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المؤلفون: Kirstin Lehmkuhl, Patrizia Diana, Hendrik Jonas, Jens Köhler, Dirk Schepmann, Daniele Aiello, Bernhard Wünsch, Bastian Frehland
المساهمون: Hendrik Jona, Daniele Aiello, Bastian Frehland, Kirstin Lehmkuhl, Dirk Schepmann, Jens Köhler, Patrizia Diana, Bernhard Wünsch
مصطلحات موضوعية: chemistry.chemical_classification, Ketone, Bicyclic molecule, Stereochemistry, Organic Chemistry, KOR agonist, opioid receptor, Biochemistry, Reductive amination, Pyrrolidine, Chiral column chromatography, chemistry.chemical_compound, chemistry, Chiral pool synthesis, 2-azabicyclo[3.2.1]octane, Moiety, Physical and Theoretical Chemistry, Enantiomer
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eaea984e7f93d339c717b4dac4c9a226
http://hdl.handle.net/10447/521671 -
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المؤلفون: Hendrik, Jonas, Daniele, Aiello, Bastian, Frehland, Kirstin, Lehmkuhl, Dirk, Schepmann, Jens, Köhler, Patrizia, Diana, Bernhard, Wünsch
المصدر: Organicbiomolecular chemistry. 19(38)
مصطلحات موضوعية: Octanes
URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::7c87747722ede1a970d4447d511798ba
https://pubmed.ncbi.nlm.nih.gov/34528988 -
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المؤلفون: Bernhard Wünsch, Simon M. Ametamey, Kirstin Lehmkuhl, Frederik Börgel, Fabian Galla, Dirk Schepmann
المصدر: Journal of Pharmaceutical and Biomedical Analysis. 172:214-222
مصطلحات موضوعية: Stereochemistry, Metabolite, Clinical Biochemistry, Glucuronidation, Pharmaceutical Science, Ether, Receptors, N-Methyl-D-Aspartate, 01 natural sciences, Analytical Chemistry, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Glucuronides, Piperidines, Drug Discovery, medicine, Ifenprodil, Animals, Humans, Rats, Wistar, Biotransformation, Spectroscopy, Phenol, 010405 organic chemistry, 010401 analytical chemistry, Stereoisomerism, Benzazepines, Human serum albumin, Rats, 0104 chemical sciences, Mice, Inbred C57BL, chemistry, Lipophilicity, Microsomes, Liver, Enantiomer, Glucuronide, Protein Binding, medicine.drug
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المؤلفون: Dirk Schepmann, Elena Bechthold, Guiscard Seebohm, Cristina García, Freddy A. Bernal, Kirstin Lehmkuhl, Constantin G. Daniliuc, Bastian Frehland, Julian A. Schreiber, Thomas J. Schmidt, Bernhard Wünsch, Inés Alvarez
المصدر: Journal of Medicinal Chemistry
مصطلحات موضوعية: Models, Molecular, medicine.drug_class, Stereochemistry, Stereoisomerism, Crystallography, X-Ray, Antiviral Agents, Receptors, N-Methyl-D-Aspartate, 01 natural sciences, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, Piperidines, Drug Discovery, medicine, Ifenprodil, Humans, Receptor, 030304 developmental biology, 0303 health sciences, Dose-Response Relationship, Drug, Molecular Structure, Absolute configuration, COVID-19, Biological activity, Receptor antagonist, Antifibrinolytic Agents, Idiopathic Pulmonary Fibrosis, COVID-19 Drug Treatment, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, chemistry, NMDA receptor, Molecular Medicine, Enantiomer
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المؤلفون: Bernhard Wünsch, R. Luise Krauth-Siegel, Marcel Kaiser, Valquíria A. P. Jabor, Thomas J. Schmidt, Kirstin Lehmkuhl, Frederik Börgel, Maria Cristina Nonato, Dirk Schepmann, Jan-Frederik Uth
المصدر: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USPمصطلحات موضوعية: Plasmodium, Erythrocytes, Alkylation, Chemistry Techniques, Synthetic, 01 natural sciences, Antimalarials, Mice, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, Biotransformation, Biomimetic Materials, Drug Discovery, medicine, Side chain, Animals, Moiety, Benzopyrans, 030304 developmental biology, Biological Products, 0303 health sciences, Natural product, Combinatorial chemistry, 0104 chemical sciences, Benzopyran, Kinetics, 010404 medicinal & biomolecular chemistry, chemistry, Mechanism of action, Molecular Medicine, medicine.symptom, Chirality (chemistry), PRODUTOS NATURAIS
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fe66ab5f7e7b353b8a514f78b4071c8
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المؤلفون: Nicole, Kopp, Catharina, Holtschulte, Frederik, Börgel, Kirstin, Lehmkuhl, Kristina, Friedland, Gianluca, Civenni, Erik, Laurini, Carlo V, Catapano, Sabrina, Pricl, Hans-Ulrich, Humpf, Dirk, Schepmann, Bernhard, Wünsch
المصدر: European journal of medicinal chemistry. 210
