المؤلفون: Knopp RC; Veterans Affairs Puget Sound Health Care System, Geriatrics Research Education and Clinical Center (GRECC), Seattle, WA 98108, USA.; Department of Medicine, Division of Gerontology and Geriatric Medicine, University of Washington School of Medicine, Seattle, WA 98195, USA., Erickson MA; Veterans Affairs Puget Sound Health Care System, Geriatrics Research Education and Clinical Center (GRECC), Seattle, WA 98108, USA.; Department of Medicine, Division of Gerontology and Geriatric Medicine, University of Washington School of Medicine, Seattle, WA 98195, USA., Rhea EM; Veterans Affairs Puget Sound Health Care System, Geriatrics Research Education and Clinical Center (GRECC), Seattle, WA 98108, USA.; Department of Medicine, Division of Gerontology and Geriatric Medicine, University of Washington School of Medicine, Seattle, WA 98195, USA., Reed MJ; Veterans Affairs Puget Sound Health Care System, Geriatrics Research Education and Clinical Center (GRECC), Seattle, WA 98108, USA.; Department of Medicine, Division of Gerontology and Geriatric Medicine, University of Washington School of Medicine, Seattle, WA 98195, USA., Banks WA; Veterans Affairs Puget Sound Health Care System, Geriatrics Research Education and Clinical Center (GRECC), Seattle, WA 98108, USA.; Department of Medicine, Division of Gerontology and Geriatric Medicine, University of Washington School of Medicine, Seattle, WA 98195, USA.

المصدر: Experimental biology and medicine (Maywood, N.J.) [Exp Biol Med (Maywood)] 2023 May; Vol. 248 (5), pp. 399-411. Date of Electronic Publication: 2023 Apr 03.

نوع المنشور: Journal Article; Review; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: Frontiers Media S.A Country of Publication: England NLM ID: 100973463 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1535-3699 (Electronic) Linking ISSN: 15353699 NLM ISO Abbreviation: Exp Biol Med (Maywood) Subsets: MEDLINE

مواضيع طبية MeSH: Blood-Brain Barrier* , Endothelial Cells*, Cellular Senescence ; Brain

المؤلفون: Knopp RC; Geriatric Research Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA USA, 98108; Division of Gerontology and Geriatric Medicine, Department of Medicine, University of Washington School of Medicine, Seattle, WA, USA. Electronic address: rcknopp@uw.edu., Banks WA; Geriatric Research Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA USA, 98108; Division of Gerontology and Geriatric Medicine, Department of Medicine, University of Washington School of Medicine, Seattle, WA, USA. Electronic address: wabanks1@uw.edu., Erickson MA; Geriatric Research Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA USA, 98108; Division of Gerontology and Geriatric Medicine, Department of Medicine, University of Washington School of Medicine, Seattle, WA, USA. Electronic address: mericks9@uw.edu.

المصدر: Current opinion in neurobiology [Curr Opin Neurobiol] 2022 Dec; Vol. 77, pp. 102648. Date of Electronic Publication: 2022 Nov 05.

نوع المنشور: Journal Article; Review; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: Current Biology Country of Publication: England NLM ID: 9111376 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-6882 (Electronic) Linking ISSN: 09594388 NLM ISO Abbreviation: Curr Opin Neurobiol Subsets: MEDLINE

مواضيع طبية MeSH: Blood-Brain Barrier* , Microglia*/physiology, Endothelial Cells ; Brain ; Neuroimmunomodulation

المؤلفون: Knopp RC; Geriatrics Research Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA 98108, USA.; Division of Gerontology and Geriatric Medicine, Department of Medicine, University of Washington School of Medicine, Seattle, WA 98195, USA., Baumann KK; Geriatrics Research Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA 98108, USA., Wilson ML; Geriatrics Research Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA 98108, USA., Banks WA; Geriatrics Research Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA 98108, USA.; Division of Gerontology and Geriatric Medicine, Department of Medicine, University of Washington School of Medicine, Seattle, WA 98195, USA., Erickson MA; Geriatrics Research Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA 98108, USA.; Division of Gerontology and Geriatric Medicine, Department of Medicine, University of Washington School of Medicine, Seattle, WA 98195, USA.

