المؤلفون: Kirstin Lehmkuhl, Patrizia Diana, Hendrik Jonas, Jens Köhler, Dirk Schepmann, Daniele Aiello, Bernhard Wünsch, Bastian Frehland

المساهمون: Hendrik Jona, Daniele Aiello, Bastian Frehland, Kirstin Lehmkuhl, Dirk Schepmann, Jens Köhler, Patrizia Diana, Bernhard Wünsch

مصطلحات موضوعية: chemistry.chemical_classification, Ketone, Bicyclic molecule, Stereochemistry, Organic Chemistry, KOR agonist, opioid receptor, Biochemistry, Reductive amination, Pyrrolidine, Chiral column chromatography, chemistry.chemical_compound, chemistry, Chiral pool synthesis, 2-azabicyclo[3.2.1]octane, Moiety, Physical and Theoretical Chemistry, Enantiomer

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eaea984e7f93d339c717b4dac4c9a226
http://hdl.handle.net/10447/521671

المؤلفون: Hendrik, Jonas, Daniele, Aiello, Bastian, Frehland, Kirstin, Lehmkuhl, Dirk, Schepmann, Jens, Köhler, Patrizia, Diana, Bernhard, Wünsch

المصدر: Organicbiomolecular chemistry. 19(38)

مصطلحات موضوعية: Octanes

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::7c87747722ede1a970d4447d511798ba
https://pubmed.ncbi.nlm.nih.gov/34528988

المؤلفون: Bernhard Wünsch, Simon M. Ametamey, Kirstin Lehmkuhl, Frederik Börgel, Fabian Galla, Dirk Schepmann

المصدر: Journal of Pharmaceutical and Biomedical Analysis. 172:214-222

مصطلحات موضوعية: Stereochemistry, Metabolite, Clinical Biochemistry, Glucuronidation, Pharmaceutical Science, Ether, Receptors, N-Methyl-D-Aspartate, 01 natural sciences, Analytical Chemistry, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Glucuronides, Piperidines, Drug Discovery, medicine, Ifenprodil, Animals, Humans, Rats, Wistar, Biotransformation, Spectroscopy, Phenol, 010405 organic chemistry, 010401 analytical chemistry, Stereoisomerism, Benzazepines, Human serum albumin, Rats, 0104 chemical sciences, Mice, Inbred C57BL, chemistry, Lipophilicity, Microsomes, Liver, Enantiomer, Glucuronide, Protein Binding, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39d66c2b353588ece084e640fc64568f
https://doi.org/10.1016/j.jpba.2019.04.032

المؤلفون: Dirk Schepmann, Elena Bechthold, Guiscard Seebohm, Cristina García, Freddy A. Bernal, Kirstin Lehmkuhl, Constantin G. Daniliuc, Bastian Frehland, Julian A. Schreiber, Thomas J. Schmidt, Bernhard Wünsch, Inés Alvarez

المصدر: Journal of Medicinal Chemistry

مصطلحات موضوعية: Models, Molecular, medicine.drug_class, Stereochemistry, Stereoisomerism, Crystallography, X-Ray, Antiviral Agents, Receptors, N-Methyl-D-Aspartate, 01 natural sciences, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, Piperidines, Drug Discovery, medicine, Ifenprodil, Humans, Receptor, 030304 developmental biology, 0303 health sciences, Dose-Response Relationship, Drug, Molecular Structure, Absolute configuration, COVID-19, Biological activity, Receptor antagonist, Antifibrinolytic Agents, Idiopathic Pulmonary Fibrosis, COVID-19 Drug Treatment, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, chemistry, NMDA receptor, Molecular Medicine, Enantiomer

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24f4742407dc98b7c2f87a33e98f7fb8

المؤلفون: Bernhard Wünsch, R. Luise Krauth-Siegel, Marcel Kaiser, Valquíria A. P. Jabor, Thomas J. Schmidt, Kirstin Lehmkuhl, Frederik Börgel, Maria Cristina Nonato, Dirk Schepmann, Jan-Frederik Uth

المصدر: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

مصطلحات موضوعية: Plasmodium, Erythrocytes, Alkylation, Chemistry Techniques, Synthetic, 01 natural sciences, Antimalarials, Mice, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, Biotransformation, Biomimetic Materials, Drug Discovery, medicine, Side chain, Animals, Moiety, Benzopyrans, 030304 developmental biology, Biological Products, 0303 health sciences, Natural product, Combinatorial chemistry, 0104 chemical sciences, Benzopyran, Kinetics, 010404 medicinal & biomolecular chemistry, chemistry, Mechanism of action, Molecular Medicine, medicine.symptom, Chirality (chemistry), PRODUTOS NATURAIS

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fe66ab5f7e7b353b8a514f78b4071c8

المؤلفون: Nicole, Kopp, Catharina, Holtschulte, Frederik, Börgel, Kirstin, Lehmkuhl, Kristina, Friedland, Gianluca, Civenni, Erik, Laurini, Carlo V, Catapano, Sabrina, Pricl, Hans-Ulrich, Humpf, Dirk, Schepmann, Bernhard, Wünsch

المصدر: European journal of medicinal chemistry. 210

مصطلحات موضوعية: Male, Mice, Structure-Activity Relationship, Cyclohexanes, Cell Line, Tumor, Animals, Humans, Prostatic Neoplasms, Receptors, sigma, Antineoplastic Agents, Amination, Cell Proliferation

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::b2d49df965ff205ea6f2f8840bc4440d
https://pubmed.ncbi.nlm.nih.gov/33148494

