المؤلفون: Kensuke Tateishi, Erik A. Williams, Joshua M. Francis, Jochen K. Lennerz, Anthony J. Iafrate, Julie M. Batten, Hiroaki Wakimoto, Koerner Mva, Fumi Higuchi, Tracy T. Batchelor, Stephen P. Schmidt, Barker Fg nd, Aymen Baig, Gregory R. Wojtkiewicz, Andrew S. Chi, Tai Tammy, Priscilla K. Brastianos, Tristan Penson, Robert Langer, Giovanni Traverso, William T. Curry, Shilpa S. Tummala, Julie J. Miller, Ameya R. Kirtane, Mikael L. Rinne, Jaimie Rogner, Matthew Meyerson, Hormoz Mazdiyasni, Daniel P. Cahill, Avner Fink, Ganesh M. Shankar, Justin T. Jordan, Tareq A. Juratli

المصدر: Proceedings of the National Academy of Sciences. 115

مصطلحات موضوعية: 0301 basic medicine, Operating Rooms, IDH1, Genotype, Nicotinamide phosphoribosyltransferase, IDH2, 03 medical and health sciences, chemistry.chemical_compound, In vivo, Glioma, Humans, Medicine, Precision Medicine, Multidisciplinary, Brain Neoplasms, business.industry, medicine.disease, 030104 developmental biology, Isocitrate dehydrogenase, PNAS Plus, chemistry, Toxicity, Drug delivery, Cancer research, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fa56287282c12514babf942cdd1c137
https://doi.org/10.1073/pnas.1805751115

المؤلفون: Higuchi F; Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.; Department of Neurosurgery, Dokkyo Medical University, Mibu, Tochigi, Japan., Nagashima H; Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Ning J; Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.; Department of Neurosurgery, University of Minnesota Medical School, Minneapolis, Minnesota., Koerner MVA; Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Wakimoto H; Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts. cahill@mgh.harvard.edu hwakimoto@mgh.harvard.edu., Cahill DP; Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts. cahill@mgh.harvard.edu hwakimoto@mgh.harvard.edu.

المصدر: Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2020 Apr 01; Vol. 26 (7), pp. 1690-1699. Date of Electronic Publication: 2020 Jan 03.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: The Association Country of Publication: United States NLM ID: 9502500 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1557-3265 (Electronic) Linking ISSN: 10780432 NLM ISO Abbreviation: Clin Cancer Res Subsets: MEDLINE

مواضيع طبية MeSH: DNA Mismatch Repair* , DNA Repair* , Drug Resistance, Neoplasm*, Glioblastoma/*drug therapy , Phthalazines/*pharmacology , Piperazines/*pharmacology , Poly(ADP-ribose) Polymerase Inhibitors/*pharmacology , Temozolomide/*pharmacology, Animals ; Antineoplastic Agents, Alkylating/pharmacology ; Cell Line, Tumor ; Female ; Glioblastoma/genetics ; Glioblastoma/metabolism ; Glioblastoma/pathology ; Humans ; Mice ; Xenograft Model Antitumor Assays