المصدر: International journal of molecular sciences [Int J Mol Sci] 2022 Feb 21; Vol. 23 (4). Date of Electronic Publication: 2022 Feb 21.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

مواضيع طبية MeSH: Amyloid beta-Peptides/*metabolism , Cytokines/*metabolism , Hippocampus/*metabolism , Lipopolysaccharides/*metabolism , Mice, Transgenic/*metabolism , Weight Loss/*physiology, Alzheimer Disease/metabolism ; Alzheimer Disease/pathology ; Amyloid beta-Protein Precursor/metabolism ; Animals ; Disease Models, Animal ; Female ; Gliosis/metabolism ; Gliosis/pathology ; Hippocampus/pathology ; Inflammation/metabolism ; Mice ; Microglia/metabolism ; Microglia/pathology ; Plaque, Amyloid/metabolism ; Plaque, Amyloid/pathology

المؤلفون: Erickson MA; Geriatric Research Education and Clinical Center, VA Puget Sound Healthcare System, Seattle, WA 98108, USA.; Division of Gerontology and Geriatric Medicine, Department of Medicine, University of Washington School of Medicine, Seattle, WA 98104, USA., Rhea EM; Geriatric Research Education and Clinical Center, VA Puget Sound Healthcare System, Seattle, WA 98108, USA.; Division of Gerontology and Geriatric Medicine, Department of Medicine, University of Washington School of Medicine, Seattle, WA 98104, USA., Knopp RC; Geriatric Research Education and Clinical Center, VA Puget Sound Healthcare System, Seattle, WA 98108, USA.; Division of Gerontology and Geriatric Medicine, Department of Medicine, University of Washington School of Medicine, Seattle, WA 98104, USA., Banks WA; Geriatric Research Education and Clinical Center, VA Puget Sound Healthcare System, Seattle, WA 98108, USA.; Division of Gerontology and Geriatric Medicine, Department of Medicine, University of Washington School of Medicine, Seattle, WA 98104, USA.

المصدر: International journal of molecular sciences [Int J Mol Sci] 2021 Mar 06; Vol. 22 (5). Date of Electronic Publication: 2021 Mar 06.

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

مواضيع طبية MeSH: Blood-Brain Barrier/*physiopathology , Blood-Brain Barrier/*virology , COVID-19/*virology , SARS-CoV-2/*metabolism, Animals ; Blood-Brain Barrier/metabolism ; Brain/virology ; COVID-19/epidemiology ; Central Nervous System Diseases/etiology ; Central Nervous System Diseases/virology ; Comorbidity ; Humans ; SARS-CoV-2/chemistry ; Viral Tropism

المؤلفون: Knopp RC; Department of Pharmaceutical Sciences, College of Pharmacy, University of Illinois at Chicago (UIC), Chicago, Illinois 60612, United States., Jastaniah A; Department of Pharmaceutical Sciences, College of Pharmacy, University of Illinois at Chicago (UIC), Chicago, Illinois 60612, United States., Dubrovskyi O; Department of Pharmaceutical Sciences, College of Pharmacy, University of Illinois at Chicago (UIC), Chicago, Illinois 60612, United States., Gaisina I; Department of Pharmaceutical Sciences, College of Pharmacy, University of Illinois at Chicago (UIC), Chicago, Illinois 60612, United States.; UICentre (Drug Discovery @ UIC), University of Illinois at Chicago (UIC), Chicago, Illinois 60612, United States., Tai L; Department of Anatomy and Cell Biology, College of Medicine, University of Illinois at Chicago (UIC), Chicago, Illinois 60612, United States., Thatcher GRJ; Department of Pharmacology & Toxicology, College of Pharmacy, University of Arizona, Tucson, Arizona 85721, United States.

