المؤلفون: Carter BZ; Section of Molecular Hematology and Therapy, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas., Mak PY; Section of Molecular Hematology and Therapy, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas., Tao W; Section of Molecular Hematology and Therapy, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas., Zhang Q; Section of Leukemia Biological Research, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas., Ruvolo V; Section of Molecular Hematology and Therapy, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas., Kuruvilla VM; Section of Leukemia Biological Research, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas., Wang X; Section of Molecular Hematology and Therapy, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas., Mak DH; Section of Molecular Hematology and Therapy, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas., Battula VL; Section of Molecular Hematology and Therapy, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas., Konopleva M; Section of Leukemia Biological Research, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas., Jabbour EJ; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas., Hughes PE; Oncology Research, Amgen Inc., Thousand Oaks, California., Chen X; Oncology Research, Amgen Inc., Thousand Oaks, California., Morrow PK; Amgen Inc., Thousand Oaks, California., Andreeff M; Section of Molecular Hematology and Therapy, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas.

المصدر: Molecular cancer therapeutics [Mol Cancer Ther] 2022 Jun 01; Vol. 21 (6), pp. 879-889.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: American Association for Cancer Research, Inc Country of Publication: United States NLM ID: 101132535 Publication Model: Print Cited Medium: Internet ISSN: 1538-8514 (Electronic) Linking ISSN: 15357163 NLM ISO Abbreviation: Mol Cancer Ther Subsets: MEDLINE

مواضيع طبية MeSH: Apoptosis Regulatory Proteins* , Biomimetic Materials*/pharmacology , Leukemia, Myeloid, Acute*/drug therapy , Leukemia, Myeloid, Acute*/metabolism, Animals ; Apoptosis ; Bridged Bicyclo Compounds, Heterocyclic/pharmacology ; Cell Line, Tumor ; Humans ; Mice ; Myeloid Cell Leukemia Sequence 1 Protein/genetics ; Proto-Oncogene Proteins c-bcl-2 ; Stem Cells/metabolism ; bcl-2-Associated X Protein/metabolism ; bcl-2-Associated X Protein/pharmacology

المؤلفون: Baran N; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Lodi A; Department of Nutritional Sciences, Dell Pediatric Research Institute, Dell Medical School, The University of Texas at Austin, Austin, TX, USA., Dhungana Y; St. Jude Graduate School of Biomedical Sciences, St. Jude Children's Research Hospital, Memphis, TN, USA., Herbrich S; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Collins M; Department of Nutritional Sciences, Dell Pediatric Research Institute, Dell Medical School, The University of Texas at Austin, Austin, TX, USA., Sweeney S; Department of Nutritional Sciences, Dell Pediatric Research Institute, Dell Medical School, The University of Texas at Austin, Austin, TX, USA., Pandey R; Department of Nutritional Sciences, Dell Pediatric Research Institute, Dell Medical School, The University of Texas at Austin, Austin, TX, USA., Skwarska A; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Patel S; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Tremblay M; Institute for Research in Immunology and Cancer, The University of Montreal, Montréal, QC, Canada., Kuruvilla VM; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Cavazos A; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Kaplan M; Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Warmoes MO; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Veiga DT; The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA., Furudate K; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Department of Oral and Maxillofacial Surgery, Hirosaki University Graduate School of Medicine, Hirosaki, Aomori, Japan., Rojas-Sutterin S; Institute for Research in Immunology and Cancer, The University of Montreal, Montréal, QC, Canada., Haman A; Institute for Research in Immunology and Cancer, The University of Montreal, Montréal, QC, Canada., Gareau Y; Institute for Research in Immunology and Cancer, The University of Montreal, Montréal, QC, Canada., Marinier A; Institute for Research in Immunology and Cancer, The University of Montreal, Montréal, QC, Canada., Ma H; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Harutyunyan K; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Daher M; Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Garcia LM; Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Al-Atrash G; Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Piya S; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Ruvolo V; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Yang W; Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN, USA., Shanmugavelandy SS; Department of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Feng N; TRACTION Platform, Therapeutics Discovery Division, University of Texas M. D. Anderson Cancer Center, Houston, USA., Gay J; TRACTION Platform, Therapeutics Discovery Division, University of Texas M. D. Anderson Cancer Center, Houston, USA., Du D; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Yang JJ; Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN, USA., Hoff FW; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Kaminski M; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA., Tomczak K; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Eric Davis R; Department of Lymphoma and Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Herranz D; Rutgers Robert Wood Johnson Medical School, Cancer Institute of New Jersey, New Brunswick, NJ, USA., Ferrando A; Irving Cancer Research Center, Columbia University Irving Medical Center, New York, NY, USA., Jabbour EJ; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Emilia Di Francesco M; Institute for Applied Cancer Science, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Teachey DT; Perelman School of Medicine, The University of Pennsylvania, Philadelphia, PA, USA., Horton TM; Texas Children's Cancer Center, Baylor College of Medicine, Houston, TX, USA., Kornblau S; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Rezvani K; Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Sauvageau G; Institute for Research in Immunology and Cancer, The University of Montreal, Montréal, QC, Canada., Gagea M; Department of Veterinary Medicine and Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Andreeff M; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Takahashi K; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Marszalek JR; TRACTION Platform, Therapeutics Discovery Division, University of Texas M. D. Anderson Cancer Center, Houston, USA., Lorenzi PL; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Yu J; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA., Tiziani S; Department of Nutritional Sciences, Dell Pediatric Research Institute, Dell Medical School, The University of Texas at Austin, Austin, TX, USA., Hoang T; Institute for Research in Immunology and Cancer, The University of Montreal, Montréal, QC, Canada.; Department of Pharmacology and Physiology, Faculty of Medicine, University of Montreal, Montreal, QC, Canada., Konopleva M; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. mkonople@mdanderson.org.

