المؤلفون: Lacher SB; Institute of Molecular Immunology, School of Medicine and Health, Technical University of Munich (TUM), Munich, Germany., Dörr J; Division of Clinical Pharmacology, Department of Medicine IV, LMU University Hospital, Member of the German Center for Lung Research (DZL), LMU Munich, Munich, Germany., de Almeida GP; Division of Animal Physiology and Immunology, School of Life Sciences Weihenstephan, TUM, Freising, Germany., Hönninger J; Institute of Molecular Immunology, School of Medicine and Health, Technical University of Munich (TUM), Munich, Germany.; Institute for Medical Microbiology, Immunology and Hygiene, School of Medicine and Health, TUM, Munich, Germany., Bayerl F; Institute of Molecular Immunology, School of Medicine and Health, Technical University of Munich (TUM), Munich, Germany., Hirschberger A; Institute of Molecular Immunology, School of Medicine and Health, Technical University of Munich (TUM), Munich, Germany., Pedde AM; Institute of Molecular Immunology, School of Medicine and Health, Technical University of Munich (TUM), Munich, Germany., Meiser P; Institute of Molecular Immunology, School of Medicine and Health, Technical University of Munich (TUM), Munich, Germany., Ramsauer L; Institute of Molecular Immunology, School of Medicine and Health, Technical University of Munich (TUM), Munich, Germany., Rudolph TJ; Institute of Molecular Immunology, School of Medicine and Health, Technical University of Munich (TUM), Munich, Germany., Spranger N; Institute of Molecular Immunology, School of Medicine and Health, Technical University of Munich (TUM), Munich, Germany., Morotti M; Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne (UNIL), Lausanne, Switzerland.; Department of Oncology, University Hospital of Lausanne (CHUV) and UNIL, Lausanne, Switzerland.; Agora Cancer Research Center, Lausanne, Switzerland., Grimm AJ; Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne (UNIL), Lausanne, Switzerland.; Department of Oncology, University Hospital of Lausanne (CHUV) and UNIL, Lausanne, Switzerland.; Agora Cancer Research Center, Lausanne, Switzerland., Jarosch S; Institute for Medical Microbiology, Immunology and Hygiene, School of Medicine and Health, TUM, Munich, Germany.; Boehringer Ingelheim, Biberach, Germany., Oner A; Division of Clinical Pharmacology, Department of Medicine IV, LMU University Hospital, Member of the German Center for Lung Research (DZL), LMU Munich, Munich, Germany., Gregor L; Division of Clinical Pharmacology, Department of Medicine IV, LMU University Hospital, Member of the German Center for Lung Research (DZL), LMU Munich, Munich, Germany., Lesch S; Division of Clinical Pharmacology, Department of Medicine IV, LMU University Hospital, Member of the German Center for Lung Research (DZL), LMU Munich, Munich, Germany., Michaelides S; Division of Clinical Pharmacology, Department of Medicine IV, LMU University Hospital, Member of the German Center for Lung Research (DZL), LMU Munich, Munich, Germany., Fertig L; Division of Clinical Pharmacology, Department of Medicine IV, LMU University Hospital, Member of the German Center for Lung Research (DZL), LMU Munich, Munich, Germany., Briukhovetska D; Division of Clinical Pharmacology, Department of Medicine IV, LMU University Hospital, Member of the German Center for Lung Research (DZL), LMU Munich, Munich, Germany., Majed L; Division of Clinical Pharmacology, Department of Medicine IV, LMU University Hospital, Member of the German Center for Lung Research (DZL), LMU Munich, Munich, Germany., Stock S; Division of Clinical Pharmacology, Department of Medicine IV, LMU University Hospital, Member of the German Center for Lung Research (DZL), LMU Munich, Munich, Germany.; Department of Medicine III, LMU University Hospital, LMU Munich, Munich, Germany.; German Cancer Consortium (DKTK), partner site Munich, a partnership between DKFZ and LMU University Hospital, Munich, Germany., Busch DH; Institute