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المؤلفون: Chang W; Merck & Co., Inc., Kenilworth, New Jersey 07033, United States., Altman MD; Merck & Co., Inc., Boston, Massachusetts 02115, United States., Lesburg CA; Merck & Co., Inc., Boston, Massachusetts 02115, United States., Perera SA; Merck & Co., Inc., Boston, Massachusetts 02115, United States., Piesvaux JA; Merck & Co., Inc., Boston, Massachusetts 02115, United States., Schroeder GK; Merck & Co., Inc., Boston, Massachusetts 02115, United States., Wyss DF; Merck & Co., Inc., Kenilworth, New Jersey 07033, United States., Cemerski S; Merck & Co., Inc., Boston, Massachusetts 02115, United States., Chen Y; Merck & Co., Inc., Boston, Massachusetts 02115, United States., DiNunzio E; Merck & Co., Inc., Kenilworth, New Jersey 07033, United States., Haidle AM; Merck & Co., Inc., Boston, Massachusetts 02115, United States., Ho T; Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Kariv I; Merck & Co., Inc., Boston, Massachusetts 02115, United States., Knemeyer I; Merck & Co., Inc., Boston, Massachusetts 02115, United States., Kopinja JE; Merck & Co., Inc., Boston, Massachusetts 02115, United States., Lacey BM; Merck & Co., Inc., Boston, Massachusetts 02115, United States., Laskey J; Merck & Co., Inc., Boston, Massachusetts 02115, United States., Lim J; Merck & Co., Inc., Boston, Massachusetts 02115, United States., Long BJ; Merck & Co., Inc., Boston, Massachusetts 02115, United States., Ma Y; Merck & Co., Inc., Boston, Massachusetts 02115, United States., Maddess ML; Merck & Co., Inc., Boston, Massachusetts 02115, United States., Pan BS; Merck & Co., Inc., Boston, Massachusetts 02115, United States., Presland JP; Merck & Co., Inc., Boston, Massachusetts 02115, United States., Spooner E; Merck & Co., Inc., Boston, Massachusetts 02115, United States., Steinhuebel D; Merck & Co., Inc., Boston, Massachusetts 02115, United States., Truong Q; Merck & Co., Inc., Kenilworth, New Jersey 07033, United States., Zhang Z; Pharmaron Beijing Co. Ltd., Beijing 100176, P. R. China., Fu J; Pharmaron Beijing Co. Ltd., Beijing 100176, P. R. China., Addona GH; Merck & Co., Inc., Boston, Massachusetts 02115, United States., Northrup AB; Merck & Co., Inc., Boston, Massachusetts 02115, United States., Parmee E; Merck & Co., Inc., Kenilworth, New Jersey 07033, United States., Tata JR; Merck & Co., Inc., Kenilworth, New Jersey 07033, United States., Bennett DJ; Merck & Co., Inc., Boston, Massachusetts 02115, United States., Cumming JN; Merck & Co., Inc., Boston, Massachusetts 02115, United States., Siu T; Merck & Co., Inc., Boston, Massachusetts 02115, United States., Trotter BW; Merck & Co., Inc., Boston, Massachusetts 02115, United States.

المصدر: Journal of medicinal chemistry [J Med Chem] 2022 Apr 14; Vol. 65 (7), pp. 5675-5689. Date of Electronic Publication: 2022 Mar 25.

نوع المنشور: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Membrane Proteins* , Neoplasms*/drug therapy, Animals ; Cytokines ; Humans ; Immunotherapy/methods ; Interferons ; Mice

