المؤلفون: Jumppanen M; Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, Viikinkaari 5 E, (P.O. Box 56), FI-00014, Helsinki, Finland., Kinnunen SM; Drug Research Program, Division of Pharmacology and Pharmacotherapy, Faculty of Pharmacy, University of Helsinki, Viikinkaari 5 E, (P.O. Box 56), FI-00014, Helsinki, Finland., Zore M; Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, Viikinkaari 5 E, (P.O. Box 56), FI-00014, Helsinki, Finland., Välimäki MJ; Drug Research Program, Division of Pharmacology and Pharmacotherapy, Faculty of Pharmacy, University of Helsinki, Viikinkaari 5 E, (P.O. Box 56), FI-00014, Helsinki, Finland., Talman V; Drug Research Program, Division of Pharmacology and Pharmacotherapy, Faculty of Pharmacy, University of Helsinki, Viikinkaari 5 E, (P.O. Box 56), FI-00014, Helsinki, Finland., Gennäs GBA; Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, Viikinkaari 5 E, (P.O. Box 56), FI-00014, Helsinki, Finland., Ruskoaho HJ; Drug Research Program, Division of Pharmacology and Pharmacotherapy, Faculty of Pharmacy, University of Helsinki, Viikinkaari 5 E, (P.O. Box 56), FI-00014, Helsinki, Finland., Yli-Kauhaluoma J; Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, Viikinkaari 5 E, (P.O. Box 56), FI-00014, Helsinki, Finland. jari.yli-kauhaluoma@helsinki.fi.

المصدر: Scientific reports [Sci Rep] 2024 Apr 18; Vol. 14 (1), pp. 8938. Date of Electronic Publication: 2024 Apr 18.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

مواضيع طبية MeSH: Transcription Factors*/metabolism , Heart Failure*, Humans ; Homeobox Protein Nkx-2.5/metabolism ; Ligands ; Chromatography, Affinity ; GATA4 Transcription Factor/metabolism ; Homeodomain Proteins/metabolism

المؤلفون: Pohjolainen L; Drug Research Program and Division of Pharmacology and Pharmacotherapy, Faculty of Pharmacy, University of Helsinki, P.O. Box 56, 00014, Helsinki, Finland., Kinnunen SM; Drug Research Program and Division of Pharmacology and Pharmacotherapy, Faculty of Pharmacy, University of Helsinki, P.O. Box 56, 00014, Helsinki, Finland., Auno S; Drug Research Program and Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland., Kiriazis A; Drug Research Program and Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland., Pohjavaara S; Drug Research Program and Division of Pharmacology and Pharmacotherapy, Faculty of Pharmacy, University of Helsinki, P.O. Box 56, 00014, Helsinki, Finland., Kari-Koskinen J; Drug Research Program and Division of Pharmacology and Pharmacotherapy, Faculty of Pharmacy, University of Helsinki, P.O. Box 56, 00014, Helsinki, Finland., Zore M; Drug Research Program and Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland., Jumppanen M; Drug Research Program and Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland., Yli-Kauhaluoma J; Drug Research Program and Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland., Talman V; Drug Research Program and Division of Pharmacology and Pharmacotherapy, Faculty of Pharmacy, University of Helsinki, P.O. Box 56, 00014, Helsinki, Finland., Ruskoaho H; Drug Research Program and Division of Pharmacology and Pharmacotherapy, Faculty of Pharmacy, University of Helsinki, P.O. Box 56, 00014, Helsinki, Finland., Välimäki MJ; Drug Research Program and Division of Pharmacology and Pharmacotherapy, Faculty of Pharmacy, University of Helsinki, P.O. Box 56, 00014, Helsinki, Finland. mika.valimaki@helsinki.fi.

