المؤلفون: Arrowsmith, CH, Audia, JE, Austin, C, Baell, J, Bennett, J, Blagg, J, Bountra, C, Brennan, PE, Brown, PJ, Bunnage, ME, Buser-Doepner, C, Campbell, RM, Carter, AJ, Cohen, P, Copeland, RA, Cravatt, B, Dahlin, JL, Dhanak, D, Edwards, AM, Frye, SV, Gray, N, Grimshaw, CE, Hepworth, D, Howe, T, Huber, KVM, Jin, J, Knapp, S, Kotz, JD, Kruger, RG, Lowe, D, Mader, MM, Marsden, B, Mueller-Fahrnow, A, Muller, S, O'Hagan, RC, Overington, JP, Owen, DR, Rosenberg, SH, Roth, B, Ross, R, Schapira, M, Schreiber, SL, Shoichet, B, Sundstrom, M, Superti-Furga, G, Taunton, J, Toledo-Sherman, L, Walpole, C, Walters, MA, Willson, TM, Workman, P, Young, RN, Zuercher, WJ

المصدر: Nature chemical biology. 11(8):536-541

مصطلحات موضوعية: Medicin och hälsovetenskap

URL الوصول: http://kipublications.ki.se/Default.aspx?queryparsed=id:131668584

المؤلفون: Rees, MG, Seashore-Ludlow, B, Cheah, JH, Adams, DJ, Price, EV, Gill, S, Javaid, S, Coletti, ME, Jones, VL, Bodycombe, NE, Soule, CK, Alexander, B, Li, A, Montgomery, P, Kotz, JD, Hon, CSY, Munoz, B, Liefeld, T, Dancik, V, Haber, DA, Clish, CB, Bittker, JA, Palmer, M, Wagner, BK, Clemons, PA, Shamji, AF, Schreiber, SL

المصدر: Nature chemical biology. 12(2):109

مصطلحات موضوعية: Medicin och hälsovetenskap

URL الوصول: http://kipublications.ki.se/Default.aspx?queryparsed=id:132916551

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المؤلفون: Sharifnia T; Broad Institute of Harvard and MIT, Cambridge, MA, USA. tanaz@broadinstitute.org., Wawer MJ; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Chen T; New York University Langone Medical Center, New York, NY, USA., Huang QY; New York University Langone Medical Center, New York, NY, USA.; Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai, China., Weir BA; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Janssen R&D, Cambridge, MA, USA., Sizemore A; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; University of Pennsylvania, Philadelphia, PA, USA., Lawlor MA; Dana-Farber Cancer Institute, Boston, MA, USA.; Massachusetts General Hospital, Charlestown, MA, USA., Goodale A; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Cowley GS; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Janssen R&D, Spring House, PA, USA., Vazquez F; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Ott CJ; Dana-Farber Cancer Institute, Boston, MA, USA.; Massachusetts General Hospital, Charlestown, MA, USA., Francis JM; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Gritstone Oncology, Cambridge, MA, USA., Sassi S; Massachusetts General Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Cogswell P; Chordoma Foundation, Durham, NC, USA., Sheppard HE; Baylor College of Medicine, Houston, TX, USA., Zhang T; Dana-Farber Cancer Institute, Boston, MA, USA., Gray NS; Dana-Farber Cancer Institute, Boston, MA, USA., Clarke PA; Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, London, UK., Blagg J; Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, London, UK., Workman P; Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, London, UK., Sommer J; Chordoma Foundation, Durham, NC, USA., Hornicek F; Massachusetts General Hospital, Boston, MA, USA.; UCLA Medical Center, Santa Monica, CA, USA., Root DE; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Hahn WC; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Dana-Farber Cancer Institute, Boston, MA, USA., Bradner JE; Dana-Farber Cancer Institute, Boston, MA, USA.; Novartis Institutes for BioMedical Research, Cambridge, MA, USA., Wong KK; New York University Langone Medical Center, New York, NY, USA., Clemons PA; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Lin CY; Baylor College of Medicine, Houston, TX, USA. Charles.Y.Lin@bcm.edu., Kotz JD; Broad Institute of Harvard and MIT, Cambridge, MA, USA. jkotz@jnanatx.com.; Jnana Therapeutics, Boston, MA, USA. jkotz@jnanatx.com., Schreiber SL; Broad Institute of Harvard and MIT, Cambridge, MA, USA. stuart_schreiber@harvard.edu.; Harvard University, Cambridge, MA, USA. stuart_schreiber@harvard.edu.; Howard Hughes Medical Institute, Chevy Chase, MD, USA. stuart_schreiber@harvard.edu.

