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المؤلفون: Krzysztof Appelt, Pranab K. Mukherjee, Gino J DiSciullo, Jyotsna Chandra, Mahmoud A. Ghannoum, N. Isham, Lisa Long
المصدر: Antimicrobial Agents and Chemotherapy. 62
مصطلحات موضوعية: 0301 basic medicine, Pharmacology, biology, Chemistry, 030106 microbiology, Biofilm, biochemical phenomena, metabolism, and nutrition, biology.organism_classification, Antimicrobial, Trimethoprim, Microbiology, 03 medical and health sciences, Catheter, 0302 clinical medicine, Infectious Diseases, Enterococcus, In vivo, medicine, Pharmacology (medical), 030212 general & internal medicine, Candida albicans, Mechanisms of Action: Physiological Effects, Bacteria, medicine.drug
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44b937654b910c75f41845bca9d6fafc
https://doi.org/10.1128/aac.00722-18 -
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المؤلفون: Bart J. A. Rijnders, Gino J DiSciullo, Roger Aitchison, Michel Jadoul, Gilad Gordon, Bolesław Rutkowski, Krzysztof Appelt, Richard Fluck, John Cheronis, Botond Csiky
المساهمون: UCL - SSS/IREC/NEFR - Pôle de Néphrologie, UCL - (SLuc) Service de néphrologie, Medical Microbiology & Infectious Diseases
المصدر: Clinical Infectious Diseases, (2018)
Clinical Infectious Diseases, 69(1), 130-136. Oxford University Pressمصطلحات موضوعية: Microbiology (medical), Adult, Male, Catheters, Adolescent, medicine.medical_treatment, 030232 urology & nephrology, Hemodialysis Catheter, Bacteremia, 030204 cardiovascular system & hematology, Trimethoprim, 03 medical and health sciences, Young Adult, 0302 clinical medicine, Anti-Infective Agents, Renal Dialysis, medicine, Clinical endpoint, Humans, Prospective Studies, Dialysis, Edetic Acid, Aged, Aged, 80 and over, Dialysis adequacy, Ethanol, business.industry, Incidence, Middle Aged, Catheter, Infectious Diseases, Anesthesia, Catheter-Related Infections, Anti-Infective Agents, Local, Female, Hemodialysis, business, Central venous catheter, Fibrinolytic agent
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19395c253f548fbf41aa064cf1d40e7d
https://pubmed.ncbi.nlm.nih.gov/30281074 -
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المؤلفون: N. Isham, Jyotsna Chandra, Gino J DiSciullo, Pranab K. Mukherjee, Mahmoud A. Ghannoum, Lisa Long, Krzysztof Appelt
مصطلحات موضوعية: Colony-forming unit, 0303 health sciences, biology, 030306 microbiology, Chemistry, Biofilm, biochemical phenomena, metabolism, and nutrition, Antimicrobial, biology.organism_classification, Corpus albicans, Microbiology, 03 medical and health sciences, Catheter, 0302 clinical medicine, Enterococcus, In vivo, 030212 general & internal medicine, Bacteria
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd59cf63a2edef6c54bbf9e400e5bea6
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المؤلفون: Victor I. Nikulin, Sam Chu, Martina E. Tedder, Kelly Sprankle, Kraig M. Yager, Mitra Khalili, Krzysztof Appelt, Li Xiaoming, James Levin, Victoria A. Feher, Stephen Margosiak, Robert Almassy, Zhe Nie
المصدر: Journal of Medicinal Chemistry. 46:5663-5673
مصطلحات موضوعية: Models, Molecular, Indazoles, Streptococcus pyogenes, Microbial Sensitivity Tests, Neisseria meningitidis, Crystallography, X-Ray, Chemical synthesis, Structure-Activity Relationship, chemistry.chemical_compound, Methylthioadenosine nucleosidase, Drug Discovery, N-Glycosyl Hydrolases, Antibacterial agent, Sulfonamides, Indazole, Binding Sites, biology, Chemistry, Biological activity, Antimicrobial, Anti-Bacterial Agents, Adenosylhomocysteine nucleosidase, Streptococcus pneumoniae, Biochemistry, Enzyme inhibitor, Drug Design, biology.protein, Molecular Medicine
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المؤلفون: Charles D. McDermott, Germaine Bergeron-Lynn, Ugur Ozerdem, William R. Freeman, Kelly S. Keefe, Lingyun Cheng, Beata Mach-Hofacre, Krzysztof Appelt, Sunan Chaidhawangul
المصدر: Current Eye Research. 20:447-453
مصطلحات موضوعية: Male, medicine.medical_specialty, Proliferative vitreoretinopathy, Prinomastat, Fundus Oculi, Matrix metalloproteinase inhibitor, Drug Evaluation, Preclinical, Antineoplastic Agents, Matrix Metalloproteinase Inhibitors, Matrix metalloproteinase, Retina, Vitreous cavity, Cellular and Molecular Neuroscience, Ophthalmology, Dispase, medicine, Animals, New zealand white, Enzyme Inhibitors, Organic Chemicals, business.industry, Vitreoretinopathy, Proliferative, Retinal detachment, Epiretinal Membrane, medicine.disease, eye diseases, Sensory Systems, Female, Rabbits, sense organs, business
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المؤلفون: Michele Ann Mctigue, Michael R Gehring, Chris Pinko, J. Ernest Villafranca, Chen-Chen Kan, Camran V Parast, Krzysztof Appelt, Richard E. Showalter, Barbara Mroczkowski, John A Wickersham, Anna Tempczyk-Russell