المصدر: Stem cell research & therapy [Stem Cell Res Ther] 2024 Jan 02; Vol. 15 (1), pp. 5. Date of Electronic Publication: 2024 Jan 02.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 101527581 Publication Model: Electronic Cited Medium: Internet ISSN: 1757-6512 (Electronic) Linking ISSN: 17576512 NLM ISO Abbreviation: Stem Cell Res Ther Subsets: MEDLINE

مواضيع طبية MeSH: Myocytes, Cardiac*/metabolism , Induced Pluripotent Stem Cells*/metabolism, Humans ; Rats ; Animals ; Hypertrophy/metabolism ; Transcription Factors/metabolism ; Signal Transduction ; GATA4 Transcription Factor/genetics ; GATA4 Transcription Factor/metabolism

المؤلفون: Vainio L; Research Unit of Biomedicine, Department of Pharmacology and Toxicology, University of Oulu, Oulu 90220, Finland.; Biocenter Oulu, University of Oulu, Oulu 90220, Finland., Taponen S; Research Unit of Biomedicine, Department of Pharmacology and Toxicology, University of Oulu, Oulu 90220, Finland.; Biocenter Oulu, University of Oulu, Oulu 90220, Finland., Kinnunen SM; Research Unit of Biomedicine, Department of Pharmacology and Toxicology, University of Oulu, Oulu 90220, Finland.; Drug Research Program, Division of Pharmacology and Pharmacotherapy, Faculty of Pharmacy, University of Helsinki, Helsinki 00014, Finland., Halmetoja E; Research Unit of Biomedicine, Department of Pharmacology and Toxicology, University of Oulu, Oulu 90220, Finland.; Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu 90220, Finland., Szabo Z; Research Unit of Biomedicine, Department of Pharmacology and Toxicology, University of Oulu, Oulu 90220, Finland., Alakoski T; Research Unit of Biomedicine, Department of Pharmacology and Toxicology, University of Oulu, Oulu 90220, Finland.; Biocenter Oulu, University of Oulu, Oulu 90220, Finland., Ulvila J; Research Unit of Biomedicine, Department of Pharmacology and Toxicology, University of Oulu, Oulu 90220, Finland., Junttila J; Biocenter Oulu, University of Oulu, Oulu 90220, Finland.; Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu 90220, Finland.; Research Unit of Internal Medicine, Division of Cardiology, Oulu University Hospital and University of Oulu, Oulu 90220, Finland., Lakkisto P; Unit of Cardiovascular Research, Minerva Institute for Medical Research, Helsinki 00014, Finland.; Department of Clinical Chemistry and Hematology, University of Helsinki and Helsinki University Hospital, Helsinki 00014, Finland., Magga J; Research Unit of Biomedicine, Department of Pharmacology and Toxicology, University of Oulu, Oulu 90220, Finland.; Biocenter Oulu, University of Oulu, Oulu 90220, Finland., Kerkelä R; Research Unit of Biomedicine, Department of Pharmacology and Toxicology, University of Oulu, Oulu 90220, Finland.; Biocenter Oulu, University of Oulu, Oulu 90220, Finland.; Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu 90220, Finland.

المصدر: International journal of molecular sciences [Int J Mol Sci] 2021 Dec 18; Vol. 22 (24). Date of Electronic Publication: 2021 Dec 18.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

مواضيع طبية MeSH: Cardiomegaly/*metabolism , Glycogen Synthase Kinase 3 beta/*metabolism , Myocardial Ischemia/*metabolism , Myocytes, Cardiac/*pathology, Animals ; Cardiomegaly/pathology ; Cell Proliferation ; Cell Survival ; Cells, Cultured ; Humans ; Male ; Mechanistic Target of Rapamycin Complex 1/metabolism ; Mice ; Mice, Inbred C57BL ; Myocardial Ischemia/pathology ; Myocytes, Cardiac/metabolism ; Phosphorylation ; Rats, Sprague-Dawley ; Rats

المؤلفون: Välimäki MJ; Drug Research Program, Division of Pharmacology and Pharmacotherapy, Faculty of Pharmacy, University of Helsinki, P.O. Box 56, FI-00014, Helsinki, Finland., Leigh RS; Drug Research Program, Division of Pharmacology and Pharmacotherapy, Faculty of Pharmacy, University of Helsinki, P.O. Box 56, FI-00014, Helsinki, Finland., Kinnunen SM; Drug Research Program, Division of Pharmacology and Pharmacotherapy, Faculty of Pharmacy, University of Helsinki, P.O. Box 56, FI-00014, Helsinki, Finland., March AR; Drug Research Program, Division of Pharmacology and Pharmacotherapy, Faculty of Pharmacy, University of Helsinki, P.O. Box 56, FI-00014, Helsinki, Finland., de Sande AH; Institute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio, Finland., Kinnunen M; Institute of Biotechnology, University of Helsinki, Helsinki, Finland.; Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland., Varjosalo M; Institute of Biotechnology, University of Helsinki, Helsinki, Finland.; Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland., Heinäniemi M; Institute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio, Finland., Kaynak BL; Drug Research Program, Division of Pharmacology and Pharmacotherapy, Faculty of Pharmacy, University of Helsinki, P.O. Box 56, FI-00014, Helsinki, Finland. bogac.kaynak@helsinki.fi., Ruskoaho H; Drug Research Program, Division of Pharmacology and Pharmacotherapy, Faculty of Pharmacy, University of Helsinki, P.O. Box 56, FI-00014, Helsinki, Finland. heikki.ruskoaho@helsinki.fi.

