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المؤلفون: L. Lepescheux, R. Gosmini, F. De Ceuninck, Thierry Christophe, E. van der Aar, I. Botez, Nele Vandervoort, Pierre Deprez, D. Amantini, Roland Blanque, D. Merciris, Robert Touitou, Philippe Clément-Lacroix, C. Cottereaux, S. Meurisse, Patrick Mollat, F. Brebion, D. Comas, Christopher B. Little, Margaret M. Smith
المصدر: Osteoarthritis and Cartilage. 30:291-301
مصطلحات موضوعية: Metalloproteinase, biology, Chemistry, Cartilage, Biomedical Engineering, Osteoarthritis, Pharmacology, medicine.disease, Piperazines, Rats, Glycosaminoglycan, Mice, medicine.anatomical_structure, Rheumatology, Proteoglycan, In vivo, biology.protein, medicine, Animals, Humans, Orthopedics and Sports Medicine, ADAMTS5 Protein, Aggrecan, Aggrecanase
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المؤلفون: F. Marsais, Fabian J. Theis, M Absmaier-Kijak, M. Jargosch, Linda Krause, Tilo Biedermann, F. Lauffer, L. Lepescheux, Cristina Albanesi, Carsten B. Schmidt-Weber, Kilian Eyerich, Nick Vandeghinste, Stefania Madonna, V. Baghin, W. Kempf, Stefan Steidl, N.S. Müller, Stefanie Eyerich, Martina Morelli
المصدر: Journal of the European Academy of Dermatology and Venereology
J. Eur. Acad. Dermatol. Venereol. 34, 800-809 (2020)مصطلحات موضوعية: Keratinocytes, 0301 basic medicine, Chemokine, Il-17c, Atopic Eczema, Drug Development, Psoriasis, Targeted-therapy, Neutrophils, medicine.medical_treatment, Gene Expression, Inflammation, Human skin, Dermatology, CCL5, Dermatitis, Atopic, Mice, 03 medical and health sciences, Th2 Cells, 0302 clinical medicine, Immune system, Cell Movement, medicine, Animals, Humans, Interleukin 8, biology, business.industry, Interleukin-17, medicine.disease, 3. Good health, Disease Models, Animal, 030104 developmental biology, Infectious Diseases, Cytokine, Immunology, biology.protein, Th17 Cells, medicine.symptom, business, 030215 immunology
وصف الملف: application/pdf
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المؤلفون: E. van der Aar, L. Lepescheux, I. Botez, Thierry Christophe, F. Brebion, Pierre Deprez, Roland Blanque, D. Merciris, S. Meurisse, Monica Borgonovi, R. Gosmini, F. De Ceuninck, Patrick Mollat, Philippe Clément-Lacroix, D. Comas, Nele Vandervoort, C. Cottereaux, D. Amantini
المصدر: FRIDAY, 15 JUNE 2018.
مصطلحات موضوعية: Fibrillation, medicine.medical_specialty, business.industry, ADAMTS, Cartilage, Arthritis, Hindlimb, Osteoarthritis, medicine.disease, medicine.anatomical_structure, Endocrinology, Internal medicine, medicine, medicine.symptom, business, Aggrecan, Aggrecanase
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::740fa263bcd0d73ca8948c97a8e26acf
https://doi.org/10.1136/annrheumdis-2018-eular.2610 -
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المؤلفون: Stefan Steidl, Stéphanie Lavazais, Maté Ongenaert, Maarten Van Balen, Catherine Jagerschmidt, Kilian Eyerich, M. Auberval, Nick Vandeghinste, Jan D. Haas, L. Lepescheux, F. Marsais, Reginald Brys, Teresa Garcia, Jürgen Klattig, Stefan Härtle, Sonia Dupont, F. Lauffer, Padraic G. Fallon, Tara Moran
المصدر: Journal of Investigative Dermatology
مصطلحات موضوعية: 0301 basic medicine, Keratinocytes, Biopsy, Primary Cell Culture, Inflammation, Dermatology, Biochemistry, Interleukin-23, Dermatitis, Atopic, Pathogenesis, 03 medical and health sciences, Mice, Immune system, Calcitriol, Psoriasis, Medicine, CCL17, Animals, Humans, Receptor, Molecular Biology, Cells, Cultured, Skin, Mice, Inbred BALB C, biology, business.industry, Interleukin-17, Cell Biology, Atopic dermatitis, medicine.disease, Antibodies, Neutralizing, 3. Good health, Mice, Inbred C57BL, Disease Models, Animal, 030104 developmental biology, Immunology, biology.protein, Female, medicine.symptom, Antibody, business, Injections, Intraperitoneal, Signal Transduction
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15ccf4284964d33d9eab7523236662f7
https://pubmed.ncbi.nlm.nih.gov/29941097 -
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المؤلفون: R Galien, Raphael Geney, Koen Kurt Smits, Béatrice Vayssière, Thierry Christophe, Reginald Brys, L. Lepescheux, Ellen van der Aar, Luc Nelles, Fabrice Ciesielski, Guy Van Lommen, Pierre Deprez, Luc Juliaan Corina Van Rompaey, Muriel Uhring, Stephen Robert Fletcher, Christel Jeanne Marie Menet, Philippe Clément-Lacroix, Javier Blanc, Nolwenn Jouannigot
المصدر: Journal of Medicinal Chemistry. 57:9323-9342
مصطلحات موضوعية: Filgotinib, Pyridines, Chemistry, Pharmaceutical, Drug Evaluation, Preclinical, Crystallography, X-Ray, Inhibitory Concentration 50, Structure-Activity Relationship, Adenosine Triphosphate, Crohn Disease, Drug Discovery, JAK1 Inhibitor, Animals, Humans, Structure–activity relationship, Phosphorylation, Protein Kinase Inhibitors, Chemistry, Arthritis, Janus Kinase 1, Triazoles, Small molecule, Recombinant Proteins, Rats, Disease Models, Animal, Kinetics, Tyrosine kinase 2, Drug Design, Immunology, Cancer research, Cytokines, Molecular Medicine, Triazolopyridine, Collagen, Janus kinase, Dimerization
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المؤلفون: R. Gosmini, E. van der Aar, Pierre Deprez, Roland Blanque, Thierry Christophe, L. Lepescheux, Christopher B. Little, Philippe Clément-Lacroix, F. Brebion, C. Cottereaux, D. Amantini, I. Botez, Patrick Mollat, D. Comas, Nele Vandervoort, F. De Ceuninck, S. Meurisse
المصدر: Oral Presentations.
