المؤلفون: Buenaventura T; MRC LMS, Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK., Bagci H; MRC LMS, Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK., Patrascan I; MRC LMS, Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK., Graham JJ; Leicester Institute of Structural and Chemical Biology, Department of Molecular and Cell Biology, University of Leicester, Leicester, UK., Hipwell KD; Leicester Institute of Structural and Chemical Biology, Department of Molecular and Cell Biology, University of Leicester, Leicester, UK., Oldenkamp R; Division of Cell Biology, Netherlands Cancer Institute, Amsterdam, The Netherlands., King JWD; MRC LMS, Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK., Urtasun J; MRC LMS, Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK., Young G; MRC LMS, Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK., Mouzo D; Translational Bioinformatics Unit, Navarrabiomed, Universidad Pública de Navarra (UPNA), Instituto de Investigación Sanitaria de Navarra (IdiSNA), Pamplona, Spain., Gomez-Cabrero D; Translational Bioinformatics Unit, Navarrabiomed, Universidad Pública de Navarra (UPNA), Instituto de Investigación Sanitaria de Navarra (IdiSNA), Pamplona, Spain.; Bioscience Program, Biological and Environmental Sciences and Engineering Division (BESE), King Abdullah University of Science and Technology KAUST, Thuwal, Saudi Arabia., Rowland BD; Division of Cell Biology, Netherlands Cancer Institute, Amsterdam, The Netherlands., Panne D; Leicester Institute of Structural and Chemical Biology, Department of Molecular and Cell Biology, University of Leicester, Leicester, UK., Fisher AG; MRC LMS, Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK.; Department of Biochemistry, University of Oxford, Oxford, UK., Merkenschlager M; MRC LMS, Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK. matthias.merkenschlager@lms.mrc.ac.uk.

المصدر: Nature genetics [Nat Genet] 2024 Jul 26. Date of Electronic Publication: 2024 Jul 26.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Pub. Co Country of Publication: United States NLM ID: 9216904 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1718 (Electronic) Linking ISSN: 10614036 NLM ISO Abbreviation: Nat Genet Subsets: MEDLINE

المؤلفون: Al-Jibury E; MRC LMS, Imperial College London, London, W12 0NN, UK. e.aljibury@lms.mrc.ac.uk.; Department of Computing, Imperial College London, London, SW7 2RH, UK. e.aljibury@lms.mrc.ac.uk., King JWD; MRC LMS, Imperial College London, London, W12 0NN, UK., Guo Y; MRC LMS, Imperial College London, London, W12 0NN, UK.; Sheng Yushou Center of Cell Biology and Immunology, Joint International Research Laboratory of Metabolic and Developmental Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, 200240, China.; WLA Laboratories, Shanghai, 201203, China., Lenhard B; MRC LMS, Imperial College London, London, W12 0NN, UK.; Sars International Centre for Marine Molecular Biology, University of Bergen, 5008, Bergen, Norway., Fisher AG; MRC LMS, Imperial College London, London, W12 0NN, UK., Merkenschlager M; MRC LMS, Imperial College London, London, W12 0NN, UK. matthias.merkenschlager@lms.mrc.ac.uk., Rueckert D; Department of Computing, Imperial College London, London, SW7 2RH, UK. d.rueckert@imperial.ac.uk.; Klinikum rechts der Isar, Technical University of Munich, 81675, Munich, Germany. d.rueckert@imperial.ac.uk.

المصدر: Nature communications [Nat Commun] 2023 Aug 17; Vol. 14 (1), pp. 5007. Date of Electronic Publication: 2023 Aug 17.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

مواضيع طبية MeSH: Deep Learning*, Chromatin/genetics ; Benchmarking ; Molecular Conformation ; Neural Networks, Computer