المؤلفون: Quiroz RV; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States., Reutershan MH; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States., Schneider SE; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States., Sloman D; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States., Lacey BM; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States., Swalm BM; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States., Yeung CS; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States., Gibeau C; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States., Spellman DS; Merck & Co., Inc., 770 Sumneytown Pike, Lansdale, Pennsylvania 19446, United States., Rankic DA; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States., Chen D; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States., Witter D; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States., Linn D; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States., Munsell E; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States., Feng G; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States., Xu H; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States., Hughes JME; Merck & Co., Inc., 126 East Lincoln Avenue, Rahway, New Jersey 07065, United States., Lim J; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States., Saurí J; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States., Geddes K; Merck & Co., Inc., 770 Sumneytown Pike, Lansdale, Pennsylvania 19446, United States., Wan M; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States., Mansueto MS; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States., Follmer NE; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States., Fier PS; Merck & Co., Inc., 126 East Lincoln Avenue, Rahway, New Jersey 07065, United States., Siliphaivanh P; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States., Daublain P; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States., Palte RL; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States., Hayes RP; Merck & Co., Inc., 770 Sumneytown Pike, Lansdale, Pennsylvania 19446, United States., Lee S; Merck & Co., Inc., 126 East Lincoln Avenue, Rahway, New Jersey 07065, United States., Kawamura S; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States., Silverman S; Merck & Co., Inc., 126 East Lincoln Avenue, Rahway, New Jersey 07065, United States., Sanyal S; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States., Henderson TJ; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States., Ye Y; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States., Gao Y; Merck & Co., Inc., 770 Sumneytown Pike, Lansdale, Pennsylvania 19446, United States., Nicholson B; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States., Machacek MR; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States.

المصدر: Journal of medicinal chemistry [J Med Chem] 2021 Apr 08; Vol. 64 (7), pp. 3911-3939. Date of Electronic Publication: 2021 Mar 23.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Aminoquinolines/*therapeutic use , Antineoplastic Agents/*therapeutic use , Enzyme Inhibitors/*therapeutic use , Neoplasms/*drug therapy , Nucleosides/*therapeutic use , Protein-Arginine N-Methyltransferases/*antagonists & inhibitors, Aminoquinolines/chemical synthesis ; Aminoquinolines/metabolism ; Animals ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/metabolism ; Cell Proliferation/drug effects ; Drug Design ; Enzyme Inhibitors/chemical synthesis ; Enzyme Inhibitors/metabolism ; Female ; Humans ; Mice, SCID ; Molecular Docking Simulation ; Molecular Structure ; Nucleosides/chemical synthesis ; Nucleosides/metabolism ; Protein Binding ; Protein-Arginine N-Methyltransferases/metabolism ; Structure-Activity Relationship ; Mice