المؤلفون: Tateishi K; Department of Neurosurgery, Yokohama City University Graduate School of Medicine, Yokohama, Japan. cahill@mgh.harvard.edu ktate12@yokohama-cu.ac.jp hwakimoto@mgh.harvard.edu.; Division of Brain Tumor Translational Research, National Cancer Center Institute, Tokyo, Japan.; Translational Neuro-Oncology Laboratory, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.; Neurosurgical-Oncology Laboratory, Yokohama City University, Yokohama, Japan., Nakamura T; Department of Neurosurgery, Yokohama City University Graduate School of Medicine, Yokohama, Japan.; Neurosurgical-Oncology Laboratory, Yokohama City University, Yokohama, Japan., Juratli TA; Translational Neuro-Oncology Laboratory, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.; Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Williams EA; Translational Neuro-Oncology Laboratory, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.; Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts., Matsushita Y; Division of Brain Tumor Translational Research, National Cancer Center Institute, Tokyo, Japan., Miyake S; Department of Neurosurgery, Yokohama City University Graduate School of Medicine, Yokohama, Japan.; Neurosurgical-Oncology Laboratory, Yokohama City University, Yokohama, Japan., Nishi M; Department of Microbiology, Yokohama City University Hospital, Yokohama, Japan., Miller JJ; Translational Neuro-Oncology Laboratory, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.; Stephen E. and Catherine Pappas Center for Neuro-Oncology, Department of Neurology, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts., Tummala SS; Translational Neuro-Oncology Laboratory, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.; Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Fink AL; Translational Neuro-Oncology Laboratory, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.; Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Lelic N; Translational Neuro-Oncology Laboratory, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.; Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Koerner MVA; Translational Neuro-Oncology Laboratory, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.; Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Miyake Y; Department of Neurosurgery, Yokohama City University Graduate School of Medicine, Yokohama, Japan.; Neurosurgical-Oncology Laboratory, Yokohama City University, Yokohama, Japan., Sasame J; Department of Neurosurgery, Yokohama City University Graduate School of Medicine, Yokohama, Japan.; Neurosurgical-Oncology Laboratory, Yokohama City University, Yokohama, Japan., Fujimoto K; Division of Brain Tumor Translational Research, National Cancer Center Institute, Tokyo, Japan., Tanaka T; Department of Neurosurgery, Yokohama City University Graduate School of Medicine, Yokohama, Japan., Minamimoto R; Department of Radiology, Division of Nuclear Medicine, National Center for Global Health and Medicine, Tokyo, Japan., Matsunaga S; Department of Neurosurgery, Yokohama Rosai Hospital, Yokohama, Japan., Mukaihara S; Department of Neurosurgery, Fujisawa Municipal Hospital, Fujisawa, Japan., Shuto T; Department of Neurosurgery, Yokohama City University Graduate School of Medicine, Yokohama, Japan.; Department of Neurosurgery, Yokohama Rosai Hospital, Yokohama, Japan., Taguchi H; Department of Neurosurgery, Taguchi Neurosurgery Clinic, Yokohama, Japan., Udaka N; Department of Pathology, Yokohama City University Hospital, Yokohama, Japan., Murata H; Department of Neurosurgery, Yokohama City University Graduate School of Medicine, Yokohama, Japan., Ryo A; Department of Microbiology, Yokohama City University Hospital, Yokohama, Japan., Yamanaka S; Department of Pathology, Yokohama City University Hospital, Yokohama, Japan., Curry WT; Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Dias-Santagata D; Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts., Yamamoto T; Department of Neurosurgery, Yokohama City University Graduate School of Medicine, Yokohama, Japan., Ichimura K; Division of Brain Tumor Translational Research, National Cancer Center Institute, Tokyo, Japan., Batchelor TT; Translational Neuro-Oncology Laboratory, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.; Stephen E. and Catherine Pappas Center for Neuro-Oncology, Department of Neurology, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts., Chi AS; Laura and Isaac Perlmutter Cancer Center, NYU Langone Medical Center, New York University, New York, New York., Iafrate AJ; Translational Neuro-Oncology Laboratory, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.; Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts., Wakimoto H; Translational Neuro-Oncology Laboratory, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts. cahill@mgh.harvard.edu ktate12@yokohama-cu.ac.jp hwakimoto@mgh.harvard.edu.; Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Cahill DP; Translational Neuro-Oncology Laboratory, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts. cahill@mgh.harvard.edu ktate12@yokohama-cu.ac.jp hwakimoto@mgh.harvard.edu.; Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.

المصدر: Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2019 Jul 15; Vol. 25 (14), pp. 4375-4387. Date of Electronic Publication: 2019 Apr 11.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: The Association Country of Publication: United States NLM ID: 9502500 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1557-3265 (Electronic) Linking ISSN: 10780432 NLM ISO Abbreviation: Clin Cancer Res Subsets: MEDLINE

مواضيع طبية MeSH: Brain Neoplasms/*pathology , Class I Phosphatidylinositol 3-Kinases/*metabolism , Oligodendroglioma/*pathology , Phosphoinositide-3 Kinase Inhibitors/*pharmacology , Proto-Oncogene Proteins c-akt/*metabolism , TOR Serine-Threonine Kinases/*metabolism, Animals ; Brain Neoplasms/drug therapy ; Brain Neoplasms/metabolism ; Cell Line, Tumor ; Class I Phosphatidylinositol 3-Kinases/antagonists & inhibitors ; Class I Phosphatidylinositol 3-Kinases/genetics ; Female ; Humans ; Mice ; Mice, SCID ; Oligodendroglioma/drug therapy ; Oligodendroglioma/metabolism ; Proto-Oncogene Proteins c-akt/antagonists & inhibitors ; Signal Transduction/drug effects ; TOR Serine-Threonine Kinases/antagonists & inhibitors ; Xenograft Model Antitumor Assays