المؤلفون: McAllan L; Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, W12 0NN, UK.; MRC London Institute of Medical Sciences, London, W12 0NN, UK., Baranasic D; Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, W12 0NN, UK.; MRC London Institute of Medical Sciences, London, W12 0NN, UK., Villicaña S; Department of Twin Research and Genetic Epidemiology, King's College London, London, UK., Brown S; Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, W12 0NN, UK.; MRC London Institute of Medical Sciences, London, W12 0NN, UK., Zhang W; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, W2 1PG, UK.; Department of Cardiology, Ealing Hospital, London North West University Healthcare NHS Trust, Middlesex, UB1 3HW, UK., Lehne B; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, W2 1PG, UK., Adamo M; UCLH Bariatric Centre for Weight Loss, Weight Management and Metabolic and Endocrine Surgery, University College London Hospitals, Ground Floor West Wing, 250 Euston Road, London, NW1 2PG, UK., Jenkinson A; UCLH Bariatric Centre for Weight Loss, Weight Management and Metabolic and Endocrine Surgery, University College London Hospitals, Ground Floor West Wing, 250 Euston Road, London, NW1 2PG, UK., Elkalaawy M; UCLH Bariatric Centre for Weight Loss, Weight Management and Metabolic and Endocrine Surgery, University College London Hospitals, Ground Floor West Wing, 250 Euston Road, London, NW1 2PG, UK., Mohammadi B; UCLH Bariatric Centre for Weight Loss, Weight Management and Metabolic and Endocrine Surgery, University College London Hospitals, Ground Floor West Wing, 250 Euston Road, London, NW1 2PG, UK., Hashemi M; UCLH Bariatric Centre for Weight Loss, Weight Management and Metabolic and Endocrine Surgery, University College London Hospitals, Ground Floor West Wing, 250 Euston Road, London, NW1 2PG, UK., Fernandes N; Imperial BRC Genomics Facility, Faculty of Medicine, Imperial College London, London, W12 0NN, UK., Lambie N; Imperial BRC Genomics Facility, Faculty of Medicine, Imperial College London, London, W12 0NN, UK., Williams R; Imperial BRC Genomics Facility, Faculty of Medicine, Imperial College London, London, W12 0NN, UK., Christiansen C; Department of Twin Research and Genetic Epidemiology, King's College London, London, UK.; School of Mathematics and Statistics, Faculty of Science, Technology, Engineering and Mathematics, The Open University, Milton Keynes, UK., Yang Y; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, W2 1PG, UK.; School of Cardiovascular and Metabolic Medicine and Sciences, James Black Centre, King's College London British Heart Foundation Centre of Excellence, 125 Coldharbour Lane, London, SE5 9NU, UK., Zudina L; Department of Clinical & Experimental Medicine, University of Surrey, Guildford, UK., Lagou V; Department of Microbiology and Immunology, Laboratory of Adaptive Immunity, KU Leuven, Leuven, Belgium.; VIB-KU Leuven Center for Brain and Disease Research, Leuven, Belgium., Tan S; Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore., Castillo-Fernandez J; Department of Twin Research and Genetic Epidemiology, King's College London, London, UK., King JWD; MRC London Institute of Medical Sciences, London, W12 0NN, UK., Soong R; Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore.; Department of Pathology, National University Hospital, Singapore, Singapore., Elliott P; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, W2 1PG, UK.; MRC Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.; National Institute for Health Research Biomedical Research Centre, Imperial College London, London, UK., Scott J; National Heart and Lung Institute, Imperial College London, London, W12 0NN, UK.; Imperial College Healthcare NHS Trust, London, W12 0HS, UK., Prokopenko I; Department of Clinical & Experimental Medicine, University of Surrey, Guildford, UK.; People-Centred Artificial Intelligence Institute, University of Surrey, Guildford, UK.; Institute of Biochemistry and Genetics, Ufa Federal Research Centre Russian Academy of Sciences, Ufa, Russian Federation., Cebola I; Section of Genetics and Genomics, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK., Loh M; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, W2 1PG, UK.; Translational Laboratory in Genetic Medicine (TLGM), Agency for Science, Technology and Research (A*STAR), 8A Biomedical Grove, Immunos, Level 5, Singapore, 138648, Singapore.; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore., Lenhard B; Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, W12 0NN, UK.; MRC London Institute of Medical Sciences, London, W12 0NN, UK., Batterham RL; UCLH Bariatric Centre for Weight Loss, Weight Management and Metabolic and Endocrine Surgery, University College London Hospitals, Ground Floor West Wing, 250 Euston Road, London, NW1 2PG, UK.; Centre for Obesity Research, Rayne Institute, Department of Medicine, University College, London, WC1E 6JJ, UK.; National Institute of Health Research University College London Hospitals Biomedical Research Centre, London, W1T 7DN, UK., Bell JT; Department of Twin Research and Genetic Epidemiology, King's College London, London, UK., Chambers JC; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, W2 1PG, UK.; Department of Cardiology, Ealing Hospital, London North West University Healthcare NHS Trust, Middlesex, UB1 3HW, UK.; MRC Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.; Imperial College Healthcare NHS Trust, London, W12 0HS, UK.; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore., Kooner JS; Department of Cardiology, Ealing Hospital, London North West University Healthcare NHS Trust, Middlesex, UB1 3HW, UK.; MRC Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.; National Heart and Lung Institute, Imperial College London, London, W12 0NN, UK.; Imperial College Healthcare NHS Trust, London, W12 0HS, UK., Scott WR; Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, W12 0NN, UK. w.scott@imperial.ac.uk.; MRC London Institute of Medical Sciences, London, W12 0NN, UK. w.scott@imperial.ac.uk.; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, W2 1PG, UK. w.scott@imperial.ac.uk.; Imperial College Healthcare NHS Trust, London, W12 0HS, UK. w.scott@imperial.ac.uk.