المؤلفون: Vara BA; Discovery Chemistry, Computational and Structural Chemistry, Quantitative Biosciences, Pharmacokinetics and Drug Metabolism, Oncology Early Discovery, Merck & Co., Inc., Boston, Massachusetts 02115, United States., Levi SM; Discovery Chemistry, Computational and Structural Chemistry, Quantitative Biosciences, Pharmacokinetics and Drug Metabolism, Oncology Early Discovery, Merck & Co., Inc., Boston, Massachusetts 02115, United States., Achab A; Discovery Chemistry, Computational and Structural Chemistry, Quantitative Biosciences, Pharmacokinetics and Drug Metabolism, Oncology Early Discovery, Merck & Co., Inc., Boston, Massachusetts 02115, United States., Candito DA; Discovery Chemistry, Computational and Structural Chemistry, Quantitative Biosciences, Pharmacokinetics and Drug Metabolism, Oncology Early Discovery, Merck & Co., Inc., Boston, Massachusetts 02115, United States., Fradera X; Discovery Chemistry, Computational and Structural Chemistry, Quantitative Biosciences, Pharmacokinetics and Drug Metabolism, Oncology Early Discovery, Merck & Co., Inc., Boston, Massachusetts 02115, United States., Lesburg CA; Discovery Chemistry, Computational and Structural Chemistry, Quantitative Biosciences, Pharmacokinetics and Drug Metabolism, Oncology Early Discovery, Merck & Co., Inc., Boston, Massachusetts 02115, United States., Kawamura S; Discovery Chemistry, Computational and Structural Chemistry, Quantitative Biosciences, Pharmacokinetics and Drug Metabolism, Oncology Early Discovery, Merck & Co., Inc., Boston, Massachusetts 02115, United States., Lacey BM; Discovery Chemistry, Computational and Structural Chemistry, Quantitative Biosciences, Pharmacokinetics and Drug Metabolism, Oncology Early Discovery, Merck & Co., Inc., Boston, Massachusetts 02115, United States., Lim J; Discovery Chemistry, Computational and Structural Chemistry, Quantitative Biosciences, Pharmacokinetics and Drug Metabolism, Oncology Early Discovery, Merck & Co., Inc., Boston, Massachusetts 02115, United States., Methot JL; Discovery Chemistry, Computational and Structural Chemistry, Quantitative Biosciences, Pharmacokinetics and Drug Metabolism, Oncology Early Discovery, Merck & Co., Inc., Boston, Massachusetts 02115, United States., Xu Z; Discovery Chemistry, Computational and Structural Chemistry, Quantitative Biosciences, Pharmacokinetics and Drug Metabolism, Oncology Early Discovery, Merck & Co., Inc., Boston, Massachusetts 02115, United States., Xu H; Discovery Chemistry, Computational and Structural Chemistry, Quantitative Biosciences, Pharmacokinetics and Drug Metabolism, Oncology Early Discovery, Merck & Co., Inc., Boston, Massachusetts 02115, United States., Smith DM; Discovery Chemistry, Computational and Structural Chemistry, Quantitative Biosciences, Pharmacokinetics and Drug Metabolism, Oncology Early Discovery, Merck & Co., Inc., Boston, Massachusetts 02115, United States., Piesvaux JA; Discovery Chemistry, Computational and Structural Chemistry, Quantitative Biosciences, Pharmacokinetics and Drug Metabolism, Oncology Early Discovery, Merck & Co., Inc., Boston, Massachusetts 02115, United States., Miller JR; Discovery Chemistry, Computational and Structural Chemistry, Quantitative Biosciences, Pharmacokinetics and Drug Metabolism, Oncology Early Discovery, Merck & Co., Inc., Boston, Massachusetts 02115, United States., Bittinger M; Discovery Chemistry, Computational and Structural Chemistry, Quantitative Biosciences, Pharmacokinetics and Drug Metabolism, Oncology Early Discovery, Merck & Co., Inc., Boston, Massachusetts 02115, United States., Ranganath SH; Discovery Chemistry, Computational and Structural Chemistry, Quantitative Biosciences, Pharmacokinetics and Drug Metabolism, Oncology Early Discovery, Merck & Co., Inc., Boston, Massachusetts 02115, United States., Bennett DJ; Discovery Chemistry, Computational and Structural Chemistry, Quantitative Biosciences, Pharmacokinetics and Drug Metabolism, Oncology Early Discovery, Merck & Co., Inc., Boston, Massachusetts 02115, United States., DiMauro EF; Discovery Chemistry, Computational and Structural Chemistry, Quantitative Biosciences, Pharmacokinetics and Drug Metabolism, Oncology Early Discovery, Merck & Co., Inc., Boston, Massachusetts 02115, United States., Pasternak A; Discovery Chemistry, Computational and Structural Chemistry, Quantitative Biosciences, Pharmacokinetics and Drug Metabolism, Oncology Early Discovery, Merck & Co., Inc., Boston, Massachusetts 02115, United States.

المصدر: ACS medicinal chemistry letters [ACS Med Chem Lett] 2021 Mar 19; Vol. 12 (4), pp. 653-661. Date of Electronic Publication: 2021 Mar 19 (Print Publication: 2021).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101521073 Publication Model: eCollection Cited Medium: Print ISSN: 1948-5875 (Print) Linking ISSN: 19485875 NLM ISO Abbreviation: ACS Med Chem Lett Subsets: PubMed not MEDLINE