المصدر: Stem cell research & therapy [Stem Cell Res Ther] 2021 Mar 18; Vol. 12 (1), pp. 190. Date of Electronic Publication: 2021 Mar 18.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 101527581 Publication Model: Electronic Cited Medium: Internet ISSN: 1757-6512 (Electronic) Linking ISSN: 17576512 NLM ISO Abbreviation: Stem Cell Res Ther Subsets: MEDLINE

مواضيع طبية MeSH: Nuclear Proteins* , Transcription Factors*/genetics, Cell Differentiation ; Cell Line ; GATA4 Transcription Factor/genetics ; Homeobox Protein Nkx-2.5/genetics ; Myocytes, Cardiac ; Organogenesis

المؤلفون: Karhu ST; Drug Research Program and Division of Pharmacology and Pharmacotherapy, Faculty of Pharmacy, University of Helsinki, P.O. Box 56, 00014, Helsinki, Finland., Kinnunen SM; Drug Research Program and Division of Pharmacology and Pharmacotherapy, Faculty of Pharmacy, University of Helsinki, P.O. Box 56, 00014, Helsinki, Finland.; Department of Pharmacology and Toxicology, Institute of Biomedicine, University of Oulu, Oulu, Finland., Tölli M; Department of Pharmacology and Toxicology, Institute of Biomedicine, University of Oulu, Oulu, Finland., Välimäki MJ; Drug Research Program and Division of Pharmacology and Pharmacotherapy, Faculty of Pharmacy, University of Helsinki, P.O. Box 56, 00014, Helsinki, Finland.; Department of Pharmacology and Toxicology, Institute of Biomedicine, University of Oulu, Oulu, Finland., Szabó Z; Department of Pharmacology and Toxicology, Institute of Biomedicine, University of Oulu, Oulu, Finland., Talman V; Drug Research Program and Division of Pharmacology and Pharmacotherapy, Faculty of Pharmacy, University of Helsinki, P.O. Box 56, 00014, Helsinki, Finland.; National Heart and Lung Institute, Imperial College London, London, UK., Ruskoaho H; Drug Research Program and Division of Pharmacology and Pharmacotherapy, Faculty of Pharmacy, University of Helsinki, P.O. Box 56, 00014, Helsinki, Finland. heikki.ruskoaho@helsinki.fi.; Department of Pharmacology and Toxicology, Institute of Biomedicine, University of Oulu, Oulu, Finland. heikki.ruskoaho@helsinki.fi.

المصدر: Archives of toxicology [Arch Toxicol] 2020 Jun; Vol. 94 (6), pp. 2113-2130. Date of Electronic Publication: 2020 Mar 17.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 0417615 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0738 (Electronic) Linking ISSN: 03405761 NLM ISO Abbreviation: Arch Toxicol Subsets: MEDLINE

مواضيع طبية MeSH: Antibiotics, Antineoplastic/*toxicity , Doxorubicin/*toxicity , GATA4 Transcription Factor/*metabolism , Heart Diseases/*prevention & control , Induced Pluripotent Stem Cells/*drug effects , Myocytes, Cardiac/*drug effects , Protective Agents/*pharmacology, Animals ; Cardiotoxicity ; Caspases, Effector/metabolism ; Cell Line ; Cell Survival/drug effects ; Disease Models, Animal ; Heart Diseases/chemically induced ; Heart Diseases/metabolism ; Heart Diseases/pathology ; Humans ; Induced Pluripotent Stem Cells/metabolism ; Induced Pluripotent Stem Cells/pathology ; Male ; Myocytes, Cardiac/metabolism ; Myocytes, Cardiac/pathology ; Natriuretic Peptide, Brain/metabolism ; Protein Precursors/metabolism ; Rats, Sprague-Dawley ; Rats, Wistar ; Signal Transduction ; Stroke Volume/drug effects ; Time Factors ; Ventricular Function, Left/drug effects

