المؤلفون: Ware SD; Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California, 91125, United States., Zhang W; Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California, 91125, United States., Charboneau DJ; Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California, 91125, United States., Klein CK; Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California, 91125, United States., Reisman SE; Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California, 91125, United States., See KA; Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California, 91125, United States.

المصدر: Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2023 Aug 15; Vol. 29 (46), pp. e202301045. Date of Electronic Publication: 2023 Jul 19.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 9513783 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-3765 (Electronic) Linking ISSN: 09476539 NLM ISO Abbreviation: Chemistry Subsets: PubMed not MEDLINE; MEDLINE

المؤلفون: Miggiolaro AFRS; Postgraduate Program of Health Sciences, School of Medicine and Life Sciences, Pontifícia Universidade Católica do Paraná-PUCPR, R. Imaculada Conceição, 1155-Prado Velho, Curitiba 80215-901, PR, Brazil., da Silva FPG; Laboratory of Experimental Pathology, School of Medicine and Life Sciences, Pontifícia Universidade Católica do Paraná-PUCPR, R. Imaculada Conceição, 1155-Prado Velho, Curitiba 80215-901, PR, Brazil., Wiedmer DB; Laboratory of Experimental Pathology, School of Medicine and Life Sciences, Pontifícia Universidade Católica do Paraná-PUCPR, R. Imaculada Conceição, 1155-Prado Velho, Curitiba 80215-901, PR, Brazil., Godoy TM; Laboratory of Experimental Pathology, School of Medicine and Life Sciences, Pontifícia Universidade Católica do Paraná-PUCPR, R. Imaculada Conceição, 1155-Prado Velho, Curitiba 80215-901, PR, Brazil., Borges NH; Laboratory of Experimental Pathology, School of Medicine and Life Sciences, Pontifícia Universidade Católica do Paraná-PUCPR, R. Imaculada Conceição, 1155-Prado Velho, Curitiba 80215-901, PR, Brazil., Piper GW; Laboratory of Experimental Pathology, School of Medicine and Life Sciences, Pontifícia Universidade Católica do Paraná-PUCPR, R. Imaculada Conceição, 1155-Prado Velho, Curitiba 80215-901, PR, Brazil., Oricil AGG; Laboratory of Experimental Pathology, School of Medicine and Life Sciences, Pontifícia Universidade Católica do Paraná-PUCPR, R. Imaculada Conceição, 1155-Prado Velho, Curitiba 80215-901, PR, Brazil., Klein CK; Laboratory of Experimental Pathology, School of Medicine and Life Sciences, Pontifícia Universidade Católica do Paraná-PUCPR, R. Imaculada Conceição, 1155-Prado Velho, Curitiba 80215-901, PR, Brazil., Hlatchuk EC; Department of Medical Pathology, School of Health Sciences, Universidade Federal do Paraná-UFPR, R. Padre Camargo, 280-Alto da Glória, Curitiba 80060-240, PR, Brazil., Dagostini JCH; Department of Medical Pathology, School of Health Sciences, Universidade Federal do Paraná-UFPR, R. Padre Camargo, 280-Alto da Glória, Curitiba 80060-240, PR, Brazil., Collete M; Postgraduate Program of Health Sciences, School of Medicine and Life Sciences, Pontifícia Universidade Católica do Paraná-PUCPR, R. Imaculada Conceição, 1155-Prado Velho, Curitiba 80215-901, PR, Brazil., Arantes MP; Postgraduate Program of Health Sciences, School of Medicine and Life Sciences, Pontifícia Universidade Católica do Paraná-PUCPR, R. Imaculada Conceição, 1155-Prado Velho, Curitiba 80215-901, PR, Brazil., D'Amico RC; Postgraduate Program of Health Sciences, School of Medicine and Life Sciences, Pontifícia Universidade Católica do Paraná-PUCPR, R. Imaculada Conceição, 1155-Prado Velho, Curitiba 80215-901, PR, Brazil., Dutra AA; Postgraduate Program of Health Sciences, School of Medicine and Life Sciences, Pontifícia Universidade Católica do Paraná-PUCPR, R. Imaculada Conceição, 1155-Prado Velho, Curitiba 80215-901, PR, Brazil., de Azevedo MLV; Postgraduate Program of Health Sciences, School of Medicine and Life Sciences, Pontifícia Universidade Católica do Paraná-PUCPR, R. Imaculada Conceição, 1155-Prado Velho, Curitiba 80215-901, PR, Brazil., de Noronha L; Laboratory of Experimental Pathology, School of Medicine and Life Sciences, Pontifícia Universidade Católica do Paraná-PUCPR, R. Imaculada Conceição, 1155-Prado Velho, Curitiba 80215-901, PR, Brazil.

