المؤلفون: Hendrix S; Department of Medical Biochemistry, Amsterdam UMC, Amsterdam Cardiovascular Sciences and Gastroenterology and Metabolism, University of Amsterdam, Meibergdreef 9, 1105AZ, Amsterdam, the Netherlands., Dartigue V; Department of Biochemistry, The University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA., Hall H; Department of Biochemistry, The University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA., Bawaria S; Department of Biochemistry, The University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA., Kingma J; Department of Medical Biochemistry, Amsterdam UMC, Amsterdam Cardiovascular Sciences and Gastroenterology and Metabolism, University of Amsterdam, Meibergdreef 9, 1105AZ, Amsterdam, the Netherlands., Bajaj B; Department of Biochemistry, The University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA., Zelcer N; Department of Medical Biochemistry, Amsterdam UMC, Amsterdam Cardiovascular Sciences and Gastroenterology and Metabolism, University of Amsterdam, Meibergdreef 9, 1105AZ, Amsterdam, the Netherlands. n.zelcer@amsterdamumc.nl., Kober DL; Department of Biochemistry, The University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA. daniel.kober@utsouthwestern.edu.

المصدر: Nature communications [Nat Commun] 2024 Jul 09; Vol. 15 (1), pp. 5732. Date of Electronic Publication: 2024 Jul 09.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

مواضيع طبية MeSH: Sterol Regulatory Element Binding Protein 2*/metabolism , Sterol Regulatory Element Binding Protein 2*/genetics , Protein Domains*, Humans ; Serine Endopeptidases/metabolism ; Serine Endopeptidases/chemistry ; Serine Endopeptidases/genetics ; Endoplasmic Reticulum/metabolism ; Cryoelectron Microscopy ; Golgi Apparatus/metabolism ; Proprotein Convertases/metabolism ; Proprotein Convertases/genetics ; Cholesterol/metabolism ; Animals ; HEK293 Cells ; Signal Transduction

المؤلفون: Kober DL; Department of Biochemistry, The University of Texas Southwestern Medical Center, Dallas, Texas, USA., Caballero Van Dyke MC; Department of Microbiology, The University of Texas Southwestern Medical Center, Dallas, Texas, USA., Eitson JL; Department of Microbiology, The University of Texas Southwestern Medical Center, Dallas, Texas, USA., Boys IN; Department of Microbiology, The University of Texas Southwestern Medical Center, Dallas, Texas, USA., McDougal MB; Department of Microbiology, The University of Texas Southwestern Medical Center, Dallas, Texas, USA., Rosenbaum DM; Department of Biophysics, The University of Texas Southwestern Medical Center, Dallas, Texas, USA., Schoggins JW; Department of Microbiology, The University of Texas Southwestern Medical Center, Dallas, Texas, USA.

المصدر: MBio [mBio] 2024 Jun 12; Vol. 15 (6), pp. e0076824. Date of Electronic Publication: 2024 May 21.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 101519231 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2150-7511 (Electronic) NLM ISO Abbreviation: mBio Subsets: MEDLINE

مواضيع طبية MeSH: Angiotensin-Converting Enzyme 2*/metabolism , Angiotensin-Converting Enzyme 2*/genetics , SARS-CoV-2*/genetics , SARS-CoV-2*/drug effects , COVID-19*/virology, Animals ; Mice ; Humans ; Spike Glycoprotein, Coronavirus/genetics ; Spike Glycoprotein, Coronavirus/metabolism ; Mutation ; Aerosols ; HEK293 Cells ; Female