المؤلفون: Higuchi F; Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Fink AL; Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Kiyokawa J; Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Miller JJ; Stephen E. and Catherine Pappas Center for Neuro-Oncology, Division of Hematology/Oncology, Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts., Koerner MVA; Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Cahill DP; Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts. hwakimoto@mgh.harvard.edu cahill@mgh.harvard.edu., Wakimoto H; Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts. hwakimoto@mgh.harvard.edu cahill@mgh.harvard.edu.

المصدر: Molecular cancer therapeutics [Mol Cancer Ther] 2018 Dec; Vol. 17 (12), pp. 2551-2563. Date of Electronic Publication: 2018 Sep 14.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Association for Cancer Research, Inc Country of Publication: United States NLM ID: 101132535 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1538-8514 (Electronic) Linking ISSN: 15357163 NLM ISO Abbreviation: Mol Cancer Ther Subsets: MEDLINE

مواضيع طبية MeSH: DNA Mismatch Repair*/drug effects , Drug Resistance, Neoplasm*/drug effects, Cell Cycle Proteins/*antagonists & inhibitors , Glioma/*drug therapy , Glioma/*pathology , Protein Serine-Threonine Kinases/*antagonists & inhibitors , Proto-Oncogene Proteins/*antagonists & inhibitors , Proto-Oncogene Proteins c-myc/*metabolism , Temozolomide/*therapeutic use, Animals ; Biomarkers, Tumor/metabolism ; Cell Cycle Checkpoints/drug effects ; Cell Cycle Proteins/metabolism ; Cell Line, Tumor ; Cell Proliferation/drug effects ; DNA Damage ; DNA-Binding Proteins/metabolism ; Down-Regulation/drug effects ; Female ; Gene Silencing/drug effects ; Humans ; Mice, Nude ; Mitosis/drug effects ; Protein Kinase Inhibitors/pharmacology ; Protein Serine-Threonine Kinases/metabolism ; Proto-Oncogene Proteins/metabolism ; Pteridines/pharmacology ; Temozolomide/pharmacology ; Up-Regulation/drug effects ; Polo-Like Kinase 1

المؤلفون: Shankar GM; Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114., Kirtane AR; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139.; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139., Miller JJ; Stephen E. and Catherine Pappas Center for Neuro-Oncology, Division of Hematology/Oncology, Department of Neurology, Massachusetts General Hospital, Boston, MA 02114., Mazdiyasni H; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139.; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139., Rogner J; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139.; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139., Tai T; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139.; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139., Williams EA; Department of Pathology, Massachusetts General Hospital, Boston, MA 02114., Higuchi F; Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114., Juratli TA; Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114., Tateishi K; Department of Neurosurgery, Yokohama City University, Yokohama, Kanagawa Prefecture, Japan 236-0027., Koerner MVA; Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114., Tummala SS; Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114., Fink AL; Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114., Penson T; Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114., Schmidt SP; Center for Systems Biology, Massachusetts General Hospital, Boston, MA 02114., Wojtkiewicz GR; Center for Systems Biology, Massachusetts General Hospital, Boston, MA 02114., Baig A; Department of Pathology, Massachusetts General Hospital, Boston, MA 02114., Francis JM; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston MA 02215.; Cancer Program, Broad Institute, Cambridge MA 02142., Rinne ML; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston MA 02215.; Cancer Program, Broad Institute, Cambridge MA 02142., Batten JM; Department of Pathology, Massachusetts General Hospital, Boston, MA 02114., Batchelor TT; Stephen E. and Catherine Pappas Center for Neuro-Oncology, Division of Hematology/Oncology, Department of Neurology, Massachusetts General Hospital, Boston, MA 02114., Brastianos PK; Stephen E. and Catherine Pappas Center for Neuro-Oncology, Division of Hematology/Oncology, Department of Neurology, Massachusetts General Hospital, Boston, MA 02114., Curry WT Jr; Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114., Barker FG 2nd; Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114., Jordan JT; Stephen E. and Catherine Pappas Center for Neuro-Oncology, Division of Hematology/Oncology, Department of Neurology, Massachusetts General Hospital, Boston, MA 02114., Iafrate AJ; Department of Pathology, Massachusetts General Hospital, Boston, MA 02114., Chi AS; Laura and Isaac Perlmutter Cancer Center, New York University School of Medicine and New York University Langone Health, New York, NY 10016., Lennerz JK; Department of Pathology, Massachusetts General Hospital, Boston, MA 02114., Meyerson M; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston MA 02215.; Cancer Program, Broad Institute, Cambridge MA 02142., Langer R; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139; rlanger@mit.edu ctraverso@bwh.harvard.edu cahill@mgh.harvard.edu.; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139., Wakimoto H; Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114., Traverso G; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139; rlanger@mit.edu ctraverso@bwh.harvard.edu cahill@mgh.harvard.edu.; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139.; Division of Gastroenterology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115., Cahill DP; Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114; rlanger@mit.edu ctraverso@bwh.harvard.edu cahill@mgh.harvard.edu.