المصدر: Nature communications [Nat Commun] 2023 May 15; Vol. 14 (1), pp. 2784. Date of Electronic Publication: 2023 May 15.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

مواضيع طبية MeSH: DNA Methylation* , Diabetes Mellitus*/metabolism, Humans ; Adipocytes/metabolism ; Obesity/metabolism ; Genomics ; Epigenesis, Genetic

المؤلفون: Guo Y; MRC London Institute of Medical Sciences, Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London W12 0NN, UK; Sheng Yushou Center of Cell Biology and Immunology, Joint International Research Laboratory of Metabolic and Developmental Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China; WLA Laboratories, Shanghai 201203, China., Al-Jibury E; MRC London Institute of Medical Sciences, Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London W12 0NN, UK; Department of Computing, Imperial College London, London SW7 2RH, UK., Garcia-Millan R; Department of Mathematics, Imperial College London, London SW7 2RH, UK; Department of Applied Mathematics and Theoretical Physics, University of Cambridge, Cambridge CB3 0WA, UK; St John's College, University of Cambridge, Cambridge CB2 1TP, UK., Ntagiantas K; Department of Mathematics, Imperial College London, London SW7 2RH, UK., King JWD; MRC London Institute of Medical Sciences, Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London W12 0NN, UK., Nash AJ; MRC London Institute of Medical Sciences, Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London W12 0NN, UK., Galjart N; Department of Cell Biology, Erasmus University Medical Center, 3015 GD Rotterdam, the Netherlands., Lenhard B; MRC London Institute of Medical Sciences, Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London W12 0NN, UK; Sars International Centre for Marine Molecular Biology, University of Bergen, 5008 Bergen, Norway., Rueckert D; Department of Computing, Imperial College London, London SW7 2RH, UK; Chair for AI in Healthcare and Medicine, Technical University of Munich, 81675 Munich, Germany., Fisher AG; MRC London Institute of Medical Sciences, Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London W12 0NN, UK., Pruessner G; Department of Mathematics, Imperial College London, London SW7 2RH, UK. Electronic address: g.pruessner@imperial.ac.uk., Merkenschlager M; MRC London Institute of Medical Sciences, Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London W12 0NN, UK. Electronic address: matthias.merkenschlager@lms.mrc.ac.uk.

المصدر: Molecular cell [Mol Cell] 2022 Oct 20; Vol. 82 (20), pp. 3769-3780.e5. Date of Electronic Publication: 2022 Sep 30.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 9802571 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4164 (Electronic) Linking ISSN: 10972765 NLM ISO Abbreviation: Mol Cell Subsets: MEDLINE

مواضيع طبية MeSH: Chromatin*/genetics , Chromosomal Proteins, Non-Histone*/genetics , Chromosomal Proteins, Non-Histone*/metabolism, Animals ; CCCTC-Binding Factor/genetics ; CCCTC-Binding Factor/metabolism ; Cell Cycle Proteins/genetics ; Cell Cycle Proteins/metabolism ; Polymers/metabolism ; Mammals/metabolism ; Cohesins

المؤلفون: Polychronopoulos D; Computational Regulatory Genomics Group, MRC London Institute of Medical Sciences, Du Cane Road, London W12 0NN, UK.; Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, Hammersmith Campus, Du Cane Road, London W12 0NN, UK., King JWD; Computational Regulatory Genomics Group, MRC London Institute of Medical Sciences, Du Cane Road, London W12 0NN, UK.; Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, Hammersmith Campus, Du Cane Road, London W12 0NN, UK., Nash AJ; Computational Regulatory Genomics Group, MRC London Institute of Medical Sciences, Du Cane Road, London W12 0NN, UK.; Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, Hammersmith Campus, Du Cane Road, London W12 0NN, UK., Tan G; Computational Regulatory Genomics Group, MRC London Institute of Medical Sciences, Du Cane Road, London W12 0NN, UK.; Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, Hammersmith Campus, Du Cane Road, London W12 0NN, UK., Lenhard B; Computational Regulatory Genomics Group, MRC London Institute of Medical Sciences, Du Cane Road, London W12 0NN, UK.; Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, Hammersmith Campus, Du Cane Road, London W12 0NN, UK.; Sars International Centre for Marine Molecular Biology, University of Bergen, Thormøhlensgate 55, N-5008 Bergen, Norway.

المصدر: Nucleic acids research [Nucleic Acids Res] 2017 Dec 15; Vol. 45 (22), pp. 12611-12624.

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN: 1362-4962 (Electronic) Linking ISSN: 03051048 NLM ISO Abbreviation: Nucleic Acids Res Subsets: MEDLINE

مواضيع طبية MeSH: Gene Expression Regulation, Developmental*, Conserved Sequence/*genetics , Genome/*genetics , Regulatory Sequences, Nucleic Acid/*genetics, Animals ; Base Sequence ; Evolution, Molecular ; Genes, Developmental/genetics ; Humans ; Sequence Homology, Nucleic Acid