المؤلفون: Rogawski DS; Department of Pathology, University of Michigan, Ann Arbor, MI, USA., Deng J; Department of Pathology, University of Michigan, Ann Arbor, MI, USA., Li H; Department of Pathology, University of Michigan, Ann Arbor, MI, USA., Miao H; Department of Pathology, University of Michigan, Ann Arbor, MI, USA., Borkin D; Department of Pathology, University of Michigan, Ann Arbor, MI, USA., Purohit T; Department of Pathology, University of Michigan, Ann Arbor, MI, USA., Song J; Department of Pathology, University of Michigan, Ann Arbor, MI, USA., Chase J; Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA., Li S; Department of Pathology, University of Michigan, Ann Arbor, MI, USA., Ndoj J; Department of Pathology, University of Michigan, Ann Arbor, MI, USA., Klossowski S; Department of Pathology, University of Michigan, Ann Arbor, MI, USA., Kim E; Department of Pathology, University of Michigan, Ann Arbor, MI, USA., Mao F; Department of Pathology, University of Michigan, Ann Arbor, MI, USA., Zhou B; Department of Pathology, University of Michigan, Ann Arbor, MI, USA., Ropa J; Department of Pathology, University of Michigan, Ann Arbor, MI, USA.; Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN, USA., Krotoska MZ; Department of Pathology, University of Michigan, Ann Arbor, MI, USA., Jin Z; Department of Pathology, University of Michigan, Ann Arbor, MI, USA., Ernst P; Department of Pediatrics, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, USA., Feng X; Department of Pathology and Laboratory Medicine, Cincinnati Children's Hospital, Cincinnati, OH, USA., Huang G; Department of Pathology and Laboratory Medicine, Cincinnati Children's Hospital, Cincinnati, OH, USA., Nishioka K; Department of Internal Medicine Musashimurayama Hospital, Enoki 1-1-5, Musashimurayama, Tokyo, Japan., Kelly S; Division of Hematology-Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., He M; College of Pharmacy, University of Michigan, Ann Arbor, MI, USA., Wen B; College of Pharmacy, University of Michigan, Ann Arbor, MI, USA., Sun D; College of Pharmacy, University of Michigan, Ann Arbor, MI, USA., Muntean A; Department of Pathology, University of Michigan, Ann Arbor, MI, USA., Dou Y; Department of Pathology, University of Michigan, Ann Arbor, MI, USA., Maillard I; Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA.; Division of Hematology-Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Cierpicki T; Department of Pathology, University of Michigan, Ann Arbor, MI, USA. tomaszc@umich.edu., Grembecka J; Department of Pathology, University of Michigan, Ann Arbor, MI, USA. jolantag@med.umich.edu.

المصدر: Nature communications [Nat Commun] 2021 May 14; Vol. 12 (1), pp. 2792. Date of Electronic Publication: 2021 May 14.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

مواضيع طبية MeSH: Antineoplastic Agents/*pharmacology , DNA-Binding Proteins/*antagonists & inhibitors , Enzyme Inhibitors/*pharmacology , Histone-Lysine N-Methyltransferase/*antagonists & inhibitors , Leukemia/*drug therapy , Leukemia/*enzymology, Animals ; Antineoplastic Agents/chemistry ; Catalytic Domain/drug effects ; Catalytic Domain/genetics ; Cell Line, Tumor ; Cell Transformation, Neoplastic/drug effects ; Cell Transformation, Neoplastic/genetics ; Crystallography, X-Ray ; DNA-Binding Proteins/chemistry ; DNA-Binding Proteins/genetics ; Drug Design ; Drug Discovery ; Enzyme Inhibitors/chemistry ; Female ; Histone-Lysine N-Methyltransferase/chemistry ; Histone-Lysine N-Methyltransferase/genetics ; Humans ; Leukemia/genetics ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Models, Molecular ; Myeloid-Lymphoid Leukemia Protein/genetics ; Oncogenes ; Protein Domains ; Recombinant Fusion Proteins/genetics