المصدر: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2018 Sep 04; Vol. 115 (36), pp. E8388-E8394. Date of Electronic Publication: 2018 Aug 06.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

مواضيع طبية MeSH: Brain Neoplasms*/drug therapy , Brain Neoplasms*/enzymology , Brain Neoplasms*/genetics , Genotype* , Glioma*/drug therapy , Glioma*/enzymology , Glioma*/genetics , Mutation*, Cyanides/*pharmacology , Guanidines/*pharmacology , Isocitrate Dehydrogenase/*genetics , Molecular Targeted Therapy/*methods , Neoplasm Proteins/*genetics, Animals ; Drug Delivery Systems/methods ; Female ; Humans ; Male ; Mice ; Mice, SCID ; Xenograft Model Antitumor Assays

المؤلفون: Juratli TA; Translational Neuro-Oncology Laboratory, Department of Neurosurgery, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts, USA.; Department of Neurosurgery, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany., Thiede C; Department of Medicine I, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany., Koerner MVA; Translational Neuro-Oncology Laboratory, Department of Neurosurgery, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts, USA., Tummala SS; Translational Neuro-Oncology Laboratory, Department of Neurosurgery, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts, USA., Daubner D; Institute of Neuroradiology, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany., Shankar GM; Translational Neuro-Oncology Laboratory, Department of Neurosurgery, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts, USA., Williams EA; Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA., Martinez-Lage M; Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA., Soucek S; Department of Neurosurgery, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany., Robel K; Department of Neurosurgery, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany., Penson T; Translational Neuro-Oncology Laboratory, Department of Neurosurgery, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts, USA., Krause M; Institute of Radiooncology, Helmholtz-Zentrum Dresden - Rossendorf, Dresden, Germany.; German Cancer Consortium (DKTK) Dresden and German Cancer Research Center (DKFZ), Heidelberg, Germany.; Department of Radiation Oncology and OncoRay, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany., Appold S; Institute of Radiooncology, Helmholtz-Zentrum Dresden - Rossendorf, Dresden, Germany.; German Cancer Consortium (DKTK) Dresden and German Cancer Research Center (DKFZ), Heidelberg, Germany.; Department of Radiation Oncology and OncoRay, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany., Meinhardt M; Institute of Pathology, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany., Pinzer T; Department of Neurosurgery, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany., Miller JJ; Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA., Krex D; Department of Neurosurgery, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.; German Cancer Consortium (DKTK) Dresden and German Cancer Research Center (DKFZ), Heidelberg, Germany., Ely HA; Ignyta, Inc., San Diego, California, USA., Silverman IM; Ignyta, Inc., San Diego, California, USA., Christiansen J; Ignyta, Inc., San Diego, California, USA., Schackert G; Department of Neurosurgery, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.; German Cancer Consortium (DKTK) Dresden and German Cancer Research Center (DKFZ), Heidelberg, Germany., Wakimoto H; Translational Neuro-Oncology Laboratory, Department of Neurosurgery, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts, USA., Kirsch M; Department of Neurosurgery, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.; German Cancer Consortium (DKTK) Dresden and German Cancer Research Center (DKFZ), Heidelberg, Germany., Brastianos PK; Department of Medicine, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA., Cahill DP; Translational Neuro-Oncology Laboratory, Department of Neurosurgery, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts, USA.

