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المؤلفون: Shin-San Michael Su, Scott A. Biller, Virginie Penard-Lacronique, Marion Dorsch, Lenny Dang, Hua Yang, Wei Liu, Lee Silverman, Shengfang Jin, Wentao Wei, Fan Jiang, Cheng Fang, YingXia Xu, Monika Pilichowska, Benoît S. Marteyn, Stéphane de Botton, Olivier A. Bernard, Sophie Broutin, Angelo Paci, Véronique Saada, Olivia Bawa, Paule Opolon, Cyril Quivoron, Francesco G. Salituro, Jeffrey O. Saunders, Giovanni Cianchetta, Zenon Konteatis, Lei Jin, Sung Choe, Raj Nagaraja, Yue Chen, Erica Tobin, Byron DeLaBarre, Stefan Gross, Anil Padyana, Kimberly Straley, Erin Artin, Muriel D. David, Fang Wang, Jeremy Travins, Katharine Yen
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11d97954935b2f34d5dfe50e66a1f7f5
https://doi.org/10.1158/2159-8290.22531945.v1 -
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المؤلفون: Shin-San Michael Su, Scott A. Biller, Virginie Penard-Lacronique, Marion Dorsch, Lenny Dang, Hua Yang, Wei Liu, Lee Silverman, Shengfang Jin, Wentao Wei, Fan Jiang, Cheng Fang, YingXia Xu, Monika Pilichowska, Benoît S. Marteyn, Stéphane de Botton, Olivier A. Bernard, Sophie Broutin, Angelo Paci, Véronique Saada, Olivia Bawa, Paule Opolon, Cyril Quivoron, Francesco G. Salituro, Jeffrey O. Saunders, Giovanni Cianchetta, Zenon Konteatis, Lei Jin, Sung Choe, Raj Nagaraja, Yue Chen, Erica Tobin, Byron DeLaBarre, Stefan Gross, Anil Padyana, Kimberly Straley, Erin Artin, Muriel D. David, Fang Wang, Jeremy Travins, Katharine Yen
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bd472a11c8ff29b3f26438ea494ea5d
https://doi.org/10.1158/2159-8290.22531936 -
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المؤلفون: Shin-San Michael Su, Scott A. Biller, Virginie Penard-Lacronique, Marion Dorsch, Lenny Dang, Hua Yang, Wei Liu, Lee Silverman, Shengfang Jin, Wentao Wei, Fan Jiang, Cheng Fang, YingXia Xu, Monika Pilichowska, Benoît S. Marteyn, Stéphane de Botton, Olivier A. Bernard, Sophie Broutin, Angelo Paci, Véronique Saada, Olivia Bawa, Paule Opolon, Cyril Quivoron, Francesco G. Salituro, Jeffrey O. Saunders, Giovanni Cianchetta, Zenon Konteatis, Lei Jin, Sung Choe, Raj Nagaraja, Yue Chen, Erica Tobin, Byron DeLaBarre, Stefan Gross, Anil Padyana, Kimberly Straley, Erin Artin, Muriel D. David, Fang Wang, Jeremy Travins, Katharine Yen
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bf9f6f1fb6d2a1049263137b504fc3a
https://doi.org/10.1158/2159-8290.22531939 -
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المؤلفون: Brandon Nicolay, Ingo K. Mellinghoff, Paolo Codega, Hua Yang, Zenon D. Konteatis, Janeta Popovici-Muller, Katharine E. Yen, Rohini Narayaraswamy, Raj Nagaraja, Zhihua Sui, Shinsan M. Su, Erin Artin, Kimberly Straley, Zhenwei Cai, Feng Wang, Shuilong Tong, Lei Jin, Yue Chen, Cui Dawei, Carl Campos, Zhiyong Luo, Cheng Fang, Xiaobing Lv, Lenny Dang, Ding Zhou, Anil K. Padyana, Huachun Tang, Scott A. Biller
المصدر: ACS Medicinal Chemistry Letters