المصدر: Nature communications [Nat Commun] 2022 May 19; Vol. 13 (1), pp. 2801. Date of Electronic Publication: 2022 May 19.

نوع المنشور: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

مواضيع طبية MeSH: Precursor T-Cell Lymphoblastic Leukemia-Lymphoma*/drug therapy , Precursor T-Cell Lymphoblastic Leukemia-Lymphoma*/genetics , Precursor T-Cell Lymphoblastic Leukemia-Lymphoma*/metabolism, Animals ; Electron Transport Complex I/genetics ; Electron Transport Complex I/metabolism ; Glutamine/metabolism ; Mice ; Receptor, Notch1/metabolism ; T-Lymphocytes/metabolism

المؤلفون: Zhang L; Oncology Discovery, AbbVie Inc., North Chicago, Illinois., Cai T; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas., Lin X; Oncology Discovery, AbbVie Inc., North Chicago, Illinois., Huang X; Oncology Discovery, AbbVie Inc., North Chicago, Illinois., Bui MH; Oncology Discovery, AbbVie Inc., North Chicago, Illinois., Plotnik JP; Oncology Discovery, AbbVie Inc., North Chicago, Illinois., Bellin RJ; Oncology Discovery, AbbVie Inc., North Chicago, Illinois., Faivre EJ; Oncology Discovery, AbbVie Inc., North Chicago, Illinois., Kuruvilla VM; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas., Lam LT; Oncology Discovery, AbbVie Inc., North Chicago, Illinois., Lu X; Genomic Research Center, AbbVie Inc., North Chicago, Illinois., Zha Z; Cyteir Therapeutics, 128 Spring Street, Lexington, Massachusetts., Feng W; Genomic Research Center, AbbVie Inc., North Chicago, Illinois., Hessler P; 190 Lisk Drive, Hainesville, Illinois., Uziel T; Oncology Discovery, AbbVie Inc., North Chicago, Illinois., Zhang Q; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas., Cavazos A; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas., Han L; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas., Ferguson DC; Oncology Discovery, AbbVie Inc., North Chicago, Illinois., Mehta G; Oncology Discovery, AbbVie Inc., North Chicago, Illinois., Shanmugavelandy SS; Oncology Discovery, AbbVie Inc., North Chicago, Illinois., Magoc TJ; Cyteir Therapeutics, 128 Spring Street, Lexington, Massachusetts., Rowe J; Charles River Laboratories, Wilmington, Massachusetts., Goodwin NC; Champions Oncology, Rockville, Maryland., Dorritie KA; Division of Hematology/Oncology, University of Pittsburgh, Pittsburgh, Pennsylvania., Boyiadzis M; Division of Hematology/Oncology, University of Pittsburgh, Pittsburgh, Pennsylvania., Albert DH; Oncology Discovery, AbbVie Inc., North Chicago, Illinois., McDaniel KF; Oncology Discovery, AbbVie Inc., North Chicago, Illinois., Kati WM; Oncology Discovery, AbbVie Inc., North Chicago, Illinois., Konopleva M; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas. yu.shen@abbvie.com mkonople@mdanderson.org., Shen Y; Oncology Discovery, AbbVie Inc., North Chicago, Illinois. yu.shen@abbvie.com mkonople@mdanderson.org.