المصدر: Nature medicine [Nat Med] 2019 Feb; Vol. 25 (2), pp. 292-300. Date of Electronic Publication: 2019 Jan 21.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Publishing Company Country of Publication: United States NLM ID: 9502015 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-170X (Electronic) Linking ISSN: 10788956 NLM ISO Abbreviation: Nat Med Subsets: MEDLINE

مواضيع طبية MeSH: Chordoma/*metabolism , Fetal Proteins/*metabolism , T-Box Domain Proteins/*metabolism , Transcription Factors/*metabolism, Cell Proliferation/drug effects ; Chordoma/genetics ; Chordoma/pathology ; Cyclin-Dependent Kinases/metabolism ; Down-Regulation/drug effects ; Genes, Essential ; Humans ; Protein Kinase Inhibitors/pharmacology ; Small Molecule Libraries/pharmacology

المؤلفون: Viswanathan VS; Broad Institute, 415 Main Street, Cambridge, Massachusetts 02142, USA., Ryan MJ; Broad Institute, 415 Main Street, Cambridge, Massachusetts 02142, USA., Dhruv HD; Cancer and Cell Biology Division, The Translational Genomics Research Institute, 445 N 5th Street, Phoenix, Arizona 85004, USA., Gill S; Broad Institute, 415 Main Street, Cambridge, Massachusetts 02142, USA., Eichhoff OM; Department of Dermatology, University of Zurich, University Hospital of Zurich, Wagistrasse 14, CH-8952, Schlieren, Zürich, Switzerland., Seashore-Ludlow B; Broad Institute, 415 Main Street, Cambridge, Massachusetts 02142, USA., Kaffenberger SD; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA., Eaton JK; Broad Institute, 415 Main Street, Cambridge, Massachusetts 02142, USA., Shimada K; Laboratory of Systems Pharmacology, Harvard Medical School, 200 Longwood Avenue, Boston, Massachusetts 02115, USA., Aguirre AJ; Broad Institute, 415 Main Street, Cambridge, Massachusetts 02142, USA.; Department of Medical Oncology, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA., Viswanathan SR; Broad Institute, 415 Main Street, Cambridge, Massachusetts 02142, USA.; Department of Medical Oncology, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA., Chattopadhyay S; Broad Institute, 415 Main Street, Cambridge, Massachusetts 02142, USA., Tamayo P; Broad Institute, 415 Main Street, Cambridge, Massachusetts 02142, USA.; Moores Cancer Center &Department of Medicine, School of Medicine, University of California San Diego, La Jolla, California 92093, USA., Yang WS; Department of Biological Sciences, St. John's University, 8000 Utopia Parkway, Queens, New York 11439, USA., Rees MG; Broad Institute, 415 Main Street, Cambridge, Massachusetts 02142, USA., Chen S; Broad Institute, 415 Main Street, Cambridge, Massachusetts 02142, USA., Boskovic ZV; Broad Institute, 415 Main Street, Cambridge, Massachusetts 02142, USA., Javaid S; Massachusetts General Hospital Cancer Center, 149 13th Street, Charlestown, Massachusetts 02129, USA., Huang C; Broad Institute, 415 Main Street, Cambridge, Massachusetts 02142, USA., Wu X; Broad Institute, 415 Main Street, Cambridge, Massachusetts 02142, USA., Tseng YY; Broad Institute, 415 Main Street, Cambridge, Massachusetts 02142, USA., Roider EM; Department of Dermatology, University of Zurich, University Hospital of Zurich, Wagistrasse 14, CH-8952, Schlieren, Zürich, Switzerland., Gao D; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA., Cleary JM; Department of Medical Oncology, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA., Wolpin BM; Department of Medical Oncology, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA., Mesirov JP; Broad Institute, 415 Main Street, Cambridge, Massachusetts 02142, USA.; Moores Cancer Center &Department of Medicine, School of Medicine, University of California San Diego, La Jolla, California 92093, USA., Haber DA; Massachusetts General Hospital Cancer Center, 149 13th Street, Charlestown, Massachusetts 02129, USA.; Howard Hughes Medical Institute, Chevy Chase, Maryland 20815, USA., Engelman JA; Oncology Disease Area, Novartis Institute for Biomedical Research, Cambridge, Massachusetts 02139, USA., Boehm JS; Broad Institute, 415 Main Street, Cambridge, Massachusetts 02142, USA., Kotz JD; Broad Institute, 415 Main Street, Cambridge, Massachusetts 02142, USA., Hon CS; Broad Institute, 415 Main Street, Cambridge, Massachusetts 02142, USA., Chen Y; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA., Hahn WC; Broad Institute, 415 Main Street, Cambridge, Massachusetts 02142, USA.; Department of Medical Oncology, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA., Levesque MP; Department of Dermatology, University of Zurich, University Hospital of Zurich, Wagistrasse 14, CH-8952, Schlieren, Zürich, Switzerland., Doench JG; Broad Institute, 415 Main Street, Cambridge, Massachusetts 02142, USA., Berens ME; Cancer and Cell Biology Division, The Translational Genomics Research Institute, 445 N 5th Street, Phoenix, Arizona 85004, USA., Shamji AF; Broad Institute, 415 Main Street, Cambridge, Massachusetts 02142, USA., Clemons PA; Broad Institute, 415 Main Street, Cambridge, Massachusetts 02142, USA., Stockwell BR; Department of Biological Sciences, Department of Chemistry, Columbia University, 550 West 120th Street, New York, New York 10027, USA., Schreiber SL; Broad Institute, 415 Main Street, Cambridge, Massachusetts 02142, USA.; Howard Hughes Medical Institute, Chevy Chase, Maryland 20815, USA.; Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford St., Cambridge, Massachusetts 02138, USA.