مصطلحات موضوعية: chemistry.chemical_classification, IDH1, Organic Chemistry, Mutant, Dual inhibitor, 2-hydroxyglutarate, medicine.disease, Biochemistry, Featured Letter, Isocitrate dehydrogenase, vorasidenib, chemistry.chemical_compound, Enzyme, AG-881, chemistry, Glioma, Drug Discovery, medicine, Cancer research, Binding site, mutant IDH1/mIDH2, Penetrant (biochemical)
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المؤلفون: Yi-Bin Chen, Gabriela S. Hobbs, Meghan Burke, Philip C. Amrein, Seth A. Wander, Ilene Galinsky, Donna Neuberg, Christelle Joseph, Darrell R. Borger, Kimberly Straley, Aura Y. Ramos, Richard Stone, Hua Yang, Eyal C. Attar, Karen K. Ballen, Hossein Sadrzadeh, Sam Agresta, Ashley M. Perry, Andrew M. Brunner, Katharine E. Yen, Timothy A. Graubert, Anthony J. Iafrate, Amir T. Fathi, Christine Connolly, Sophia Adamia
المصدر: Cancer. 125:541-549
مصطلحات موضوعية: Adult, Male, Cancer Research, medicine.medical_specialty, IDH1, medicine.medical_treatment, Gastroenterology, IDH2, Glutarates, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Antineoplastic Combined Chemotherapy Protocols, Biomarkers, Tumor, medicine, Humans, Prospective Studies, 030212 general & internal medicine, Aged, Aged, 80 and over, Chemotherapy, business.industry, Proportional hazards model, Myeloid leukemia, Middle Aged, Prognosis, Isocitrate Dehydrogenase, Survival Rate, Leukemia, Myeloid, Acute, Exact test, medicine.anatomical_structure, Isocitrate dehydrogenase, Oncology, 030220 oncology & carcinogenesis, Mutation, Female, Bone marrow, business, Follow-Up Studies
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المؤلفون: Hua Yang, Muriel D. David, Jeffrey O. Saunders, Lemieux Rene M, Gui Yao, Luke Utley, Véronique Saada, Xiaobing Lv, Yue Chen, Fang Wang, Shengfang Jin, Ping Chen, Erin Artin, Stéphane de Botton, Cheng Fang, Hyeryun Kim, Giovanni Cianchetta, Stefan Gross, Lenny Dang, Zhenwei Cai, Scott A. Biller, Andrew J. Olaharski, Erica Tobin, Cui Dawei, Katharine E. Yen, Virginie Penard-Lacronique, Liping Yan, Ding Zhou, Lee Silverman, Cyril Quivoron, Zhiyong Luo, Jeremy Travins, Janeta Popovici-Muller, Shinsan M. Su, Kimberly Straley, Zhiwei Gu, Francesco G. Salituro
المصدر: ACS Medicinal Chemistry Letters
مصطلحات موضوعية: mutant IDH1, 0301 basic medicine, Letter, IDH1, ivosidenib, Cellular differentiation, Point mutation, Organic Chemistry, Mutant, 2-hydroxyglutarate, Biology, Biochemistry, AG-120, 03 medical and health sciences, differentiation therapy, 030104 developmental biology, 0302 clinical medicine, Isocitrate dehydrogenase, Differentiation therapy, 030220 oncology & carcinogenesis, Drug Discovery, Cancer cell, Cancer research, isocitrate dehydrogenase, Ex vivo
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7AG-221, a First-in-Class Therapy Targeting Acute Myeloid Leukemia Harboring Oncogenic IDH2 Mutations
المؤلفون: Olivia Bawa, Monika Pilichowska, Paule Opolon, Jeffrey O. Saunders, Fang Wang, Cyril Quivoron, Anil K. Padyana, Zenon D. Konteatis, Kimberly Straley, Erica Tobin, Sophie Broutin, Marion Dorsch, Hua Yang, Byron DeLaBarre, Jeremy Travins, Sung Choe, Yue Chen, Lei Jin, Wentao Wei, Virginie Penard-Lacronique, Raj Nagaraja, Wei Liu, Lenny Dang, Shengfang Jin, Cheng Fang, Lee Silverman, Fan Jiang, Katharine E. Yen, Giovanni Cianchetta, Olivier Bernard, Erin Artin, Muriel D. David, Shin-San Michael Su, Stefan Gross, Francesco G. Salituro, Véronique Saada, Stéphane de Botton, Scott A. Biller, Angelo Paci, Benoit S. Marteyn, Yingxia Xu
