المؤلفون: Jennifer Lee, Sydney Shuster

المصدر: The Journal of Biological Chemistry

مصطلحات موضوعية: liquid–liquid phase separation, Amyloid, Accelerated Communication, TDP-43, Amyloidogenic Proteins, Spectrum Analysis, Raman, Biochemistry, TEV, tobacco etch virus, Humans, TEM, transmission electron microscopy, Molecular Biology, TDP-43CTD, CTD of TDP-43, ThT, thioflavin-T, Amyotrophic Lateral Sclerosis, FRAP, fluorescence recovery after photobleaching, Nuclear Proteins, RNA-Binding Proteins, Cell Biology, CTD, C-terminal domain, liquid droplets, LLPS, liquid–liquid phase separation, DNA-Binding Proteins, Raman spectroscopy, FRAP, TEM, TDP-43, TAR DNA-binding protein 43, NHLBI, National Heart, Lung, and Blood Institute

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bf72c4aa921bfca6d504d02fe5c1e0e
http://europepmc.org/articles/PMC8784639

المؤلفون: Janine Kamps, Konstanze F. Winklhofer, Roland Winter, Yu-Hsuan Lin, Jörg Tatzelt, Rosario Oliva, Verian Bader

المساهمون: Kamps, Janine, Lin, Yu-Hsuan, Oliva, Rosario, Bader, Verian, Winter, Roland, Winklhofer, Konstanze F, Tatzelt, Jörg

المصدر: The Journal of Biological Chemistry

مصطلحات موضوعية: 0301 basic medicine, liquid–liquid phase separation, Protein Folding, Accelerated Communication, animal diseases, Protein aggregation, Biochemistry, Prion Diseases, Maltose-binding protein, neurodegenerative disease, PrPC, cellular prion protein, DLS, dynamic light scattering, biology, Tobacco etch virus, Chemistry, Neurodegeneration, aggregation, Neurodegenerative Diseases, Folding (chemistry), LLPS, liquid–liquid phase separation, Prion, Binding domain, Human, Amyloid, Protein Domain, Prions, prion disease, MBP, maltose-binding protein, Liquid-Liquid Extraction, Biophysical Phenomena, Prion Proteins, TEV, tobacco etch virus, 03 medical and health sciences, Protein Domains, medicine, Animals, Humans, Binding site, Molecular Biology, PrP, prion protein, 030102 biochemistry & molecular biology, Animal, Fluorescence recovery after photobleaching, FRAP, fluorescence recovery after photobleaching, Cell Biology, biology.organism_classification, medicine.disease, protein self-assembly, intrinsically disordered protein, nervous system diseases, Intrinsically Disordered Proteins, 030104 developmental biology, prion protein, biology.protein, Biophysics

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2991f2f914d33e0afc0ae93c3ca3f40
http://europepmc.org/articles/PMC8254114

المؤلفون: Na Zhang, Tao Zhong, Li-Qiang Wang, Xiao-Ling Liu, Bin Dai, Yi Liang, Zhi-Xian Chen, Wang Chen, Jie Chen

المصدر: The Journal of Biological Chemistry

مصطلحات موضوعية: Tau toxicity, ATG5, Tau protein, tau Proteins, Protein aggregation, Biochemistry, protein liquid–liquid phase separation, Autophagy-Related Protein 5, protein aggregation, PI, propidium iodide, chemistry.chemical_compound, Protein Aggregates, myricetin, Alzheimer Disease, ATG, autophagy-related, Cell Line, Tumor, LC3, microtubule-associated protein 1 light chain 3, mental disorders, Autophagy, Humans, Propidium iodide, TEM, transmission electron microscopy, Molecular Biology, PI3K/AKT/mTOR pathway, TAMRA, 5(6)-carboxy-tetramethylrhodamine N-succinimidyl ester, Flavonoids, biology, Fluorescence recovery after photobleaching, FRAP, fluorescence recovery after photobleaching, IP, immunoprecipitation, Cell Biology, Alzheimer's disease, Cell biology, LLPS, liquid–liquid phase separation, ATG5, autophagy-related protein 5, chemistry, biology.protein, Myricetin, Signal Transduction, Research Article

