clark, Steven B. Coffey, Collin Crowley, Anne-Marie Dechert-Schmitt, Matthew S. Dowling, Robert Dullea, James R. Gosset, Amit S. Kalgutkar, Kou Kou, Qifang Li, Yajing Lian, Paula M. Loria, Allyn T. Londregan, Mark Niosi, Christine Orozco, John C. Pettersen, Jeffrey A. Pfefferkorn, Jana Polivkova, Trenton T. Ross, Raman Sharma, Ingrid A. Stock, Gregory Tesz, Hanna Wisniewska, Bryan Goodwin, David A. Price

المصدر: Journal of medicinal chemistry. 65(22)

مصطلحات موضوعية: Liver Cirrhosis, Non-alcoholic Fatty Liver Disease, Drug Design, Drug Discovery, Molecular Medicine, Humans, Diacylglycerol O-Acyltransferase

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa977ae5e310187c2ba612493f2df69d
https://pubmed.ncbi.nlm.nih.gov/36322383

المؤلفون: Shawn D. Doran, Jana Polivkova, James A. Southers, Scott W. Bagley, Kim Huard, Dilinie P. Fernando, Manthena V.S. Varma, David A. Beebe, David J. Edmonds, Robert L. Dow, Benjamin A. Thuma, Collin Crowley, William P. Esler, Trenton T. Ross, David A. Tess, Mark Niosi, Amit S. Kalgutkar, Jeffrey A. Pfefferkorn, Norimitsu Shirai, David A. Griffith, Shawn Cabral, Andrew H. Smith, Gregg D. Cappon, Vincent Mascitti, Matthew S. Dowling, Andre Shavnya, David Price, Ayman El-Kattan, Aaron C. Smith, Yi-an Bi, Spiros Liras, Xiaojing Helen Yang, Cathy Préville

المصدر: Journal of Medicinal Chemistry. 63:10879-10896

مصطلحات موضوعية: Pharmacology, 01 natural sciences, Substrate Specificity, 03 medical and health sciences, chemistry.chemical_compound, Drug Delivery Systems, Non-alcoholic Fatty Liver Disease, Drug Discovery, medicine, Animals, Humans, Platelet, Enzyme Inhibitors, Fatty acid synthesis, 030304 developmental biology, 0303 health sciences, biology, Lipogenesis, Acetyl-CoA carboxylase, Lipid metabolism, 0104 chemical sciences, Pyruvate carboxylase, Organic anion-transporting polypeptide, 010404 medicinal & biomolecular chemistry, medicine.anatomical_structure, Liver, chemistry, biology.protein, Molecular Medicine, Bone marrow, Acetyl-CoA Carboxylase

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07da4330450bd15b2bafcbaadc0cc94b
https://doi.org/10.1021/acs.jmedchem.0c00640

المؤلفون: Gang Xing, David Price, Aaron C. Smith, Jayasankar Jasti, Kentaro Futatsugi, Steven B. Coffey, Meihua Tu, Kevin D. Parris, Yan Weng, Dilinie P. Fernando, Kay Ahn, Matthew S. Dowling, Kim Huard, Jayvardhan Pandit, Jeffrey A. Pfefferkorn, Benjamin A. Thuma, Brian Raymer, Tim F. Ryder, Gregory J. Tesz, Andre Shavnya, Amit S. Kalgutkar, Jun Zhou, Hanna M. Wisniewska, Jemy A. Gutierrez, John D. Knafels, Magee Thomas Victor, Ingrid A. Stock, Sylvie Perez, Tsai Andy

المصدر: Journal of medicinal chemistry. 63(22)

مصطلحات موضوعية: Drug, Male, media_common.quotation_subject, Fructose, Crystallography, X-Ray, 01 natural sciences, Protein Structure, Secondary, Fructokinases, 03 medical and health sciences, chemistry.chemical_compound, Residue (chemistry), Insulin resistance, Dogs, Metabolic Diseases, Nonalcoholic fatty liver disease, Drug Discovery, medicine, Moiety, Animals, Humans, Enzyme Inhibitors, Rats, Wistar, 030304 developmental biology, media_common, 0303 health sciences, Dose-Response Relationship, Drug, Chemistry, Metabolism, medicine.disease, 0104 chemical sciences, Rats, 010404 medicinal & biomolecular chemistry, Biochemistry, Hepatocytes, Molecular Medicine, Steatohepatitis, Insulin Resistance

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c107a413095d612ee94dff2632747e3a
https://pubmed.ncbi.nlm.nih.gov/32910646

المؤلفون: John D. Knafels, David Price, Matthew Gorgoglione, Aaron C. Smith, Kevin D. Parris, Jemy A. Gutierrez, Magee Thomas Victor, Erik Alphie Lachapelle, Yan Weng, Edward L. Conn, Jeffrey A. Pfefferkorn, Jane M. Withka, Kim Huard, Matthew S. Dowling, Timothy A. Subashi, Trenton T. Ross, Benjamin A. Thuma, Kris A. Borzilleri, Paul A. Amor, Jeffrey S. Culp, Meihua Tu, Sylvie Perez, Jayvardhan Pandit, Andre Shavnya, Boris A. Chrunyk, Gang Xing, John D. Weaver, Yang Cong, Kay Ahn, David A. Beebe, Brian Raymer, Gregory J. Tesz, Steven B. Coffey