المصدر: Viruses [Viruses] 2023 Mar 08; Vol. 15 (3). Date of Electronic Publication: 2023 Mar 08.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101509722 Publication Model: Electronic Cited Medium: Internet ISSN: 1999-4915 (Electronic) Linking ISSN: 19994915 NLM ISO Abbreviation: Viruses Subsets: MEDLINE

مواضيع طبية MeSH: COVID-19* , Influenza A Virus, H1N1 Subtype* , Vascular Diseases* , Thrombosis*, Humans ; Lung/metabolism ; Hypoxia/metabolism ; Hypertrophy

المؤلفون: Nagashima S; Postgraduate Program of Health Sciences, School of Medicine, Pontifícia Universidade Católica do Paraná, Curitiba 80910-215, Brazil., Dutra AA; Postgraduate Program of Health Sciences, School of Medicine, Pontifícia Universidade Católica do Paraná, Curitiba 80910-215, Brazil., Arantes MP; Postgraduate Program of Health Sciences, School of Medicine, Pontifícia Universidade Católica do Paraná, Curitiba 80910-215, Brazil., Zeni RC; Postgraduate Program of Health Sciences, School of Medicine, Pontifícia Universidade Católica do Paraná, Curitiba 80910-215, Brazil., Klein CK; Postgraduate Program of Health Sciences, School of Medicine, Pontifícia Universidade Católica do Paraná, Curitiba 80910-215, Brazil., de Oliveira FC; Postgraduate Program of Health Sciences, School of Medicine, Pontifícia Universidade Católica do Paraná, Curitiba 80910-215, Brazil., Piper GW; Postgraduate Program of Health Sciences, School of Medicine, Pontifícia Universidade Católica do Paraná, Curitiba 80910-215, Brazil., Brenny ID; Postgraduate Program of Health Sciences, School of Medicine, Pontifícia Universidade Católica do Paraná, Curitiba 80910-215, Brazil., Pereira MRC; Postgraduate Program of Health Sciences, School of Medicine, Pontifícia Universidade Católica do Paraná, Curitiba 80910-215, Brazil., Stocco RB; Postgraduate Program of Health Sciences, School of Medicine, Pontifícia Universidade Católica do Paraná, Curitiba 80910-215, Brazil., Martins APC; Postgraduate Program of Health Sciences, School of Medicine, Pontifícia Universidade Católica do Paraná, Curitiba 80910-215, Brazil., de Castro EM; Postgraduate Program in Biotechnology Applied in Health of Children and Adolescent, Instituto de Pesquisa Pelé Pequeno Príncipe, Faculdades Pequeno Príncipe, Curitiba 80250-060, Brazil., Vaz de Paula CB; Postgraduate Program of Health Sciences, School of Medicine, Pontifícia Universidade Católica do Paraná, Curitiba 80910-215, Brazil., Amaral ANM; Postgraduate Program of Health Sciences, School of Medicine, Pontifícia Universidade Católica do Paraná, Curitiba 80910-215, Brazil., Machado-Souza C; Postgraduate Program in Biotechnology Applied in Health of Children and Adolescent, Instituto de Pesquisa Pelé Pequeno Príncipe, Faculdades Pequeno Príncipe, Curitiba 80250-060, Brazil., Baena CP; Postgraduate Program of Health Sciences, School of Medicine, Pontifícia Universidade Católica do Paraná, Curitiba 80910-215, Brazil.; Marcelino Champagnat Hospital, Curitiba 80020-110, Brazil., Noronha L; Postgraduate Program of Health Sciences, School of Medicine, Pontifícia Universidade Católica do Paraná, Curitiba 80910-215, Brazil.

