نتائج البحث - "Léopold Thabault"

المصدر: International Journal of Molecular Sciences
Volume 22
Issue 21
International Journal of Molecular Sciences, Vol 22, Iss 11938, p 11938 (2021)

مصطلحات موضوعية: cancer metabolism, Apoptosis, temozolomide (TMZ), Piperazines, chemistry.chemical_compound, 0302 clinical medicine, Mitophagy, Tumor Cells, Cultured, Biology (General), PARP inhibitors, Spectroscopy, 0303 health sciences, Brain Neoplasms, chemoresistance, General Medicine, 3. Good health, Computer Science Applications, mitochondria, Chemistry, 030220 oncology & carcinogenesis, PARP inhibitor, DNA methylation, medicine.drug, QH301-705.5, Poly(ADP-ribose) Polymerase Inhibitors, DNA methyltransferase, Catalysis, Article, Olaparib, Inorganic Chemistry, 03 medical and health sciences, Temozolomide, medicine, Humans, Physical and Theoretical Chemistry, QD1-999, Antineoplastic Agents, Alkylating, Molecular Biology, Cell Proliferation, 030304 developmental biology, business.industry, Organic Chemistry, glioblastoma, Cancer, medicine.disease, chemistry, Drug Resistance, Neoplasm, Cancer cell, Cancer research, Phthalazines, business, metformin

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a4f09177ef90e2008865b246390f1d4
http://europepmc.org/articles/PMC8584761

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4

Rational design of original fused-cycle selective inhibitors of tryptophan 2,3-dioxygenase

المؤلفون: Arina Kozlova, Benoît Van den Eynde, Raphaël Frédérick, Simon Klaessens, Léopold Thabault, Caroline Mathieu, Vincent Stroobant, Maxime Liberelle, Luc Pilotte, Julien R. C. Prevost

المساهمون: UCL - SSS/LDRI - Louvain Drug Research Institute, UCL - SSS/DDUV/GECE - Génétique cellulaire

المصدر: Journal of Medicinal Chemistry, (2021)

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed66b155772394bcb38fa4f79f3912a7
https://ora.ox.ac.uk/objects/uuid:e29d5aba-ce71-44d4-83fb-2dea9a0345b2

5

Investigation of chalcogen bioisosteric replacement in a series of heterocyclic inhibitors of tryptophan 2,3-dioxygenase

المؤلفون: Arina Kozlova, Marine Deskeuvre, Vincent Stroobant, Maxime Liberelle, Léopold Thabault, Luc Pilotte, Raphaël Frédérick, Benoît Van den Eynde, Nicolas Dauguet

المصدر: European journal of medicinal chemistry. 227

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99be572a174b290c3fac0aaae25c2a80
https://pubmed.ncbi.nlm.nih.gov/34678572

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6

The metalloprotein YhcH is an anomerase providing N-acetylneuraminate aldolase with the open form of its substrate

المؤلفون: Raphaël Frédérick, Gladys Deumer, Alessio Peracchi, Takfarinas Kentache, Maria Veiga-da-Cunha, Vincent Haufroid, Guido T. Bommer, Carole L. Linster, Emile Van Schaftingen, Léopold Thabault

المساهمون: UCL - SSS/DDUV/BCHM - Biochimie-Recherche métabolique, UCL - SSS/LDRI - Louvain Drug Research Institute

المصدر: Journal of Biological Chemistry, Vol. 296, p. 100699 (2021)
The Journal of Biological Chemistry

مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, 2-KDXyl, 2-keto-3-deoxyxylonate, NPL, human Neu5Ac aldolase, Glycan, Protein Conformation, 2,3-EN, 2,3-dehydro-2-deoxy-N-acetylneuraminate, NanA, E. coli Neu5Ac aldolase, Biochemistry, biophysics & molecular biology [F05] [Life sciences], medicine.disease_cause, Biochemistry, aldolase, 03 medical and health sciences, N acetylneuraminate, Fructose-Bisphosphate Aldolase, Escherichia coli, medicine, Metalloprotein, Biochimie, biophysique & biologie moléculaire [F05] [Sciences du vivant], Molecular Biology, chemistry.chemical_classification, 030102 biochemistry & molecular biology, biology, Chemistry, Neu5Ac, N-acetylneuraminate, Aldolase A, metalloprotein, TMSP, 2,2,3,3-2H4 (trimethylsilyl)propionic acid sodium salt, Substrate (chemistry), Stereoisomerism, anomerase, Cell Biology, biology.organism_classification, N-Acetylneuraminic Acid, Protein Transport, 030104 developmental biology, sialic acid, Periplasm, biology.protein, Energy source, mutarotase, KDN, 2-keto-3-deoxynonanoate, Bacteria, Research Article, 2,7-AN, 2,7-anhydro-Neu5Ac

