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المؤلفون: Kiev S. Ly, Andrew Richard Hudson, Christine Hoffmaster, James T. Limberis, J. Guy Breitenbucher, Richard Barido, De Michael Chung, Yingzhuo Yan, Gary Anderson, Vincent J. Santora, Dany Gitnick, Dong Lee, Brett C. Bookser, Anne Danks, Robert E. Petroski, Graeme Freestone, Varsha Gupta, Clifford Cabebe, Andrew Morse, Michael R. Kennedy, Kristen Sebring, Zachary W. Yoder, Douglas Zook, Marco Peters, Chih-Kun Chai, Joel Renick, Jim Na, Theresa A. Almos, Shouzhen Xia, Ali Tabatabaei, John Nikpur, Samantha Sevidal, Stephine Chow, Mi Chen, Jillian Basinger, Chris L. Bellows, Lindsay Heger, David Neul, Jenny Wen, Brittany Masatsugu, Nicola J. Broadbent, Alan P. Kaplan, Chi Ching Mak
المصدر: Bioorganicmedicinal chemistry letters. 30(14)
مصطلحات موضوعية: Bitopertin, Clinical Biochemistry, Azetidine, Pharmaceutical Science, Pharmacology, 01 natural sciences, Biochemistry, chemistry.chemical_compound, Structure-Activity Relationship, In vivo, Glycine Plasma Membrane Transport Proteins, Memory, Drug Discovery, Potency, Humans, Receptor, Molecular Biology, Conformational isomerism, biology, Dose-Response Relationship, Drug, Molecular Structure, 010405 organic chemistry, Chemistry, Organic Chemistry, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, HEK293 Cells, Glycine transporter 1, Glycine, biology.protein, Molecular Medicine, Azetidines
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المؤلفون: Kiev S. Ly, Laurent Gomez, Mark Eben Massari, Markus Metz, Rui Xu, Tami Jo Marrone, W. Sinko, J.G. Breitenbucher, B. Appleton, R. Truong, B. Selfridge, Kathleen Aertgeerts, William F. Vernier, Yingzhuo Yan, Kristen Sebring
المصدر: Journal of Medicinal Chemistry. 61:7754-7766
مصطلحات موضوعية: 0301 basic medicine, Protein Conformation, Stereochemistry, Binding pocket, Plasma protein binding, Crystallography, X-Ray, Ligands, 010402 general chemistry, 01 natural sciences, Structure-Activity Relationship, 03 medical and health sciences, Protein structure, Additive function, Drug Discovery, Hydrolase, Humans, Structure–activity relationship, Enzyme Inhibitors, Binding site, skin and connective tissue diseases, Binding Sites, Chemistry, fungi, Models, Theoretical, Triazoles, Cyclic Nucleotide Phosphodiesterases, Type 2, 0104 chemical sciences, 030104 developmental biology, Structural change, Quinazolines, Molecular Medicine, Hydrophobic and Hydrophilic Interactions, Protein Binding
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المؤلفون: David Neul, Andrew Morse, Joel Renick, Brittany Masatsugu, Chi Ching Mak, James T. Limberis, Dany Gitnick, Zachary W. Yoder, Michael R. Kennedy, Kiev S. Ly, Samantha Sevidal, Richard Barido, Robert E. Petroski, Graeme Freestone, Clifford Cabebe, Jillian Basinger, Vincent J. Santora, Christine Hoffmaster, Chris L. Bellows, Yingzhuo Yan, Mi Chen, De Michael Chung, John Nikpur, Kristen Sebring, Jenny Wen, Ali Tabatabaei, Brett C. Bookser, Theresa A. Almos, Andrew Richard Hudson, J. Guy Breitenbucher, Chih-Kun Chai, Dong Lee, Lindsay Crickard, Anne Danks, Varsha Gupta, Marco Peters, Alan P. Kaplan, Jim Na, Nicola J. Broadbent, Stephine Chow, Douglas Zook
المصدر: Journal of Medicinal Chemistry. 61:6018-6033
مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, Molecular Conformation, Chemistry Techniques, Synthetic, Pharmacology, Permeability, 03 medical and health sciences, 0302 clinical medicine, Pharmacokinetics, Glycine Plasma Membrane Transport Proteins, Memory, In vivo, Drug Discovery, Animals, Humans, Potency, ADME, biology, Chemistry, Ligand (biochemistry), In vitro, Rats, HEK293 Cells, 030104 developmental biology, Drug Design, Glycine transporter 1, Glycine, biology.protein, Pyrazoles, Molecular Medicine, 030217 neurology & neurosurgery
