المؤلفون: Tuomas Lilius, Hanna Viisanen, Katarzyna Anna Dudek, Fredrik Harry Gustav Ahlström, Jouko Laitila, Eija Kalso, Kert Mätlik, Pekka Rauhala, Kim Juhani Blomqvist

المساهمون: Department of Pharmacology, Faculty of Medicine, University of Helsinki, INDIVIDRUG - Individualized Drug Therapy, Operations Management Unit, Research Programs Unit, HUSLAB, Department of Clinical Pharmacology, Helsinki University Hospital Area, HUS Perioperative, Intensive Care and Pain Medicine, Eija Kalso / Principal Investigator, Department of Diagnostics and Therapeutics, Anestesiologian yksikkö, Pekka Rauhala / Principal Investigator, Medicum

المصدر: Blomqvist, K J, Dudek, K A, Viisanen, H, Matlik, K, Ahlstrom, F H G, Laitila, J, Kalso, E A, Rauhala, P V & Lilius, T O 2022, ' Antagonism of peripheral opioid receptors by methylnaltrexone does not prevent morphine tolerance in rats ', Journal of Neuroscience Research, vol. 100, no. 1, pp. 329-338 . https://doi.org/10.1002/jnr.24638
Journal of Neuroscience Research

مصطلحات موضوعية: 0301 basic medicine, Male, Narcotic Antagonists, Receptors, Opioid, mu, methylnaltrexone, Pharmacology, Naltrexone, 3124 Neurology and psychiatry, Rats, Sprague-Dawley, 0302 clinical medicine, Drug tolerance, Opioid receptor, ANTINOCICEPTION, PHARMACOLOGY, Morphine, SCR_002798, PAIN, morphine, Drug Tolerance, Methylnaltrexone, NOCICEPTION, 3. Good health, Analgesics, Opioid, Nociception, DOGS, 317 Pharmacy, analgesics, naltrexone, medicine.drug, medicine.drug_class, INHIBITION, METABOLISM, 03 medical and health sciences, Cellular and Molecular Neuroscience, QUATERNARY NARCOTIC-ANTAGONISTS, drug tolerance, medicine, Animals, RRID, Dose-Response Relationship, Drug, business.industry, Antagonist, 3112 Neurosciences, Rats, Quaternary Ammonium Compounds, MICE, 030104 developmental biology, Opioid, Receptors, Opioid, opioid, business, 030217 neurology & neurosurgery, N-METHYLNALTREXONE

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abc143dc2a9cc9d9140206a8fec43310
https://curis.ku.dk/ws/files/289227935/Antagonism_of_peripheral_opioid.pdf

المؤلفون: Tuomas Lilius, Kim Juhani Blomqvist, Pekka Rauhala, Hanna Viisanen, Fredrik Harry Gustav Ahlström, Kert Mätlik, Yulia Sidorova, Eija Kalso, X. Liu

المساهمون: Department of Pharmacology, Faculty of Medicine, University of Helsinki, INDIVIDRUG - Individualized Drug Therapy, Research Programs Unit, Medicum, Institute of Biotechnology, Molecular Systems Biology, Helsinki Institute of Life Science HiLIFE, HUSLAB, Department of Clinical Pharmacology, HUS Emergency Medicine and Services, Helsinki University Hospital Area, Divisions of Faculty of Pharmacy, HUS Perioperative, Intensive Care and Pain Medicine, Eija Kalso / Principal Investigator, Department of Diagnostics and Therapeutics, Clinicum, Anestesiologian yksikkö, Pekka Rauhala / Principal Investigator

المصدر: Ahlstrom, F H G, Matlik, K, Viisanen, H, Blomqvist, K J, Liu, X, Lilius, T O, Sidorova, Y, Kalso, E A & Rauhala, P V 2021, ' Spared Nerve Injury Causes Sexually Dimorphic Mechanical Allodynia and Differential Gene Expression in Spinal Cords and Dorsal Root Ganglia in Rats ', Molecular Neurobiology, vol. 58, pp. 5396–5419 . https://doi.org/10.1007/s12035-021-02447-1
Molecular Neurobiology