المصدر: Oncotarget [Oncotarget] 2017 Nov 24; Vol. 8 (65), pp. 109228-109237. Date of Electronic Publication: 2017 Nov 24 (Print Publication: 2017).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Impact Journals Country of Publication: United States NLM ID: 101532965 Publication Model: eCollection Cited Medium: Internet ISSN: 1949-2553 (Electronic) Linking ISSN: 19492553 NLM ISO Abbreviation: Oncotarget Subsets: PubMed not MEDLINE

المؤلفون: Tateishi K; Department of Neurosurgery, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts.; Department of Neurosurgery, Yokohama City University, Yokohama, Kanagawa, Japan.; Translational Neuro-Oncology Laboratory, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts., Higuchi F; Department of Neurosurgery, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts.; Translational Neuro-Oncology Laboratory, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts., Miller JJ; Translational Neuro-Oncology Laboratory, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts.; Division of Hematology/Oncology, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts.; Stephen E. and Catherine Pappas Center for Neuro-Oncology, Department of Neurology, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts., Koerner MVA; Department of Neurosurgery, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts.; Translational Neuro-Oncology Laboratory, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts., Lelic N; Department of Neurosurgery, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts.; Translational Neuro-Oncology Laboratory, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts., Shankar GM; Department of Neurosurgery, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts.; Translational Neuro-Oncology Laboratory, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts., Tanaka S; Translational Neuro-Oncology Laboratory, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts.; Division of Hematology/Oncology, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts.; Stephen E. and Catherine Pappas Center for Neuro-Oncology, Department of Neurology, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts., Fisher DE; Department of Dermatology, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts., Batchelor TT; Division of Hematology/Oncology, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts.; Stephen E. and Catherine Pappas Center for Neuro-Oncology, Department of Neurology, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts., Iafrate AJ; Translational Neuro-Oncology Laboratory, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts.; Department of Pathology, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts., Wakimoto H; Department of Neurosurgery, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts. cahill@mgh.harvard.edu hwakimoto@mgh.harvard.edu chia01@nyumc.org.; Translational Neuro-Oncology Laboratory, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts., Chi AS; Translational Neuro-Oncology Laboratory, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts. cahill@mgh.harvard.edu hwakimoto@mgh.harvard.edu chia01@nyumc.org.; Laura and Isaac Perlmutter Cancer Center, NYU Langone Medical Center, New York, New York., Cahill DP; Department of Neurosurgery, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts. cahill@mgh.harvard.edu hwakimoto@mgh.harvard.edu chia01@nyumc.org.; Translational Neuro-Oncology Laboratory, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts.

المصدر: Cancer research [Cancer Res] 2017 Aug 01; Vol. 77 (15), pp. 4102-4115. Date of Electronic Publication: 2017 Jun 16.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 2984705R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1538-7445 (Electronic) Linking ISSN: 00085472 NLM ISO Abbreviation: Cancer Res Subsets: MEDLINE

مواضيع طبية MeSH: Antineoplastic Agents, Alkylating/*pharmacology , Dacarbazine/*analogs & derivatives , Glioma/*metabolism , Stress, Physiological/*drug effects, Acrylamides/pharmacology ; Animals ; Cell Line, Tumor ; Dacarbazine/pharmacology ; Enzyme Inhibitors/pharmacology ; Female ; Glioma/genetics ; Humans ; Isocitrate Dehydrogenase/genetics ; Mice ; Mice, SCID ; Mutation ; NAD ; Nicotinamide Phosphoribosyltransferase/antagonists & inhibitors ; Piperidines/pharmacology ; Random Allocation ; Temozolomide ; Xenograft Model Antitumor Assays

