المؤلفون: van Huizen M; Molecular Virology Laboratory, Leiden University Center of Infectious Diseases (LU-CID), Leiden University Medical Center, Leiden, Netherlands., Bloeme-Ter Horst JR; Molecular Virology Laboratory, Leiden University Center of Infectious Diseases (LU-CID), Leiden University Medical Center, Leiden, Netherlands., de Gruyter HLM; Molecular Virology Laboratory, Leiden University Center of Infectious Diseases (LU-CID), Leiden University Medical Center, Leiden, Netherlands., Geurink PP; Department of Cell and Chemical Biology, Division of Chemical Biology and Drug Discovery, Leiden University Medical Centre, Leiden, The Netherlands., van der Heden van Noort GJ; Department of Cell and Chemical Biology, Division of Chemical Biology and Drug Discovery, Leiden University Medical Centre, Leiden, The Netherlands., Knaap RCM; Molecular Virology Laboratory, Leiden University Center of Infectious Diseases (LU-CID), Leiden University Medical Center, Leiden, Netherlands., Nelemans T; Molecular Virology Laboratory, Leiden University Center of Infectious Diseases (LU-CID), Leiden University Medical Center, Leiden, Netherlands., Ogando NS; Molecular Virology Laboratory, Leiden University Center of Infectious Diseases (LU-CID), Leiden University Medical Center, Leiden, Netherlands., Leijs AA; Molecular Virology Laboratory, Leiden University Center of Infectious Diseases (LU-CID), Leiden University Medical Center, Leiden, Netherlands., Urakova N; Molecular Virology Laboratory, Leiden University Center of Infectious Diseases (LU-CID), Leiden University Medical Center, Leiden, Netherlands., Mark BL; Department of Microbiology, University of Manitoba, Winnipeg, Canada., Snijder EJ; Molecular Virology Laboratory, Leiden University Center of Infectious Diseases (LU-CID), Leiden University Medical Center, Leiden, Netherlands., Myeni SK; Molecular Virology Laboratory, Leiden University Center of Infectious Diseases (LU-CID), Leiden University Medical Center, Leiden, Netherlands., Kikkert M; Molecular Virology Laboratory, Leiden University Center of Infectious Diseases (LU-CID), Leiden University Medical Center, Leiden, Netherlands.

المصدر: PLoS pathogens [PLoS Pathog] 2024 Mar 25; Vol. 20 (3), pp. e1012100. Date of Electronic Publication: 2024 Mar 25 (Print Publication: 2024).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101238921 Publication Model: eCollection Cited Medium: Internet ISSN: 1553-7374 (Electronic) Linking ISSN: 15537366 NLM ISO Abbreviation: PLoS Pathog Subsets: MEDLINE

مواضيع طبية MeSH: Coronavirus Papain-Like Proteases*/genetics , COVID-19*, Humans ; Animals ; Mice ; SARS-CoV-2/metabolism ; Immunity, Innate ; Papain/genetics ; Papain/metabolism ; Peptide Hydrolases/metabolism ; Virus Replication ; Polyproteins

المؤلفون: Bailey-Elkin BA; Department of Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada., Knaap RCM; Molecular Virology Laboratory, Department of Medical Microbiology, Leiden University Center of Infectious Diseases (LU-CID), Leiden University Medical Center, Leiden, The Netherlands., De Silva A; Department of Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada., Boekhoud IM; Molecular Virology Laboratory, Department of Medical Microbiology, Leiden University Center of Infectious Diseases (LU-CID), Leiden University Medical Center, Leiden, The Netherlands., Mous S; Molecular Virology Laboratory, Department of Medical Microbiology, Leiden University Center of Infectious Diseases (LU-CID), Leiden University Medical Center, Leiden, The Netherlands., van Vught N; Molecular Virology Laboratory, Department of Medical Microbiology, Leiden University Center of Infectious Diseases (LU-CID), Leiden University Medical Center, Leiden, The Netherlands., Khajehpour M; Department of Chemistry, University of Manitoba, Winnipeg, Manitoba, Canada., van den Born E; MSD Animal Health, Boxmeer, The Netherlands., Kikkert M; Molecular Virology Laboratory, Department of Medical Microbiology, Leiden University Center of Infectious Diseases (LU-CID), Leiden University Medical Center, Leiden, The Netherlands., Mark BL; Department of Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada.