مصطلحات موضوعية: 0301 basic medicine, Male, Proteomics, Sex Differentiation, Gene Expression, Neuropathic pain, 3124 Neurology and psychiatry, Rats, Sprague-Dawley, ACTIVATION, 0302 clinical medicine, Ganglia, Spinal, Pain Measurement, Microfilament Proteins, NEUROPATHIC PAIN, LOCALIZATION, CANCER, RECEPTORS, medicine.anatomical_structure, Allodynia, Neurology, Spinal Cord, Hyperalgesia, Peripheral nerve injury, Female, medicine.symptom, medicine.medical_specialty, SNi, Calcitonin Gene-Related Peptide, Neuroscience (miscellaneous), Calcitonin gene-related peptide, Biology, Article, CONTRIBUTES, MICROGLIA, 03 medical and health sciences, Cellular and Molecular Neuroscience, FEMALE RATS, Internal medicine, Glial Fibrillary Acidic Protein, medicine, Animals, Behaviour, Transcriptomics, ATF3, Calcium-Binding Proteins, 3112 Neurosciences, Nerve injury, Spinal cord, MAP KINASE, Sex-differences, Rats, DIPEPTIDYL PEPTIDASE-IV, 030104 developmental biology, Endocrinology, Rat, Sciatic Neuropathy, 030217 neurology & neurosurgery

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17884155d892aae330010fb7e2df8981
https://doi.org/10.21203/rs.3.rs-33768/v1

المؤلفون: Fredrik Harry Gustav Ahlström, Hanna Viisanen, Jouko Laitila, Kim Juhani Blomqvist, Tuomas Lilius, Pekka Rauhala, Kert Mätlik, Katarzyna Anna Dudek, Eija Kalso

مصطلحات موضوعية: Opioid, business.industry, Morphine tolerance, medicine, Pharmacology, Receptor, Methylnaltrexone, Antagonism, business, medicine.drug, Peripheral

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c589ffe1ea4313e22c279c8717b29973
https://doi.org/10.1002/jnr.24638/v3/response1

المؤلفون: Tuomas Lilius, Viljami Jokinen, Hanna Viisanen, Fredrik Harry Gustav Ahlström, Pekka Rauhala, Yulia Sidorova, Kim Juhani Blomqvist, Ilida Suleymanova, Eija Kalso

المساهمون: Department of Pharmacology, Clinicum, Faculty of Medicine, INDIVIDRUG - Individualized Drug Therapy, Research Programs Unit, University of Helsinki, Institute of Biotechnology, Helsinki Institute of Life Science HiLIFE, HUSLAB, Pekka Rauhala / Principal Investigator, HUS Perioperative, Intensive Care and Pain Medicine, Eija Kalso / Principal Investigator, Department of Diagnostics and Therapeutics, Medicum, Anestesiologian yksikkö, Department of Clinical Pharmacology

المصدر: Blomqvist, K J, Viisanen, H, Ahlstrom, F H G, Jokinen, V, Sidorova, Y A, Suleymanova, I, Rauhala, P V, Kalso, E A & Lilius, T O 2020, ' Morphine-3-glucuronide causes antinociceptive cross-tolerance to morphine and increases spinal substance P expression ', European Journal of Pharmacology, vol. 875, 173021 . https://doi.org/10.1016/j.ejphar.2020.173021
European Journal of Pharmacology

مصطلحات موضوعية: Male, Nociception, 0301 basic medicine, Dose-response relationship, Substance P, Pharmacology, ACTIVATION, chemistry.chemical_compound, 0302 clinical medicine, RAT MODEL, Morphine-3-glucuronide, Injections, Spinal, Pain Measurement, Morphine, PAIN, Drug Tolerance, Spinal Cord, 317 Pharmacy, Hyperalgesia, medicine.symptom, medicine.drug, MORPHINE-6-GLUCURONIDE, Opioid, Drug Administration Schedule, 03 medical and health sciences, OPIOID-INDUCED HYPERALGESIA, medicine, Animals, Humans, Opioid-induced hyperalgesia, Morphine Derivatives, business.industry, Morphine-6-glucuronide, Rats, Disease Models, Animal, 030104 developmental biology, chemistry, Central Nervous System Stimulants, 3111 Biomedicine, business, Drug tolerance, 030217 neurology & neurosurgery

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::673c616608f79bac53572a6cbb3569fc
https://curis.ku.dk/ws/files/239562235/Morphine_3_glucuronide_causes_antinociceptive_cross_tolerance_to_morphine_and_increases_spinal_substance_P_expression.pdf