المؤلفون: Julian A. Schreiber, Thomas J. Schmidt, Louisa Temme, Marina Szermerski, Guiscard Seebohm, Simon M. Ametamey, Bernhard Wünsch, Dirk Schepmann, Nathalie Strutz-Seebohm, Kirstin Lehmkuhl, Frederik Börgel

المصدر: ChemMedChem. 13:1580-1587

مصطلحات موضوعية: 0301 basic medicine, Circular dichroism, Eudysmic ratio, Stereochemistry, Drug Evaluation, Preclinical, Receptors, N-Methyl-D-Aspartate, 01 natural sciences, Biochemistry, Mice, 03 medical and health sciences, chemistry.chemical_compound, Hydrogenolysis, Drug Discovery, Animals, Humans, Phenols, General Pharmacology, Toxicology and Pharmaceutics, Electrodes, Chromatography, High Pressure Liquid, Pharmacology, 010405 organic chemistry, Circular Dichroism, Organic Chemistry, Stereoisomerism, Electrochemical Techniques, Ligand (biochemistry), 0104 chemical sciences, Chiral column chromatography, 030104 developmental biology, chemistry, Molecular Medicine, NMDA receptor, Enantiomer, Excitatory Amino Acid Antagonists

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a939ab5ca52046364ee6fb0f46fc0525
https://doi.org/10.1002/cmdc.201800214

المؤلفون: Julian A. Schreiber, Dirk Schepmann, Guiscard Seebohm, Nathalie Strutz-Seebohm, Bastian Frehland, Bernhard Wünsch, Kirstin Lehmkuhl, Louisa Temme, Sougata Dey

المصدر: European Journal of Medicinal Chemistry. 138:552-564

مصطلحات موضوعية: Models, Molecular, Stereochemistry, Receptors, N-Methyl-D-Aspartate, 01 natural sciences, Benzazepine, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, Ifenprodil, Humans, Moiety, Binding site, Receptor, Pharmacology, Dose-Response Relationship, Drug, Molecular Structure, 010405 organic chemistry, Organic Chemistry, Glutamate receptor, General Medicine, Benzazepines, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, chemistry, Docking (molecular), NMDA receptor

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9a0c5f14df92b275cc32b81d3cd8549
https://doi.org/10.1016/j.ejmech.2017.06.068

المؤلفون: Jens Köhler, Martin Giera, Franz Bracher, Bernhard Wünsch, Kirstin Lehmkuhl, Dirk Schepmann, Inga Knappmann

المصدر: Bioorganic and Medicinal Chemistry, 25(13), 3384-3395

مصطلحات موضوعية: Burkholderia, Swine, Stereochemistry, Clinical Biochemistry, Late stage diversification, Pharmaceutical Science, Sterol Delta(8)/Delta(7)-isomerase, Ligands, Pseudomonas fluorescens, 010402 general chemistry, 01 natural sciences, Biochemistry, Kinetic resolution, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, Animals, Receptors, sigma, Benzopyrans, sigma ligands, Lipases, Lipase, Enantiomeric excess, Molecular Biology, 2-Benzopyrans, Candida, Spirocyclic compounds, Dose-Response Relationship, Drug, Molecular Structure, biology, 010405 organic chemistry, Organic Chemistry, Acetal, Absolute configuration, Stereoisomerism, Exciton coupled CD spectroscopy, 0104 chemical sciences, Benzopyran, Isopropenyl acetate, chemistry, Mucor, Biocatalysis, biology.protein, Molecular Medicine, Enantiomer, Oxa-Pictet-Spengler reaction, Simulation

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b82bf750d80668166d836dd1cd4e148
https://doi.org/10.1016/j.bmc.2017.04.042

المؤلفون: Frederik Börgel, Bernhard Wünsch, Kristina Friedland, Catharina Holtschulte, Kirstin Lehmkuhl, Carlo V. Catapano, Nicole Kopp, Gianluca Civenni, Erik Laurini, Hans-Ulrich Humpf, Dirk Schepmann, Sabrina Pricl

المساهمون: Kopp, N., Holtschulte, C., Borgel, F., Lehmkuhl, K., Friedland, K., Civenni, G., Laurini, E., Catapano, C. V., Pricl, S., Humpf, H. -U., Schepmann, D., Wunsch, B.

المصدر: European Journal of Medicinal Chemistry. 210:112950

مصطلحات موضوعية: DU145 tumor cells, Ca, channel, Primary alcohol, 01 natural sciences, Aminoethylcyclohexanes, Antagonistic activity, Biotransformation, 2+, influx assay, Calculated free energy of binding, CD spectroscopy, Chiral HPLC, Inhibition of human prostate tumor cell growth, Lipophilicity, Molecular dynamics simulations, Molecular interactions, per-residue binding free energy, Selectivity, Stereochemistry, Structure affinity relationships, Voltage gated Ca, σ receptors, σ, 1, receptor affinity, Drug Discovery, Moiety, σ receptor, 0303 health sciences, Chemistry, Absolute configuration, Aminoethylcyclohexane, Molecular interaction, General Medicine, Retinal ganglion, 03 medical and health sciences, Molecular dynamics simulation, Structure affinity relationship, 030304 developmental biology, Pharmacology, DU145 tumor cell, 010405 organic chemistry, Organic Chemistry, Diastereomer, 0104 chemical sciences, Chiral column chromatography, Enantiomer

وصف الملف: STAMPA

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cddc41665abc8893323282efce506edb
https://doi.org/10.1016/j.ejmech.2020.112950