المؤلفون: Jumppanen M, Kinnunen SM, Välimäki MJ, Talman V; Imperial College London, Imperial Centre for Translational and Experimental Medicine , National Heart and Lung Institute , Du Cane Road , London W12 0NN , United Kingdom., Auno S, Bruun T, Boije Af Gennäs G, Xhaard H, Aumüller IB, Ruskoaho H, Yli-Kauhaluoma J

المصدر: Journal of medicinal chemistry [J Med Chem] 2019 Sep 12; Vol. 62 (17), pp. 8284-8310. Date of Electronic Publication: 2019 Sep 03.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: GATA4 Transcription Factor/*antagonists & inhibitors , Homeobox Protein Nkx-2.5/*antagonists & inhibitors , Isoxazoles/*pharmacology, Animals ; COS Cells ; Cell Survival/drug effects ; Cells, Cultured ; Chlorocebus aethiops ; Dose-Response Relationship, Drug ; GATA4 Transcription Factor/chemistry ; GATA4 Transcription Factor/metabolism ; Homeobox Protein Nkx-2.5/chemistry ; Homeobox Protein Nkx-2.5/metabolism ; Isoxazoles/chemical synthesis ; Isoxazoles/chemistry ; Molecular Structure ; Protein Binding/drug effects ; Rats ; Rats, Wistar ; Structure-Activity Relationship

المؤلفون: Karhu ST; Drug Research Program and Division of Pharmacology and Pharmacotherapy, Faculty of Pharmacy, University of Helsinki, P.O. Box 56, 00014, Helsinki, Finland., Välimäki MJ; Drug Research Program and Division of Pharmacology and Pharmacotherapy, Faculty of Pharmacy, University of Helsinki, P.O. Box 56, 00014, Helsinki, Finland.; Department of Pharmacology and Toxicology, Institute of Biomedicine, University of Oulu, Oulu, Finland., Jumppanen M; Drug Research Program and Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, P.O. Box 56, 00014, Helsinki, Finland., Kinnunen SM; Drug Research Program and Division of Pharmacology and Pharmacotherapy, Faculty of Pharmacy, University of Helsinki, P.O. Box 56, 00014, Helsinki, Finland.; Department of Pharmacology and Toxicology, Institute of Biomedicine, University of Oulu, Oulu, Finland., Pohjolainen L; Drug Research Program and Division of Pharmacology and Pharmacotherapy, Faculty of Pharmacy, University of Helsinki, P.O. Box 56, 00014, Helsinki, Finland., Leigh RS; Drug Research Program and Division of Pharmacology and Pharmacotherapy, Faculty of Pharmacy, University of Helsinki, P.O. Box 56, 00014, Helsinki, Finland., Auno S; Drug Research Program and Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, P.O. Box 56, 00014, Helsinki, Finland., Földes G; National Heart and Lung Institute, Imperial College London, London, UK.; Heart and Vascular Center, Semmelweis University, Budapest, Hungary., Boije Af Gennäs G; Drug Research Program and Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, P.O. Box 56, 00014, Helsinki, Finland., Yli-Kauhaluoma J; Drug Research Program and Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, P.O. Box 56, 00014, Helsinki, Finland., Ruskoaho H; Drug Research Program and Division of Pharmacology and Pharmacotherapy, Faculty of Pharmacy, University of Helsinki, P.O. Box 56, 00014, Helsinki, Finland., Talman V; Drug Research Program and Division of Pharmacology and Pharmacotherapy, Faculty of Pharmacy, University of Helsinki, P.O. Box 56, 00014, Helsinki, Finland. virpi.talman@helsinki.fi.