المصدر: PLoS pathogens [PLoS Pathog] 2023 Dec 14; Vol. 19 (12), pp. e1011872. Date of Electronic Publication: 2023 Dec 14 (Print Publication: 2023).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101238921 Publication Model: eCollection Cited Medium: Internet ISSN: 1553-7374 (Electronic) Linking ISSN: 15537366 NLM ISO Abbreviation: PLoS Pathog Subsets: MEDLINE

مواضيع طبية MeSH: Porcine respiratory and reproductive syndrome virus*/genetics , Porcine respiratory and reproductive syndrome virus*/metabolism , Equartevirus*, Animals ; Horses ; Swine ; Humans ; Papain/chemistry ; Papain/genetics ; Papain/metabolism ; Mutagenesis ; Peptide Hydrolases/genetics ; Virus Replication ; Interferons/genetics ; Viral Nonstructural Proteins/metabolism

المؤلفون: Myeni SK; Molecular Virology Laboratory, Department of Medical Microbiology, Leiden University Medical Center, Leiden, the Netherlands. s.k.myeni@lumc.nl., Bredenbeek PJ; Molecular Virology Laboratory, Department of Medical Microbiology, Leiden University Medical Center, Leiden, the Netherlands., Knaap RCM; Molecular Virology Laboratory, Department of Medical Microbiology, Leiden University Medical Center, Leiden, the Netherlands., Dalebout TJ; Molecular Virology Laboratory, Department of Medical Microbiology, Leiden University Medical Center, Leiden, the Netherlands., Morales ST; Molecular Virology Laboratory, Department of Medical Microbiology, Leiden University Medical Center, Leiden, the Netherlands., Sidorov IA; Molecular Virology Laboratory, Department of Medical Microbiology, Leiden University Medical Center, Leiden, the Netherlands., Linger ME; Molecular Virology Laboratory, Department of Medical Microbiology, Leiden University Medical Center, Leiden, the Netherlands., Oreshkova N; Molecular Virology Laboratory, Department of Medical Microbiology, Leiden University Medical Center, Leiden, the Netherlands., van Zanen-Gerhardt S; Experimental Pathology Services Lab, Central Laboratory Animal Facility, Leiden University Medical Center, Leiden, The Netherlands., Zander SAL; Experimental Pathology Services Lab, Central Laboratory Animal Facility, Leiden University Medical Center, Leiden, The Netherlands., Enjuanes L; Department of Molecular and Cell Biology, National Center of Biotechnology (CNB-CSIC), Campus Universidad Autonoma de Madrid, Madrid, Spain., Sola I; Department of Molecular and Cell Biology, National Center of Biotechnology (CNB-CSIC), Campus Universidad Autonoma de Madrid, Madrid, Spain., Snijder EJ; Molecular Virology Laboratory, Department of Medical Microbiology, Leiden University Medical Center, Leiden, the Netherlands., Kikkert M; Molecular Virology Laboratory, Department of Medical Microbiology, Leiden University Medical Center, Leiden, the Netherlands. m.kikkert@lumc.nl.

المصدر: Nature communications [Nat Commun] 2023 Feb 28; Vol. 14 (1), pp. 1141. Date of Electronic Publication: 2023 Feb 28.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

مواضيع طبية MeSH: COVID-19 Vaccines*, Animals ; Humans ; Mice ; Deubiquitinating Enzymes ; Papain ; Peptide Hydrolases ; Vaccines, Attenuated ; Vaccine Development

المؤلفون: Geurink PP; Department of Cell and Chemical Biology, Chemical Immunology, Oncode Institute, Leiden University Medical Centre, Leiden, The Netherlands., van der Heden van Noort GJ; Department of Cell and Chemical Biology, Chemical Immunology, Oncode Institute, Leiden University Medical Centre, Leiden, The Netherlands., Mulder MPC; Department of Cell and Chemical Biology, Chemical Immunology, Oncode Institute, Leiden University Medical Centre, Leiden, The Netherlands., Knaap RCM; Department of Medical Microbiology, Section Molecular Virology, Leiden University Medical Centre, Leiden, The Netherlands., Kikkert M; Department of Medical Microbiology, Section Molecular Virology, Leiden University Medical Centre, Leiden, The Netherlands., Ovaa H; Department of Cell and Chemical Biology, Chemical Immunology, Oncode Institute, Leiden University Medical Centre, Leiden, The Netherlands. Electronic address: h.ovaa@lumc.nl.

