المؤلفون: Dorothee Dormann, Mario Hofweber, Imke Baade, Ralph H. Kehlenbach, Saskia Hutten, Erin L. Sternburg, Marius Pörschke

المصدر: The Journal of Biological Chemistry

مصطلحات موضوعية: 0301 basic medicine, FTD, frontotemporal dementia, RNA-binding protein, importins, RG/RGG motifs, Nuclear Localization Signals, Receptors, Cytoplasmic and Nuclear, Biochemistry, T, tyrosine, PY, proline–tyrosine, R, arginine, TNPO, transportin, Chemistry, NTR, nuclear transport receptor, LCD, low-complexity domain, TB, transport buffer, beta Karyopherins, EGFP, enhanced green fluorescent protein, Cell biology, LLPS, liquid–liquid phase separation, Transportin 1, RBP, RNA-binding protein, transportin, RGG3, arginine–glycine–rich, Research Article, Protein Binding, rps, ribosomal proteins, SEC, size-exclusion chromatography, Importin, nuclear transport, Karyopherins, unme, unmethylated, PRMT1, protein arginine N-methyltransferase 1, 03 medical and health sciences, Stress granule, S, supernatant, Ribosomal protein, CIRBP, cold-inducible RNA-binding protein, Humans, Molecular Biology, Xpo 4, exportin 4, CRM1, chromosome region maintenance 1, Cell Nucleus, 030102 biochemistry & molecular biology, Cell Biology, SG, stress granule, TNPO3, transportin-3, TNPO1, transportin-1, 030104 developmental biology, MBP, maltose binding protein, NLS, nuclear localization signal, RNA-Binding Protein FUS, BSA, bovine serum albumin, Nuclear transport, phase separation, TDP-43, TAR DNA-binding protein 43, RS, arginine–serine, fused in sarcoma (FUS), Nuclear localization sequence, TNPO2, transportin-2, DAPI, 4′,6-diamidino-2-phenylindole, FUS, fused in sarcoma, HeLa Cells, Molecular Chaperones

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30987084425aae85f9e9ab0bd8b3bb2e
http://europepmc.org/articles/PMC8131929

المؤلفون: Michael P. Hughes, Lukasz Goldschmidt, David Eisenberg

المصدر: The Journal of biological chemistry, vol 297, iss 4
The Journal of Biological Chemistry

مصطلحات موضوعية: LARKS, low-complexity amyloid-like reversible kinked segment, Amyloid, Biochemistry & Molecular Biology, Saccharomyces cerevisiae Proteins, LARKS ∩ LCD residue, an amino acid residue that is a predicted LARKS within a LCD, Amino Acid Motifs, Saccharomyces cerevisiae, LARKS, Protein Data Bank (RCSB PDB), Computational biology, Medical and Health Sciences, Biochemistry, Rare Diseases, PDB, Protein Data Bank, membraneless organelles, GO, Gene Ontology, Animals, Humans, Drosophila Proteins, Structural motif, Molecular Biology, low-complexity domains, LARKS ∩ LCD protein, protein that has at least one LCD and for which the fraction of LARKS is greater than average for its proteome, biology, amyloid, LCD, low-complexity domain, Cell Biology, computer.file_format, SG, stress granule, Biological Sciences, Protein Data Bank, biology.organism_classification, MLO, membraneless organelle, phase-separation, IDR, intrinsically disordered region, Drosophila melanogaster, Good Health and Well Being, Cytoplasm, Chemical Sciences, Proteome, Generic health relevance, computer, Research Article

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d419d0f6f4d0e8ebfba58c330caae1f
https://doi.org/10.1016/j.jbc.2021.101194

المؤلفون: Adam S. Mastrocola, Weiyan Jia, Peter Tonzi, William M. Guns, Lu Liu, Robert J. Millikin, Randal S. Tibbetts, Sang Hwa Kim, Tony T. Huang, Mark Scalf, Lloyd M. Smith

المصدر: The Journal of Biological Chemistry

مصطلحات موضوعية: Genome instability, FTD, frontotemporal dementia, amyotrophic lateral sclerosis (ALS), DNA Repair, BrdU, 5-bromo-2′-deoxyuridine, CF, chromatin fraction, Biochemistry, DNA Replication Timing, DNA Breaks, Double-Stranded, LRD, late replication domain, HDR, homology-directed repair, LOF, loss-of-function, iPOND, isolation of proteins on nascent DNA, ORC, origin recognition complex, CLM, calicheamicin γ1, BRCA1 Protein, PAR, poly(ADP)-ribosyl, PARP, poly(ADP)-ribosyl polymerase, EdU, 5-ethynyl-2′-deoxyuridine, CHOP, CCAAT/enhancer-binding protein homologous protein, Sarcoma, IP, immunoprecipitation, LCD, low-complexity domain, ALS, amyotrophic lateral sclerosis, MRD, mid replication domain, RF, replication fork, Cell biology, CSK, cytoskeleton, NHEJ, nonhomologous end joining, ERD, early replication domain, RIPA, radioimmunoprecipitation assay, Tumor Suppressor p53-Binding Protein 1, Research Article, RGG, arginine–glycine–glycine repeat, DNA repair, pre-RC, prereplication complex, PCNA, proliferating cell nuclear antigen, replication timing, DNA replication, SSB, single-strand break, Biology, DDR, DNA damage response, PI, propidium iodide, cDNA, complementary DNA, GO, Gene Ontology, Humans, DSB, double-strand break, Molecular Biology, FET, FUS, EWSR1, TAF15, MMC, mitomycin C, Cell Proliferation, Transcriptionally active chromatin, Replication timing, RD, replication domain, CldU, 5-chloro-2′-deoxyuridine, Cell Biology, HEK293T, human embryonic kidney 293T, RNA binding protein, SCAI, suppressor of cancer cell invasion, Proliferating cell nuclear antigen, Kinetics, RT, replication timing, biology.protein, RNA-Binding Protein FUS, Origin recognition complex, BSA, bovine serum albumin, qPCR, quantitative PCR, fused in sarcoma (FUS), HU, hydroxyurea, DAPI, 4′,6-diamidino-2-phenylindole, FUS, fused in sarcoma

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43a9a44d7275f5becac62657ed50f32a
https://doi.org/10.1016/j.jbc.2021.101049