for Medical Microbiology, Immunology and Hygiene, School of Medicine and Health, TUM, Munich, Germany., Buchholz VR; Institute for Medical Microbiology, Immunology and Hygiene, School of Medicine and Health, TUM, Munich, Germany., Knolle PA; Institute of Molecular Immunology, School of Medicine and Health, Technical University of Munich (TUM), Munich, Germany., Zehn D; Division of Animal Physiology and Immunology, School of Life Sciences Weihenstephan, TUM, Freising, Germany., Dangaj Laniti D; Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne (UNIL), Lausanne, Switzerland.; Department of Oncology, University Hospital of Lausanne (CHUV) and UNIL, Lausanne, Switzerland.; Agora Cancer Research Center, Lausanne, Switzerland., Kobold S; Division of Clinical Pharmacology, Department of Medicine IV, LMU University Hospital, Member of the German Center for Lung Research (DZL), LMU Munich, Munich, Germany.; German Cancer Consortium (DKTK), partner site Munich, a partnership between DKFZ and LMU University Hospital, Munich, Germany.; Einheit für Klinische Pharmakologie (EKLiP), Helmholtz Munich, Research Center for Environmental Health (HMGU), Neuherberg, Germany., Böttcher JP; Institute of Molecular Immunology, School of Medicine and Health, Technical University of Munich (TUM), Munich, Germany. j.boettcher@tum.de.

المصدر: Nature [Nature] 2024 May; Vol. 629 (8011), pp. 417-425. Date of Electronic Publication: 2024 Apr 24.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE

مواضيع طبية MeSH: CD8-Positive T-Lymphocytes*/cytology , CD8-Positive T-Lymphocytes*/immunology , CD8-Positive T-Lymphocytes*/metabolism , Cell Proliferation* , Dinoprostone*/metabolism , Lymphocytes, Tumor-Infiltrating*/cytology , Lymphocytes, Tumor-Infiltrating*/immunology , Lymphocytes, Tumor-Infiltrating*/metabolism , Neoplasms*/immunology , Neoplasms*/prevention & control , Stem Cells*/cytology , Stem Cells*/immunology , Stem Cells*/metabolism , Tumor Escape*/immunology, Animals ; Female ; Humans ; Male ; Mice ; Cell Differentiation ; Cell Line, Tumor ; Disease Models, Animal ; Hepatocyte Nuclear Factor 1-alpha/metabolism ; Interleukin-2 ; Lymph Nodes/cytology ; Lymph Nodes/immunology ; Mice, Inbred C57BL ; Receptors, Prostaglandin E, EP2 Subtype/deficiency ; Receptors, Prostaglandin E, EP2 Subtype/metabolism ; Receptors, Prostaglandin E, EP4 Subtype/deficiency ; Receptors, Prostaglandin E, EP4 Subtype/metabolism ; Signal Transduction

المؤلفون: Morotti M; Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne (UNIL), Lausanne, Switzerland.; Department of Oncology, Lausanne University Hospital (CHUV) and University of Lausanne, Lausanne, Switzerland.; Agora Cancer Research Center, Lausanne, Switzerland., Grimm AJ; Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne (UNIL), Lausanne, Switzerland.; Department of Oncology, Lausanne University Hospital (CHUV) and University of Lausanne, Lausanne, Switzerland.; Agora Cancer Research Center, Lausanne, Switzerland., Hope HC; Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne (UNIL), Lausanne, Switzerland.; Department of Oncology, Lausanne University Hospital (CHUV) and University of Lausanne, Lausanne, Switzerland., Arnaud M; Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne (UNIL), Lausanne, Switzerland.; Department of Oncology, Lausanne University Hospital (CHUV) and University of Lausanne, Lausanne, Switzerland.; Agora Cancer Research Center, Lausanne, Switzerland., Desbuisson M; Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne (UNIL), Lausanne, Switzerland.; Department of Oncology, Lausanne University Hospital (CHUV) and University of Lausanne, Lausanne, Switzerland.; Agora Cancer Research Center, Lausanne, Switzerland., Rayroux N; Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne (UNIL), Lausanne, Switzerland.; Department of Oncology, Lausanne University Hospital (CHUV) and University of Lausanne, Lausanne, Switzerland.; Agora Cancer Research