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32d945a07d5290584f199a75af829d5e
https://pubmed.ncbi.nlm.nih.gov/34560101

المؤلفون: Tompa, Peter

المصدر: Datacite

مصطلحات موضوعية: IDP -intriscically disordered proteins, PhasAGE, Phase separation, LLPS- liquid-liquid phase separation, Expert Seminar Series

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fced00ef0d0e1eee88ad042ff6fecd1
https://doi.org/10.5281/zenodo.4737320

المؤلفون: Dorothee Dormann, Mario Hofweber, Imke Baade, Ralph H. Kehlenbach, Saskia Hutten, Erin L. Sternburg, Marius Pörschke

المصدر: The Journal of Biological Chemistry

مصطلحات موضوعية: 0301 basic medicine, FTD, frontotemporal dementia, RNA-binding protein, importins, RG/RGG motifs, Nuclear Localization Signals, Receptors, Cytoplasmic and Nuclear, Biochemistry, T, tyrosine, PY, proline–tyrosine, R, arginine, TNPO, transportin, Chemistry, NTR, nuclear transport receptor, LCD, low-complexity domain, TB, transport buffer, beta Karyopherins, EGFP, enhanced green fluorescent protein, Cell biology, LLPS, liquid–liquid phase separation, Transportin 1, RBP, RNA-binding protein, transportin, RGG3, arginine–glycine–rich, Research Article, Protein Binding, rps, ribosomal proteins, SEC, size-exclusion chromatography, Importin, nuclear transport, Karyopherins, unme, unmethylated, PRMT1, protein arginine N-methyltransferase 1, 03 medical and health sciences, Stress granule, S, supernatant, Ribosomal protein, CIRBP, cold-inducible RNA-binding protein, Humans, Molecular Biology, Xpo 4, exportin 4, CRM1, chromosome region maintenance 1, Cell Nucleus, 030102 biochemistry & molecular biology, Cell Biology, SG, stress granule, TNPO3, transportin-3, TNPO1, transportin-1, 030104 developmental biology, MBP, maltose binding protein, NLS, nuclear localization signal, RNA-Binding Protein FUS, BSA, bovine serum albumin, Nuclear transport, phase separation, TDP-43, TAR DNA-binding protein 43, RS, arginine–serine, fused in sarcoma (FUS), Nuclear localization sequence, TNPO2, transportin-2, DAPI, 4′,6-diamidino-2-phenylindole, FUS, fused in sarcoma, HeLa Cells, Molecular Chaperones

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30987084425aae85f9e9ab0bd8b3bb2e
http://europepmc.org/articles/PMC8131929

المؤلفون: Felipe Garcia Quiroz, Alexa Regina Chua Avecilla

المصدر: JID Innovations
JID Innovations, Vol 1, Iss 3, Pp 100036-(2021)

مصطلحات موضوعية: Skin barrier, KG, keratohyalin granule, PTM, post-translational modification, EDC, epidermal differentiation complex, Context (language use), Dermatology, Review, LLPS, liquid-liquid phase separation, Cornified envelope, ER, endoplasmic reticulum, CE, cornified envelope, Keratohyalin granules, Skin surface, medicine, Liquid liquid, Epidermal differentiation complex, UCST, upper critical solution temperature, TG, trichohyalin granule, integumentary system, IDP, intrinsically-disordered protein, 3D, three-dimensional, KC, keratinocyte, AD, atopic dermatitis, Cell biology, medicine.anatomical_structure, RL1-803, Keratinocyte, LCST, lower critical solution temperature

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b896ce0cd095e0fa4409c88ddb39f25
https://pubmed.ncbi.nlm.nih.gov/34909733