SCR Organism: SARS-CoV-2 variants

المؤلفون: Hendrix S; Department of Medical Biochemistry, Amsterdam UMC, Amsterdam Cardiovascular Sciences and Gastroenterology and Metabolism, University of Amsterdam, Amsterdam, The Netherlands., Tan JME; Department of Medical Biochemistry, Amsterdam UMC, Amsterdam Cardiovascular Sciences and Gastroenterology and Metabolism, University of Amsterdam, Amsterdam, The Netherlands., Ndoj K; Department of Medical Biochemistry, Amsterdam UMC, Amsterdam Cardiovascular Sciences and Gastroenterology and Metabolism, University of Amsterdam, Amsterdam, The Netherlands., Kingma J; Department of Medical Biochemistry, Amsterdam UMC, Amsterdam Cardiovascular Sciences and Gastroenterology and Metabolism, University of Amsterdam, Amsterdam, The Netherlands., Valiloo M; Department of Medical Biochemistry, Amsterdam UMC, Amsterdam Cardiovascular Sciences and Gastroenterology and Metabolism, University of Amsterdam, Amsterdam, The Netherlands., Zijlstra LF; Department of Medical Biochemistry, Amsterdam UMC, Amsterdam Cardiovascular Sciences and Gastroenterology and Metabolism, University of Amsterdam, Amsterdam, The Netherlands., Ottenhoff R; Department of Medical Biochemistry, Amsterdam UMC, Amsterdam Cardiovascular Sciences and Gastroenterology and Metabolism, University of Amsterdam, Amsterdam, The Netherlands., Seidah NG; Laboratory of Biochemical Neuroendocrinology, Montreal Clinical Research Institute (IRCM), University of Montreal, Montréal, Québec, Canada., Loregger A; Department of Medical Biochemistry, Amsterdam UMC, Amsterdam Cardiovascular Sciences and Gastroenterology and Metabolism, University of Amsterdam, Amsterdam, The Netherlands., Kober DL; Department of Biochemistry, The University of Texas Southwestern Medical Center, Dallas, Texas, USA., Zelcer N; Department of Medical Biochemistry, Amsterdam UMC, Amsterdam Cardiovascular Sciences and Gastroenterology and Metabolism, University of Amsterdam, Amsterdam, The Netherlands.

المصدر: Molecular and cellular biology [Mol Cell Biol] 2024; Vol. 44 (4), pp. 123-137. Date of Electronic Publication: 2024 May 15.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 8109087 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-5549 (Electronic) Linking ISSN: 02707306 NLM ISO Abbreviation: Mol Cell Biol Subsets: MEDLINE

مواضيع طبية MeSH: Proprotein Convertases*/metabolism , Proprotein Convertases*/genetics , Serine Endopeptidases*/metabolism , Serine Endopeptidases*/genetics, Animals ; Humans ; Mice ; Endoplasmic Reticulum/metabolism ; Golgi Apparatus/metabolism ; HEK293 Cells ; Liver/metabolism ; Mice, Knockout ; Proteolysis ; Signal Transduction ; Sterol Regulatory Element Binding Proteins/metabolism ; Sterol Regulatory Element Binding Proteins/genetics

المؤلفون: Kober DL; Department of Biochemistry, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Caballero Van Dyke MC; Department of Microbiology, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Eitson JL; Department of Microbiology, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Boys IN; Department of Microbiology, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., McDougal MB; Department of Microbiology, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Rosenbaum DM; Department of Biophysics, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Schoggins JW; Department of Microbiology, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

المصدر: BioRxiv : the preprint server for biology [bioRxiv] 2023 Oct 05. Date of Electronic Publication: 2023 Oct 05.

نوع المنشور: Preprint

بيانات الدورية: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE

المؤلفون: Kober DL; Department of Biophysics, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Department of Molecular Genetics, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Radhakrishnan A; Department of Molecular Genetics, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address: arun.radhakrishnan@utsouthwestern.edu., Goldstein JL; Department of Molecular Genetics, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Brown MS; Department of Molecular Genetics, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Clark LD; Department of Biophysics, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Bai XC; Department of Biophysics, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address: xiaochen.bai@utsouthwestern.edu., Rosenbaum DM; Department of Biophysics, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address: dan.rosenbaum@utsouthwestern.edu.

