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المؤلفون: Leah Fung, Hans C. Lee, Richard J. Jones, Frank Mercurio, Robert W. Sullivan, Imelda Lam, David I. Stirling, Fazal Shirazi, Jianxuan Zou, Paul Erdman, David Hecht, Hua Wang, Normand Richard, Kyle W. H. Chan, Brooke McElwee, Aparajita Hoskote Chourasia, Elisabet E. Manasanch, Isere Kuiatse, Robert Z. Orlowski, Eduardo Torres
المصدر: Journal of Molecular Medicine. 98:1161-1173
مصطلحات موضوعية: Ubiquitin-Protein Ligases, Antineoplastic Agents, Apoptosis, Bortezomib, Mice, 03 medical and health sciences, 0302 clinical medicine, In vivo, Cell Line, Tumor, hemic and lymphatic diseases, Drug Discovery, Biomarkers, Tumor, medicine, Animals, Humans, Lenalidomide, Genetics (clinical), Multiple myeloma, Dexamethasone, Cell Proliferation, Chemistry, Cereblon, medicine.disease, Pomalidomide, Thalidomide, Disease Models, Animal, Drug Resistance, Neoplasm, Proteostasis, Cancer research, Molecular Medicine, Multiple Myeloma, 030215 immunology, medicine.drug
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المؤلفون: Donatas Kraskauskas, Cathy A. Swindlehurst, Sayantanee Das, Kyle W. H. Chan, Adolfo G Mauro, Leah Fung, Sahak Hovsepian, Fadi N Salloum, Chad Cain, Arun Samidurai, Laura G. Corral, Robert W. Sullivan, Anindita Das
المصدر: Circulation. 142
مصطلحات موضوعية: Cardiotoxicity, business.industry, Activator (genetics), AMPK, Discovery and development of mTOR inhibitors, Anticancer drug, Physiology (medical), polycyclic compounds, Cancer research, Medicine, Doxorubicin, Cardiology and Cardiovascular Medicine, business, Doxorubicin cardiotoxicity, Triple-negative breast cancer, medicine.drug
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::2e7b44870efc8f76d83255dcb52ab03e
https://doi.org/10.1161/circ.142.suppl_3.17055 -
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المؤلفون: Crystal Murray, Gautam Borthakur, Anthony S. Stein, Kyle W. H. Chan, Brian Ball, Eytan M. Stein, Karin Kook
المصدر: Blood. 136:18-19
مصطلحات موضوعية: Oncology, medicine.medical_specialty, Venetoclax, business.industry, Immunology, Cancer, Cell Biology, Hematology, medicine.disease, Biochemistry, Tumor lysis syndrome, Transplantation, chemistry.chemical_compound, Leukemia, European LeukemiaNet, chemistry, Internal medicine, Medicine, Liver function, Dosing, business
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::27285dcaeb056a247fe1d324cc313c2c
https://doi.org/10.1182/blood-2020-142557 -
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المصدر: Cancer Research. 80:LB-211
مصطلحات موضوعية: Agonist, Cancer Research, Oncology, medicine.drug_class, business.industry, medicine, Cancer research, AMPK, Pembrolizumab, mTORC1, business, Triple-negative breast cancer
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::51f958692e6977570c8f925a79fb859c
https://doi.org/10.1158/1538-7445.am2020-lb-211 -
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المؤلفون: Angela Pasis, Frank Mercurio, Chourasia Aparajita Hoskote, Paul Erdman, Kyle W. H. Chan, David I. Stirling, Sullivan Robert, Brooke McElwee, Normand Richard, Angela Schoolmeesters, Imelda Lam, David Hecht, Eduardo Torres, Leah Fung
المصدر: Cancer Research. 80:1963-1963
مصطلحات موضوعية: Cancer Research, biology, Chemistry, T cell, Cereblon, Protein degradation, Pomalidomide, Ubiquitin ligase, Proinflammatory cytokine, medicine.anatomical_structure, Oncology, medicine, biology.protein, Cancer research, Cytotoxic T cell, Lenalidomide, medicine.drug
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::e4b0878842e64e80c644e917c0c54718
https://doi.org/10.1158/1538-7445.am2020-1963 -
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المؤلفون: David I. Stirling, Yinon Ben-Neriah, Imelda Lam, David Hecht, Irit Snir-Alkalay, Paul Erdman, Leah Fung, Kyle W. H. Chan, Frank Mercurio, Robert W. Sullivan, Eduardo Torres, Brooke McElwee, Aparajita Hoskote Chourasia, Normand Richard, Avanthika Venkatachalam
المصدر: Blood. 134:4643-4643
مصطلحات موضوعية: biology, Chemistry, Cell growth, Cereblon, Immunology, Cell Biology, Hematology, Biochemistry, Ubiquitin ligase, Cell biology, Proteasome, Cyclin-dependent kinase, biology.protein, Cyclin-dependent kinase 9, Target protein, Casein kinase 1
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::7901d7e81d16150b5040f43fb830384b
https://doi.org/10.1182/blood-2019-131834 -