المؤلفون: Yu EC; Discovery Chemistry, Merck & Co., Inc., Boston, Massachusetts, 02115, United States., Methot JL; Discovery Chemistry, Merck & Co., Inc., Boston, Massachusetts, 02115, United States., Fradera X; Computational and Structural Chemistry, Merck & Co., Inc., Boston, Massachusetts, 02115, United States., Lesburg CA; Computational and Structural Chemistry, Merck & Co., Inc., Boston, Massachusetts, 02115, United States., Lacey BM; Quantitative Biosciences, Merck & Co., Inc., Boston, Massachusetts, 02115, United States., Siliphaivanh P; Discovery Chemistry, Merck & Co., Inc., Boston, Massachusetts, 02115, United States., Liu P; External Discovery Chemistry, Merck & Co Inc., Rahway, New Jersey, 07065, United States., Smith DM; Pharmacokinetics and Drug Metabolism, Merck & Co., Inc., Boston, Massachusetts, 02115, United States., Xu Z; Quantitative Biosciences, Merck & Co., Inc., Boston, Massachusetts, 02115, United States., Piesvaux JA; Quantitative Biosciences, Merck & Co., Inc., Boston, Massachusetts, 02115, United States., Kawamura S; Discovery Chemistry, Merck & Co., Inc., Boston, Massachusetts, 02115, United States., Xu H; Quantitative Biosciences, Merck & Co., Inc., Boston, Massachusetts, 02115, United States., Miller JR; Quantitative Biosciences, Merck & Co., Inc., Boston, Massachusetts, 02115, United States., Bittinger M; Oncology Early Discovery, Merck & Co., Inc., Boston, Massachusetts, 02115, United States., Pasternak A; Discovery Chemistry, Merck & Co., Inc., Boston, Massachusetts, 02115, United States.

المصدر: ACS medicinal chemistry letters [ACS Med Chem Lett] 2021 Mar 01; Vol. 12 (3), pp. 459-466. Date of Electronic Publication: 2021 Mar 01 (Print Publication: 2021).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101521073 Publication Model: eCollection Cited Medium: Print ISSN: 1948-5875 (Print) Linking ISSN: 19485875 NLM ISO Abbreviation: ACS Med Chem Lett Subsets: PubMed not MEDLINE

المؤلفون: Lacey BM; Department of Quantitative Biosciences, Merck & Co., Inc., Boston, MA, USA., Xu Z; Department of Quantitative Biosciences, Merck & Co., Inc., Boston, MA, USA., Chai X; Department of Quantitative Biosciences, Merck & Co., Inc., Boston, MA, USA., Laskey J; Department of Quantitative Biosciences, Merck & Co., Inc., Boston, MA, USA., Fradera X; Department of Computational and Structural Chemistry, Merck & Co., Inc., Boston, MA, USA., Mittal P; Department of Oncology Early Discovery, Merck & Co., Inc., Boston, MA, USA., Mishra S; Department of Quantitative Biosciences, Merck & Co., Inc., Boston, MA, USA., Piesvaux J; Department of Quantitative Biosciences, Merck & Co., Inc., Boston, MA, USA., Saradjian P; Department of Quantitative Biosciences, Merck & Co., Inc., Boston, MA, USA., Shaffer L; Department of Quantitative Biosciences, Merck & Co., Inc., Boston, MA, USA., Vassileva G; Department of Genetics and Pharmacogenomics, Merck & Co., Inc., Boston, MA, USA., Gerdt C; Department of Quantitative Biosciences, Merck & Co., Inc., Boston, MA, USA., Wang Y; Department of Oncology Early Discovery, Merck & Co., Inc., Boston, MA, USA., Ferguson H; Department of Preclinical Development, Merck & Co., Inc., Boston, MA, USA., Smith DM; Department of PPDM, Merck & Co., Inc., Boston, MA, USA., Ballard J; Department of PPDM, Merck & Co., Inc., Boston, MA, USA., Wells S; Department of Oncology Early Discovery, Merck & Co., Inc., Boston, MA, USA., Jain R; Department of Quantitative Biosciences, Merck & Co., Inc., Boston, MA, USA., Mueller U; Department of Quantitative Biosciences, Merck & Co., Inc., Boston, MA, USA., Addona G; Department of Quantitative Biosciences, Merck & Co., Inc., Boston, MA, USA., Kariv I; Department of Quantitative Biosciences, Merck & Co., Inc., Boston, MA, USA., Methot JL; Department of Discovery Chemistry, Merck & Co., Inc., Boston, MA, USA., Bittinger M; Department of Oncology Early Discovery, Merck & Co., Inc., Boston, MA, USA., Ranganath S; Department of Oncology Early Discovery, Merck & Co., Inc., Boston, MA, USA., Mcleod R; Department of Quantitative Biosciences, Merck & Co., Inc., Boston, MA, USA., Pasternak A; Department of Discovery Chemistry, Merck & Co., Inc., Boston, MA, USA., Miller JR; Department of Quantitative Biosciences, Merck & Co., Inc., Boston, MA, USA., Xu H; Department of Quantitative Biosciences, Merck & Co., Inc., Boston, MA, USA.

