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المؤلفون: Valliere MA; Department of Chemistry and Biochemistry, Molecular Biology Institute, UCLA-DOE Institute, University of California, Los Angeles, CA, USA.; Conagen, Inc., Bedford, MA, USA., Korman TP; Department of Chemistry and Biochemistry, Molecular Biology Institute, UCLA-DOE Institute, University of California, Los Angeles, CA, USA.; Invizyne Technologies, Inc., Monrovia, CA, USA., Arbing MA; Department of Chemistry and Biochemistry, Molecular Biology Institute, UCLA-DOE Institute, University of California, Los Angeles, CA, USA., Bowie JU; Department of Chemistry and Biochemistry, Molecular Biology Institute, UCLA-DOE Institute, University of California, Los Angeles, CA, USA. bowie@mbi.ucla.edu.

المصدر: Nature chemical biology [Nat Chem Biol] 2020 Dec; Vol. 16 (12), pp. 1427-1433. Date of Electronic Publication: 2020 Aug 24.

نوع المنشور: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101231976 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-4469 (Electronic) Linking ISSN: 15524450 NLM ISO Abbreviation: Nat Chem Biol Subsets: MEDLINE

مواضيع طبية MeSH: Cannabinoids/*biosynthesis , Cell-Free System/*metabolism , Malonyl Coenzyme A/*metabolism , Metabolic Engineering/*methods , Polyketides/*metabolism , Terpenes/*metabolism, Adenosine Triphosphate/biosynthesis ; Benzoates/isolation & purification ; Benzoates/metabolism ; Cannabinoids/isolation & purification ; Cell-Free System/chemistry ; Escherichia coli/enzymology ; Escherichia coli/genetics ; Gene Expression ; Humans ; Kinetics ; Metabolic Engineering/economics ; Organophosphates/metabolism ; Plasmids/chemistry ; Plasmids/metabolism ; Polyketides/chemistry ; Recombinant Proteins/biosynthesis ; Recombinant Proteins/genetics ; Recombinant Proteins/isolation & purification ; Terpenes/chemistry ; Thermodynamics

المؤلفون: Sherkhanov S; Department of Chemistry and Biochemistry, Molecular Biology Institute, UCLA-DOE Institute, University of California, Los Angeles, CA, USA., Korman TP; Department of Chemistry and Biochemistry, Molecular Biology Institute, UCLA-DOE Institute, University of California, Los Angeles, CA, USA.; Invizyne Technologies, Inc., Monrovia, CA, USA., Chan S; Department of Chemistry and Biochemistry, Molecular Biology Institute, UCLA-DOE Institute, University of California, Los Angeles, CA, USA., Faham S; Vertex Pharmaceuticals, Boston, MA, USA., Liu H; Department of Chemistry and Biochemistry, Molecular Biology Institute, UCLA-DOE Institute, University of California, Los Angeles, CA, USA., Sawaya MR; Department of Chemistry and Biochemistry, Molecular Biology Institute, UCLA-DOE Institute, University of California, Los Angeles, CA, USA., Hsu WT; Department of Chemistry and Biochemistry, Molecular Biology Institute, UCLA-DOE Institute, University of California, Los Angeles, CA, USA., Vikram E; Department of Chemistry and Biochemistry, Molecular Biology Institute, UCLA-DOE Institute, University of California, Los Angeles, CA, USA., Cheng T; Department of Chemistry and Biochemistry, Molecular Biology Institute, UCLA-DOE Institute, University of California, Los Angeles, CA, USA., Bowie JU; Department of Chemistry and Biochemistry, Molecular Biology Institute, UCLA-DOE Institute, University of California, Los Angeles, CA, USA. bowie@mbi.ucla.edu.

المصدر: Nature communications [Nat Commun] 2020 Aug 27; Vol. 11 (1), pp. 4292. Date of Electronic Publication: 2020 Aug 27.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

مواضيع طبية MeSH: Biochemistry/*methods , Butanols/*metabolism , Enzymes/*metabolism, Acetolactate Synthase/chemistry ; Acetolactate Synthase/metabolism ; Adenosine Triphosphate ; Alcohol Oxidoreductases/genetics ; Alcohol Oxidoreductases/metabolism ; Biochemistry/instrumentation ; Bioreactors ; Cell-Free System ; Directed Molecular Evolution ; Enzymes/chemistry ; Enzymes/genetics ; Escherichia coli Proteins/genetics ; Escherichia coli Proteins/metabolism ; Glucose/metabolism ; Temperature ; Thermodynamics