المساهمون: Agios Pharmaceuticals, Hématopoïèse normale et pathologique (U1170 Inserm), Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Gustave Roussy (IGR)-Université Paris-Sud - Paris 11 (UP11), Institut Gustave Roussy (IGR), Plateforme d’évaluation préclinique (PFEP), Analyse moléculaire, modélisation et imagerie de la maladie cancéreuse (AMMICa), Université Paris-Sud - Paris 11 (UP11)-Institut Gustave Roussy (IGR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris-Sud - Paris 11 (UP11)-Institut Gustave Roussy (IGR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Pharmacologie, Département de biologie et pathologie médicales [Gustave Roussy], Institut Gustave Roussy (IGR)-Institut Gustave Roussy (IGR), Laboratoire de thérapie cellulaire, Département de médecine oncologique [Gustave Roussy], Pathogénie microbienne moléculaire, Institut Pasteur [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM), Tufts Medical Center, ShangPharma, Viva Biotech Ltd., This work was funded by Agios Pharmaceuticals, Inc., the French National Institute of Health (INSERM-AVIESAN), the National Cancer Institute (INCa-DGOS-Inserm_6043 and INCa 2012-1-RT-09), and the Fondation Association pour la Recherche sur le Cancer (ARC, SL220130607089 Programme Labellisé to V. Penard-Lacronique and S. de Botton). M.D. David is funded by a fellowship from the Institut National du Cancer (INCa-DGOS_5733).
المصدر: Cancer Discovery
Cancer Discovery, American Association for Cancer Research, 2017, 7 (5), pp.478-493. ⟨10.1158/2159-8290.CD-16-1034⟩مصطلحات موضوعية: 0301 basic medicine, Myeloid, IDH1, Cellular differentiation, Myeloid leukemia, [SDV.CAN]Life Sciences [q-bio]/Cancer, Biology, Enasidenib, medicine.disease, Molecular biology, IDH2, 03 medical and health sciences, Leukemia, 030104 developmental biology, 0302 clinical medicine, medicine.anatomical_structure, Isocitrate dehydrogenase, Oncology, 030220 oncology & carcinogenesis, medicine
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e5319b71d47ef568ebb071e758566cc
https://doi.org/10.1158/2159-8290.cd-16-1034 -
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المؤلفون: Gajja S. Salomons, Yong Cang, Scott A. Biller, Hua Yang, Josh Powe, Dongwei Zhu, Stefan Gross, Stuart Murray, Kimberly Straley, Samuel V. Agresta, Karen S. Regan, Katharine E. Yen, Yaguang Si, Mya Steadman, Wei Liu, Lenny Dang, Ana Pop, Yue Chen, Erin Artin, Marion Dorsch, Jeremy Travins, Stephanie Santiago, Shengfang Jin, Muriel D. David, Cyril Quivoron, Andrew Kernytsky, Virginie Penard-Lacronique, Lee Silverman, Chenming Lu, Shin San Michael Su, Zhizhong Lin, Erwin E.W. Jansen, Fang Wang, Eduard A. Struys
المساهمون: Laboratory Medicine, Amsterdam Neuroscience - Cellular & Molecular Mechanisms
المصدر: Journal of Inherited Metabolic Disease
Journal of Inherited Metabolic Disease, 39(6), 807-820. Springer Netherlands