المصدر: Structure. 7:319-330
مصطلحات موضوعية: Models, Molecular, Protein Folding, Protein Conformation, Recombinant Fusion Proteins, Molecular Sequence Data, Neovascularization, Physiologic, Mitogen-activated protein kinase kinase, Crystallography, X-Ray, Protein Structure, Secondary, Receptor tyrosine kinase, Substrate Specificity, MAP2K7, angiogenesis, Structure-Activity Relationship, kinase insert domain, Adenosine Triphosphate, Structural Biology, Catalytic Domain, Humans, Receptors, Growth Factor, ASK1, Amino Acid Sequence, Kinase activity, Growth Substances, Molecular Biology, Binding Sites, Sequence Homology, Amino Acid, biology, MAP kinase kinase kinase, tyrosine kinase, Receptor Protein-Tyrosine Kinases, Protein-Tyrosine Kinases, Peptide Fragments, Cell biology, Kinetics, Receptors, Vascular Endothelial Growth Factor, Biochemistry, Multigene Family, Mutagenesis, Site-Directed, biology.protein, Cyclin-dependent kinase 9, X-ray structure, Sequence Alignment, signal transduction, Proto-oncogene tyrosine-protein kinase Src
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المؤلفون: S. D. Hatch, Mark A. Muesing, Deborah A. Khalil, Nickolay Y. Chirgadze, Siegfried H. Reich, Vincent J. Kalish, Kenneth S. Su, Jeffrey A. Burgess, Krzysztof Appelt, Bruce A. Dressman, Penny P. Lubbehusen, Stephen W. Kaldor, Bhasker V. Shetty, Kristina M. Campanale, Jay F. Davies, David K. Clawson, John H. Tatlock, Maha B. Kosa, James E. Fritz, Amy K. Patick
المصدر: Journal of Medicinal Chemistry. 40:3979-3985
مصطلحات موضوعية: Male, Anti-HIV Agents, medicine.medical_treatment, Administration, Oral, Biological Availability, Rats, Sprague-Dawley, Structure-Activity Relationship, Dogs, HIV-1 protease, Pharmacokinetics, Oral administration, In vivo, Drug Discovery, medicine, Animals, Structure–activity relationship, Nelfinavir, Protease, Dose-Response Relationship, Drug, biology, Chemistry, Callithrix, HIV Protease Inhibitors, Rats, Macaca fascicularis, Biochemistry, Enzyme inhibitor, HIV-1, biology.protein, Molecular Medicine, Female, Nelfinavir mesylate
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المصدر: Clinical and Experimental Metastasis. 15:499-508
مصطلحات موضوعية: Cancer Research, Prinomastat, Chemistry, Lewis lung carcinoma, General Medicine, Pharmacology, Matrix metalloproteinase, medicine.disease, Primary tumor, Bioavailability, Metastasis, Extracellular matrix, Oncology, Pharmacokinetics, medicine
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المؤلفون: Krzysztof Appelt, Melnick Michael J, B.‐W. Wu, L. Musick, Mary Ann M. Fuhry, Reich Siegfried Heinz, Mark J. Pino, Jay F. Davies, Anthony J. Trippe
المصدر: Journal of Medicinal Chemistry. 39:2781-2794
مصطلحات موضوعية: Models, Molecular, Peptidomimetic, Stereochemistry, Butanols, medicine.medical_treatment, Crystallography, X-Ray, Antiviral Agents, Cocrystal, Chemical synthesis, Cell Line, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, medicine, Humans, chemistry.chemical_classification, Protease, biology, HIV Protease Inhibitors, Amides, Combinatorial chemistry, Enzyme, chemistry, Enzyme inhibitor, Drug Design, HIV-1, biology.protein, Molecular Medicine, Racemic mixture, Lead compound
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8fb4e29ab3ee5663fc2578cdd634cef
https://doi.org/10.1021/jm960093o -
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المؤلفون: Jesus Ernesto Villafranca, Carol L. J. Booth, Charlotte A. Bartlett, Stephanie Webber, Cindy L. Palmer, C. A. Morse, Varney Michael D, Ellen W. Moomaw, Jones Terence R, S. M. Herrmann, Krzysztof Appelt, Kathleen K. Lewis, Katharine M. Welsh, Robert William Ward, Cheryl Ann Janson, Russell J. Bacquet, Eleanor F. Howland, Ward W. Smith, Stephen E. Webber, Vinit Kathardekar, David A. Matthews, Jennifer White, Marzoni Gifford P
المصدر: Journal of Medicinal Chemistry. 39:904-917
مصطلحات موضوعية: Models, Molecular, Tertiary amine, Protein Conformation, Stereochemistry, Molecular Conformation, Antineoplastic Agents, Adenocarcinoma, Crystallography, X-Ray, medicine.disease_cause, Thymidylate synthase, Cell Line, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, Escherichia coli, Tumor Cells, Cultured, medicine, Quinazoline, Animals, Humans, Enzyme Inhibitors, Leukemia L1210, Ternary complex, chemistry.chemical_classification, Binding Sites, Leukemia, Molecular Structure, biology, Chemistry, Thymidylate Synthase, Enzyme, Enzyme inhibitor, Drug Design, Quinazolines, biology.protein, Folic Acid Antagonists, Molecular Medicine, Thymidine
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f33e515142229b5c112750e718425e0
https://doi.org/10.1021/jm9502652