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المؤلفون: Dilip Narayanan, Kim T. Tran, Jakob S. Pallesen, Sara M. Ø. Solbak, Yuting Qin, Elina Mukminova, Martina Luchini, Kristina O. Vasilyeva, Dorleta González Chichón, Georgia Goutsiou, Cecilie Poulsen, Nanna Haapanen, Grzegorz M. Popowicz, Michael Sattler, David Olagnier, Michael Gajhede, Anders Bach
المصدر: Narayanan, D, Tran, K T, Pallesen, J S, Solbak, S M Ø, Qin, Y, Mukminova, E, Luchini, M, Vasilyeva, K O, González Chichón, D, Goutsiou, G, Poulsen, C, Haapanen, N, Popowicz, G M, Sattler, M, Olagnier, D, Gajhede, M & Bach, A 2022, ' Development of Noncovalent Small-Molecule Keap1-Nrf2 Inhibitors by Fragment-Based Drug Discovery ', Journal of Medicinal Chemistry, vol. 65, no. 21, pp. 14481–14526 . https://doi.org/10.1021/acs.jmedchem.2c00830
مصطلحات موضوعية: Oxidative Stress, Kelch-Like ECH-Associated Protein 1, NF-E2-Related Factor 2, NF-E2-Related Factor 2/metabolism, Drug Discovery, Molecular Medicine, Drug Discovery/methods, Kelch-Like ECH-Associated Protein 1/metabolism, Protein Binding
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المؤلفون: Nga N Q Tra, Kim T Tran, Nghia H Ho, Hoai C Huynh, Bay T Nguyen
المصدر: IOP Conference Series: Earth and Environmental Science. 1091:012016
مصطلحات موضوعية: General Medicine, General Chemistry
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المؤلفون: Anthony D. Garcia, Kim T. Tran, Lars Jakobsen Høj, Jakob S. Pallesen, Tommy N. Johansen, Giuseppe Marseglia, Michael Gajhede, Federico Munafò, Michael Sattler, Grzegorz M Popowicz, Haritha L. Desu, Dilip Narayanan, Sara Marie Øie Solbak, Anders Bach, Louis M.E. Sørensen, Rosa M. C. Carmona, Roberta Brambilla
المساهمون: University of Copenhagen = Københavns Universitet (KU), University of Parma = Università degli studi di Parma [Parme, Italie], Institut des Sciences Chimiques de Rennes (ISCR), Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Ecole Nationale Supérieure de Chimie de Rennes (ENSCR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA), University of Miami Leonard M. Miller School of Medicine (UMMSM), University of Southern Denmark (SDU), Helmholtz-Zentrum München (HZM), This research was supported by the Lundbeck Foundation (grant R190-2014-3710 for A.B.), the A. P. MøllerFoundation for the Advancement of Medical Science (grant 14-28 for A.B.), the Hørslev Foundation (grant203866-MIA for A.B.), the Augustinus Foundation (grant 14-1571 for A.B.), and the Drug ResearchAcademy/Lundbeck Foundation (scholarship for K.T.T.). We also acknowledge funding from the EuropeanUnion’s Framework Programme for Researc and Innovation Horizon 2020 (2014-2020) under the MarieSkłodowska-Curie Grant Agreement No. 675555, Accelerated Early staGe drug discovery (AEGIS) and theHelmholtz Center Munich to M.S. and G.P., and access to NMR measurements at the Bavarian NMR Center andat University of Copenhagen (the latter supported by grant #10-085264 from The Danish Research Council forIndependent Research | Nature and Universe and grant R77-A6742 from the Lundbeck Foundation). We thankall the staff at the European beamlines (BioMAX at MAX IV, Sweden, ID29 and ID30a at ESRF, France, and P13and P14 at DESY, Germany) for beamtime and their support and help., University of Copenhagen = Københavns Universitet (UCPH), Università degli studi di Parma = University of Parma (UNIPR), Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Ecole Nationale Supérieure de Chimie de Rennes (ENSCR)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Helmholtz Zentrum München = German Research Center for Environmental Health
المصدر: Pallesen, J S, Narayanan, D, Tran, K T, Solbak, S M Ø, Marseglia, G, Sørensen, L M E, Høj, L J, Munafò, F, Carmona, R M C, Garcia, A D, Desu, H L, Brambilla, R, Johansen, T N, Popowicz, G M, Sattler, M, Gajhede, M & Bach, A 2021, ' Deconstructing Noncovalent Kelch-like ECH-Associated Protein 1 (Keap1) Inhibitors into Fragments to Reconstruct New Potent Compounds ', Journal of Medicinal Chemistry, vol. 64, no. 8, pp. 4623-4661 . https://doi.org/10.1021/acs.jmedchem.0c02094
Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, American Chemical Society, 2021, 64 (8), pp.4623-4661. ⟨10.1021/acs.jmedchem.0c02094⟩
J. Med. Chem. 64, 4623-4661 (2021)
Journal of Medicinal Chemistry, 2021, 64 (8), pp.4623-4661. ⟨10.1021/acs.jmedchem.0c02094⟩
Pallesen, J S, Narayanan, D, Tran, K T, Solbak, S M Ø, Marseglia, G, Sørensen, L M E, Høj, L J, Munafò, F, Carmona, R M C, Garcia, A D, Desu, H L, Brambilla, R, Johansen, T N, Popowicz, G M, Sattler, M, Gajhede, M & Bach, A 2021, ' Deconstructing Noncovalent Kelch-like ECH-Associated Protein 1 (Keap1) Inhibitors into Fragments to Reconstruct New Potent Compounds ', Journal of Medicinal Chemistry, vol. 64, no. 8, pp. 4623–4661 . https://doi.org/10.1021/acs.jmedchem.0c02094مصطلحات موضوعية: Magnetic Resonance Spectroscopy, Stereochemistry, NF-E2-Related Factor 2, Binding pocket, Molecular Dynamics Simulation, Crystallography, X-Ray, Ligands, 01 natural sciences, Small Molecule Libraries, 03 medical and health sciences, Structure-Activity Relationship, Drug Stability, Microsomes, Drug Discovery, [CHIM]Chemical Sciences, Humans, Protein Interaction Maps, 030304 developmental biology, Therapeutic strategy, 0303 health sciences, Control diseases, Binding Sites, Kelch-Like ECH-Associated Protein 1, Chemistry, Surface Plasmon Resonance, KEAP1, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Microsome, Molecular Medicine, Protein Binding
وصف الملف: application/vnd.openxmlformats-officedocument.wordprocessingml.document; application/pdf
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المؤلفون: Arjen J. Roem, Mahmoud N. Haidar, João Sendão, Kim T. Tran-Ngoc, Johan W. Schrama, Johan A.J. Verreth
المصدر: Aquaculture Research 50 (2019) 9
Aquaculture Research, 50(9), 2577-2590مصطلحات موضوعية: 0303 health sciences, Meal, Rapeseed, Bran, biology, Feather meal, Aquacultuur en Visserij, Soybean meal, 04 agricultural and veterinary sciences, Aquatic Science, intestinal morphology, biology.organism_classification, nitrogen and energy balance, Distillers grains, 03 medical and health sciences, Nile tilapia, Oreochromis, Animal science, Aquaculture and Fisheries, digestibility, feed ingredient, 040102 fisheries, WIAS, 0401 agriculture, forestry, and fisheries, 030304 developmental biology
وصف الملف: application/pdf; application/octet-stream
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54abdc407d92bbbc57daada2c8734f61
https://doi.org/10.1111/are.14214 -
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المؤلفون: Son T. Huynh, Arjen J. Roem, Thinh H. Nguyen, Johan W. Schrama, Johan A.J. Verreth, Kim T. Tran-Ngoc, João Sendão
المصدر: Aquaculture Nutrition, 25(1), 134-144
Aquaculture Nutrition 25 (2019) 1مصطلحات موضوعية: normoxia, Potassium, Soybean meal, chemistry.chemical_element, Butyrate, Aquatic Science, Calcium, Butyric acid, 03 medical and health sciences, chemistry.chemical_compound, Nile tilapia, Animal science, Aquaculture and Fisheries, 030304 developmental biology, chemistry.chemical_classification, organic acid, 0303 health sciences, biology, hypoxia, Aquacultuur en Visserij, 04 agricultural and veterinary sciences, intestinal morphology, biology.organism_classification, Oreochromis, chemistry, digestibility, soybean meal diet, 040102 fisheries, WIAS, 0401 agriculture, forestry, and fisheries, Organic acid
وصف الملف: application/octet-stream; application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b7a5e8fe743ddbd2183becae4fdc6bd
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المؤلفون: S. Lawrence Librach, Malcolm J. Moore, Kenneth Mah, Kim T. Tran, David Warr, Camilla Zimmermann, Frances A. Shepherd, Gary Rodin, Lynn R. Gauthier, Lucia Gagliese
المصدر: The Journal of Pain. 18:811-824