المصدر: Journal of Medicinal Chemistry. 60:7835-7849

مصطلحات موضوعية: Male, 0301 basic medicine, Pyridines, Pharmacology, Crystallography, X-Ray, 01 natural sciences, Fructokinases, Rats, Sprague-Dawley, Small Molecule Libraries, 03 medical and health sciences, Insulin resistance, In vivo, Drug Discovery, medicine, Animals, Humans, Transferase, Protein Kinase Inhibitors, chemistry.chemical_classification, 010405 organic chemistry, Chemistry, Metabolism, medicine.disease, Small molecule, Rats, 0104 chemical sciences, Molecular Docking Simulation, 030104 developmental biology, Fructose metabolism, Enzyme, Biochemistry, Drug Design, Molecular Medicine, Steatosis

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b654213309542f5b2a14a9d23ebc4df8
https://doi.org/10.1021/acs.jmedchem.7b00947

المؤلفون: Dilinie P. Fernando, Gary Erik Aspnes, Sophie Y. Lavergne, Daniel W. Kung, Michael Herr, I. D. Pardo, Qifang Li, Norimitsu Shirai, Bryan Goodwin, Suvi T. M. Orr, Jun Zhou, Julie Purkal, Matthew S. Dowling, Kentaro Futatsugi, R. J. Barnes, Declan Flynn, Ahmed M. Shoieb, David Hepworth, T. J. Schmahai, Mark Niosi, W. P. Gorczyca, Kim Huard, John C. Pettersen, Sylvie Perez, Shawn Cabral, James R. Gosset, Theunis C. Goosen

المصدر: MedChemComm. 8:771-779

مصطلحات موضوعية: 0301 basic medicine, Pharmacology, Imidazopyridine, Mechanism (biology), Chemistry, Organic Chemistry, nutritional and metabolic diseases, Pharmaceutical Science, Biochemistry, Small molecule, 03 medical and health sciences, Safety profile, 030104 developmental biology, Drug Discovery, Molecular Medicine, lipids (amino acids, peptides, and proteins), Diacylglycerol Acyltransferase

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::343a6e4a5a0b00a3db0ba47eb2198e13
https://doi.org/10.1039/c6md00564k

المؤلفون: Gregory W. Kauffman, Christopher Keefer, Kim Huard, George Chang, Antonia F. Stepan

المصدر: Bioorganic & Medicinal Chemistry. 25:381-388

مصطلحات موضوعية: 0301 basic medicine, Cell Membrane Permeability, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Context (language use), Ring (chemistry), 01 natural sciences, Biochemistry, Madin Darby Canine Kidney Cells, Heterocyclic Compounds, 1-Ring, 03 medical and health sciences, Dogs, Drug Discovery, Animals, Humans, ATP Binding Cassette Transporter, Subfamily B, Member 1, Ideal (ring theory), Molecular Biology, P gp efflux, Drug discovery, Chemistry, Organic Chemistry, Aromaticity, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Passive permeability, 030104 developmental biology, Microsomes, Liver, Molecular Medicine, Biological system

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0468bf020d053d3c19fb21fa4d1c3814
https://doi.org/10.1016/j.bmc.2016.11.004

المؤلفون: Zhenhong Li, James R. Gosset, Matthew Gorgoglione, Keith Riccardi, Li Di, Derek M. Erion, Janice A. Brown, Mark Niosi, Kim Huard

المصدر: Drug Metabolism and Disposition. 44:1633-1642

مصطلحات موضوعية: Pharmaceutical Science, In Vitro Techniques, 030226 pharmacology & pharmacy, 03 medical and health sciences, 0302 clinical medicine, Tandem Mass Spectrometry, In vivo, Animals, Humans, Bovine serum albumin, Cation Transport Proteins, Sodium Sulfate Cotransporter, Pharmacology, Symporters, biology, Chemistry, Biological activity, Transporter, Prodrug, In vitro, Culture Media, Rats, HEK293 Cells, Biochemistry, Cell culture, 030220 oncology & carcinogenesis, Hepatocytes, biology.protein, Intracellular, Chromatography, Liquid

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc15d29bc763bc803d4c2d961ca04b87
https://doi.org/10.1124/dmd.116.071837

المؤلفون: Michael Herr, Daniel P. Canterbury, Derek M. Erion, Janice A. Brown, Mark Niosi, Bhagyashree Khunte, Matthew Gorgoglione, Jaclyn Siderewicz, Jana Polivkova, Carmen N. Garcia-Irizarry, Nathan E. Genung, Adam M. Gilbert, Justin I. Montgomery, Daniel P. Uccello, Timothy P. Rolph, Adhiraj Lanba, Qifang Li, Nicholas B. Vera, Kentaro Futatsugi, Gary Erik Aspnes, Zhenhong Li, James R. Gosset, Kim Huard, Matthew Merrill Hayward, Shawn Cabral, Magee Thomas Victor, Julie Purkal, Kevin B. Bahnck

المصدر: Journal of Medicinal Chemistry. 59:1165-1175

مصطلحات موضوعية: Blood Glucose, Male, 0301 basic medicine, Pyridines, Malates, Mice, Obese, Pharmacology, Kidney, Phenylbutyrate, Rats, Sprague-Dawley, Mice, Structure-Activity Relationship, 03 medical and health sciences, Pharmacokinetics, In vivo, Drug Discovery, Animals, Humans, Citrates, Dose-Response Relationship, Drug, Molecular Structure, Symporters, Chemistry, Kidney metabolism, Biological Transport, Citrate transport, Phenylbutyrates, In vitro, Rats, Solute carrier family, Mice, Inbred C57BL, HEK293 Cells, 030104 developmental biology, Liver, Biochemistry, Symporter, Hepatocytes, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87b4cd858c5eae974c53ce91c3e64131
https://doi.org/10.1021/acs.jmedchem.5b01752