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المؤلفون: William McDowell, Julia Swierkosz, George Badescu, Andrew F. Kyle, Mark Frigerio, Amrita Abhilash, Ji-Won Choi, Estera Jamieson, Matthew P. Baker, XiaoBo Sheng, Matthew Bird, Penny Bryant, Ruslan Grygorash, Katarzyna Kozakowska, Korinna Henseleit, Rita Tommasi, Vimal Parekh, Kosma Jurlewicz, Karolina Peciak, Emmanuelle Laurine, Martin Pabst, Nicolas Camper, Antony Godwin, Anaïs Manin, Jeff Edwards, David Morris
المصدر: Molecular Pharmaceutics. 12:1872-1879
مصطلحات موضوعية: Immunoconjugates, Pharmaceutical Science, Mice, chemistry.chemical_compound, In vivo, Cell Line, Tumor, parasitic diseases, Drug Discovery, Animals, Humans, Potency, Cysteine, Maleimide, Chemistry, fungi, Mammary Neoplasms, Experimental, Trastuzumab, Xenograft Model Antitumor Assays, In vitro, Monomethyl auristatin E, Biochemistry, Molecular Medicine, Female, Linker, Conjugate
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المؤلفون: Gillian May, Rosa Portero Migueles, Hakan Goker, Louise Shaw, Marella F. T. R. de Bruijn, Kathryn G. V. Anderson, Korinna Henseleit, C. Michael Jones, Neil P. Rodrigues, Tariq Enver, Joshua M. Brickman
مصطلحات موضوعية: 0301 basic medicine, Transcription, Genetic, Green Fluorescent Proteins, Mice, Transgenic, Biology, Regulatory Sequences, Nucleic Acid, Q1, Colony-Forming Units Assay, 03 medical and health sciences, Dorsal aorta, Transcriptional regulation, medicine, Animals, Cell Lineage, Enhancer, Molecular Biology, Transcription factor, Conserved Sequence, Hemogenic endothelium, Homeodomain Proteins, GATA2, Hematopoietic stem cell, Cell Biology, Embryo, Mammalian, Hematopoietic Stem Cells, Cell biology, Cell Compartmentation, Hematopoiesis, Mice, Inbred C57BL, 030104 developmental biology, medicine.anatomical_structure, Gene Expression Regulation, Genetic Loci, Cancer research, Stem cell, Developmental Biology, Transcription Factors
وصف الملف: application/pdf
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المؤلفون: Korinna Henseleit, Mark Frigerio, Antony Godwin, Jeff Edwards, XiaoBo Sheng, Matthew Bird, Martin Fisher, Kosma Jurlewicz, George Badescu, Amrita Abhilash, Penny Bryant, Estera Pawlisz, Ruslan Grygorash, Julia Swierkosz, Andrew F. Kyle, Monika Farys, Nicolas Camper, Vimal Parekh, Rita Tommasi
المصدر: Bioconjugate Chemistry. 25:1124-1136
مصطلحات موضوعية: Cell Survival, Stereochemistry, Biomedical Engineering, Pharmaceutical Science, Antineoplastic Agents, Bioengineering, Conjugated system, Antibodies, Monoclonal, Humanized, Structure-Activity Relationship, chemistry.chemical_compound, Cell Line, Tumor, Humans, Moiety, Disulfides, Cell Proliferation, Pharmacology, Dose-Response Relationship, Drug, Molecular Structure, Chemistry, Organic Chemistry, Proteolytic enzymes, Trastuzumab, Cell killing, Monomethyl auristatin E, Covalent bond, Reagent, MCF-7 Cells, Drug Screening Assays, Antitumor, Oligopeptides, Linker, Biotechnology