المؤلفون: Amie K. Boal, Scott A. Showalter, Nafiseh Sabri, Roman Rohac, Emery T. Usher, Tanja Mittag

المصدر: The Journal of Biological Chemistry

مصطلحات موضوعية: 0301 basic medicine, Models, Molecular, endocrine system diseases, SBM1, SB motif 1, Amino Acid Motifs, SPOP, Biochemistry, IDRs, intrinsically disordered regions, PBST, Triton X-100 in PBS, Ubiquitin, Pdx1, biology, diabetes, FA, fluorescence anisotropy, Nuclear Proteins, Editors' Pick, multivalency, MATH, meprin and tumor necrosis factor receptor-associated factor homology, Ubiquitin ligase, Cell biology, LLPS, liquid–liquid phase separation, Protein Transport, Ni-NTA, nickel-nitrilotriacetic acid, PDX1, SBM2, SB motif 2, Protein Binding, Research Article, DAXX, death domain-associated protein 6, SPOP, speckle-type POZ protein, endocrine system, ubiquitination, digestive system, 03 medical and health sciences, Death-associated protein 6, Humans, structure, Molecular Biology, Transcription factor, Puc, puckered protein, Homeodomain Proteins, Nucleoplasm, 030102 biochemistry & molecular biology, Cell Biology, Repressor Proteins, 030104 developmental biology, SB, SPOP-binding, biology.protein, Trans-Activators, Homeobox, AR, androgen receptor, Pdx1, pancreatic and duodenal homeobox 1, DAPI, 4′,6-diamidino-2-phenylindole

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::865b2261c9773bb5532b2ebeb6469bac
https://pubmed.ncbi.nlm.nih.gov/33894201

المؤلفون: Matthias Geyer, Ines H. Kaltheuner, Robert Düster, Maximilian Schmitz

المصدر: The Journal of Biological Chemistry

مصطلحات موضوعية: 0301 basic medicine, Phosphatase, Phase separation, CDK7, PBS, phosphate-buffered saline, CDK9, DNA-Directed DNA Polymerase, Biochemistry, GST, glutathione S-transferase, P-TEFb, 03 medical and health sciences, Glycols, Protein Domains, Cyclin-dependent kinase, Phase (matter), TFIIH, transcription factor II human, GSH, glutathione, Cdk, Cyclin-dependent kinase, Protein phosphorylation, Phosphorylation, DYRK1A, dual-specificity tyrosine phosphorylation regulated kinase 1A, Molecular Biology, CTD, C-terminal domain (of RNA polymerase II), chemistry.chemical_classification, Organelles, 1,6-Hexanediol, 030102 biochemistry & molecular biology, biology, Kinase, Phosphotransferases, Cell Biology, Phosphoric Monoester Hydrolases, LLPS, liquid–liquid phase separation, IDR, intrinsically disordered region, 030104 developmental biology, Enzyme, chemistry, Biophysics, biology.protein, LLPS, Cyclin-dependent kinase 9, Cyclin-dependent kinase 7, nanoDSF, nano differential scanning fluorimetry, Research Article, RNA polymerase II CTD, P-TEFb, positive transcription elongation factor b

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7969621984bc4a26a43efd29a43fdb29
https://pubmed.ncbi.nlm.nih.gov/33814344

المؤلفون: Bingkuan Xu, Shuai Huang, Yinghui Liu, Chun Wan, Yuanyuan Gu, Dianliang Wang, Haijia Yu

المصدر: The Journal of Biological Chemistry

مصطلحات موضوعية: Amyloid, animal diseases, α-Syn, α-synuclein, Amyloidogenic Proteins, Protein Aggregation, Pathological, Biochemistry, condensate, Protein Aggregates, α-synuclein, ThT, thioflavin T, Humans, heterocyclic compounds, Molecular Biology, PD, Parkinson’s disease, Manganese, ThS, thioflavin S, aggregation, FRAP, fluorescence recovery after photobleaching, Parkinson Disease, Amyloidosis, Cell Biology, nervous system diseases, LLPS, liquid–liquid phase separation, IDR, intrinsically disordered region, nervous system, phase transition, health occupations, alpha-Synuclein, liquid–liquid phase separation (LLPS), Lewy Bodies, Research Article