المصدر: ACS pharmacology & translational science [ACS Pharmacol Transl Sci] 2021 Feb 02; Vol. 4 (1), pp. 372-385. Date of Electronic Publication: 2021 Feb 02 (Print Publication: 2021).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101721411 Publication Model: eCollection Cited Medium: Internet ISSN: 2575-9108 (Electronic) Linking ISSN: 25759108 NLM ISO Abbreviation: ACS Pharmacol Transl Sci Subsets: PubMed not MEDLINE

المؤلفون: Jastaniah A; Department of Pharmaceutical Sciences, University of Illinois at Chicago, 833 S. Wood Street, Chicago, IL., 60612, USA., Gaisina IN; Department of Pharmaceutical Sciences, University of Illinois at Chicago, 833 S. Wood Street, Chicago, IL., 60612, USA., Knopp RC; Department of Pharmaceutical Sciences, University of Illinois at Chicago, 833 S. Wood Street, Chicago, IL., 60612, USA., Thatcher GRJ; Department of Pharmaceutical Sciences, University of Illinois at Chicago, 833 S. Wood Street, Chicago, IL., 60612, USA.

المصدر: ChemMedChem [ChemMedChem] 2020 Dec 03; Vol. 15 (23), pp. 2280-2285. Date of Electronic Publication: 2020 Sep 18.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101259013 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1860-7187 (Electronic) Linking ISSN: 18607179 NLM ISO Abbreviation: ChemMedChem Subsets: MEDLINE

مواضيع طبية MeSH: Amnesia/*drug therapy , Calpain/*antagonists & inhibitors , Glycoproteins/*pharmacology , Neuroprotective Agents/*pharmacology , Pyrrolidines/*pharmacology, Amnesia/chemically induced ; Amnesia/metabolism ; Animals ; Calpain/metabolism ; Glycoproteins/chemical synthesis ; Glycoproteins/chemistry ; Mice ; Molecular Structure ; Neuroprotective Agents/chemical synthesis ; Neuroprotective Agents/chemistry ; Pyrrolidines/chemical synthesis ; Pyrrolidines/chemistry ; Scopolamine ; Stereoisomerism

المؤلفون: Knopp RC; Department of Pharmaceutical Science, College of Pharmacy, University of Illinois at Chicago, Chicago, IL, 60612, USA., Lee SH; Department of Pharmaceutical Science, College of Pharmacy, University of Illinois at Chicago, Chicago, IL, 60612, USA., Hollas M; Department of Pharmaceutical Science, College of Pharmacy, University of Illinois at Chicago, Chicago, IL, 60612, USA; UICentre (Drug Discovery @ UIC), University of Illinois at Chicago, 833 S. Wood St, Chicago, IL, 60612, USA., Nepomuceno E; Department of Pharmaceutical Science, College of Pharmacy, University of Illinois at Chicago, Chicago, IL, 60612, USA., Gonzalez D; Department of Pharmaceutical Science, College of Pharmacy, University of Illinois at Chicago, Chicago, IL, 60612, USA., Tam K; Department of Pharmaceutical Science, College of Pharmacy, University of Illinois at Chicago, Chicago, IL, 60612, USA., Aamir D; Department of Pharmaceutical Science, College of Pharmacy, University of Illinois at Chicago, Chicago, IL, 60612, USA., Wang Y; Department of Pharmaceutical Science, College of Pharmacy, University of Illinois at Chicago, Chicago, IL, 60612, USA., Pierce E; Department of Pharmaceutical Science, College of Pharmacy, University of Illinois at Chicago, Chicago, IL, 60612, USA., BenAissa M; Department of Pharmaceutical Science, College of Pharmacy, University of Illinois at Chicago, Chicago, IL, 60612, USA; UICentre (Drug Discovery @ UIC), University of Illinois at Chicago, 833 S. Wood St, Chicago, IL, 60612, USA., Thatcher GRJ; Department of Pharmaceutical Science, College of Pharmacy, University of Illinois at Chicago, Chicago, IL, 60612, USA; UICentre (Drug Discovery @ UIC), University of Illinois at Chicago, 833 S. Wood St, Chicago, IL, 60612, USA. Electronic address: thatcher@uic.edu.

المصدر: Redox biology [Redox Biol] 2020 May; Vol. 32, pp. 101486. Date of Electronic Publication: 2020 Mar 02.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: Elsevier, B.V Country of Publication: Netherlands NLM ID: 101605639 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2213-2317 (Electronic) Linking ISSN: 22132317 NLM ISO Abbreviation: Redox Biol Subsets: MEDLINE

مواضيع طبية MeSH: Brain Concussion* , Neuroprotective Agents*, Aldehyde Dehydrogenase, Mitochondrial/genetics ; Animals ; Disease Models, Animal ; Mice ; Oxidative Stress

المؤلفون: Taha TY, Aboukhatwa SM, Knopp RC, Ikegaki N, Abdelkarim H, Neerasa J, Lu Y, Neelarapu R, Hanigan TW, Thatcher GRJ, Petukhov PA

المصدر: ACS medicinal chemistry letters [ACS Med Chem Lett] 2019 Aug 02; Vol. 10 (9), pp. 1358. Date of Electronic Publication: 2019 Aug 02 (Print Publication: 2019).