المصدر: International journal of molecular sciences [Int J Mol Sci] 2022 Feb 02; Vol. 23 (3). Date of Electronic Publication: 2022 Feb 02.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

مواضيع طبية MeSH: Capillary Permeability*, Angiotensin-Converting Enzyme 2/*metabolism , COVID-19/*pathology , Kallikrein-Kinin System/*physiology , Lung/*pathology , Mast Cells/*immunology , SARS-CoV-2/*immunology, Adult ; Aged ; Autopsy ; COVID-19/immunology ; COVID-19/virology ; Caspase 1/metabolism ; Female ; Humans ; Interleukin-33/metabolism ; Lung/immunology ; Lung/metabolism ; Lung/virology ; Male ; Mast Cells/metabolism ; Mast Cells/virology ; Middle Aged ; SARS-CoV-2/isolation & purification ; SARS-CoV-2/pathogenicity

المؤلفون: Ramos Castrillo AI; Glaucoma Unit, Ophthalmology Service, La Paz University Hospital, Madrid, Spain.; Ophthalmology Service, La Paz University Hospital, Madrid, Spain., Cores ML; Ophthalmology Service, La Paz University Hospital, Madrid, Spain., Reyes MGA; Ophthalmology Service, La Paz University Hospital, Madrid, Spain., Gutiérrez EF; Ophthalmology Service, La Paz University Hospital, Madrid, Spain., Burgos CK; Ophthalmology Service, La Paz University Hospital, Madrid, Spain.

المصدر: Romanian journal of ophthalmology [Rom J Ophthalmol] 2021 Jul-Sep; Vol. 65 (3), pp. 279-281.

نوع المنشور: Case Reports

بيانات الدورية: Publisher: Romanian Society of Ophthalmology Country of Publication: Romania NLM ID: 101677459 Publication Model: Print Cited Medium: Internet ISSN: 2501-2533 (Electronic) Linking ISSN: 24574325 NLM ISO Abbreviation: Rom J Ophthalmol Subsets: MEDLINE

مواضيع طبية MeSH: Glaucoma, Angle-Closure*/diagnosis , Glaucoma, Angle-Closure*/drug therapy , Glaucoma, Angle-Closure*/surgery , Laser Therapy*, Adult ; Female ; Gonioscopy ; Humans ; Intraocular Pressure ; Iris ; Venlafaxine Hydrochloride

المؤلفون: See XY; Department of Chemistry, University of Minnesota-Twin Cities, Minneapolis, Minnesota 55455, United States., Wen X; Department of Chemistry, University of Minnesota-Twin Cities, Minneapolis, Minnesota 55455, United States., Wheeler TA; Department of Chemistry, University of Minnesota-Twin Cities, Minneapolis, Minnesota 55455, United States., Klein CK; Department of Chemistry, University of Minnesota-Twin Cities, Minneapolis, Minnesota 55455, United States., Goodpaster JD; Department of Chemistry, University of Minnesota-Twin Cities, Minneapolis, Minnesota 55455, United States., Reiner BR; Department of Chemistry, University of Minnesota-Twin Cities, Minneapolis, Minnesota 55455, United States., Tonks IA; Department of Chemistry, University of Minnesota-Twin Cities, Minneapolis, Minnesota 55455, United States.

المصدر: ACS catalysis [ACS Catal] 2020 Nov 20; Vol. 10 (22), pp. 13504-13517. Date of Electronic Publication: 2020 Nov 05.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101562209 Publication Model: Print-Electronic Cited Medium: Print ISSN: 2155-5435 (Print) NLM ISO Abbreviation: ACS Catal Subsets: PubMed not MEDLINE

المؤلفون: Cheng Y; Department of Chemistry, University of Minnesota - Twin Cities 207 Pleasant St SE Minneapolis Minnesota 55455 USA itonks@umn.edu., Klein CK; Department of Chemistry, University of Minnesota - Twin Cities 207 Pleasant St SE Minneapolis Minnesota 55455 USA itonks@umn.edu., Tonks IA; Department of Chemistry, University of Minnesota - Twin Cities 207 Pleasant St SE Minneapolis Minnesota 55455 USA itonks@umn.edu.