المصدر: Molecular cancer therapeutics [Mol Cancer Ther] 2021 Oct; Vol. 20 (10), pp. 1809-1819. Date of Electronic Publication: 2021 Jul 12.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Association for Cancer Research, Inc Country of Publication: United States NLM ID: 101132535 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1538-8514 (Electronic) Linking ISSN: 15357163 NLM ISO Abbreviation: Mol Cancer Ther Subsets: MEDLINE

مواضيع طبية MeSH: Bridged Bicyclo Compounds, Heterocyclic/*pharmacology , Leukemia, Myeloid, Acute/*drug therapy , Proteins/*antagonists & inhibitors , Proto-Oncogene Proteins c-bcl-2/*antagonists & inhibitors , Pyridines/*pharmacology , Pyrroles/*pharmacology , Sulfonamides/*pharmacology, Animals ; Antineoplastic Agents/pharmacology ; Apoptosis ; Cell Proliferation ; Drug Therapy, Combination ; Female ; Humans ; Leukemia, Myeloid, Acute/metabolism ; Leukemia, Myeloid, Acute/pathology ; Mice ; Mice, Inbred NOD ; Mice, SCID ; Tumor Cells, Cultured ; Xenograft Model Antitumor Assays

المؤلفون: Singh Mali R; Department of Translational Oncology, Genentech, Inc., South San Francisco, CA, USA., Zhang Q; Department of Leukemia, The University of Texas, MD Anderson Cancer Center, Houston, TX, USA., DeFilippis RA; Division of Hematology and Oncology, University of California at San Francisco, San Francisco, USA., Cavazos A; Department of Leukemia, The University of Texas, MD Anderson Cancer Center, Houston, TX, USA., Kuruvilla VM; Department of Leukemia, The University of Texas, MD Anderson Cancer Center, Houston, TX, USA., Raman J; Division of Hematology and Oncology, University of California at San Francisco, San Francisco, USA., Mody V; Department of Drug Metabolism and Pharmacokinetics, Genentech, Inc., South San Francisco, CA, USA., Choo EF; Department of Drug Metabolism and Pharmacokinetics, Genentech, Inc., South San Francisco, CA, USA., Dail M; Oncology Biomarker Development, Genentech, Inc., South San Francisco, CA, USA., Shah NP; Helen Diller Comprehensive Cancer Center, University of California at San Francisco, USA., Konopleva M; Department of Leukemia, The University of Texas, MD Anderson Cancer Center, Houston, TX, USA., Sampath D; Department of Translational Oncology, Genentech, Inc., South San Francisco, CA, USA., Lasater EA; Department of Translational Oncology, Genentech, Inc., South San Francisco, CA, USA.