المصدر: Methods in enzymology [Methods Enzymol] 2019; Vol. 618, pp. 357-387. Date of Electronic Publication: 2019 Feb 14.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Academic Press Country of Publication: United States NLM ID: 0212271 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1557-7988 (Electronic) Linking ISSN: 00766879 NLM ISO Abbreviation: Methods Enzymol Subsets: MEDLINE

مواضيع طبية MeSH: Deubiquitinating Enzymes/*metabolism , Ubiquitins/*metabolism, Animals ; Enzyme Assays/methods ; Humans ; Inteins ; Molecular Probes/chemistry ; Molecular Probes/metabolism ; Peptide Hydrolases/metabolism ; Substrate Specificity ; Ubiquitin/metabolism ; Viruses/enzymology

المؤلفون: Bailey-Elkin BA; Department of Microbiology, University of Manitoba, Winnipeg, Manitoba R3T2N2, Canada., Knaap RCM; Department of Medical Microbiology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands., Kikkert M; Department of Medical Microbiology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands., Mark BL; Department of Microbiology, University of Manitoba, Winnipeg, Manitoba R3T2N2, Canada. Electronic address: brian.mark@umanitoba.ca.

المصدر: Journal of molecular biology [J Mol Biol] 2017 Nov 10; Vol. 429 (22), pp. 3441-3470. Date of Electronic Publication: 2017 Jun 16.

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 2985088R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1089-8638 (Electronic) Linking ISSN: 00222836 NLM ISO Abbreviation: J Mol Biol Subsets: MEDLINE

مواضيع طبية MeSH: Deubiquitinating Enzymes/*chemistry , Deubiquitinating Enzymes/*metabolism , Viral Proteins/*chemistry , Viral Proteins/*metabolism , Viruses/*enzymology, Host-Pathogen Interactions ; Immune Evasion ; Immunity, Innate ; Viruses/immunology

المؤلفون: Zhang W; Donnelly Centre for Cellular and Biomolecular Research, Banting and Best Department of Medical Research, and Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada., Bailey-Elkin BA; Department of Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada., Knaap RCM; Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands., Khare B; Department of Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada., Dalebout TJ; Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands., Johnson GG; Department of Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada., van Kasteren PB; Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands., McLeish NJ; Department of Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada., Gu J; Donnelly Centre for Cellular and Biomolecular Research, Banting and Best Department of Medical Research, and Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada., He W; Department of Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada., Kikkert M; Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands., Mark BL; Department of Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada., Sidhu SS; Donnelly Centre for Cellular and Biomolecular Research, Banting and Best Department of Medical Research, and Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.

المصدر: PLoS pathogens [PLoS Pathog] 2017 May 18; Vol. 13 (5), pp. e1006372. Date of Electronic Publication: 2017 May 18 (Print Publication: 2017).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101238921 Publication Model: eCollection Cited Medium: Internet ISSN: 1553-7374 (Electronic) Linking ISSN: 15537366 NLM ISO Abbreviation: PLoS Pathog Subsets: MEDLINE

مواضيع طبية MeSH: Antiviral Agents/*pharmacology , Coronavirus Infections/*virology , Enzyme Inhibitors/*pharmacology , Hemorrhagic Fever Virus, Crimean-Congo/*drug effects , Hemorrhagic Fever, Crimean/*virology , Middle East Respiratory Syndrome Coronavirus/*drug effects , Ubiquitin/*metabolism , Viral Proteins/*antagonists & inhibitors, Antiviral Agents/chemistry ; Coronavirus Infections/metabolism ; Drug Evaluation, Preclinical ; Enzyme Inhibitors/chemistry ; Hemorrhagic Fever Virus, Crimean-Congo/enzymology ; Hemorrhagic Fever Virus, Crimean-Congo/genetics ; Hemorrhagic Fever, Crimean/metabolism ; Humans ; Middle East Respiratory Syndrome Coronavirus/enzymology ; Middle East Respiratory Syndrome Coronavirus/genetics ; Ubiquitination/drug effects ; Viral Proteins/chemistry ; Viral Proteins/genetics ; Viral Proteins/metabolism