المصدر: Chemical science [Chem Sci] 2020 Sep 08; Vol. 11 (37), pp. 10236-10242. Date of Electronic Publication: 2020 Sep 08.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101545951 Publication Model: Electronic Cited Medium: Print ISSN: 2041-6520 (Print) Linking ISSN: 20416520 NLM ISO Abbreviation: Chem Sci Subsets: PubMed not MEDLINE

المؤلفون: Jimenez-Vargas NN; Gastrointestinal Diseases Research Unit, Division of Gastroenterology, Queen's University, Kingston, ON K7L 2V7, Canada., Pattison LA; Monash Institute of Pharmaceutical Sciences and Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash University, Parkville, VIC 3052, Australia., Zhao P; Monash Institute of Pharmaceutical Sciences and Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash University, Parkville, VIC 3052, Australia., Lieu T; Monash Institute of Pharmaceutical Sciences and Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash University, Parkville, VIC 3052, Australia., Latorre R; Department of Surgery, Columbia University College of Physicians and Surgeons, Columbia University, New York, NY 10032.; Department of Pharmacology, Columbia University College of Physicians and Surgeons, Columbia University, New York, NY 10032., Jensen DD; Department of Surgery, Columbia University College of Physicians and Surgeons, Columbia University, New York, NY 10032.; Department of Pharmacology, Columbia University College of Physicians and Surgeons, Columbia University, New York, NY 10032., Castro J; Visceral Pain Research Group, Human Physiology, Centre for Neuroscience, Flinders University, Adelaide, SA 5000, Australia.; Centre for Nutrition and Gastrointestinal Diseases, Discipline of Medicine, University of Adelaide, South Australian Health and Medical Research Institute, Adelaide, SA 5000, Australia., Aurelio L; Monash Institute of Pharmaceutical Sciences and Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash University, Parkville, VIC 3052, Australia., Le GT; Monash Institute of Pharmaceutical Sciences and Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash University, Parkville, VIC 3052, Australia., Flynn B; Monash Institute of Pharmaceutical Sciences and Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash University, Parkville, VIC 3052, Australia., Herenbrink CK; Monash Institute of Pharmaceutical Sciences and Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash University, Parkville, VIC 3052, Australia., Yeatman HR; Monash Institute of Pharmaceutical Sciences and Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash University, Parkville, VIC 3052, Australia., Edgington-Mitchell L; Monash Institute of Pharmaceutical Sciences and Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash University, Parkville, VIC 3052, Australia., Porter CJH; Monash Institute of Pharmaceutical Sciences and Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash University, Parkville, VIC 3052, Australia., Halls ML; Monash Institute of Pharmaceutical Sciences and Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash University, Parkville, VIC 3052, Australia., Canals M; Monash Institute of Pharmaceutical Sciences and Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash University, Parkville, VIC 3052, Australia., Veldhuis NA; Monash Institute of Pharmaceutical Sciences and Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash University, Parkville, VIC 3052, Australia., Poole DP; Monash Institute of Pharmaceutical Sciences and Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash University, Parkville, VIC 3052, Australia.; Department of Anatomy and Neuroscience, University of Melbourne, Parkville, VIC 3010, Australia., McLean P; Gastrointestinal Drug Discovery Unit, Takeda Pharmaceuticals, Inc., Cambridge, MA 02139., Hicks GA; Gastrointestinal Drug Discovery Unit, Takeda Pharmaceuticals, Inc., Cambridge, MA 02139., Scheff N; Bluestone Center for Clinical Research, New York University College of Dentistry, New York, NY 10010., Chen E; Bluestone Center for Clinical Research, New York University College of Dentistry, New York, NY 10010., Bhattacharya A; Bluestone Center for Clinical Research, New York University College of Dentistry, New York, NY 10010., Schmidt BL; Bluestone Center for Clinical Research, New York University College of Dentistry, New York, NY 10010., Brierley SM; Visceral Pain Research Group, Human Physiology, Centre for Neuroscience, Flinders University, Adelaide, SA 5000, Australia.; Centre for Nutrition and Gastrointestinal Diseases, Discipline of Medicine, University of Adelaide, South Australian Health and Medical Research Institute, Adelaide, SA 5000, Australia., Vanner SJ; Gastrointestinal Diseases Research Unit, Division of Gastroenterology, Queen's University, Kingston, ON K7L 2V7, Canada., Bunnett NW; Monash Institute of Pharmaceutical Sciences and Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash University, Parkville, VIC 3052, Australia; nb2733@cumc.columbia.edu.; Department of Surgery, Columbia University College of Physicians and Surgeons, Columbia University, New York, NY 10032.; Department of Pharmacology, Columbia University College of Physicians and Surgeons, Columbia University, New York, NY 10032.; Department of Pharmacology and Therapeutics, University of Melbourne, Parkville, VIC 3010, Australia.