المصدر: Archives of toxicology [Arch Toxicol] 2018 Sep; Vol. 92 (9), pp. 2897-2911. Date of Electronic Publication: 2018 Jul 09.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 0417615 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0738 (Electronic) Linking ISSN: 03405761 NLM ISO Abbreviation: Arch Toxicol Subsets: MEDLINE

مواضيع طبية MeSH: GATA4 Transcription Factor/*metabolism , High-Throughput Screening Assays/*methods , Induced Pluripotent Stem Cells/*drug effects , Small Molecule Libraries/*toxicity , Toxicity Tests/*methods, Animals ; COS Cells ; Cell Survival/drug effects ; Cells, Cultured ; Chlorocebus aethiops ; Fibroblasts/drug effects ; GATA4 Transcription Factor/genetics ; Homeobox Protein Nkx-2.5/genetics ; Homeobox Protein Nkx-2.5/metabolism ; Myocytes, Cardiac/drug effects ; Rats ; Small Molecule Libraries/chemistry ; Structure-Activity Relationship

المؤلفون: Kinnunen SM; Drug Research Program, Division of Pharmacology and Pharmacotherapy, University of Helsinki, Helsinki, Finland.; Department of Pharmacology and Toxicology, Institute of Biomedicine, University of Oulu, Oulu, Finland., Tölli M; Department of Pharmacology and Toxicology, Institute of Biomedicine, University of Oulu, Oulu, Finland., Välimäki MJ; Drug Research Program, Division of Pharmacology and Pharmacotherapy, University of Helsinki, Helsinki, Finland.; Department of Pharmacology and Toxicology, Institute of Biomedicine, University of Oulu, Oulu, Finland., Gao E; Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania, United States of America., Szabo Z; Department of Pharmacology and Toxicology, Institute of Biomedicine, University of Oulu, Oulu, Finland., Rysä J; School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland., Ferreira MPA; Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland., Ohukainen P; Computational Medicine, Faculty of Medicine, University of Oulu and Biocenter Oulu, Oulu, Finland., Serpi R; Department of Pharmacology and Toxicology, Institute of Biomedicine, University of Oulu, Oulu, Finland., Correia A; Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland., Mäkilä E; Laboratory of Industrial Physics, Department of Physics and Astronomy, University of Turku, Turku, Finland., Salonen J; Laboratory of Industrial Physics, Department of Physics and Astronomy, University of Turku, Turku, Finland., Hirvonen J; Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland., Santos HA; Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland.; Helsinki Institute of Life Sciences (HiLIFE), University of Helsinki, Helsinki, Finland., Ruskoaho H; Drug Research Program, Division of Pharmacology and Pharmacotherapy, University of Helsinki, Helsinki, Finland. heikki.ruskoaho@helsinki.fi.; Department of Pharmacology and Toxicology, Institute of Biomedicine, University of Oulu, Oulu, Finland. heikki.ruskoaho@helsinki.fi.

المصدر: Scientific reports [Sci Rep] 2018 Mar 15; Vol. 8 (1), pp. 4611. Date of Electronic Publication: 2018 Mar 15.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

مواضيع طبية MeSH: GATA4 Transcription Factor/*antagonists & inhibitors , Homeobox Protein Nkx-2.5/*antagonists & inhibitors , Hypertension/*prevention & control , Isoxazoles/*pharmacology , Myocardial Infarction/*prevention & control , Protein Interaction Domains and Motifs/*drug effects , Reperfusion Injury/*prevention & control , Small Molecule Libraries/*pharmacology, Angiotensin II/toxicity ; Animals ; GATA4 Transcription Factor/metabolism ; Gene Expression Regulation/drug effects ; Homeobox Protein Nkx-2.5/metabolism ; Hypertension/chemically induced ; Hypertension/metabolism ; Hypertension/pathology ; Male ; Mice ; Mice, Inbred C57BL ; Myocardial Infarction/metabolism ; Myocardial Infarction/pathology ; Phosphorylation ; Rats, Sprague-Dawley ; Reperfusion Injury/metabolism ; Reperfusion Injury/pathology