المصدر: SLAS discovery : advancing life sciences R & D [SLAS Discov] 2021 Jan; Vol. 26 (1), pp. 88-99. Date of Electronic Publication: 2020 Aug 26.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: SAGE Publications Country of Publication: United States NLM ID: 101697563 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2472-5560 (Electronic) Linking ISSN: 24725552 NLM ISO Abbreviation: SLAS Discov Subsets: MEDLINE

مواضيع طبية MeSH: Drug Discovery/*methods , High-Throughput Screening Assays/*methods , Protein Kinase Inhibitors/*chemistry , Protein Kinase Inhibitors/*pharmacology , Protein Serine-Threonine Kinases/*antagonists & inhibitors , Protein Serine-Threonine Kinases/*chemistry, Animals ; Cell Line ; Humans ; Leukocytes, Mononuclear/drug effects ; Leukocytes, Mononuclear/metabolism ; Mice ; T-Lymphocytes/drug effects ; T-Lymphocytes/metabolism

المؤلفون: Wang Y; Department of Oncology Early Discovery, Merck & Co., Inc., Boston, Massachusetts, United States of America., Zhang K; Department of Genetics and Pharmacogenomics, Merck & Co., Inc., Boston, Massachusetts, United States of America., Georgiev P; Department of Oncology Early Discovery, Merck & Co., Inc., Boston, Massachusetts, United States of America., Wells S; Department of Oncology Early Discovery, Merck & Co., Inc., Boston, Massachusetts, United States of America., Xu H; Department of Quantitative Biosciences, Merck & Co., Inc., Boston, Massachusetts, United States of America., Lacey BM; Department of Quantitative Biosciences, Merck & Co., Inc., Boston, Massachusetts, United States of America., Xu Z; Department of Quantitative Biosciences, Merck & Co., Inc., Boston, Massachusetts, United States of America., Laskey J; Department of Quantitative Biosciences, Merck & Co., Inc., Boston, Massachusetts, United States of America., Mcleod R; Department of Quantitative Biosciences, Merck & Co., Inc., Boston, Massachusetts, United States of America., Methot JL; Department of Discovery Chemistry, Merck & Co., Inc., Boston, Massachusetts, United States of America., Bittinger M; Department of Oncology Early Discovery, Merck & Co., Inc., Boston, Massachusetts, United States of America., Pasternak A; Department of Discovery Chemistry, Merck & Co., Inc., Boston, Massachusetts, United States of America., Ranganath S; Department of Oncology Early Discovery, Merck & Co., Inc., Boston, Massachusetts, United States of America.

المصدر: PloS one [PLoS One] 2020 Dec 03; Vol. 15 (12), pp. e0243145. Date of Electronic Publication: 2020 Dec 03 (Print Publication: 2020).