المؤلفون: Bowie JU; Department of Chemistry and Biochemistry, UCLA-DOE Institute, Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA, USA. Electronic address: bowie@mbi.ucla.edu., Sherkhanov S; Department of Chemistry and Biochemistry, UCLA-DOE Institute, Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA, USA., Korman TP; Department of Chemistry and Biochemistry, UCLA-DOE Institute, Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA, USA; Invizyne Technologies, Monrovia, CA, USA., Valliere MA; Department of Chemistry and Biochemistry, UCLA-DOE Institute, Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA, USA., Opgenorth PH; Invizyne Technologies, Monrovia, CA, USA., Liu H; Department of Chemistry and Biochemistry, UCLA-DOE Institute, Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA, USA.

المصدر: Trends in biotechnology [Trends Biotechnol] 2020 Jul; Vol. 38 (7), pp. 766-778. Date of Electronic Publication: 2020 Jan 23.

نوع المنشور: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Review

بيانات الدورية: Publisher: Elsevier Science Publishers Country of Publication: England NLM ID: 8310903 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-3096 (Electronic) Linking ISSN: 01677799 NLM ISO Abbreviation: Trends Biotechnol Subsets: MEDLINE

مواضيع طبية MeSH: Cell-Free System* , Metabolic Engineering*, Biochemistry/*trends , Synthetic Biology/*trends, Biomass

المؤلفون: Valliere MA; Department of Chemistry and Biochemistry, Molecular Biology Institute, UCLA-DOE Institute, University of California, Los Angeles, 90095, CA, USA., Korman TP; Department of Chemistry and Biochemistry, Molecular Biology Institute, UCLA-DOE Institute, University of California, Los Angeles, 90095, CA, USA., Woodall NB; Department of Biochemistry, Institute for Protein Design, University of Washington, Seattle, 98105, WA, USA., Khitrov GA; Department of Chemistry and Biochemistry, Molecular Biology Institute, UCLA-DOE Institute, University of California, Los Angeles, 90095, CA, USA., Taylor RE; Department of Chemistry and Biochemistry, Molecular Biology Institute, UCLA-DOE Institute, University of California, Los Angeles, 90095, CA, USA., Baker D; Department of Biochemistry, Institute for Protein Design, University of Washington, Seattle, 98105, WA, USA., Bowie JU; Department of Chemistry and Biochemistry, Molecular Biology Institute, UCLA-DOE Institute, University of California, Los Angeles, 90095, CA, USA. bowie@mbi.ucla.edu.

المصدر: Nature communications [Nat Commun] 2019 May 24; Vol. 10 (1), pp. 2363. Date of Electronic Publication: 2019 May 24.

نوع المنشور: Published Erratum

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: PubMed not MEDLINE

المؤلفون: Valliere MA; Department of Chemistry and Biochemistry, Molecular Biology Institute, UCLA-DOE Institute, University of California, Los Angeles, 90095, CA, USA., Korman TP; Department of Chemistry and Biochemistry, Molecular Biology Institute, UCLA-DOE Institute, University of California, Los Angeles, 90095, CA, USA., Woodall NB; Department of Biochemistry, Institute for Protein Design, University of Washington, Seattle, 98105, WA, USA., Khitrov GA; Department of Chemistry and Biochemistry, Molecular Biology Institute, UCLA-DOE Institute, University of California, Los Angeles, 90095, CA, USA., Taylor RE; Department of Chemistry and Biochemistry, Molecular Biology Institute, UCLA-DOE Institute, University of California, Los Angeles, 90095, CA, USA., Baker D; Department of Biochemistry, Institute for Protein Design, University of Washington, Seattle, 98105, WA, USA., Bowie JU; Department of Chemistry and Biochemistry, Molecular Biology Institute, UCLA-DOE Institute, University of California, Los Angeles, 90095, CA, USA. bowie@mbi.ucla.edu.