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المؤلفون: Margaret McCarrick, Richard Barido, Troy Vickers, Ali Tabatabaei, J. Guy Breitenbucher, Mark Eben Massari, Robert Lemus, Laurent Gomez, Marco Peters, Markus Metz, Rui Xu, Xianbo Zhou, David Neul, William F. Vernier, Nicola J. Broadbent, Yingzhou G. Yan, Graeme Freestone, Kathleen Aertgeerts, Zachary W. Yoder, Noelle Warren, Carsten B. Andersen, Kara Schmelzer, Kristen Sebring, Kiev S. Ly, Tami Jo Marrone, Dong Lee
المصدر: Journal of medicinal chemistry. 60(5)
مصطلحات موضوعية: 0301 basic medicine, Exonucleases, Pyrimidine, Stereochemistry, Phosphodiesterase Inhibitors, Proton Magnetic Resonance Spectroscopy, 01 natural sciences, 03 medical and health sciences, chemistry.chemical_compound, In vivo, Drug Discovery, Potency, Humans, chemistry.chemical_classification, Memory Disorders, Halogen bond, biology, 010405 organic chemistry, Active site, Combinatorial chemistry, 0104 chemical sciences, 030104 developmental biology, Enzyme, chemistry, Enzyme inhibitor, biology.protein, Molecular Medicine, Phosphodiesterase 2, Chromatography, Liquid
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المؤلفون: Kristen Sebring, Dominic P. Behan, James N. Leonard, Chris Carroll, Annette Lucman, Jinyao Zhou, Charles Xing, Robert M. Jones, David J. Unett, Jean Alfonso, Veronica Gutierrez, Hongmei He, Ruoping Chen, Brandee Wagner, Zhi-Liang Chu
المصدر: Molecular Endocrinology. 24:161-170
مصطلحات موضوعية: Blood Glucose, Male, Agonist, medicine.medical_specialty, medicine.drug_class, Dopamine, Mice, Inbred Strains, Endogeny, Biology, Glucagon, Cell Line, Receptors, G-Protein-Coupled, Mice, Oleoylethanolamide, chemistry.chemical_compound, Paracrine signalling, Endocrinology, Cricetinae, Insulin-Secreting Cells, Internal medicine, Insulin Secretion, medicine, Animals, Homeostasis, Humans, Insulin, Glucose homeostasis, Receptor, Molecular Biology, Original Research, Mice, Knockout, Dose-Response Relationship, Drug, Pancreatic islets, Fatty Acids, General Medicine, Amides, Rats, medicine.anatomical_structure, chemistry, Organ Specificity, Female
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::336465d38f95787a87db01093b7487a0
https://doi.org/10.1210/me.2009-0239 -
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المؤلفون: Kevin J. Tomaselli, Julia Herrmann, Robert O. Sayers, Joe C. Wu, Lalitha Kodandapani, Kathy G. Jahangiri, Craig D. Fisher, David T. Winn, Edward D. Robinson, Steven P. Meduna, Robert J. Ternansky, Pauline Yeo, Karen L. Valentino, Jose-Luis Diaz, Vincent J. Kalish, Steven D. Linton, Kristen Sebring, Robert A. Armstrong, Joseph F. Krebs, Niel C. Hoglen, Alfred P. Spada, Brad P. Hirakawa, Ning Chen, Brett R. Ullman, Brett Weylan Ching, Cheng-zhi Zhang, Xu Bai, Xin Gu, Kip Nalley, Long-Shiuh Chen, Patricia L. Gladstone, Jeff McQuiston, Teresa Aja, Todd Groessl, Donald S. Karanewsky, Suzanne Weeks, Lawrence C. Fritz, Patricia C. Contreras
المصدر: Journal of Medicinal Chemistry. 48:6779-6782
مصطلحات موضوعية: Adult, Biological Availability, Phases of clinical research, Apoptosis, Pharmacology, Jurkat Cells, Mice, Structure-Activity Relationship, Liver disease, Pharmacokinetics, In vivo, Drug Discovery, medicine, Animals, Humans, Aspartate Aminotransferases, Pentanoic Acids, Caspase, Liver injury, Cholestasis, Clinical Trials, Phase I as Topic, biology, Caspase 3, Chemistry, Liver Diseases, Alanine Transaminase, Hepatitis C, Chronic, medicine.disease, Caspase Inhibitors, In vitro, Rats, Liver, Biochemistry, Enzyme inhibitor, Hepatocytes, biology.protein, Molecular Medicine, Half-Life
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