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE

مواضيع طبية MeSH: Lymphocyte Activation/*drug effects , Protein Kinase Inhibitors/*pharmacology , Protein Serine-Threonine Kinases/*antagonists & inhibitors , T-Lymphocytes/*drug effects, Animals ; Cytokines/immunology ; Female ; Mice, Inbred C57BL ; Protein Serine-Threonine Kinases/immunology ; T-Lymphocytes/immunology

المؤلفون: Pan BS; Department of Quantitative Biosciences, Merck & Co., Inc., Kenilworth, NJ, USA., Perera SA; Department of Quantitative Biosciences, Merck & Co., Inc., Kenilworth, NJ, USA. samanthi_perera@merck.com gottfried.schroeder@merck.com wes.trotter@kronosbio.com jonathan.bennett@merck.com george_addona@merck.com., Piesvaux JA; Department of Quantitative Biosciences, Merck & Co., Inc., Kenilworth, NJ, USA., Presland JP; Department of Quantitative Biosciences, Merck & Co., Inc., Kenilworth, NJ, USA., Schroeder GK; Department of Quantitative Biosciences, Merck & Co., Inc., Kenilworth, NJ, USA. samanthi_perera@merck.com gottfried.schroeder@merck.com wes.trotter@kronosbio.com jonathan.bennett@merck.com george_addona@merck.com., Cumming JN; Department of Discovery Chemistry, Merck & Co., Inc., Kenilworth, NJ, USA., Trotter BW; Department of Discovery Chemistry, Merck & Co., Inc., Kenilworth, NJ, USA. samanthi_perera@merck.com gottfried.schroeder@merck.com wes.trotter@kronosbio.com jonathan.bennett@merck.com george_addona@merck.com., Altman MD; Department of Discovery Chemistry, Merck & Co., Inc., Kenilworth, NJ, USA., Buevich AV; Department of Discovery Chemistry, Merck & Co., Inc., Kenilworth, NJ, USA., Cash B; Department of Discovery Chemistry, Merck & Co., Inc., Kenilworth, NJ, USA., Cemerski S; Department of Discovery Oncology, Merck & Co., Inc., Kenilworth, NJ, USA., Chang W; Department of Discovery Chemistry, Merck & Co., Inc., Kenilworth, NJ, USA., Chen Y; Department of Quantitative Biosciences, Merck & Co., Inc., Kenilworth, NJ, USA., Dandliker PJ; Department of Quantitative Biosciences, Merck & Co., Inc., Kenilworth, NJ, USA., Feng G; Department of Quantitative Biosciences, Merck & Co., Inc., Kenilworth, NJ, USA., Haidle A; Department of Discovery Chemistry, Merck & Co., Inc., Kenilworth, NJ, USA., Henderson T; Department of Discovery Chemistry, Merck & Co., Inc., Kenilworth, NJ, USA., Jewell J; Department of Discovery Chemistry, Merck & Co., Inc., Kenilworth, NJ, USA., Kariv I; Department of Quantitative Biosciences, Merck & Co., Inc., Kenilworth, NJ, USA., Knemeyer I; Department of Pharmacokinetics, Merck & Co., Inc., Kenilworth, NJ, USA., Kopinja J; Department of Quantitative Biosciences, Merck & Co., Inc., Kenilworth, NJ, USA., Lacey BM; Department of Quantitative Biosciences, Merck & Co., Inc., Kenilworth, NJ, USA., Laskey J; Department of Quantitative Biosciences, Merck & Co., Inc., Kenilworth, NJ, USA., Lesburg CA; Department of Discovery Chemistry, Merck & Co., Inc., Kenilworth, NJ, USA., Liang R; Department of Discovery Chemistry, Merck & Co., Inc., Kenilworth, NJ, USA., Long BJ; Department of Quantitative Biosciences, Merck & Co., Inc., Kenilworth, NJ, USA., Lu M; Department of Discovery Chemistry, Merck & Co., Inc., Kenilworth, NJ, USA., Ma Y; Department of Quantitative Biosciences, Merck & Co., Inc., Kenilworth, NJ, USA., Minnihan EC; Department of Discovery Pharmaceutical Sciences, Merck & Co., Inc., Kenilworth, NJ, USA., O'Donnell G; Department of Quantitative Biosciences, Merck & Co., Inc., Kenilworth, NJ, USA., Otte R; Department of Discovery Chemistry, Merck & Co., Inc., Kenilworth, NJ, USA., Price L; Department of Quantitative Biosciences, Merck & Co., Inc., Kenilworth, NJ, USA., Rakhilina L; Department of Quantitative Biosciences, Merck & Co., Inc., Kenilworth, NJ, USA., Sauvagnat B; Department of Quantitative Biosciences, Merck & Co., Inc., Kenilworth, NJ, USA., Sharma S; Department of Discovery Oncology, Merck & Co., Inc., Kenilworth, NJ, USA., Tyagarajan S; Department of Discovery Chemistry, Merck & Co., Inc., Kenilworth, NJ, USA., Woo H; Department of Pharmacokinetics, Merck & Co., Inc., Kenilworth, NJ, USA., Wyss DF; Department of Discovery Chemistry, Merck & Co., Inc., Kenilworth, NJ, USA., Xu S; Department of Quantitative Biosciences, Merck & Co., Inc., Kenilworth, NJ, USA., Bennett DJ; Department of Discovery Chemistry, Merck & Co., Inc., Kenilworth, NJ, USA. samanthi_perera@merck.com gottfried.schroeder@merck.com wes.trotter@kronosbio.com jonathan.bennett@merck.com george_addona@merck.com., Addona GH; Department of Quantitative Biosciences, Merck & Co., Inc., Kenilworth, NJ, USA. samanthi_perera@merck.com gottfried.schroeder@merck.com wes.trotter@kronosbio.com jonathan.bennett@merck.com george_addona@merck.com.