المصدر: Nature [Nature] 2017 Jul 27; Vol. 547 (7664), pp. 453-457. Date of Electronic Publication: 2017 Jul 05.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE

مواضيع طبية MeSH: Glutathione Peroxidase/*metabolism , Lipid Peroxidation/*drug effects , Neoplasms/*drug therapy , Neoplasms/*enzymology, Cadherins/metabolism ; Cell Death ; Cell Line, Tumor ; Cell Lineage ; Cell Transdifferentiation ; Drug Resistance, Neoplasm/genetics ; Epithelial-Mesenchymal Transition ; Humans ; Iron/metabolism ; Lipid Peroxides/metabolism ; Male ; Melanoma/drug therapy ; Melanoma/enzymology ; Melanoma/metabolism ; Melanoma/pathology ; Mesoderm/drug effects ; Mesoderm/enzymology ; Mesoderm/metabolism ; Mesoderm/pathology ; Neoplasms/genetics ; Neoplasms/pathology ; Phospholipid Hydroperoxide Glutathione Peroxidase ; Prostatic Neoplasms/drug therapy ; Prostatic Neoplasms/enzymology ; Prostatic Neoplasms/metabolism ; Prostatic Neoplasms/pathology ; Proteomics ; Proto-Oncogene Proteins B-raf/genetics ; Reproducibility of Results ; Zinc Finger E-box-Binding Homeobox 1/genetics