المصدر: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2018 Jul 31; Vol. 115 (31), pp. E7438-E7447. Date of Electronic Publication: 2018 Jul 16.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

مواضيع طبية MeSH: Chronic Pain/*etiology , Endosomes/*physiology , Irritable Bowel Syndrome/*physiopathology , Receptor, PAR-2/*physiology , Signal Transduction/*physiology, Animals ; Endocytosis ; Extracellular Signal-Regulated MAP Kinases/physiology ; Humans ; Nociception ; Nociceptors/physiology ; Trypsin/pharmacology

المؤلفون: Jensen DD; Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia.; Australia Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash University, Parkville, Victoria 3052, Australia., Lieu T; Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia.; Australia Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash University, Parkville, Victoria 3052, Australia., Halls ML; Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia., Veldhuis NA; Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia.; Australia Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash University, Parkville, Victoria 3052, Australia., Imlach WL; Discipline of Pharmacology, University of Sydney, New South Wales 2006, Australia., Mai QN; Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia.; Australia Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash University, Parkville, Victoria 3052, Australia., Poole DP; Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia.; Australia Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash University, Parkville, Victoria 3052, Australia., Quach T; Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia.; Australia Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash University, Parkville, Victoria 3052, Australia., Aurelio L; Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia.; Australia Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash University, Parkville, Victoria 3052, Australia., Conner J; Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia.; Australia Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash University, Parkville, Victoria 3052, Australia., Herenbrink CK; Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia.; Australia Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash University, Parkville, Victoria 3052, Australia., Barlow N; Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia., Simpson JS; Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia., Scanlon MJ; Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia., Graham B; Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia., McCluskey A; School of Environmental and Life Sciences, University of Newcastle, New South Wales 2308, Australia., Robinson PJ; Children's Medical Research Institute, University of Sydney, New South Wales 2145, Australia., Escriou V; Unité de Technologies Chimiques et Biologiques pour la Sante, CNRS UMR8258, INSERM U1022, Université Paris Descartes, Chimie ParisTech, 75006 Paris, France., Nassini R; Department of Health Sciences, Clinical Pharmacology Unit, University of Florence, 6-50139 Florence, Italy., Materazzi S; Department of Health Sciences, Clinical Pharmacology Unit, University of Florence, 6-50139 Florence, Italy., Geppetti P; Department of Health Sciences, Clinical Pharmacology Unit, University of Florence, 6-50139 Florence, Italy., Hicks GA; Takeda Pharmaceuticals, Boston, MA 02139, USA., Christie MJ; Discipline of Pharmacology, University of Sydney, New South Wales 2006, Australia., Porter CJH; Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia. nb2733@cumc.columbia.edu chris.porter@monash.edu meri.canals@monash.edu.; Australia Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash University, Parkville, Victoria 3052, Australia., Canals M; Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia. nb2733@cumc.columbia.edu chris.porter@monash.edu meri.canals@monash.edu.; Australia Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash University, Parkville, Victoria 3052, Australia., Bunnett NW; Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia. nb2733@cumc.columbia.edu chris.porter@monash.edu meri.canals@monash.edu.; Australia Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash University, Parkville, Victoria 3052, Australia.; Department of Pharmacology and Therapeutics, University of Melbourne, Victoria 3010, Australia.; Departments of Surgery and Pharmacology, Columbia University College of Physicians and Surgeons, Columbia University, 21 Audubon Avenue, Room 209, New York City, NY 10032, USA.