مصطلحات موضوعية: Adult, Male, Health Knowledge, Attitudes, Practice, medicine.medical_specialty, Psychometrics, Severity of Illness Index, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Age groups, Older patients, Neoplasms, Surveys and Questionnaires, medicine, Humans, Aged, Pain Measurement, Aged, 80 and over, business.industry, Perspective (graphical), Chronic pain, Reproducibility of Results, Cancer Pain, Middle Aged, Pain management, medicine.disease, Advanced cancer, Test (assessment), Philosophy, Anesthesiology and Pain Medicine, Neurology, 030220 oncology & carcinogenesis, Physical therapy, Female, Neurology (clinical), business, Cancer pain, 030217 neurology & neurosurgery, Clinical psychology
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المؤلفون: Arjen J. Roem, Thinh H. Nguyen, Kim T. Tran-Ngoc, Johan A.J. Verreth, Johan W. Schrama, Ngu T. Dinh
المصدر: Aquaculture, 462, 101-108
Aquaculture 462 (2016)مصطلحات موضوعية: 0301 basic medicine, Nile Tilapia, Soybean meal, Aquatic Science, 03 medical and health sciences, Nile tilapia, Animal science, Fish meal, Aquaculture and Fisheries, Aquaculture, Meal, biology, Aquacultuur en Visserij, business.industry, 04 agricultural and veterinary sciences, biology.organism_classification, Intestial morphology, intestial health, Oreochromis, 030104 developmental biology, Biochemistry, Plant protein, Digestibility, Oxygen level, WIAS, 040102 fisheries, 0401 agriculture, forestry, and fisheries, Limiting oxygen concentration, business
وصف الملف: application/octet-stream; application/pdf
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المؤلفون: Kim T. Tran, Anders Bach, Jakob S. Pallesen
المصدر: Journal of medicinal chemistry. 61(18)
مصطلحات موضوعية: 0301 basic medicine, chemistry.chemical_classification, Kelch-Like ECH-Associated Protein 1, Molecular Structure, Chemistry, NF-E2-Related Factor 2, Repressor, Biological activity, respiratory system, environment and public health, Small molecule, KEAP1, Cell biology, Small Molecule Libraries, 03 medical and health sciences, Cytosol, 030104 developmental biology, Enzyme, Central Nervous System Diseases, Drug Discovery, Molecular Medicine, Humans, Protein Interaction Domains and Motifs, Transcription factor
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المؤلفون: Gary Rodin, Camilla Zimmermann, Lynn R. Gauthier, Malcolm J. Moore, David Warr, Frances A. Shepherd, Kenneth Mah, Lucia Gagliese, Kim T. Tran, S. Lawrence Librach
المصدر: The journal of pain. 19(3)
مصطلحات موضوعية: Biopsychosocial model, Adult, Male, Aging, Psychological intervention, Stoicism, 03 medical and health sciences, Young Adult, 0302 clinical medicine, Surveys and Questionnaires, Adaptation, Psychological, Medicine, Humans, Association (psychology), Aged, Pain Measurement, Aged, 80 and over, business.industry, Mood Disorders, Perspective (graphical), Cancer Pain, Middle Aged, Philosophy, Anesthesiology and Pain Medicine, Cross-Sectional Studies, Neurology, Attitude, 030220 oncology & carcinogenesis, Female, Neurology (clinical), Self Report, Cancer pain, business, Cognition Disorders, Psychosocial, 030217 neurology & neurosurgery, Intrapersonal communication, Clinical psychology
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المؤلفون: Mai T.T. Le, Thinh H. Nguyen, Johan W. Schrama, Johan A.J. Verreth, Arjen J. Roem, Kim T. Tran-Ngoc
المصدر: Aquaculture 469 (2017)
Aquaculture, 469, 36-43مصطلحات موضوعية: 0301 basic medicine, Lamina propria, Quantitative histology, biology, Ecology, Aquacultuur en Visserij, Diet composition, Soybean meal, 04 agricultural and veterinary sciences, Aquatic Science, Intestinal morphology, biology.organism_classification, Salinity, 03 medical and health sciences, Oreochromis, Nile tilapia, 030104 developmental biology, Animal science, medicine.anatomical_structure, Aquaculture and Fisheries, 040102 fisheries, medicine, WIAS, 0401 agriculture, forestry, and fisheries, Life Science
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