المؤلفون: Välimäki MJ; Division of Pharmacology and Pharmacotherapy, Faculty of Pharmacy, University of Helsinki , Helsinki FI-00014, Finland.; Research Unit of Biomedicine, Department of Pharmacology and Toxicology, University of Oulu , Oulu FI-90014, Finland., Tölli MA; Research Unit of Biomedicine, Department of Pharmacology and Toxicology, University of Oulu , Oulu FI-90014, Finland., Kinnunen SM; Division of Pharmacology and Pharmacotherapy, Faculty of Pharmacy, University of Helsinki , Helsinki FI-00014, Finland.; Research Unit of Biomedicine, Department of Pharmacology and Toxicology, University of Oulu , Oulu FI-90014, Finland., Aro J; Research Unit of Biomedicine, Department of Pharmacology and Toxicology, University of Oulu , Oulu FI-90014, Finland., Serpi R; Research Unit of Biomedicine, Department of Pharmacology and Toxicology, University of Oulu , Oulu FI-90014, Finland., Pohjolainen L; Division of Pharmacology and Pharmacotherapy, Faculty of Pharmacy, University of Helsinki , Helsinki FI-00014, Finland., Talman V; Division of Pharmacology and Pharmacotherapy, Faculty of Pharmacy, University of Helsinki , Helsinki FI-00014, Finland., Poso A; Faculty of Health Sciences, School of Pharmacy, University of Eastern Finland , Kuopio FI-70211, Finland., Ruskoaho HJ; Division of Pharmacology and Pharmacotherapy, Faculty of Pharmacy, University of Helsinki , Helsinki FI-00014, Finland.; Research Unit of Biomedicine, Department of Pharmacology and Toxicology, University of Oulu , Oulu FI-90014, Finland.

المصدر: Journal of medicinal chemistry [J Med Chem] 2017 Sep 28; Vol. 60 (18), pp. 7781-7798. Date of Electronic Publication: 2017 Sep 15.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: GATA4 Transcription Factor/*metabolism , Homeobox Protein Nkx-2.5/*metabolism , Isoxazoles/*chemistry , Isoxazoles/*pharmacology , Small Molecule Libraries/*chemistry , Small Molecule Libraries/*pharmacology , Transcriptional Activation/*drug effects, Animals ; Cell Line ; GATA4 Transcription Factor/agonists ; GATA4 Transcription Factor/antagonists & inhibitors ; Homeobox Protein Nkx-2.5/agonists ; Homeobox Protein Nkx-2.5/antagonists & inhibitors ; Humans ; Mice ; Models, Molecular ; Protein Interaction Maps/drug effects

المؤلفون: Ferreira MP; Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, FI-00014 Helsinki, Finland. Electronic address: monica.ferreira@helsinki.fi., Ranjan S; Laboratory of Radiochemistry, Department of Chemistry, University of Helsinki, FI-00014 Helsinki, Finland., Correia AM; Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, FI-00014 Helsinki, Finland., Mäkilä EM; Laboratory of Industrial Physics, Department of Physics and Astronomy, University of Turku, FI-20014 Turku, Finland., Kinnunen SM; Division of Pharmacology and Pharmacotherapy, Faculty of Pharmacy, University of Helsinki, FI-00014 Helsinki, Finland., Zhang H; Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, FI-00014 Helsinki, Finland; School of Applied Science and Engineering, Harvard University, 02138 Cambridge MA, USA., Shahbazi MA; Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, FI-00014 Helsinki, Finland., Almeida PV; Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, FI-00014 Helsinki, Finland., Salonen JJ; Laboratory of Industrial Physics, Department of Physics and Astronomy, University of Turku, FI-20014 Turku, Finland., Ruskoaho HJ; Division of Pharmacology and Pharmacotherapy, Faculty of Pharmacy, University of Helsinki, FI-00014 Helsinki, Finland., Airaksinen AJ; Laboratory of Radiochemistry, Department of Chemistry, University of Helsinki, FI-00014 Helsinki, Finland., Hirvonen JT; Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, FI-00014 Helsinki, Finland. Electronic address: jouni.hirvonen@helsinki.fi., Santos HA; Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, FI-00014 Helsinki, Finland. Electronic address: helder.santos@helsinki.fi.

المصدر: Biomaterials [Biomaterials] 2016 Jul; Vol. 94, pp. 93-104. Date of Electronic Publication: 2016 Apr 11.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 8100316 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-5905 (Electronic) Linking ISSN: 01429612 NLM ISO Abbreviation: Biomaterials Subsets: MEDLINE

مواضيع طبية MeSH: Heart/*physiology , Nanoparticles/*chemistry , Silicon/*chemistry, Adsorption ; Animals ; Atrial Natriuretic Factor/metabolism ; Blood Proteins/metabolism ; Cell Survival ; Colloids ; Humans ; Male ; Myocytes, Cardiac/metabolism ; Nanoparticles/ultrastructure ; Peptides/chemistry ; Porosity ; Rats, Wistar ; Temperature ; Tomography, Emission-Computed, Single-Photon ; Undecylenic Acids/chemistry