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المؤلفون: Robert W. Sullivan, Eduardo Torres, Paul Erdman, Leah Fung, David Hecht, Imelda Lam, Frank Mercurio, Brooke McElwee, Aparajita Hoskote Chourasia, David I. Stirling, Normand Richard, Kyle W. H. Chan
المصدر: Blood. 134:3361-3361
مصطلحات موضوعية: biology, Drug discovery, Cereblon, Immunology, Cell Biology, Hematology, Biochemistry, Phenotype, Cell biology, Proteostasis, Ubiquitin, Cell culture, Aldesleukin, biology.protein, Homeostasis
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::e47590684ddbee080a7c800653f35ab3
https://doi.org/10.1182/blood-2019-131872 -
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المؤلفون: David J. Lefer, Laura G. Corral, Jessica M. Bradley, Zhen Li, Pablo Spaletra, Kyle W. H. Chan, Robert W. Sullivan, Thomas E. Sharp rd, Cathy A. Swindlehurst, Leah Fung, Traci T. Goodchild
المصدر: American journal of physiology. Heart and circulatory physiology. 315(3)
مصطلحات موضوعية: 0301 basic medicine, Cardiac function curve, Male, STAT3 Transcription Factor, medicine.medical_specialty, Cardiotonic Agents, Physiology, Cardiac fibrosis, 030204 cardiovascular system & hematology, Protein-Lysine 6-Oxidase, 03 medical and health sciences, Mice, 0302 clinical medicine, Transforming Growth Factor beta, Physiology (medical), Internal medicine, medicine, Animals, Humans, Ventricular remodeling, Myofibroblasts, Cells, Cultured, Pressure overload, Heart Failure, Sulfonamides, Ejection fraction, Ventricular Remodeling, business.industry, Myocardium, Ribosomal Protein S6 Kinases, 70-kDa, Editorial Focus, Fibroblasts, medicine.disease, Mice, Inbred C57BL, 030104 developmental biology, Heart failure, Cardiology, Myocardial fibrosis, Collagen, Cardiology and Cardiovascular Medicine, business, Myofibroblast, Proto-Oncogene Proteins c-akt, Research Article
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8e90bafbc46d42c8bfcfc9b7835a98a
https://pubmed.ncbi.nlm.nih.gov/30004238 -
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المؤلفون: Philippe Marambaud, Mingzhu He, Sehba Husain-Krautter, Yousef Al-Abed, Michael Gould, Julien Papoin, Naomi Taylor, Johnson M. Liu, Kyle W. H. Chan, Narla Mohandas, Sebastien Didier, Adrianna Vlachos, Jeffrey M. Lipton, Sharon A. Singh, Steven L. Allen, Xiuli An, Abena Appiah-Kubi, Brian M. Dulmovits, Lionel Blanc, Patrick G. Gallagher, John Hale
مصطلحات موضوعية: Adult, 0301 basic medicine, Proteasome Endopeptidase Complex, Transcription, Genetic, Genetic Vectors, Immunology, Kruppel-Like Transcription Factors, KLF1, Anemia, Sickle Cell, beta-Globins, Biology, Biochemistry, Ikaros Transcription Factor, 03 medical and health sciences, Red Cells, Iron, and Erythropoiesis, hemic and lymphatic diseases, Fetal hemoglobin, medicine, Humans, Erythropoiesis, gamma-Globins, RNA, Small Interfering, Progenitor cell, Fetal Hemoglobin, Erythroid Precursor Cells, Histone Demethylases, Lentivirus, Gene Expression Regulation, Developmental, Nuclear Proteins, Cell Biology, Hematology, Pomalidomide, Hematopoietic Stem Cells, Neoplasm Proteins, Thalidomide, Repressor Proteins, 030104 developmental biology, Cancer research, RNA Interference, Carrier Proteins, Multiple Myeloma, SOXD Transcription Factors, Reprogramming, medicine.drug
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa1eae0abcf145c9c72e954744cbd052
https://europepmc.org/articles/PMC4797024/ -
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المؤلفون: Laura G. Corral, Emilia Glezer, Christopher L. Morris, Helen Brady, Dominique Verhelle, Laure A. Moutouh-De Parseval, Gregory D. Ferguson, Kristen Jensen-Pergakes, George W. Muller, Kyle W. H. Chan
المصدر: Journal of Clinical Investigation. 118:248-258
مصطلحات موضوعية: congenital, hereditary, and neonatal diseases and abnormalities, Anemia, Drug Evaluation, Preclinical, Antigens, CD34, Antineoplastic Agents, Anemia, Sickle Cell, Pharmacology, Models, Biological, Erythroid Cells, Antisickling Agents, hemic and lymphatic diseases, Fetal hemoglobin, medicine, Humans, Hydroxyurea, Blood Transfusion, Erythropoiesis, Progenitor cell, Lenalidomide, Cells, Cultured, Fetal Hemoglobin, Clinical Trials as Topic, business.industry, beta-Thalassemia, Beta thalassemia, Drug Synergism, General Medicine, Pomalidomide, medicine.disease, Thalidomide, Up-Regulation, business, Research Article, medicine.drug