المصدر: Science translational medicine [Sci Transl Med] 2017 May 31; Vol. 9 (392).

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE

مواضيع طبية MeSH: Molecular Targeted Therapy* , Nociception*/drug effects , Signal Transduction*/drug effects, Endosomes/*metabolism , Pain/*drug therapy , Receptors, Neurokinin-1/*metabolism, Animals ; Cell Compartmentation ; Clathrin/metabolism ; Dynamins/metabolism ; Endocytosis/drug effects ; Endosomes/drug effects ; GTP-Binding Proteins/metabolism ; HEK293 Cells ; Humans ; Lipids/chemistry ; Models, Biological ; Neurokinin-1 Receptor Antagonists/pharmacology ; Neurokinin-1 Receptor Antagonists/therapeutic use ; Neurons/drug effects ; Neurons/metabolism ; Neurons/pathology ; Pain/pathology ; Protein Binding/drug effects ; Rats ; Spinal Cord/pathology ; Subcellular Fractions/metabolism ; Substance P/metabolism ; beta-Arrestins/metabolism

المؤلفون: Szabo M; Medicinal Chemistry, and ‡Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University , 381 Royal Parade, Parkville 3052, Victoria, Australia., Lim HD, Herenbrink CK, Christopoulos A, Lane JR, Capuano B

المصدر: Journal of medicinal chemistry [J Med Chem] 2015 Feb 12; Vol. 58 (3), pp. 1550-5. Date of Electronic Publication: 2015 Jan 30.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Drug Design*, Benzoxazines/*pharmacology , Dopamine D2 Receptor Antagonists/*pharmacology , Receptor, Muscarinic M1/*antagonists & inhibitors , Receptor, Serotonin, 5-HT2A/*metabolism , Receptors, Dopamine D2/*metabolism , Serotonin 5-HT2 Receptor Antagonists/*pharmacology, Benzoxazines/chemical synthesis ; Benzoxazines/chemistry ; Dopamine D2 Receptor Antagonists/chemical synthesis ; Dopamine D2 Receptor Antagonists/chemistry ; Dose-Response Relationship, Drug ; Ligands ; Molecular Structure ; Receptor, Muscarinic M1/metabolism ; Serotonin 5-HT2 Receptor Antagonists/chemical synthesis ; Serotonin 5-HT2 Receptor Antagonists/chemistry ; Structure-Activity Relationship

المؤلفون: Shonberg J; Medicinal Chemistry, ‡Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University (Parkville Campus) , 381 Royal Parade, Parkville, Victoria 3052, Australia., Herenbrink CK, López L, Christopoulos A, Scammells PJ, Capuano B, Lane JR

المصدر: Journal of medicinal chemistry [J Med Chem] 2013 Nov 27; Vol. 56 (22), pp. 9199-221. Date of Electronic Publication: 2013 Nov 08.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Receptors, Dopamine D2/*agonists, Animals ; CHO Cells ; Cricetinae ; Cricetulus ; Dose-Response Relationship, Drug ; Humans ; Isoquinolines/chemical synthesis ; Isoquinolines/chemistry ; Isoquinolines/metabolism ; Isoquinolines/pharmacology ; Molecular Docking Simulation ; Protein Conformation ; Receptors, Dopamine D2/chemistry ; Receptors, Dopamine D2/metabolism ; Stereoisomerism ; Structure-Activity Relationship