المؤلفون: Sykes DB; Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA 02114, USA; Cancer Center, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA. Electronic address: dbsykes@mgh.harvard.edu., Kfoury YS; Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA., Mercier FE; Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA., Wawer MJ; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Law JM; Center for the Science of Therapeutics, Broad Institute, Cambridge, MA 02142, USA; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA., Haynes MK; Center for Molecular Discovery, University of New Mexico, Albuquerque, NM 87131, USA., Lewis TA; Center for the Science of Therapeutics, Broad Institute, Cambridge, MA 02142, USA., Schajnovitz A; Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA., Jain E; Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA 02114, USA., Lee D; Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA., Meyer H; Bayer Pharma AG, Berlin 13353, Germany., Pierce KA; Metabolite Profiling Platform, Broad Institute, Cambridge, MA 02142, USA., Tolliday NJ; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Waller A; Center for Molecular Discovery, University of New Mexico, Albuquerque, NM 87131, USA., Ferrara SJ; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Eheim AL; Bayer Pharma AG, Berlin 13353, Germany., Stoeckigt D; Bayer Pharma AG, Berlin 13353, Germany., Maxcy KL; Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA 02114, USA., Cobert JM; Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA 02114, USA., Bachand J; Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA 02114, USA., Szekely BA; Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA 02114, USA., Mukherjee S; Irving Cancer Research Center, Columbia University School of Medicine, New York, NY 10032, USA., Sklar LA; Center for Molecular Discovery, University of New Mexico, Albuquerque, NM 87131, USA., Kotz JD; Center for the Science of Therapeutics, Broad Institute, Cambridge, MA 02142, USA., Clish CB; Metabolite Profiling Platform, Broad Institute, Cambridge, MA 02142, USA., Sadreyev RI; Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA., Clemons PA; Center for the Science of Therapeutics, Broad Institute, Cambridge, MA 02142, USA., Janzer A; Bayer Pharma AG, Berlin 13353, Germany., Schreiber SL; Center for the Science of Therapeutics, Broad Institute, Cambridge, MA 02142, USA; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA; Howard Hughes Medical Institute, Cambridge, MA 02138, USA., Scadden DT; Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA 02114, USA; Cancer Center, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA. Electronic address: dscadden@mgh.harvard.edu.

المصدر: Cell [Cell] 2016 Sep 22; Vol. 167 (1), pp. 171-186.e15. Date of Electronic Publication: 2016 Sep 15.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 0413066 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4172 (Electronic) Linking ISSN: 00928674 NLM ISO Abbreviation: Cell Subsets: MEDLINE

مواضيع طبية MeSH: Molecular Targeted Therapy*, Antineoplastic Agents/*therapeutic use , Enzyme Inhibitors/*therapeutic use , Leukemia, Myeloid, Acute/*drug therapy , Leukemia, Myeloid, Acute/*pathology , Oxidoreductases Acting on CH-CH Group Donors/*antagonists & inhibitors, Animals ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/isolation & purification ; Cell Differentiation ; Dihydroorotate Dehydrogenase ; Enzyme Inhibitors/chemistry ; Enzyme Inhibitors/isolation & purification ; High-Throughput Screening Assays ; Homeodomain Proteins/genetics ; Humans ; Leukemia, Myeloid, Acute/genetics ; Mice ; Myeloid Cells/pathology ; Oxidoreductases Acting on CH-CH Group Donors/metabolism ; Pyrimidines/metabolism ; Small Molecule Libraries/chemistry ; Small Molecule Libraries/isolation & purification ; Small Molecule Libraries/therapeutic use ; Xenograft Model Antitumor Assays

المؤلفون: Weninger S; F-Prime Biomedical Research Initiative, Cambridge, MA, USA. Electronic address: sweninger@fbri.com., Carrillo MC; Medical & Scientific Relations Division, Alzheimer's Association, Chicago, IL, USA. Electronic address: mcarrillo@alz.org., Dunn B; Division of Neurology Products, U.S. Food and Drug Administration, Silver Spring, MD, USA., Aisen PS; University of Southern California Alzheimer's Therapeutic Research Institute, San Diego, CA, USA., Bateman RJ; Department of Neurology, Washington University, St Louis, MO, USA., Kotz JD; F-Prime Biomedical Research Initiative, Cambridge, MA, USA., Langbaum JB; Banner Alzheimer's Institute, Phoenix, AZ, USA., Mills SL; Department of Neurology, Washington University, St Louis, MO, USA., Reiman EM; Banner Alzheimer's Institute, Phoenix, AZ, USA., Sperling R; Department of Neurology, Brigham and Women's Hospital, Boston, MA, USA., Santacruz AM; Department of Neurology, Washington University, St Louis, MO, USA., Tariot PN; Banner Alzheimer's Institute, Phoenix, AZ, USA., Welsh-Bohmer KA; Departments of Neurology & Psychiatry, Duke University, Durham, NC, USA.