Center, Lausanne, Switzerland., Barras D; Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne (UNIL), Lausanne, Switzerland.; Department of Oncology, Lausanne University Hospital (CHUV) and University of Lausanne, Lausanne, Switzerland.; Agora Cancer Research Center, Lausanne, Switzerland., Masid M; Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne (UNIL), Lausanne, Switzerland.; Department of Oncology, Lausanne University Hospital (CHUV) and University of Lausanne, Lausanne, Switzerland.; Agora Cancer Research Center, Lausanne, Switzerland., Murgues B; Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne (UNIL), Lausanne, Switzerland.; Department of Oncology, Lausanne University Hospital (CHUV) and University of Lausanne, Lausanne, Switzerland.; Agora Cancer Research Center, Lausanne, Switzerland., Chap BS; Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne (UNIL), Lausanne, Switzerland.; Department of Oncology, Lausanne University Hospital (CHUV) and University of Lausanne, Lausanne, Switzerland.; Agora Cancer Research Center, Lausanne, Switzerland., Ongaro M; Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne (UNIL), Lausanne, Switzerland.; Department of Oncology, Lausanne University Hospital (CHUV) and University of Lausanne, Lausanne, Switzerland., Rota IA; Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne (UNIL), Lausanne, Switzerland.; Agora Cancer Research Center, Lausanne, Switzerland., Ronet C; Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne (UNIL), Lausanne, Switzerland.; Agora Cancer Research Center, Lausanne, Switzerland., Minasyan A; Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne (UNIL), Lausanne, Switzerland.; Department of Oncology, Lausanne University Hospital (CHUV) and University of Lausanne, Lausanne, Switzerland.; Agora Cancer Research Center, Lausanne, Switzerland., Chiffelle J; Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne (UNIL), Lausanne, Switzerland.; Department of Oncology, Lausanne University Hospital (CHUV) and University of Lausanne, Lausanne, Switzerland.; Agora Cancer Research Center, Lausanne, Switzerland., Lacher SB; Institute of Molecular Immunology, School of Medicine and Health, Technical University of Munich (TUM), Munich, Germany., Bobisse S; Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne (UNIL), Lausanne, Switzerland.; Agora Cancer Research Center, Lausanne, Switzerland., Murgues C; Center of Experimental Therapeutics, Department of Oncology, Lausanne University Hospital (CHUV), Lausanne, Switzerland., Ghisoni E; Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne (UNIL), Lausanne, Switzerland.; Department of Oncology, Lausanne University Hospital (CHUV) and University of Lausanne, Lausanne, Switzerland.; Agora Cancer Research Center, Lausanne, Switzerland., Ouchen K; Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne (UNIL), Lausanne, Switzerland.; Agora Cancer Research Center, Lausanne, Switzerland., Bou Mjahed R; Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne (UNIL), Lausanne, Switzerland.; Department of Oncology, Lausanne University Hospital (CHUV) and University of Lausanne, Lausanne, Switzerland., Benedetti F; Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne (UNIL), Lausanne, Switzerland.; Department of Oncology, Lausanne University Hospital (CHUV) and University of Lausanne, Lausanne, Switzerland., Abdellaoui N; Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne (UNIL), Lausanne, Switzerland.; Department of Oncology, Lausanne University Hospital (CHUV) and University of Lausanne, Lausanne, Switzerland.; Agora Cancer Research Center, Lausanne, Switzerland., Turrini R; Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne (UNIL), Lausanne, Switzerland., Gannon PO; Center of Experimental Therapeutics, Department of Oncology, Lausanne University Hospital (CHUV), Lausanne, Switzerland., Zaman K; Department of Oncology, Lausanne University Hospital (CHUV) and University of Lausanne, Lausanne, Switzerland., Mathevet