المصدر: Cell [Cell] 2021 Jul 08; Vol. 184 (14), pp. 3689-3701.e22. Date of Electronic Publication: 2021 Jun 16.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 0413066 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4172 (Electronic) Linking ISSN: 00928674 NLM ISO Abbreviation: Cell Subsets: MEDLINE

مواضيع طبية MeSH: Cholesterol/*metabolism , Membrane Proteins/*chemistry , Membrane Proteins/*metabolism, Amino Acid Sequence ; Animals ; Antibodies/metabolism ; Chickens ; Membrane Proteins/isolation & purification ; Membrane Proteins/ultrastructure ; Models, Biological ; Models, Molecular ; Protein Binding ; Protein Domains ; Protein Structure, Secondary ; Structure-Activity Relationship

المؤلفون: Kober DL; Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX 75390., Xu S; Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390., Li S; Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390., Bajaj B; Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390., Liang G; Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390.; The Center for Human Nutrition, University of Texas Southwestern Medical Center, Dallas, TX 75390., Rosenbaum DM; Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX 75390; dan.rosenbaum@utsouthwestern.edu arun.radhakrishnan@utsouthwestern.edu., Radhakrishnan A; Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390; dan.rosenbaum@utsouthwestern.edu arun.radhakrishnan@utsouthwestern.edu.

المصدر: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Nov 10; Vol. 117 (45), pp. 28080-28091. Date of Electronic Publication: 2020 Oct 26.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

مواضيع طبية MeSH: Sterol Regulatory Element Binding Protein 2*/chemistry , Sterol Regulatory Element Binding Protein 2*/metabolism, Cholesterol/*metabolism , Proteasome Endopeptidase Complex/*metabolism, Amino Acid Motifs ; Animals ; Endoplasmic Reticulum/metabolism ; Golgi Apparatus/metabolism ; Humans ; Intracellular Signaling Peptides and Proteins/chemistry ; Intracellular Signaling Peptides and Proteins/metabolism ; Membrane Proteins/chemistry ; Membrane Proteins/metabolism ; Protein Binding ; Protein Domains ; Proteolysis

المؤلفون: Kober DL; Molecular Microbiology and Microbial Pathogenesis Program.; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine., Stuchell-Brereton MD; Department of Biochemistry and Molecular Biophysics., Kluender CE; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine.; Biochemistry, Biophysics, and Structural Biology Program, Washington University School of Medicine, St. Louis, Missouri, USA., Dean HB; Center for Neurodegeneration and Experimental Therapeutics, Alzheimer's Disease Center, Departments of Neurology and Neurobiology, University of Alabama at Birmingham, Alabama, USA.; Department of Biomedical Engineering, University of Alabama at Birmingham, Alabama, USA., Strickland MR; Department of Neurology., Steinberg DF; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine., Nelson SS; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine., Baban B; Department of Biochemistry and Molecular Biophysics., Holtzman DM; Department of Neurology.; Charles F. and Joanne Knight Alzheimer's Disease Research Center.; Hope Center for Neurological Disorders., Frieden C; Department of Biochemistry and Molecular Biophysics.; Hope Center for Neurological Disorders., Alexander-Brett J; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine.; Department of Pathology and Immunology., Roberson ED; Center for Neurodegeneration and Experimental Therapeutics, Alzheimer's Disease Center, Departments of Neurology and Neurobiology, University of Alabama at Birmingham, Alabama, USA., Song Y; Department of Biomedical Engineering, University of Alabama at Birmingham, Alabama, USA., Brett TJ; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine.; Department of Biochemistry and Molecular Biophysics.; Hope Center for Neurological Disorders.; Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, Missouri, USA.

المصدر: Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2020 Oct 08. Date of Electronic Publication: 2020 Oct 08.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: John Wiley & Sons, Ltd Country of Publication: United States NLM ID: 101231978 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-5279 (Electronic) Linking ISSN: 15525260 NLM ISO Abbreviation: Alzheimers Dement Subsets: MEDLINE

المؤلفون: Ohlemacher SI; From the Center for Women's Infectious Diseases Research.; Division of Infectious Diseases.; Department of Internal Medicine, and., Xu Y; From the Center for Women's Infectious Diseases Research.; Division of Infectious Diseases.; Department of Internal Medicine, and., Kober DL; Department of Internal Medicine, and.; Division of Pulmonary and Critical Care Medicine.; Department of Cell Biology and Physiology, Washington University, St. Louis, Missouri 63110 and., Malik M; From the Center for Women's Infectious Diseases Research.; Division of Infectious Diseases.; Department of Internal Medicine, and., Nix JC; the Molecular Biology Consortium, Advanced Light Source, Lawrence Berkeley National Laboratory, Berkeley, California 94720., Brett TJ; Department of Internal Medicine, and tbrett@wustl.edu.; Division of Pulmonary and Critical Care Medicine.; Department of Cell Biology and Physiology, Washington University, St. Louis, Missouri 63110 and., Henderson JP; From the Center for Women's Infectious Diseases Research, hendersonj@wustl.edu.; Division of Infectious Diseases.; Department of Internal Medicine, and.

