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1دورية أكاديمية
المؤلفون: JP Johnson, Thilo Focken, Kuldip Khakh, Parisa Karimi Tari, Celine Dube, Samuel J Goodchild, Jean-Christophe Andrez, Girish Bankar, David Bogucki, Kristen Burford, Elaine Chang, Sultan Chowdhury, Richard Dean, Gina de Boer, Shannon Decker, Christoph Dehnhardt, Mandy Feng, Wei Gong, Michael Grimwood, Abid Hasan, Angela Hussainkhel, Qi Jia, Stephanie Lee, Jenny Li, Sophia Lin, Andrea Lindgren, Verner Lofstrand, Janette Mezeyova, Rostam Namdari, Karen Nelkenbrecher, Noah Gregory Shuart, Luis Sojo, Shaoyi Sun, Matthew Taron, Matthew Waldbrook, Diana Weeratunge, Steven Wesolowski, Aaron Williams, Michael Wilson, Zhiwei Xie, Rhena Yoo, Clint Young, Alla Zenova, Wei Zhang, Alison J Cutts, Robin P Sherrington, Simon N Pimstone, Raymond Winquist, Charles J Cohen, James R Empfield
المصدر: eLife, Vol 11 (2022)
مصطلحات موضوعية: epilepsy, SCN8A, NBI-921352, anti-seizure medicine, Medicine, Science, Biology (General), QH301-705.5
وصف الملف: electronic resource
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المؤلفون: Sultan Chowdhury, David Bogucki, Rostam Namdari, Girish Bankar, Wei Zhang, James Roy Empfield, Matthew Waldbrook, Stephanie M Lee, Lofstrand Verner Alexander, Karen Nelkenbrecher, Samuel J. Goodchild, Rhena Yoo, Noah G. Shuart, Wesolowski Steven Sigmund, Elaine Chang, Mandy Feng, Clint Young, Christoph Martin Dehnhardt, Jenny Li, Zhiwei Xie, Michael Edward Grimwood, Abid Hasan, Sophia Lin, Kristen Burford, Raymond J. Winquist, Charles J. Cohen, Alla Yurevna Zenova, Simon N. Pimstone, Michael R. Wilson, Parisa Karimi Tari, Kuldip Khakh, Celine Dube, Aaron M. Williams, Robin Sherrington, Luis Sojo, Andrea Lindgren, J. P. Johnson, Thilo Focken, Qi Jia, Jean-Christophe Andrez, Shannon Decker, Matthew Taron, Diana Weeratunge, Richard T. Dean, Janette Mezeyova, Shaoyi Sun, Wei Gong, Angela Hussainkhel, Gina de Boer, Alison Jane Cutts
مصطلحات موضوعية: Phenytoin, Glutamatergic, Lacosamide, Chemistry, Sodium channel, Excitatory postsynaptic potential, medicine, Carbamazepine, Pharmacology, Inhibitory postsynaptic potential, IC50, medicine.drug
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::32e2e6674136369f3abcd5070b52e762
https://doi.org/10.1101/2021.08.29.458125 -
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المؤلفون: J P, Johnson, Thilo, Focken, Kuldip, Khakh, Parisa Karimi, Tari, Celine, Dube, Samuel J, Goodchild, Jean-Christophe, Andrez, Girish, Bankar, David, Bogucki, Kristen, Burford, Elaine, Chang, Sultan, Chowdhury, Richard, Dean, Gina, de Boer, Shannon, Decker, Christoph, Dehnhardt, Mandy, Feng, Wei, Gong, Michael, Grimwood, Abid, Hasan, Angela, Hussainkhel, Qi, Jia, Stephanie, Lee, Jenny, Li, Sophia, Lin, Andrea, Lindgren, Verner, Lofstrand, Janette, Mezeyova, Rostam, Namdari, Karen, Nelkenbrecher, Noah Gregory, Shuart, Luis, Sojo, Shaoyi, Sun, Matthew, Taron, Matthew, Waldbrook, Diana, Weeratunge, Steven, Wesolowski, Aaron, Williams, Michael, Wilson, Zhiwei, Xie, Rhena, Yoo, Clint, Young, Alla, Zenova, Wei, Zhang, Alison J, Cutts, Robin P, Sherrington, Simon N, Pimstone, Raymond, Winquist, Charles J, Cohen, James R, Empfield
المصدر: eLife. 11
مصطلحات موضوعية: Neurons, Mice, Epilepsy, NAV1.6 Voltage-Gated Sodium Channel, Gain of Function Mutation, Mutation, Sodium, Animals, Rats, Sodium Channel Blockers
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المؤلفون: Parisa Karimi Tari, Charles J. Cohen, Matthew Waldbrook, Christoph Martin Dehnhardt, Clint Young, Maegan Soriano, Rainbow Kwan, Matt Taron, Kristen Burford, Sultan Chowdhury, Noah G. Shuart, Lofstrand Verner Alexander, Michael D. Wilson, Karen Nelkenbrecher, Jean-Christophe Andrez, Michael Edward Grimwood, Wei Gong, Robert J. DeVita, J. P. Johnson, James Roy Empfield, Alla Yurevna Zenova, Luis Sojo, Andrea Lindgren, Thilo Focken, Shannon Decker, Gina de Boer, Samuel J. Goodchild, Wesolowski Steven Sigmund, Sophia Lin, Stephanie Lee
المصدر: Journal of Medicinal Chemistry. 62:9618-9641