P; Department of Gynaecology, Lausanne University Hospital (CHUV), Lausanne, Switzerland., Lelievre L; Department of Gynaecology, Lausanne University Hospital (CHUV), Lausanne, Switzerland., Crespo I; Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne (UNIL), Lausanne, Switzerland.; Department of Oncology, Lausanne University Hospital (CHUV) and University of Lausanne, Lausanne, Switzerland.; Agora Cancer Research Center, Lausanne, Switzerland., Conrad M; Institute of Metabolism and Cell Death, Molecular Target and Therapeutics Centre, Helmholtz Munich, Neuherberg, Germany., Verdeil G; Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne (UNIL), Lausanne, Switzerland.; Department of Oncology, Lausanne University Hospital (CHUV) and University of Lausanne, Lausanne, Switzerland., Kandalaft LE; Center of Experimental Therapeutics, Department of Oncology, Lausanne University Hospital (CHUV), Lausanne, Switzerland., Dagher J; Unit of Translational Oncopathology, Institute of Pathology, Lausanne University Hospital (CHUV), Lausanne, Switzerland., Corria-Osorio J; Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne (UNIL), Lausanne, Switzerland.; Agora Cancer Research Center, Lausanne, Switzerland., Doucey MA; Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne (UNIL), Lausanne, Switzerland., Ho PC; Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne (UNIL), Lausanne, Switzerland.; Department of Oncology, Lausanne University Hospital (CHUV) and University of Lausanne, Lausanne, Switzerland., Harari A; Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne (UNIL), Lausanne, Switzerland.; Department of Oncology, Lausanne University Hospital (CHUV) and University of Lausanne, Lausanne, Switzerland.; Agora Cancer Research Center, Lausanne, Switzerland., Vannini N; Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne (UNIL), Lausanne, Switzerland.; Department of Oncology, Lausanne University Hospital (CHUV) and University of Lausanne, Lausanne, Switzerland., Böttcher JP; Institute of Molecular Immunology, School of Medicine and Health, Technical University of Munich (TUM), Munich, Germany., Dangaj Laniti D; Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne (UNIL), Lausanne, Switzerland. denarda.dangaj@chuv.ch.; Department of Oncology, Lausanne University Hospital (CHUV) and University of Lausanne, Lausanne, Switzerland. denarda.dangaj@chuv.ch.; Agora Cancer Research Center, Lausanne, Switzerland. denarda.dangaj@chuv.ch., Coukos G; Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne (UNIL), Lausanne, Switzerland. george.coukos@chuv.ch.; Department of Oncology, Lausanne University Hospital (CHUV) and University of Lausanne, Lausanne, Switzerland. george.coukos@chuv.ch.; Agora Cancer Research Center, Lausanne, Switzerland. george.coukos@chuv.ch.

المصدر: Nature [Nature] 2024 May; Vol. 629 (8011), pp. 426-434. Date of Electronic Publication: 2024 Apr 24.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE

مواضيع طبية MeSH: CD8-Positive T-Lymphocytes*/cytology , CD8-Positive T-Lymphocytes*/immunology , CD8-Positive T-Lymphocytes*/metabolism , Cell Proliferation* , Dinoprostone*/metabolism , Interleukin-2*/antagonists & inhibitors , Interleukin-2*/immunology , Interleukin-2*/metabolism , Lymphocytes, Tumor-Infiltrating*/cytology , Lymphocytes, Tumor-Infiltrating*/immunology , Lymphocytes, Tumor-Infiltrating*/metabolism , Mitochondria*/metabolism , Signal Transduction*, Animals ; Humans ; Mice ; Down-Regulation ; Ferroptosis ; Interleukin Receptor Common gamma Subunit/biosynthesis ; Interleukin Receptor Common gamma Subunit/deficiency ; Interleukin Receptor Common gamma Subunit/metabolism ; Interleukin-2 Receptor beta Subunit/metabolism ; Oxidative Stress ; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha/metabolism ; Receptors, Prostaglandin E, EP2 Subtype/metabolism ; Receptors, Prostaglandin E, EP2 Subtype/antagonists & inhibitors ; Receptors, Prostaglandin E, EP4 Subtype/metabolism ; Receptors, Prostaglandin E, EP4 Subtype/antagonists & inhibitors ; TOR Serine-Threonine Kinases/metabolism ; Tumor Microenvironment/immunology

