المؤلفون: Oz-Levi D; Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel., Olender T; Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel., Bar-Joseph I; The Danek Gertner Institute of Human Genetics, Sheba Medical Center, Ramat Gan, Israel.; The Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel., Zhu Y; Division of Environmental Genomics and Systems Biology, Lawrence Berkeley National Laboratory, Berkeley, CA, USA., Marek-Yagel D; The Danek Gertner Institute of Human Genetics, Sheba Medical Center, Ramat Gan, Israel.; The Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.; Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Ramat Gan, Israel., Barozzi I; Division of Environmental Genomics and Systems Biology, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.; Department of Surgery and Cancer, Imperial College London, London, UK., Osterwalder M; Division of Environmental Genomics and Systems Biology, Lawrence Berkeley National Laboratory, Berkeley, CA, USA., Alkelai A; Institute for Genomic Medicine, Columbia University Medical Center, New York, NY, USA., Ruzzo EK; Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles, Los Angeles, CA, USA., Han Y; Center for Human Genome Variation, Duke University School of Medicine, Durham, NC, USA., Vos ESM; Oncode Institute, Hubrecht Institute-KNAW and University Medical Center Utrecht, Utrecht, the Netherlands., Reznik-Wolf H; The Danek Gertner Institute of Human Genetics, Sheba Medical Center, Ramat Gan, Israel.; The Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel., Hartman C; The Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.; Schneider Children's Medical Center, Petach Tikva, Israel., Shamir R; The Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.; Schneider Children's Medical Center, Petach Tikva, Israel., Weiss B; The Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.; Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Ramat Gan, Israel., Shapiro R; The Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.; Schneider Children's Medical Center, Petach Tikva, Israel., Pode-Shakked B; The Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.; Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Ramat Gan, Israel., Tatarskyy P; Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel., Milgrom R; Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel., Schvimer M; Department of Pathology, Sheba Medical Center, Ramat Gan, Israel., Barshack I; The Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.; Department of Pathology, Sheba Medical Center, Ramat Gan, Israel., Imai DM; Comparative Pathology Laboratory, University of California Davis, Davis, CA, USA., Coleman-Derr D; Plant Gene Expression Center, USDA ARS, Albany, CA, USA., Dickel DE; Division of Environmental Genomics and Systems Biology, Lawrence Berkeley National Laboratory, Berkeley, CA, USA., Nord AS; Division of Environmental Genomics and Systems Biology, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.; Center for Neuroscience, University of California Davis, Davis, CA, USA., Afzal V; Division of Environmental Genomics and Systems Biology, Lawrence Berkeley National Laboratory, Berkeley, CA, USA., van Bueren KL; Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA, USA., Barnes RM; Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA, USA., Black BL; Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA, USA., Mayhew CN; Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA., Kuhar MF; Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA., Pitstick A; Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA., Tekman M; Centre for Nephrology, University College London, London, UK., Stanescu HC; Centre for Nephrology, University College London, London, UK., Wells JM; Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.; Division of Endocrinology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.; Center for Stem Cell and Organoid Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA., Kleta R; Centre for Nephrology, University College London, London, UK., de Laat W; Oncode Institute, Hubrecht Institute-KNAW and University Medical Center Utrecht, Utrecht, the Netherlands., Goldstein DB; Institute for Genomic Medicine, Columbia University Medical Center, New York, NY, USA., Pras E; The Danek Gertner Institute of Human Genetics, Sheba Medical Center, Ramat Gan, Israel.; The Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel., Visel A; Division of Environmental Genomics and Systems Biology, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.; School of Natural Sciences, University of California, Merced, CA, USA.; US Department of Energy Joint Genome Institute, Walnut Creek, CA, USA., Lancet D; Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel. Doron.Lancet@weizmann.ac.il., Anikster Y; The Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel. Yair.Anikster@sheba.health.gov.il.; Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Ramat Gan, Israel. Yair.Anikster@sheba.health.gov.il.; Wohl Institute for Translational Medicine, Sheba Medical Center, Ramat Gan, Israel. Yair.Anikster@sheba.health.gov.il., Pennacchio LA; Division of Environmental Genomics and Systems Biology, Lawrence Berkeley National Laboratory, Berkeley, CA, USA. LAPennacchio@lbl.gov.; US Department of Energy Joint Genome Institute, Walnut Creek, CA, USA. LAPennacchio@lbl.gov.; Comparative Biochemistry Program, University of California Berkeley, Berkeley, CA, USA. LAPennacchio@lbl.gov.

المصدر: Nature [Nature] 2019 Jul; Vol. 571 (7763), pp. 107-111. Date of Electronic Publication: 2019 Jun 19.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE

مواضيع طبية MeSH: Gene Expression Regulation, Developmental* , Genes*, Diarrhea/*congenital , Diarrhea/*genetics , Enhancer Elements, Genetic/*genetics , Intestines/*physiology , Sequence Deletion/*genetics, Animals ; Chromosomes, Human, Pair 16/genetics ; Disease Models, Animal ; Female ; Genes, Reporter ; Genetic Loci/genetics ; Humans ; Male ; Mice ; Mice, Knockout ; Mice, Transgenic ; Pedigree ; Phenotype ; Transcriptional Activation ; Transcriptome/genetics ; Transgenes/genetics

المؤلفون: Spence JR; Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, Ohio 45229-3039, USA., Mayhew CN, Rankin SA, Kuhar MF, Vallance JE, Tolle K, Hoskins EE, Kalinichenko VV, Wells SI, Zorn AM, Shroyer NF, Wells JM

المصدر: Nature [Nature] 2011 Feb 03; Vol. 470 (7332), pp. 105-9. Date of Electronic Publication: 2010 Dec 12.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE

مواضيع طبية MeSH: Cell Differentiation/*drug effects , Embryonic Stem Cells/*cytology , Induced Pluripotent Stem Cells/*cytology , Intercellular Signaling Peptides and Proteins/*pharmacology , Intestines/*cytology, Activins/pharmacology ; Basic Helix-Loop-Helix Transcription Factors/genetics ; Basic Helix-Loop-Helix Transcription Factors/metabolism ; Body Patterning/drug effects ; Cell Culture Techniques ; Cells, Cultured ; Culture Media/chemistry ; Culture Media/pharmacology ; Embryonic Stem Cells/drug effects ; Endoderm/cytology ; Endoderm/drug effects ; Endoderm/embryology ; Fibroblast Growth Factor 4/pharmacology ; Humans ; Induced Pluripotent Stem Cells/drug effects ; Intestines/anatomy & histology ; Intestines/drug effects ; Intestines/embryology ; Microvilli/drug effects ; Morphogenesis/drug effects ; Nerve Tissue Proteins/genetics ; Nerve Tissue Proteins/metabolism ; Organogenesis/drug effects ; Time Factors ; Wnt Proteins/pharmacology ; Wnt3 Protein ; Wnt3A Protein