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74a534334d50ff20c8eb7c4ef96a68a1
http://orbilu.uni.lu/handle/10993/47745

7

Discovery of small molecules interacting at lactate dehydrogenases tetrameric interface using a biophysical screening cascade

المؤلفون: Léopold Thabault, Chiara Brustenga, Perrine Savoyen, Mégane Van Gysel, Johan Wouters, Pierre Sonveaux, Raphaël Frédérick, Maxime Liberelle

المساهمون: UCL - SSS/IREC/FATH - Pôle de Pharmacologie et thérapeutique, UCL - SSS/LDRI - Louvain Drug Research Institute, UNamur - SCHI_GCPTS (groupe de chimie physique, théorique et structurale)

المصدر: European Journal of Medicinal Chemistry, Vol. 230, p. 114102 (2022)

مصطلحات موضوعية: Pharmacology, Lactate dehydrogenases, Magnetic Resonance Spectroscopy, Organic Chemistry, Biophysics, MicroScale thermophoresis (MST), General Medicine, Nanoscale differential fluorimetry (NanoDSF), Ligands, Protein-protein interaction, Drug screening, Drug Discovery, Oligomerization, Fluorometry, Nuclear magnetic resonance (NMR), Lactate Dehydrogenases, Cancer

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5496d6d7186a6b672d0f23cca50637f8
https://doi.org/10.1016/j.ejmech.2022.114102

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8

Discovery of a novel lactate dehydrogenase tetramerization domain using epitope mapping and peptides

المؤلفون: Pierre Sonveaux, Raphaël Frédérick, Johan Wouters, Nicolas Joudiou, Katarina Koruza, Léopold Thabault, Maxime Liberelle, Joris Messens, Esra Yildiz, Lucie Brisson

المساهمون: Department of Bio-engineering Sciences, Structural Biology Brussels, Université Catholique de Louvain = Catholic University of Louvain (UCL), Vrije Universiteit Brussel (VUB), Nutrition, croissance et cancer (U 1069) (N2C), Université de Tours (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Namur [Namur] (UNamur), Brisson, Lucie, UCL - SSS/LDRI - Louvain Drug Research Institute, UCL - SSS/IREC/FATH - Pôle de Pharmacologie et thérapeutique, UNamur - SCHI_GCPTS (groupe de chimie physique, théorique et structurale), Université de Tours-Institut National de la Santé et de la Recherche Médicale (INSERM)

المصدر: Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2021, 296, pp.100422. ⟨10.1016/j.jbc.2021.100422⟩
Journal of Biological Chemistry, 2021, 296, pp.100422. ⟨10.1016/j.jbc.2021.100422⟩
The Journal of Biological Chemistry
Journal of Biological Chemistry, Vol. 296, p. 100422 (2021)

مصطلحات موضوعية: 0301 basic medicine, [SDV]Life Sciences [q-bio], LDH-Htr, truncated dimeric version of LDH, MST, microscale thermophoresis, Druggability, Ligands, Biochemistry, chemistry.chemical_compound, WaterLOGSY, water–ligand observed via gradient spectroscopy, biophysics, Denaturation (biochemistry), ComputingMilieux_MISCELLANEOUS, biology, LDH, lactate dehydrogenase, Chemistry, WaterLOGSY, Magnetic Resonance Imaging, MOE, Molecular Operating Environment, [SDV] Life Sciences [q-bio], Research Article, [SDV.CAN]Life Sciences [q-bio]/Cancer, [SDV.BC]Life Sciences [q-bio]/Cellular Biology, LDH-H, lactate dehydrogenase heart isozyme, Protein–protein interaction, oligomerization, 03 medical and health sciences, Tetramer, [SDV.CAN] Life Sciences [q-bio]/Cancer, Lactate dehydrogenase, mass photometry, LDH-M, lactate dehydrogenase muscle isozyme, Humans, cancer, Lactic Acid, Molecular Biology, Lactate Dehydrogenases, [SDV.BC] Life Sciences [q-bio]/Cellular Biology, LDH-1, lactate dehydrogenase heart isozyme homotetramer, 030102 biochemistry & molecular biology, L-Lactate Dehydrogenase, Microscale thermophoresis, Active site, Cell Biology, MP, mass photometry, microscale thermophoresis, NMR, Citric acid cycle, nanoDSF, nanoscale differential scanning fluorimetry, [SDV.AEN] Life Sciences [q-bio]/Food and Nutrition, 030104 developmental biology, protein–protein interaction, disruptors, biology.protein, LDH-5, lactate dehydrogenase muscle isozyme homotetramer, Peptides, nanoDSF, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition, Epitope Mapping