المؤلفون: Brindani, Nicoletta, Vuong, Linh, La Serra, Maria, Salvador, Noel, Menichetti, Andrea, Acquistapace, Isabella, Ortega, Jose, Veronesi, Marina, Bertozzi, Sine, Summa, Maria, Girotto, Stefania, Bertorelli, Rosalia, Armirotti, Andrea, Ganesan, Anand, De Vivo, Marco

المصدر: Journal of medicinal and pharmaceutical chemistry. 67(12)

مصطلحات موضوعية: Animals, Antineoplastic Agents, Humans, Mice, cdc42 GTP-Binding Protein, Cell Line, Tumor, Drug Discovery, Structure-Activity Relationship, Xenograft Model Antitumor Assays, Pyrimidines, Female

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/3db4936c
https://escholarship.org/content/qt3db4936c/qt3db4936c.pdf

المؤلفون: Brindani, Nicoletta, Vuong, Linh M, Acquistapace, Isabella Maria, La Serra, Maria Antonietta, Ortega, José Antonio, Veronesi, Marina, Bertozzi, Sine Mandrup, Summa, Maria, Girotto, Stefania, Bertorelli, Rosalia, Armirotti, Andrea, Ganesan, Anand K, De Vivo, Marco

المصدر: Journal of Medicinal Chemistry. 66(8)

مصطلحات موضوعية: Biomedical and Clinical Sciences, Medicinal and Biomolecular Chemistry, Chemical Sciences, Oncology and Carcinogenesis, Cancer, Development of treatments and therapeutic interventions, 5.1 Pharmaceuticals, Good Health and Well Being, Animals, Humans, Mice, Cell Line, Tumor, Neoplasms, Neovascularization, Pathologic, p21-Activated Kinases, Protein Binding, rho GTP-Binding Proteins, Organic Chemistry, Pharmacology and Pharmaceutical Sciences, Medicinal & Biomolecular Chemistry, Pharmacology and pharmaceutical sciences, Medicinal and biomolecular chemistry, Organic chemistry

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/92c849tj

المؤلفون: La Serra, Maria Antonietta, Vidossich, Pietro, Acquistapace, Isabella, Ganesan, Anand K, De Vivo, Marco

المصدر: Journal of Chemical Information and Modeling. 62(12)

مصطلحات موضوعية: Medicinal and Biomolecular Chemistry, Chemical Sciences, Theoretical and Computational Chemistry, Cancer, Genetics, Generic health relevance, Mutagenesis, Mutation, Protein Serine-Threonine Kinases, Proteins, p21-Activated Kinases, Computation Theory and Mathematics, Medicinal & Biomolecular Chemistry, Medicinal and biomolecular chemistry, Theoretical and computational chemistry

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/6m3780w9

المؤلفون: Jahid, Sohail, Ortega, Jose A, Vuong, Linh M, Acquistapace, Isabella Maria, Hachey, Stephanie J, Flesher, Jessica L, La Serra, Maria Antonietta, Brindani, Nicoletta, La Sala, Giuseppina, Manigrasso, Jacopo, Arencibia, Jose M, Bertozzi, Sine Mandrup, Summa, Maria, Bertorelli, Rosalia, Armirotti, Andrea, Jin, Rongsheng, Liu, Zheng, Chen, Chi-Fen, Edwards, Robert, Hughes, Christopher CW, De Vivo, Marco, Ganesan, Anand K

المصدر: Cell reports. 39(4)

مصطلحات موضوعية: Biochemistry and Cell Biology, Medical Physiology, Biological sciences

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/07h508gt

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المؤلفون: Brindani, Nicoletta, Vuong, Linh M., Acquistapace, Isabella Maria, La Serra, Maria Antonietta, Ortega, José Antonio, Veronesi, Marina, Bertozzi, Sine Mandrup, Summa, Maria, Girotto, Stefania, Bertorelli, Rosalia, Armirotti, Andrea, Ganesan, Anand K., De Vivo, Marco

المصدر: Journal of Medicinal Chemistry; 20230101, Issue: Preprints

المؤلفون: Brindani N; Molecular Modeling and Drug Discovery Lab, Istituto Italiano di Tecnologia, via Morego 30, 16163 Genova, Italy., Vuong LM; Department of Dermatology, University of California, Irvine, California 92697, United States., La Serra MA; Molecular Modeling and Drug Discovery Lab, Istituto Italiano di Tecnologia, via Morego 30, 16163 Genova, Italy., Salvador N; Department of Dermatology, University of California, Irvine, California 92697, United States., Menichetti A; Molecular Modeling and Drug Discovery Lab, Istituto Italiano di Tecnologia, via Morego 30, 16163 Genova, Italy., Acquistapace IM; Molecular Modeling and Drug Discovery Lab, Istituto Italiano di Tecnologia, via Morego 30, 16163 Genova, Italy., Ortega JA; Molecular Modeling and Drug Discovery Lab, Istituto Italiano di Tecnologia, via Morego 30, 16163 Genova, Italy., Veronesi M; Structural Biophysics Facility, Istituto Italiano di Tecnologia, via Morego 30, 16163 Genova, Italy., Bertozzi SM; Analytical Chemistry Facility, Istituto Italiano di Tecnologia, via Morego 30, 16163 Genova, Italy., Summa M; Translational Pharmacology Facility, Istituto Italiano di Tecnologia, via Morego 30, 16163 Genova, Italy., Girotto S; Structural Biophysics Facility, Istituto Italiano di Tecnologia, via Morego 30, 16163 Genova, Italy., Bertorelli R; Translational Pharmacology Facility, Istituto Italiano di Tecnologia, via Morego 30, 16163 Genova, Italy., Armirotti A; Analytical Chemistry Facility, Istituto Italiano di Tecnologia, via Morego 30, 16163 Genova, Italy., Ganesan AK; Department of Dermatology, University of California, Irvine, California 92697, United States., De Vivo M; Molecular Modeling and Drug Discovery Lab, Istituto Italiano di Tecnologia, via Morego 30, 16163 Genova, Italy.

المصدر: Journal of medicinal chemistry [J Med Chem] 2024 Jun 27; Vol. 67 (12), pp. 10401-10424. Date of Electronic Publication: 2024 Jun 12.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Antineoplastic Agents*/pharmacokinetics , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemistry , cdc42 GTP-Binding Protein*/antagonists & inhibitors , cdc42 GTP-Binding Protein*/metabolism, Animals ; Humans ; Mice ; Cell Line, Tumor ; Drug Discovery ; Structure-Activity Relationship ; Xenograft Model Antitumor Assays ; Pyrimidines/pharmacokinetics ; Pyrimidines/chemistry ; Pyrimidines/pharmacology ; Pyrimidines/chemical synthesis ; Female