مصطلحات موضوعية: Male, Mice, Structure-Activity Relationship, Cyclohexanes, Cell Line, Tumor, Animals, Humans, Prostatic Neoplasms, Receptors, sigma, Antineoplastic Agents, Amination, Cell Proliferation
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المؤلفون: Julian A. Schreiber, Thomas J. Schmidt, Louisa Temme, Marina Szermerski, Guiscard Seebohm, Simon M. Ametamey, Bernhard Wünsch, Dirk Schepmann, Nathalie Strutz-Seebohm, Kirstin Lehmkuhl, Frederik Börgel
المصدر: ChemMedChem. 13:1580-1587
مصطلحات موضوعية: 0301 basic medicine, Circular dichroism, Eudysmic ratio, Stereochemistry, Drug Evaluation, Preclinical, Receptors, N-Methyl-D-Aspartate, 01 natural sciences, Biochemistry, Mice, 03 medical and health sciences, chemistry.chemical_compound, Hydrogenolysis, Drug Discovery, Animals, Humans, Phenols, General Pharmacology, Toxicology and Pharmaceutics, Electrodes, Chromatography, High Pressure Liquid, Pharmacology, 010405 organic chemistry, Circular Dichroism, Organic Chemistry, Stereoisomerism, Electrochemical Techniques, Ligand (biochemistry), 0104 chemical sciences, Chiral column chromatography, 030104 developmental biology, chemistry, Molecular Medicine, NMDA receptor, Enantiomer, Excitatory Amino Acid Antagonists
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المؤلفون: Julian A. Schreiber, Dirk Schepmann, Guiscard Seebohm, Nathalie Strutz-Seebohm, Bastian Frehland, Bernhard Wünsch, Kirstin Lehmkuhl, Louisa Temme, Sougata Dey
المصدر: European Journal of Medicinal Chemistry. 138:552-564
مصطلحات موضوعية: Models, Molecular, Stereochemistry, Receptors, N-Methyl-D-Aspartate, 01 natural sciences, Benzazepine, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, Ifenprodil, Humans, Moiety, Binding site, Receptor, Pharmacology, Dose-Response Relationship, Drug, Molecular Structure, 010405 organic chemistry, Organic Chemistry, Glutamate receptor, General Medicine, Benzazepines, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, chemistry, Docking (molecular), NMDA receptor
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المؤلفون: Jens Köhler, Martin Giera, Franz Bracher, Bernhard Wünsch, Kirstin Lehmkuhl, Dirk Schepmann, Inga Knappmann
المصدر: Bioorganic and Medicinal Chemistry, 25(13), 3384-3395
مصطلحات موضوعية: Burkholderia, Swine, Stereochemistry, Clinical Biochemistry, Late stage diversification, Pharmaceutical Science, Sterol Delta(8)/Delta(7)-isomerase, Ligands, Pseudomonas fluorescens, 010402 general chemistry, 01 natural sciences, Biochemistry, Kinetic resolution, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, Animals, Receptors, sigma, Benzopyrans, sigma ligands, Lipases, Lipase, Enantiomeric excess, Molecular Biology, 2-Benzopyrans, Candida, Spirocyclic compounds, Dose-Response Relationship, Drug, Molecular Structure, biology, 010405 organic chemistry, Organic Chemistry, Acetal, Absolute configuration, Stereoisomerism, Exciton coupled CD spectroscopy, 0104 chemical sciences, Benzopyran, Isopropenyl acetate, chemistry, Mucor, Biocatalysis, biology.protein, Molecular Medicine, Enantiomer, Oxa-Pictet-Spengler reaction, Simulation
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المؤلفون: Frederik Börgel, Bernhard Wünsch, Kristina Friedland, Catharina Holtschulte, Kirstin Lehmkuhl, Carlo V. Catapano, Nicole Kopp, Gianluca Civenni, Erik Laurini, Hans-Ulrich Humpf, Dirk Schepmann, Sabrina Pricl
المساهمون: Kopp, N., Holtschulte, C., Borgel, F., Lehmkuhl, K., Friedland, K., Civenni, G., Laurini, E., Catapano, C. V., Pricl, S., Humpf, H. -U., Schepmann, D., Wunsch, B.
المصدر: European Journal of Medicinal Chemistry. 210:112950
مصطلحات موضوعية: DU145 tumor cells, Ca, channel, Primary alcohol, 01 natural sciences, Aminoethylcyclohexanes, Antagonistic activity, Biotransformation, 2+, influx assay, Calculated free energy of binding, CD spectroscopy, Chiral HPLC, Inhibition of human prostate tumor cell growth, Lipophilicity, Molecular dynamics simulations, Molecular interactions, per-residue binding free energy, Selectivity, Stereochemistry, Structure affinity relationships, Voltage gated Ca, σ receptors, σ, 1, receptor affinity, Drug Discovery, Moiety, σ receptor, 0303 health sciences, Chemistry, Absolute configuration, Aminoethylcyclohexane, Molecular interaction, General Medicine, Retinal ganglion, 03 medical and health sciences, Molecular dynamics simulation, Structure affinity relationship, 030304 developmental biology, Pharmacology, DU145 tumor cell, 010405 organic chemistry, Organic Chemistry, Diastereomer, 0104 chemical sciences, Chiral column chromatography, Enantiomer
وصف الملف: STAMPA