المصدر: Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2016 May; Vol. 12 (5), pp. 631-2.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: John Wiley & Sons, Ltd Country of Publication: United States NLM ID: 101231978 Publication Model: Print Cited Medium: Internet ISSN: 1552-5279 (Electronic) Linking ISSN: 15525260 NLM ISO Abbreviation: Alzheimers Dement Subsets: MEDLINE

مواضيع طبية MeSH: Clinical Trials as Topic* , Cooperative Behavior*, Alzheimer Disease/*prevention & control , Information Dissemination/*methods, Biomarkers ; Data Collection/standards ; Drug Evaluation, Preclinical ; Humans

المؤلفون: Seashore-Ludlow B; Center for the Science of Therapeutics, Broad Institute, Cambridge, Massachusetts., Rees MG; Center for the Science of Therapeutics, Broad Institute, Cambridge, Massachusetts., Cheah JH; Center for the Science of Therapeutics, Broad Institute, Cambridge, Massachusetts., Cokol M; Faculty of Engineering and Natural Sciences, Sabanci University, Istanbul, Turkey., Price EV; Center for the Science of Therapeutics, Broad Institute, Cambridge, Massachusetts., Coletti ME; Center for the Science of Therapeutics, Broad Institute, Cambridge, Massachusetts., Jones V; Center for the Science of Therapeutics, Broad Institute, Cambridge, Massachusetts., Bodycombe NE; Center for the Science of Therapeutics, Broad Institute, Cambridge, Massachusetts., Soule CK; Center for the Science of Therapeutics, Broad Institute, Cambridge, Massachusetts., Gould J; Center for the Science of Therapeutics, Broad Institute, Cambridge, Massachusetts., Alexander B; Center for the Science of Therapeutics, Broad Institute, Cambridge, Massachusetts., Li A; Center for the Science of Therapeutics, Broad Institute, Cambridge, Massachusetts., Montgomery P; Center for the Science of Therapeutics, Broad Institute, Cambridge, Massachusetts., Wawer MJ; Center for the Science of Therapeutics, Broad Institute, Cambridge, Massachusetts., Kuru N; Faculty of Engineering and Natural Sciences, Sabanci University, Istanbul, Turkey., Kotz JD; Center for the Science of Therapeutics, Broad Institute, Cambridge, Massachusetts., Hon CS; Center for the Science of Therapeutics, Broad Institute, Cambridge, Massachusetts., Munoz B; Center for the Science of Therapeutics, Broad Institute, Cambridge, Massachusetts., Liefeld T; Center for the Science of Therapeutics, Broad Institute, Cambridge, Massachusetts., Dančík V; Center for the Science of Therapeutics, Broad Institute, Cambridge, Massachusetts., Bittker JA; Center for the Science of Therapeutics, Broad Institute, Cambridge, Massachusetts., Palmer M; Center for the Science of Therapeutics, Broad Institute, Cambridge, Massachusetts., Bradner JE; Center for the Science of Therapeutics, Broad Institute, Cambridge, Massachusetts. Cancer Biology and Medical Oncology, Harvard Medical School, Boston, Massachusetts., Shamji AF; Center for the Science of Therapeutics, Broad Institute, Cambridge, Massachusetts. pclemons@broadinstitute.org stuart_schreiber@harvard.edu ashamji@broadinstitute.org., Clemons PA; Center for the Science of Therapeutics, Broad Institute, Cambridge, Massachusetts. pclemons@broadinstitute.org stuart_schreiber@harvard.edu ashamji@broadinstitute.org., Schreiber SL; Center for the Science of Therapeutics, Broad Institute, Cambridge, Massachusetts.

المصدر: Cancer discovery [Cancer Discov] 2015 Nov; Vol. 5 (11), pp. 1210-23. Date of Electronic Publication: 2015 Oct 19.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 101561693 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2159-8290 (Electronic) Linking ISSN: 21598274 NLM ISO Abbreviation: Cancer Discov Subsets: MEDLINE

مواضيع طبية MeSH: Drug Screening Assays, Antitumor* , Small Molecule Libraries*, Computational Biology/*methods , Drug Resistance, Neoplasm/*genetics , Gene Expression Regulation, Neoplastic/*drug effects , Neoplasms/*genetics, Antineoplastic Agents/pharmacology ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Cluster Analysis ; Datasets as Topic ; Dose-Response Relationship, Drug ; Drug Synergism ; Humans ; Mutation ; Neoplasms/drug therapy ; Protein Kinase Inhibitors/pharmacology