المصدر: Science (New York, N.Y.) [Science] 2020 Aug 21; Vol. 369 (6506).

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE

مواضيع طبية MeSH: Antineoplastic Agents/*pharmacology , Membrane Proteins/*metabolism, Administration, Oral ; Animals ; Antineoplastic Agents/administration & dosage ; Antineoplastic Agents/pharmacokinetics ; Humans

المؤلفون: Palte RL; Computational and Structural Chemistry, Discovery Chemistry, and Quantitative Biosciences, Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States., Schneider SE; Computational and Structural Chemistry, Discovery Chemistry, and Quantitative Biosciences, Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States., Altman MD; Computational and Structural Chemistry, Discovery Chemistry, and Quantitative Biosciences, Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States., Hayes RP; Computational and Structural Chemistry, West Point, Pennsylvania 19486, United States., Kawamura S; Computational and Structural Chemistry, Discovery Chemistry, and Quantitative Biosciences, Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States., Lacey BM; Computational and Structural Chemistry, Discovery Chemistry, and Quantitative Biosciences, Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States., Mansueto MS; Computational and Structural Chemistry, Discovery Chemistry, and Quantitative Biosciences, Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States., Reutershan M; Computational and Structural Chemistry, Discovery Chemistry, and Quantitative Biosciences, Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States., Siliphaivanh P; Computational and Structural Chemistry, Discovery Chemistry, and Quantitative Biosciences, Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States., Sondey C; Computational and Structural Chemistry, Discovery Chemistry, and Quantitative Biosciences, Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States., Xu H; Computational and Structural Chemistry, Discovery Chemistry, and Quantitative Biosciences, Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States., Xu Z; Computational and Structural Chemistry, Discovery Chemistry, and Quantitative Biosciences, Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States., Ye Y; Computational and Structural Chemistry, Discovery Chemistry, and Quantitative Biosciences, Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States., Machacek MR; Computational and Structural Chemistry, Discovery Chemistry, and Quantitative Biosciences, Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States.

المصدر: ACS medicinal chemistry letters [ACS Med Chem Lett] 2020 Aug 07; Vol. 11 (9), pp. 1688-1693. Date of Electronic Publication: 2020 Aug 07 (Print Publication: 2020).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101521073 Publication Model: eCollection Cited Medium: Print ISSN: 1948-5875 (Print) Linking ISSN: 19485875 NLM ISO Abbreviation: ACS Med Chem Lett Subsets: PubMed not MEDLINE