المؤلفون: Jin Zhai, Mary Jo Wildey, Elisa Passini, John Imredy, Frederick Sannajust, Kevin Fitzgerald, Anne Chain, Sebastian Polak, Christopher P. Regan, Pierre Morissette, Patrick Fanelli, Jeffrey Travis, Blanca Rodriguez

المصدر: Toxicology and Applied Pharmacology

مصطلحات موضوعية: 0301 basic medicine, ICH, The International Council for Harmonization of Technical Requirements for Pharmaceuticals for Human Use, TN, True Negative, PPV, Positive Predictive Value, Pharmacology, TdP, Torsade de Pointes, Toxicology, Membrane Potentials, 0302 clinical medicine, HTS, High Throughput Screening, QTcVdW, Van de Water's Heart Rate QT-corrected Interval, In Silico modeling, Medicine, Translational PKPD modeling, NCEs, New Chemical Entities, CTD90, Ca2+-Transient Duration at 90% repolarization, education.field_of_study, Anesthetized Cardiovascular Guinea Pig, HR, Heart Rate, PNV, Predictive Negative Value, Safety pharmacology, ECG, Electrocardiogram, FIH, First in Human, IKr, rapidly-activating delayed rectifier potassium current, AP, Action Potential, QTc, Heart Rate corrected QT Interval, PX, PatchXpress®, 030220 oncology & carcinogenesis, Electrophysiologic Techniques, Cardiac, FP, False Positive, LVP, Left Ventricular Pressure, Anti-Arrhythmia Agents, In silico, Population, Guinea Pigs, QT interval, Models, Biological, Article, Ventricular action potential, Cell Line, CVGP, Cardiovascular Anesthetized Guinea Pig, GP, Guinea Pig, 03 medical and health sciences, hERG, Human Ether-a-go-go Related Gene, Pharmacokinetics, In vivo, Animals, Humans, Computer Simulation, education, QT corrected interval, BP, Blood Pressure, business.industry, M5P, M5 trees automated pruning model, tPKPD, thranslational pharmacokinetic/pharmacodynamic, FLIPR, Fluorescent Imaging Plate Reader, Arrhythmias, Cardiac, ORd, O'Hara Rudy model, Electrophysiological Phenomena, 030104 developmental biology, HEK293 Cells, Models, Chemical, Pharmacodynamics, Torsade de Pointes, EMw, Electromechanical window, FN, False Negative, TP, True Positive, Calcium, Calcium Channels, LOO, Leave-One-Out, business, APD90, Action Potential Duration at 90% repolarization

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::291b9744f97d46ac0f6fd500ad2e1c0f
http://europepmc.org/articles/PMC7322544

المؤلفون: Chauhan, Reshma A., Coote, John, Allen, Emily, Pongpaopattanakul, Pott, Brack, Kieran E., Ng, G. Andre

المصدر: International Journal of Cardiology

مصطلحات موضوعية: Ganglia, Sympathetic, CL, cycle length, Cardiac electrophysiology, Action Potentials, Heart, VA, ventriculo-atrial, Article, Electric Stimulation, MAP, monophasic action potential, LV, left ventricle, Cardiotopic, Neurons, Efferent, LVP, left ventricular pressure, ERP, effective refractory period, Heart Rate, APD, action potential duration, Sympathetic nervous system, Models, Animal, Ventricular Fibrillation, Animals, Sympathetic chain, Rabbits, RT, restitution, VFT, ventricular fibrillation threshold

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::97059a0ea0c2236f0820ad976ec12dc4
http://europepmc.org/articles/PMC5968349

المؤلفون: Gareth L. Ackland, Svetlana Mastitskaya, Patrick S. Hosford, Alex Dyson, Asif Machhada, Alexander V. Gourine

المصدر: JACC: Basic to Translational Science

مصطلحات موضوعية: 0301 basic medicine, medicine.medical_specialty, Efferent, medicine.medical_treatment, LVEDP, left ventricular end-diastolic pressure, heart failure, ABP, arterial blood pressure, LVESP, left ventricular end-systolic pressure, Stimulation, 030204 cardiovascular system & hematology, Optogenetics, LV dP/dtMAX, maximum rate of rise of left ventricular pressure, vagal nerve stimulation, PRECLINICAL RESEARCH, 03 medical and health sciences, 0302 clinical medicine, DVMN, dorsal motor nucleus of the vagus nerve, Internal medicine, LVV, lentiviral vector, medicine, Myocardial infarction, optogenetics, business.industry, autonomic nervous system, vagus nerve stimulation, medicine.disease, Neuromodulation (medicine), LAD, left anterior descending coronary artery, VNS, vagus nerve stimulation, Autonomic nervous system, myocardial infarction, GRK2, G-protein−coupled receptor kinase 2, LV, left ventricle, 030104 developmental biology, eGFP, enhanced green fluorescent protein, LVP, left ventricular pressure, Heart failure, cardiac contractility, neuromodulation, MI, myocardial infarction, Cardiology, Cardiology and Cardiovascular Medicine, business, Editorial Comment, Vagus nerve stimulation

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a68f79ec73b22fafafa1cdb6958e38be

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المؤلفون: Machhada A; Centre for Cardiovascular and Metabolic Neuroscience, Department of Neuroscience, Physiology and Pharmacology, University College London, London, United Kingdom., Hosford PS; Centre for Cardiovascular and Metabolic Neuroscience, Department of Neuroscience, Physiology and Pharmacology, University College London, London, United Kingdom.; Translational Medicine and Therapeutics, William Harvey Research Institute, Queen Mary University of London, London, United Kingdom., Dyson A; Clinical Physiology, Division of Medicine, University College London, London, United Kingdom., Ackland GL; Translational Medicine and Therapeutics, William Harvey Research Institute, Queen Mary University of London, London, United Kingdom., Mastitskaya S; Centre for Cardiovascular and Metabolic Neuroscience, Department of Neuroscience, Physiology and Pharmacology, University College London, London, United Kingdom., Gourine AV; Centre for Cardiovascular and Metabolic Neuroscience, Department of Neuroscience, Physiology and Pharmacology, University College London, London, United Kingdom.

المصدر: JACC. Basic to translational science [JACC Basic Transl Sci] 2020 Jul 15; Vol. 5 (8), pp. 799-810. Date of Electronic Publication: 2020 Jul 15 (Print Publication: 2020).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier on behalf of the American College of Cardiology Foundation Country of Publication: United States NLM ID: 101677259 Publication Model: eCollection Cited Medium: Internet ISSN: 2452-302X (Electronic) Linking ISSN: 2452302X NLM ISO Abbreviation: JACC Basic Transl Sci Subsets: PubMed not MEDLINE