المؤلفون: Arrowsmith CH, Audia JE, Austin C, Baell J, Bennett J, Blagg J, Bountra C, Brennan PE, Brown PJ, Bunnage ME, Buser-Doepner C, Campbell RM, Carter AJ, Cohen P, Copeland RA, Cravatt B, Dahlin JL, Dhanak D, Edwards AM, Frederiksen M, Frye SV, Gray N, Grimshaw CE, Hepworth D, Howe T, Huber KV, Jin J, Knapp S, Kotz JD, Kruger RG, Lowe D, Mader MM, Marsden B, Mueller-Fahrnow A, Müller S, O'Hagan RC, Overington JP, Owen DR, Rosenberg SH, Ross R, Roth B, Schapira M, Schreiber SL, Shoichet B, Sundström M, Superti-Furga G, Taunton J, Toledo-Sherman L, Walpole C, Walters MA, Willson TM, Workman P, Young RN, Zuercher WJ

المصدر: Nature chemical biology [Nat Chem Biol] 2015 Nov; Vol. 11 (11), pp. 887.

نوع المنشور: Published Erratum

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101231976 Publication Model: Print Cited Medium: Internet ISSN: 1552-4469 (Electronic) Linking ISSN: 15524450 NLM ISO Abbreviation: Nat Chem Biol Subsets: PubMed not MEDLINE