المصدر: Nature communications [Nat Commun] 2019 Feb 04; Vol. 10 (1), pp. 565. Date of Electronic Publication: 2019 Feb 04.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

مواضيع طبية MeSH: Biological Products/*metabolism , Cannabinoids/*metabolism, Fungal Proteins/metabolism ; Gas Chromatography-Mass Spectrometry ; Metabolic Engineering/methods ; Molecular Structure ; Prenylation/physiology ; Substrate Specificity

المؤلفون: Opgenorth PH; Department of Chemistry and Biochemistry, UCLA-DOE Institute for Genomics and Proteomics, Molecular Biology Institute, University of California, Los Angeles, Los Angeles, California, USA., Korman TP; Department of Chemistry and Biochemistry, UCLA-DOE Institute for Genomics and Proteomics, Molecular Biology Institute, University of California, Los Angeles, Los Angeles, California, USA., Iancu L; Department of Chemistry and Biochemistry, UCLA-DOE Institute for Genomics and Proteomics, Molecular Biology Institute, University of California, Los Angeles, Los Angeles, California, USA., Bowie JU; Department of Chemistry and Biochemistry, UCLA-DOE Institute for Genomics and Proteomics, Molecular Biology Institute, University of California, Los Angeles, Los Angeles, California, USA.

المصدر: Nature chemical biology [Nat Chem Biol] 2017 Sep; Vol. 13 (9), pp. 938-942. Date of Electronic Publication: 2017 Jul 03.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101231976 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-4469 (Electronic) Linking ISSN: 15524450 NLM ISO Abbreviation: Nat Chem Biol Subsets: MEDLINE

مواضيع طبية MeSH: Metabolic Engineering*, Adenosine Triphosphate/*metabolism , Butanols/*metabolism, Cell-Free System ; Models, Molecular ; Signal Transduction

المؤلفون: Korman TP; Department of Chemistry and Biochemistry, UCLA-DOE Institute, Molecular Biology Institute, University of California, Los Angeles, California 90095-1570, USA., Opgenorth PH; Department of Chemistry and Biochemistry, UCLA-DOE Institute, Molecular Biology Institute, University of California, Los Angeles, California 90095-1570, USA., Bowie JU; Department of Chemistry and Biochemistry, UCLA-DOE Institute, Molecular Biology Institute, University of California, Los Angeles, California 90095-1570, USA.

المصدر: Nature communications [Nat Commun] 2017 May 24; Vol. 8, pp. 15526. Date of Electronic Publication: 2017 May 24.

نوع المنشور: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

مواضيع طبية MeSH: Alkyl and Aryl Transferases/*metabolism , Glucose/*metabolism , Monoterpenes/*metabolism, Biochemistry/methods ; Biosynthetic Pathways ; Cell-Free System/metabolism ; Synthetic Biology/methods

المؤلفون: Vinokur JM; Department of Chemistry and Biochemistry, University of California, Los Angeles, CA, 90095, USA., Cummins MC; Department of Chemistry and Biochemistry, University of California, Los Angeles, CA, 90095, USA., Korman TP; Department of Chemistry and Biochemistry, University of California, Los Angeles, CA, 90095, USA., Bowie JU; Department of Chemistry and Biochemistry, University of California, Los Angeles, CA, 90095, USA.

المصدر: Scientific reports [Sci Rep] 2016 Dec 22; Vol. 6, pp. 39737. Date of Electronic Publication: 2016 Dec 22.

نوع المنشور: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

مواضيع طبية MeSH: Adaptation, Biological/*physiology , Mevalonic Acid/*metabolism , Thermoplasma/*metabolism, Hydrogen-Ion Concentration ; Thermoplasma/genetics

المؤلفون: Opgenorth PH; Department of Chemistry and Biochemistry, UCLA-DOE Institute, Molecular Biology Institute, University of California, Los Angeles, Los Angeles, California, USA., Korman TP; Department of Chemistry and Biochemistry, UCLA-DOE Institute, Molecular Biology Institute, University of California, Los Angeles, Los Angeles, California, USA., Bowie JU; Department of Chemistry and Biochemistry, UCLA-DOE Institute, Molecular Biology Institute, University of California, Los Angeles, Los Angeles, California, USA.

المصدر: Nature chemical biology [Nat Chem Biol] 2016 Jun; Vol. 12 (6), pp. 393-5. Date of Electronic Publication: 2016 Apr 11.

نوع المنشور: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101231976 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-4469 (Electronic) Linking ISSN: 15524450 NLM ISO Abbreviation: Nat Chem Biol Subsets: MEDLINE

مواضيع طبية MeSH: Biosynthetic Pathways*, Glucose/*chemistry , Glucose/*metabolism , Hydroxybutyrates/*chemistry , Hydroxybutyrates/*metabolism , Synthetic Biology/*methods, Cell-Free System