المصدر: Haematologica [Haematologica] 2021 Apr 01; Vol. 106 (4), pp. 1034-1046. Date of Electronic Publication: 2021 Apr 01.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Ferrata Storti Foundation Country of Publication: Italy NLM ID: 0417435 Publication Model: Electronic Cited Medium: Internet ISSN: 1592-8721 (Electronic) Linking ISSN: 03906078 NLM ISO Abbreviation: Haematologica Subsets: MEDLINE

مواضيع طبية MeSH: Leukemia, Myeloid, Acute*/drug therapy , Leukemia, Myeloid, Acute*/genetics, Adult ; Bridged Bicyclo Compounds, Heterocyclic/pharmacology ; Cell Line, Tumor ; Humans ; Protein Kinase Inhibitors ; Sulfonamides/pharmacology ; Tumor Microenvironment ; fms-Like Tyrosine Kinase 3/genetics

المؤلفون: Khan S; Department of Pharmacodynamics, University of Florida, Gainesville, FL, USA., Zhang X; Department of Medicinal Chemistry, College of Pharmacy, University of Florida, Gainesville, FL, USA., Lv D; Department of Pharmacodynamics, University of Florida, Gainesville, FL, USA., Zhang Q; Department of Leukemia, University of Texas M.D. Anderson Cancer Center, Houston, TX, USA., He Y; Department of Pharmacodynamics, University of Florida, Gainesville, FL, USA., Zhang P; Department of Medicinal Chemistry, College of Pharmacy, University of Florida, Gainesville, FL, USA., Liu X; Department of Pharmacodynamics, University of Florida, Gainesville, FL, USA., Thummuri D; Department of Pharmacodynamics, University of Florida, Gainesville, FL, USA., Yuan Y; Department of Pharmacodynamics, University of Florida, Gainesville, FL, USA., Wiegand JS; Department of Pharmacodynamics, University of Florida, Gainesville, FL, USA., Pei J; Department of Pharmacodynamics, University of Florida, Gainesville, FL, USA., Zhang W; Department of Pathology, Immunology and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, FL, USA., Sharma A; Department of Pharmaceutics, College of Pharmacy, University of Florida, Gainesville, FL, USA., McCurdy CR; Department of Medicinal Chemistry, College of Pharmacy, University of Florida, Gainesville, FL, USA., Kuruvilla VM; Department of Leukemia, University of Texas M.D. Anderson Cancer Center, Houston, TX, USA., Baran N; Department of Leukemia, University of Texas M.D. Anderson Cancer Center, Houston, TX, USA., Ferrando AA; Department of Pediatrics, Pathology, Cell Biology and Systems of Biology and Institute for Cancer Genetics, Columbia University, New York, NY, USA., Kim YM; Department of Pediatrics, Children's Hospital Los Angeles, Los Angeles, CA, USA., Rogojina A; Greehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA., Houghton PJ; Greehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA., Huang G; Department of Medicine, the Long School of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA., Hromas R; Department of Medicine, the Long School of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA., Konopleva M; Department of Leukemia, University of Texas M.D. Anderson Cancer Center, Houston, TX, USA., Zheng G; Department of Medicinal Chemistry, College of Pharmacy, University of Florida, Gainesville, FL, USA. zhengg@cop.ufl.edu., Zhou D; Department of Pharmacodynamics, University of Florida, Gainesville, FL, USA. zhoudaohong@cop.ufl.edu.

المصدر: Nature medicine [Nat Med] 2019 Dec; Vol. 25 (12), pp. 1938-1947. Date of Electronic Publication: 2019 Dec 02.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: Nature Publishing Company Country of Publication: United States NLM ID: 9502015 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-170X (Electronic) Linking ISSN: 10788956 NLM ISO Abbreviation: Nat Med Subsets: MEDLINE

مواضيع طبية MeSH: Aniline Compounds/*pharmacology , Sulfonamides/*pharmacology , Thrombocytopenia/*drug therapy , Von Hippel-Lindau Tumor Suppressor Protein/*genetics , bcl-X Protein/*genetics, Aniline Compounds/chemistry ; Animals ; Antineoplastic Agents/pharmacology ; Blood Platelets/drug effects ; Blood Platelets/metabolism ; Gene Expression Regulation, Neoplastic/drug effects ; Heterografts ; Humans ; Mice ; Proteolysis ; Sulfonamides/chemistry ; Thrombocytopenia/genetics ; Thrombocytopenia/pathology ; bcl-X Protein/antagonists & inhibitors