Wang, F, Travins, J, Lin, Z, Si, Y, Chen, Y, Powe, J, Murray, S, Zhu, D, Artin, E, Gross, S, Santiago, S, Steadman, M, Kernytsky, A, Straley, K, Lu, C, Pop, A, Struys, E A, Jansen, E E W, Salomons, G S, David, M D, Quivoron, C, Penard-Lacronique, V, Regan, K S, Liu, W, Dang, L, Yang, H, Silverman, L, Agresta, S, Dorsch, M, Biller, S, Yen, K, Cang, Y, Su, S S M & Jin, S 2016, ' A small molecule inhibitor of mutant IDH2 rescues cardiomyopathy in a D-2-hydroxyglutaric aciduria type II mouse model ', Journal of Inherited Metabolic Disease, vol. 39, no. 6, pp. 807-820 . https://doi.org/10.1007/s10545-016-9960-yمصطلحات موضوعية: 0301 basic medicine, Mutant, Cardiomyopathy, Locus (genetics), Biology, IDH2, Germline, Small Molecule Libraries, 03 medical and health sciences, Epilepsy, Mice, Genetics, medicine, Animals, Genetics(clinical), Gene, Genetics (clinical), chemistry.chemical_classification, Brain Diseases, Metabolic, Inborn, medicine.disease, Isocitrate Dehydrogenase, Disease Models, Animal, 030104 developmental biology, Enzyme, chemistry, Mutation, Cancer research, Original Article, Cardiomyopathies
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المؤلفون: Rob A. Cairns, Yi Sheng, Tak W. Mak, Erica Tobin, Jing Ye, Carmen Dominguez-Brauer, Rohini Narayanaswamy, Kimberly Straley, Wanda Y. Li, Dana M. Larsen, François Lemonnier, Satoshi Inoue, Philippe Gaulard, Andrew Wakeham, Zhenyue Hao, Bryan E. Snow
المصدر: Proceedings of the National Academy of Sciences. 113:1387-1392
مصطلحات موضوعية: 0301 basic medicine, Multidisciplinary, Myeloid, IDH1, Lineage (genetic), T cell, Mutant, Biological Sciences, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Biology, Genes, p53, Bioinformatics, Isocitrate Dehydrogenase, Glutamine, Mice, 03 medical and health sciences, Haematopoiesis, 030104 developmental biology, medicine.anatomical_structure, Isocitrate dehydrogenase, Mutation, medicine, Cancer research, Animals, Exome
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6719bc5c07b09dbdc858148ff023f45f
https://doi.org/10.1073/pnas.1525354113 -
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المؤلفون: Zhuyin Li, Anton Simeonov, Douglas S. Auld, Lenny Dang, Mindy I. Davis, Rajan Pragani, Erin Artin, Min Shen, Matthew B. Boxer, Janeta Popovici-Muller, Kimberly Straley, Wendy A. Lea, Natasha Thorne, Byron DeLaBarre, Stefan Gross
المصدر: Journal of Biological Chemistry. 289:13717-13725
مصطلحات موضوعية: IDH1, Mutant, Dehydrogenase, Biology, Biochemistry, Biophysical Phenomena, Small Molecule Libraries, Mice, hemic and lymphatic diseases, Cell Line, Tumor, Acetamides, medicine, Animals, Humans, Enzyme Inhibitors, neoplasms, Molecular Biology, chemistry.chemical_classification, Microscale thermophoresis, Molecular Bases of Disease, Cell Biology, Molecular biology, Isocitrate Dehydrogenase, nervous system diseases, Enzyme, Isocitrate dehydrogenase, Mechanism of action, chemistry, Product inhibition, Mutation, Benzimidazoles, Mutant Proteins, medicine.symptom
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e376e467bd08b4ee964f82f3fa066e4b
https://doi.org/10.1074/jbc.m113.511030
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