مصطلحات موضوعية: Metalloproteinase, business.industry, ADAMTS, Cartilage, Assay, Osteoarthritis, Matrix metalloproteinase, Pharmacology, medicine.disease, In vitro, medicine.anatomical_structure, In vivo, Medicine, business
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::9202796e0b4780d3509f8d554349e78c
https://doi.org/10.1136/annrheumdis-2017-eular.3775 -
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المؤلفون: Stéphanie Lavazais, M. Auberval, F Marsais, A. Monjardet, E Chanudet, D. Merciris, A Cauvin, C Saccomani, C Robin-Jagerschmidt, L. Lepescheux, S. Dupont, Philippe Clément-Lacroix, I Parent, M. Borgonovi, R Galien
المصدر: Oral Presentations.
مصطلحات موضوعية: 030203 arthritis & rheumatology, Filgotinib, business.industry, Inflammation, medicine.disease, Enthesis, Inflammatory bowel disease, 03 medical and health sciences, Psoriatic arthritis, 0302 clinical medicine, 030220 oncology & carcinogenesis, Rheumatoid arthritis, Psoriasis, Immunology, medicine, Biomarker (medicine), medicine.symptom, business
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::23acd3cdcf678f53aa8832a04ac36ac5
https://doi.org/10.1136/annrheumdis-2017-eular.1977 -
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المؤلفون: Jean Feyen, L. Lepescheux, Thierry Christophe, Luc Juliaan Corina Van Rompaey, Luc Nelles, Reginald Brys, Steve De Vos, Nick Vandeghinste, Gerben van ’t Klooster, Ellen van der Aar, Bart Smets, Stephen Robert Fletcher, Philippe Clément-Lacroix, Béatrice Vayssière, R Galien, Katja Conrath, Christel Jeanne Marie Menet
المصدر: The Journal of Immunology. 191:3568-3577
مصطلحات موضوعية: Male, Filgotinib, Pyridines, medicine.medical_treatment, Immunology, Drug Evaluation, Preclinical, Arthritis, Pharmacology, Biology, Proinflammatory cytokine, Etanercept, Inhibitory Concentration 50, Mice, JAK1 Inhibitor, medicine, Animals, Humans, Immunology and Allergy, Gene Silencing, Phosphorylation, Protein Kinase Inhibitors, Inflammation, Interleukin-6, Cell Differentiation, Janus Kinase 1, T-Lymphocytes, Helper-Inducer, Triazoles, medicine.disease, Rats, Disease Models, Animal, STAT1 Transcription Factor, Cytokine, Rheumatoid arthritis, Female, Signal transduction, medicine.drug
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed129cea4d418b29aaf896dc9e7f5b99
https://doi.org/10.4049/jimmunol.1201348 -
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المؤلفون: P. Pastoureau, L. Lepescheux, P. Ammann, S. Meurisse, D. Merciris, P. Deprez, Philippe Clément-Lacroix, V. Gaillard, D. Amantini, C. Lavet
المصدر: Osteoarthritis and Cartilage. 24
مصطلحات موضوعية: medicine.anatomical_structure, Materials science, Rheumatology, Indentation, media_common.quotation_subject, Cartilage, medicine, Biomedical Engineering, Quality (business), Orthopedics and Sports Medicine, Anatomy, Biomedical engineering, media_common
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المؤلفون: C. Cottereaux, R. Gosmini, E. van der Aar, D. Amantini, Nele Vandervoort, L. Lepescheux, Patrick Mollat, D. Comas, Pierre Deprez, Roland Blanque, Thierry Christophe, F. Brebion, Christopher B. Little, I. Botez, Philippe Clément-Lacroix, F. De Ceuninck, S. Meurisse
المصدر: Osteoarthritis and Cartilage. 25:S58-S59
مصطلحات موضوعية: 030203 arthritis & rheumatology, 0301 basic medicine, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Rheumatology, business.industry, ADAMTS, Biomedical Engineering, Medicine, Orthopedics and Sports Medicine, Pharmacology, business