مصطلحات موضوعية: Drug, 0303 health sciences, media_common.quotation_subject, Sodium channel, medicine.medical_treatment, Pregnane, Pharmacology, medicine.disease, 01 natural sciences, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, 03 medical and health sciences, Epilepsy, chemistry.chemical_compound, Anticonvulsant, chemistry, Drug Discovery, medicine, Molecular Medicine, Structure–activity relationship, Efflux, Penetrant (biochemical), 030304 developmental biology, media_common
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المؤلفون: Thilo, Focken, Kristen, Burford, Michael E, Grimwood, Alla, Zenova, Jean-Christophe, Andrez, Wei, Gong, Michael, Wilson, Matt, Taron, Shannon, Decker, Verner, Lofstrand, Sultan, Chowdhury, Noah, Shuart, Sophia, Lin, Samuel J, Goodchild, Clint, Young, Maegan, Soriano, Parisa K, Tari, Matthew, Waldbrook, Karen, Nelkenbrecher, Rainbow, Kwan, Andrea, Lindgren, Gina, de Boer, Stephanie, Lee, Luis, Sojo, Robert J, DeVita, Charles J, Cohen, Steven S, Wesolowski, J P, Johnson, Christoph M, Dehnhardt, James R, Empfield
المصدر: Journal of medicinal chemistry. 62(21)
مصطلحات موضوعية: Central Nervous System, Models, Molecular, Epilepsy, Hep G2 Cells, Amides, Madin Darby Canine Kidney Cells, Mice, Structure-Activity Relationship, Dogs, Protein Domains, NAV1.6 Voltage-Gated Sodium Channel, Animals, Humans, Protein Isoforms, Sodium Channel Blockers
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المؤلفون: Kristen Burford, Allyn T. Londregan, Yajing Lian
المصدر: Tetrahedron. 71:9509-9514
مصطلحات موضوعية: endocrine system diseases, Organic Chemistry, Quinoline, Triazole, Pyrazole, Biochemistry, Combinatorial chemistry, chemistry.chemical_compound, chemistry, Drug Discovery, Pyridine, Imidazole, Molecule, Triflic acid, Friedel–Crafts reaction
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المؤلفون: Kristen Burford, Daniel P. Canterbury, Wenhua Jiao, Kun Song, Saket Agarwal, Elnaz Menhaji-Klotz, Allyn T. Londregan, Karen Atkinson, Jun Xiao, Jessica Ward, John Litchfield, Kevin Beaumont, David W. Piotrowski, Janice A. Brown, Amit S. Kalgutkar, Danielle M. Crowell, Kevin D. Hesp, Tim F. Ryder, Scott W. Bagley, David Price, Stephen Pazdziorko, Benjamin A. Thuma, Markus Boehm, Valerie Clerin, Rhys M. Jones, Chris Limberakis
المصدر: Journal of medicinal chemistry. 61(8)
مصطلحات موضوعية: 0301 basic medicine, Male, Cardiotonic Agents, Heart Diseases, Cardiac fibrosis, Adrenergic, Pharmacology, Madin Darby Canine Kidney Cells, 03 medical and health sciences, Chemokine receptor, Structure-Activity Relationship, 0302 clinical medicine, Dogs, Drug Discovery, Acetamides, medicine, Structure–activity relationship, Animals, Humans, Receptor, Receptors, CXCR, Mice, Inbred BALB C, Molecular Structure, Chemistry, Isoproterenol, Azepines, medicine.disease, Small molecule, Fibrosis, Mice, Inbred C57BL, 030104 developmental biology, 030220 oncology & carcinogenesis, Lipophilicity, Microsome, Microsomes, Liver, Molecular Medicine, Hydrophobic and Hydrophilic Interactions
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المؤلفون: Kevin D. Hesp, Allyn T. Londregan, Kristen Burford, Edward L. Conn
المصدر: Organic Letters. 16:3336-3339
مصطلحات موضوعية: Aza Compounds, Molecular Structure, Silylation, Organic Chemistry, Ketene, Phosphonium salt, Oxides, Stereoisomerism, Acetates, Ethylenes, Ketones, Silanes, Biochemistry, Azine, chemistry.chemical_compound, Acetals, Organophosphorus Compounds, chemistry, Molecule, Organic chemistry, Physical and Theoretical Chemistry, Derivative (chemistry)
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المؤلفون: Kristen Burford, Allyn T. Londregan, Yajing Lian
المصدر: ChemInform. 47
مصطلحات موضوعية: chemistry.chemical_compound, endocrine system diseases, chemistry, Pyridine, Quinoline, Triazole, Imidazole, Organic chemistry, Molecule, General Medicine, Pyrazole
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المؤلفون: Edward L. Conn, Kevin D. Hesp, Kristen Burford, Allyn T. Londregan
المصدر: ChemInform. 45
مصطلحات موضوعية: Azine, chemistry.chemical_compound, chemistry, Silylation, Ketene, General Medicine, Medicinal chemistry, Derivative (chemistry)