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88d4e4b1349f879b0af226bdc274af50
https://doi.org/10.1016/j.jbc.2021.101469

المؤلفون: Juan Li, Fei Wang, Cheng Huang, Zhigang Jin, Shengjie Fan

المصدر: Pharmacological Research

مصطلحات موضوعية: 0301 basic medicine, FTD, frontotemporal dementia, Aging, ATF4, activating transcription factor 4, 4E-BP1, eIF4E-binding protein 1, GCN4, general control non-derepressible 4, PKR, protein kinase RNA-activated, SA, sodium arsenite, TIA-1, T cell restricted intracellular antigen-1, eIF4F, eukaryotic initiation factor 4F, TIAR-2, homolog of human TIA-1 inC. elegans pharyngeal muscles, Disease, Caprin 1, cell cycle associated protein 1, FUS/TLS, fused in sarcoma/translocated in liposarcoma, Sorafenib (PubChem CID: 216239), Puromycin (PubChem CID: 439530), Pathogenesis, G3BP, 0302 clinical medicine, neurodegenerative disease, ERK, extracellular signal-regulated kinase, 5-Fluorouracil (PubChem CID: 3385), Neoplasms, HDAC, histone deacetylases, virus infection, PERK, PKR-like endoplasmatic reticulum kinase, Chronic stress, P-body, processing body, HRI, heme-regulated inhibitor, Psammaplysin F (PubChem CID: 46888580), Neurodegenerative Diseases, ALS, amyotrophic lateral sclerosis, ISRIB (PubChem CID: 1011240), Cell biology, E)-3-(2,3,4,5-tetrabromophenyl)prop-2-enoic acid (PubChem CID: 16760346), PAI-1, plasminogen activator inhibitor-1, Virus Diseases, 030220 oncology & carcinogenesis, JNK, c-Jun N-terminal kinase, RBP, RNA-binding protein, medicine.symptom, DDX3X, DEAD box RNA helicase 3 X-linked, NLRP3, NLR Family, Pyrin Domain Containing Protein 3, microtubule, Signal Transduction, TDP-43, TAR DNA binding protein 43, Olaparib (PubChem CID: 23725625), eIF2α, Inflammation, Antineoplastic Agents, mTOR, mammalian target of rapamycin, Biology, LLPS, liquid-liquid phase separation, AD, Alzheimer’s disease, Cytoplasmic Granules, Antiviral Agents, Article, eIF2, eukaryotic initiation factor 2, 03 medical and health sciences, Stress granule, Eukaryotic translation, ROS, reactive oxygen species, stomatognathic system, Stress, Physiological, medicine, Animals, Humans, RNA, Messenger, ComputingMethodologies_COMPUTERGRAPHICS, Pharmacology, hsp, heat shock protein, Messenger RNA, GCN2, general control non-derepressible 2, Paclitaxel (PubChem CID: 36314), CK2, Casein kinase 2, Proteins, G3BP1/2, Ras GTPase-activating protein-binding protein 1 and 2, SG, stress granule, DOX, doxorubicin, N protein, nucleocapsid protein, VCP, valosin-containing protein, 030104 developmental biology, post-translational modification, Apoptosis, Silvestrol (PubChem CID: 11787114), PP242 (PubChem CID:135565635), mRNP, messenger ribonucleoprotein, 5-FU, 5-fluorouracil, Bortezomib (PubChem CID: 387447), PTM, post-translational modifications, Trehalose (PubChem CID: 7427)

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b80e1d4bdb2336a5aaab712b58bc9286
http://europepmc.org/articles/PMC7428673