نوع المنشور: Published Erratum

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101521073 Publication Model: eCollection Cited Medium: Print ISSN: 1948-5875 (Print) Linking ISSN: 19485875 NLM ISO Abbreviation: ACS Med Chem Lett Subsets: PubMed not MEDLINE

المؤلفون: Taha TY; Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois 60612, United States., Aboukhatwa SM; Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois 60612, United States.; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Tanta University, Tanta 31527, Egypt., Knopp RC; Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois 60612, United States., Ikegaki N; Department of Anatomy and Cell Biology, College of Medicine, University of Illinois at Chicago, Chicago, Illinois 60612, United States., Abdelkarim H; Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois 60612, United States., Neerasa J; Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois 60612, United States., Lu Y; Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois 60612, United States., Neelarapu R; Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois 60612, United States., Hanigan TW; Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois 60612, United States., Thatcher GRJ; Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois 60612, United States., Petukhov PA; Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois 60612, United States.

المصدر: ACS medicinal chemistry letters [ACS Med Chem Lett] 2017 Aug 01; Vol. 8 (8), pp. 824-829. Date of Electronic Publication: 2017 Aug 01 (Print Publication: 2017).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101521073 Publication Model: eCollection Cited Medium: Print ISSN: 1948-5875 (Print) Linking ISSN: 19485875 NLM ISO Abbreviation: ACS Med Chem Lett Subsets: PubMed not MEDLINE

المؤلفون: Kent CR; Department of Chemistry, DePaul University, 1110 W Belden Ave, Chicago, IL 60614, United States., Bryja M; Department of Chemistry, DePaul University, 1110 W Belden Ave, Chicago, IL 60614, United States., Gustafson HA; Department of Chemistry, DePaul University, 1110 W Belden Ave, Chicago, IL 60614, United States., Kawarski MY; Department of Chemistry, DePaul University, 1110 W Belden Ave, Chicago, IL 60614, United States., Lenti G; Department of Chemistry, DePaul University, 1110 W Belden Ave, Chicago, IL 60614, United States., Pierce EN; Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, 833 S Wood St, Chicago, IL 60612, United States., Knopp RC; Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, 833 S Wood St, Chicago, IL 60612, United States., Ceja V; Department of Pharmaceutical Sciences, College of Pharmacy, Rosalind Franklin University of Medicine and Science, 3333 Green Bay Rd, North Chicago, IL 60064, United States., Pati B; Department of Pharmaceutical Sciences, College of Pharmacy, Rosalind Franklin University of Medicine and Science, 3333 Green Bay Rd, North Chicago, IL 60064, United States., Walters DE; Department of Pharmaceutical Sciences, College of Pharmacy, Rosalind Franklin University of Medicine and Science, 3333 Green Bay Rd, North Chicago, IL 60064, United States., Karver CE; Department of Chemistry, DePaul University, 1110 W Belden Ave, Chicago, IL 60614, United States. Electronic address: ckarver@depaul.edu.

المصدر: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2016 Nov 15; Vol. 26 (22), pp. 5476-5480. Date of Electronic Publication: 2016 Oct 12.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

مواضيع طبية MeSH: Caspase 1/*metabolism , Caspase Inhibitors/*chemistry , Caspase Inhibitors/*pharmacology , Caspases/*metabolism , Caspases, Initiator/*metabolism , Piperazines/*chemistry , Piperazines/*pharmacology, Caspase 1/chemistry ; Caspases/chemistry ; Caspases, Initiator/chemistry ; Humans ; Inflammation/drug therapy ; Inflammation/enzymology ; Molecular Docking Simulation ; Pyrimidines/chemistry ; Pyrimidines/pharmacology ; Small Molecule Libraries/chemistry ; Small Molecule Libraries/pharmacology