المصدر: The Journal of biological chemistry [J Biol Chem] 2018 Dec 21; Vol. 293 (51), pp. 19572-19585. Date of Electronic Publication: 2018 Oct 24.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1083-351X (Electronic) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE

مواضيع طبية MeSH: Enterobacteriaceae/*enzymology , Fatty Acid Synthases/*chemistry , Fatty Acid Synthases/*metabolism , Phenols/*metabolism , Thiazoles/*metabolism , Thiolester Hydrolases/*chemistry , Thiolester Hydrolases/*metabolism, Biocatalysis ; Catalytic Domain ; Crystallography, X-Ray ; Enterobacteriaceae/metabolism ; Fatty Acid Synthases/genetics ; Hydrolysis ; Kinetics ; Models, Molecular ; Mutation ; Thiolester Hydrolases/genetics

المؤلفون: Berry KN; Division of Pulmonary and Critical Care, Department of Internal Medicine, Washington University School of Medicine, St. Louis 63110, Missouri.; Immunology Program, Washington University School of Medicine, St. Louis 63110, Missouri.; Medical Scientist Training Program, Washington University School of Medicine, St. Louis 63110, Missouri., Kober DL; Division of Pulmonary and Critical Care, Department of Internal Medicine, Washington University School of Medicine, St. Louis 63110, Missouri.; Microbiology Program, Washington University School of Medicine, St. Louis 63110, Missouri., Su A; Division of Pulmonary and Critical Care, Department of Internal Medicine, Washington University School of Medicine, St. Louis 63110, Missouri., Brett TJ; Division of Pulmonary and Critical Care, Department of Internal Medicine, Washington University School of Medicine, St. Louis 63110, Missouri.; Department of Medicine, and Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis 63110, Missouri.

المصدر: BioEssays : news and reviews in molecular, cellular and developmental biology [Bioessays] 2018 Oct; Vol. 40 (10), pp. e1800086. Date of Electronic Publication: 2018 Aug 16.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review

بيانات الدورية: Publisher: Wiley Country of Publication: United States NLM ID: 8510851 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-1878 (Electronic) Linking ISSN: 02659247 NLM ISO Abbreviation: Bioessays Subsets: MEDLINE

مواضيع طبية MeSH: Antigens, CD/*physiology , Host-Pathogen Interactions/*physiology , Respiratory Tract Infections/*virology, Antigens, CD/chemistry ; GPI-Linked Proteins/antagonists & inhibitors ; GPI-Linked Proteins/chemistry ; GPI-Linked Proteins/physiology ; Humans ; Molecular Targeted Therapy/methods ; Signal Transduction ; Virion ; Virus Diseases/immunology ; Virus Release ; Virus Replication/drug effects

المؤلفون: Kober DL; Molecular Microbiology and Microbial Pathogenesis Program, Washington University School of Medicine, St. Louis, MO 63110, USA; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA., Brett TJ; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address: tbrett@wustl.edu.

المصدر: Journal of molecular biology [J Mol Biol] 2017 Jun 02; Vol. 429 (11), pp. 1607-1629. Date of Electronic Publication: 2017 Apr 19.

نوع المنشور: Journal Article; Review; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 2985088R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1089-8638 (Electronic) Linking ISSN: 00222836 NLM ISO Abbreviation: J Mol Biol Subsets: MEDLINE

مواضيع طبية MeSH: Health*, Membrane Glycoproteins/*metabolism , Neurodegenerative Diseases/*pathology , Receptors, Immunologic/*metabolism, Animals ; Disease Models, Animal ; Humans ; Protein Binding