المؤلفون: Schreiber SL; Probe Development Center, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA; Howard Hughes Medical Institute, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Center for the Science of Therapeutics, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA. Electronic address: stuart_schreiber@harvard.edu., Kotz JD; Probe Development Center, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Center for the Science of Therapeutics, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA. Electronic address: jkotz@broadinstitute.org., Li M; Johns Hopkins School of Medicine Ion Channel Center, Baltimore, MD 21205, USA., Aubé J; University of Kansas Specialized Chemistry Center, Lawrence, KS 66045, USA; Department of Medicinal Chemistry, University of Kansas, Lawrence, KS, 66045, USA., Austin CP; NIH Chemical Genomics Center, National Institutes of Health, Rockville, MD 20850, USA; National Center for Advancing Translational Sciences, Bethesda, MD 20892, USA., Reed JC; Conrad Prebys Center for Chemical Genomics, Sanford-Burnham Medical Research Institute, La Jolla, CA 92037, and Lake Nona, FL 32827, USA., Rosen H; Molecular Screening Center, The Scripps Research Institute, La Jolla, CA 92037, and Jupiter, FL 33458, USA; Department of Chemical Physiology, The Scripps Research Institute, La Jolla, CA, 92037, USA., White EL; Southern Research Specialized Biocontainment Screening Center, Southern Research Institute, Birmingham, AL 35205, USA., Sklar LA; University of New Mexico Center for Molecular Discovery, Albuquerque, NM 87131, USA; Department of Pathology, University of New Mexico School of Medicine, Albuquerque, NM, 87131, USA., Lindsley CW; The Vanderbilt Specialized Chemistry Center for Accelerated Probe Development, Vanderbilt University Medical Center, Nashville, TN 37232, USA; Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University Medical Center, Nashville, TN, 37232, USA., Alexander BR; Probe Development Center, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA., Bittker JA; Probe Development Center, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Center for the Development of Therapeutics, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA., Clemons PA; Probe Development Center, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Center for the Science of Therapeutics, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA., de Souza A; Probe Development Center, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA., Foley MA; Probe Development Center, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA., Palmer M; Probe Development Center, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA., Shamji AF; Probe Development Center, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Center for the Science of Therapeutics, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA., Wawer MJ; Probe Development Center, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Center for the Science of Therapeutics, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA., McManus O; Johns Hopkins School of Medicine Ion Channel Center, Baltimore, MD 21205, USA., Wu M; Johns Hopkins School of Medicine Ion Channel Center, Baltimore, MD 21205, USA., Zou B; Johns Hopkins School of Medicine Ion Channel Center, Baltimore, MD 21205, USA., Yu H; Johns Hopkins School of Medicine Ion Channel Center, Baltimore, MD 21205, USA., Golden JE; University of Kansas Specialized Chemistry Center, Lawrence, KS 66045, USA., Schoenen FJ; University of Kansas Specialized Chemistry Center, Lawrence, KS 66045, USA., Simeonov A; NIH Chemical Genomics Center, National Institutes of Health, Rockville, MD 20850, USA; National Center for Advancing Translational Sciences, Bethesda, MD 20892, USA., Jadhav A; NIH Chemical Genomics Center, National Institutes of Health, Rockville, MD 20850, USA; National Center for Advancing Translational Sciences, Bethesda, MD 20892, USA., Jackson MR; Conrad Prebys Center for Chemical Genomics, Sanford-Burnham Medical Research Institute, La Jolla, CA 92037, and Lake Nona, FL 32827, USA., Pinkerton AB; Conrad Prebys Center for Chemical Genomics, Sanford-Burnham Medical Research Institute, La Jolla, CA 92037, and Lake Nona, FL 32827, USA., Chung TD; Conrad Prebys Center for Chemical Genomics, Sanford-Burnham Medical Research Institute, La Jolla, CA 92037, and Lake Nona, FL 32827, USA., Griffin PR; Molecular Screening Center, The Scripps Research Institute, La Jolla, CA 92037, and Jupiter, FL 33458, USA; Department of Molecular Therapeutics, The Scripps Research Institute, Jupiter, FL, 33458, USA., Cravatt BF; Molecular Screening Center, The Scripps Research Institute, La Jolla, CA 92037, and Jupiter, FL 33458, USA; Department of Chemical Physiology, The Scripps Research Institute, La Jolla, CA, 92037, USA., Hodder PS; Molecular Screening Center, The Scripps Research Institute, La Jolla, CA 92037, and Jupiter, FL 33458, USA., Roush WR; Molecular Screening Center, The Scripps Research Institute, La Jolla, CA 92037, and Jupiter, FL 33458, USA; Department of Chemistry, The Scripps Research Institute, Jupiter, FL, 33458, USA., Roberts E; Molecular Screening Center, The Scripps Research Institute, La Jolla, CA 92037, and Jupiter, FL 33458, USA., Chung DH; Southern Research Specialized Biocontainment Screening Center, Southern Research Institute, Birmingham, AL 35205, USA., Jonsson CB; Southern Research Specialized Biocontainment Screening Center, Southern Research Institute, Birmingham, AL 35205, USA., Noah JW; Southern Research Specialized Biocontainment Screening Center, Southern Research Institute, Birmingham, AL 35205, USA., Severson WE; Southern Research Specialized Biocontainment Screening Center, Southern Research Institute, Birmingham, AL 35205, USA., Ananthan S; Southern Research Specialized Biocontainment Screening Center, Southern Research Institute, Birmingham, AL 35205, USA., Edwards B; University of New Mexico Center for Molecular Discovery, Albuquerque, NM 87131, USA; Department of Pathology, University of New Mexico School of Medicine, Albuquerque, NM, 87131, USA., Oprea TI; University of New Mexico Center for Molecular Discovery, Albuquerque, NM 87131, USA; Department of Internal Medicine, University of New Mexico, Albuquerque, NM, 87131, USA., Conn PJ; The Vanderbilt Specialized Chemistry Center for Accelerated Probe Development, Vanderbilt University Medical Center, Nashville, TN 37232, USA; Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University Medical Center, Nashville, TN, 37232, USA., Hopkins CR; 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مؤلفون مشاركون: NIH Molecular Libraries Project Team

المصدر: Cell [Cell] 2015 Jun 04; Vol. 161 (6), pp. 1252-65.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Review

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 0413066 Publication Model: Print Cited Medium: Internet ISSN: 1097-4172 (Electronic) Linking ISSN: 00928674 NLM ISO Abbreviation: Cell Subsets: MEDLINE

مواضيع طبية MeSH: Drug Discovery* , Small Molecule Libraries*, Animals ; Enzyme Inhibitors/chemistry ; Enzyme Inhibitors/pharmacology ; High-Throughput Screening Assays ; Humans ; National Institutes of Health (U.S.) ; United States