المؤلفون: Bayerl F; Institute of Molecular Immunology, School of Medicine, Technical University of Munich, Munich, Germany., Meiser P; Institute of Molecular Immunology, School of Medicine, Technical University of Munich, Munich, Germany., Donakonda S; Institute of Molecular Immunology, School of Medicine, Technical University of Munich, Munich, Germany; German Center for Infection Research, Munich, Germany., Hirschberger A; Institute of Molecular Immunology, School of Medicine, Technical University of Munich, Munich, Germany., Lacher SB; Institute of Molecular Immunology, School of Medicine, Technical University of Munich, Munich, Germany., Pedde AM; Institute of Molecular Immunology, School of Medicine, Technical University of Munich, Munich, Germany., Hermann CD; Institute of Experimental Oncology, School of Medicine, Technical University of Munich, Munich, Germany., Elewaut A; Research Institute of Molecular Pathology, Vienna Biocenter, Vienna, Austria., Knolle M; Institute for Artificial Intelligence in Medicine & Healthcare, School of Medicine, Technical University of Munich, Munich, Germany., Ramsauer L; Institute of Molecular Immunology, School of Medicine, Technical University of Munich, Munich, Germany., Rudolph TJ; Institute of Molecular Immunology, School of Medicine, Technical University of Munich, Munich, Germany., Grassmann S; Institute for Medical Microbiology, Immunology and Hygiene, School of Medicine, Technical University of Munich, Munich, Germany., Öllinger R; Institute of Molecular Oncology and Functional Genomics, School of Medicine, Technical University of Munich, Munich, Germany., Kirchhammer N; Cancer Immunology, Department of Biomedicine, University and University Hospital Basel, Basel, Switzerland., Trefny M; Cancer Immunology, Department of Biomedicine, University and University Hospital Basel, Basel, Switzerland., Anton M; Institute of Molecular Immunology, School of Medicine, Technical University of Munich, Munich, Germany., Wohlleber D; Institute of Molecular Immunology, School of Medicine, Technical University of Munich, Munich, Germany., Höchst B; Institute of Molecular Immunology, School of Medicine, Technical University of Munich, Munich, Germany., Zaremba A; Department for Dermatology, University Hospital Essen, Essen, Germany., Krüger A; Institute of Experimental Oncology, School of Medicine, Technical University of Munich, Munich, Germany., Rad R; Institute of Molecular Oncology and Functional Genomics, School of Medicine, Technical University of Munich, Munich, Germany., Obenauf AC; Research Institute of Molecular Pathology, Vienna Biocenter, Vienna, Austria., Schadendorf D; Department for Dermatology, University Hospital Essen, Essen, Germany., Zippelius A; Cancer Immunology, Department of Biomedicine, University and University Hospital Basel, Basel, Switzerland., Buchholz VR; Institute for Medical Microbiology, Immunology and Hygiene, School of Medicine, Technical University of Munich, Munich, Germany., Schraml BU; Walter-Brendel Center for Experimental Medicine, LMU Munich, Planegg-Martinsried, Germany; Biomedical Center, Institute for Cardiovascular Physiology and Pathophysiology, LMU Munich, Planegg-Martinsried, Germany., Böttcher JP; Institute of Molecular Immunology, School of Medicine, Technical University of Munich, Munich, Germany. Electronic address: j.boettcher@tum.de.

المصدر: Immunity [Immunity] 2023 Jun 13; Vol. 56 (6), pp. 1341-1358.e11.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 9432918 Publication Model: Print Cited Medium: Internet ISSN: 1097-4180 (Electronic) Linking ISSN: 10747613 NLM ISO Abbreviation: Immunity Subsets: MEDLINE

مواضيع طبية MeSH: Dinoprostone* , Neoplasms*, Humans ; Antibodies ; CD8-Positive T-Lymphocytes ; Dendritic Cells ; Receptors, Prostaglandin E