المؤلفون: Tateishi K; Department of Neurosurgery, Translational Neuro-Oncology Laboratory, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA., Wakimoto H; Department of Neurosurgery, Translational Neuro-Oncology Laboratory, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA., Iafrate AJ; Department of Pathology, Translational Neuro-Oncology Laboratory, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA., Tanaka S; Divisions of Neuro-Oncology and Hematology/Oncology, Department of Neurology, Translational Neuro-Oncology Laboratory, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA., Loebel F; Department of Neurosurgery, Translational Neuro-Oncology Laboratory, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA., Lelic N; Department of Neurosurgery, Translational Neuro-Oncology Laboratory, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA., Wiederschain D; Sanofi Oncology, Cambridge, MA 02139, USA., Bedel O; Sanofi Oncology, Cambridge, MA 02139, USA., Deng G; Sanofi Oncology, Cambridge, MA 02139, USA., Zhang B; Sanofi Oncology, Cambridge, MA 02139, USA., He T; Sanofi Oncology, Cambridge, MA 02139, USA., Shi X; Cardiovascular Research Center, Cardiology Division, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA., Gerszten RE; Cardiovascular Research Center, Cardiology Division, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA., Zhang Y; Cardiovascular Research Center, Cardiology Division, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA., Yeh JJ; Cardiovascular Research Center, Cardiology Division, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA., Curry WT; Department of Neurosurgery, Translational Neuro-Oncology Laboratory, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA., Zhao D; Divisions of Neuro-Oncology and Hematology/Oncology, Department of Neurology, Translational Neuro-Oncology Laboratory, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA., Sundaram S; Divisions of Neuro-Oncology and Hematology/Oncology, Department of Neurology, Translational Neuro-Oncology Laboratory, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA., Nigim F; Department of Neurosurgery, Translational Neuro-Oncology Laboratory, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA., Koerner MVA; Department of Neurosurgery, Translational Neuro-Oncology Laboratory, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA., Ho Q; Department of Pathology, Translational Neuro-Oncology Laboratory, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA., Fisher DE; Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA., Roider EM; Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA., Kemeny LV; Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA., Samuels Y; Weizmann Institute of Science, Rehovot 7610001, Israel., Flaherty KT; Division of Hematology/Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA., Batchelor TT; Divisions of Neuro-Oncology and Hematology/Oncology, Department of Neurology, Translational Neuro-Oncology Laboratory, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA., Chi AS; Divisions of Neuro-Oncology and Hematology/Oncology, Department of Neurology, Translational Neuro-Oncology Laboratory, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA. Electronic address: chia01@nyumc.org., Cahill DP; Department of Neurosurgery, Translational Neuro-Oncology Laboratory, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA. Electronic address: cahill@mgh.harvard.edu.

المصدر: Cancer cell [Cancer Cell] 2015 Dec 14; Vol. 28 (6), pp. 773-784.

نوع المنشور: Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101130617 Publication Model: Print Cited Medium: Internet ISSN: 1878-3686 (Electronic) Linking ISSN: 15356108 NLM ISO Abbreviation: Cancer Cell Subsets: MEDLINE

مواضيع طبية MeSH: Mutation*, Antineoplastic Agents/*pharmacology , Brain Neoplasms/*drug therapy , Cytokines/*antagonists & inhibitors , Enzyme Inhibitors/*pharmacology , Glioblastoma/*drug therapy , Isocitrate Dehydrogenase/*genetics , NAD/*deficiency , Nicotinamide Phosphoribosyltransferase/*antagonists & inhibitors, AMP-Activated Protein Kinases/metabolism ; Animals ; Autophagy/drug effects ; Brain Neoplasms/enzymology ; Brain Neoplasms/genetics ; Brain Neoplasms/pathology ; Cell Proliferation/drug effects ; Cytokines/metabolism ; Energy Metabolism/drug effects ; Enzyme Activation ; Female ; Glioblastoma/enzymology ; Glioblastoma/genetics ; Glioblastoma/pathology ; Glutarates/metabolism ; HEK293 Cells ; Humans ; Isocitrate Dehydrogenase/antagonists & inhibitors ; Isocitrate Dehydrogenase/metabolism ; Metabolomics/methods ; Mice, SCID ; Molecular Targeted Therapy ; Nicotinamide Phosphoribosyltransferase/metabolism ; Pentosyltransferases/metabolism ; Signal Transduction/drug effects ; Spheroids, Cellular ; Time Factors ; Transfection ; Tumor Cells, Cultured ; Xenograft Model Antitumor Assays