المؤلفون: Phillips, MA, White, KL, Kokkonda, S, Deng, X, White, J, El Mazouni, F, Marsh, KC, Tomchick, DR, Manjalanagara, K, Rudra, KR, Wirjanata, G, Noviyanti, R, Price, R, Marfurt, J, Shackleford, DM, Chiu, FCK, Campbell, M, Jimenez Diaz, MB, Ferrer-Bazaga, S, Angulo-Barturen, I, Martínez-Martínez, MS, Lafuente-Monasterio, MJ, Kaminsky, W, Silue, K, Zeeman, AM, Kocken, C, Leroy, D, Blasco, B, Rossignol, E, Rueckle, T, Matthews, D, Burrows, JN, Waterson, D, Palmer, MJ, Rathod, PK, Charman, SA

مصطلحات موضوعية: parasitic diseases

URL الوصول: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::00e11b608b9c68666f8abe95af7f779d
https://doi.org/10.1021/acsinfecdis.6b00144

المؤلفون: Mandt REK; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, United States., Luth MR; Division of Host Pathogen Systems and Therapeutics, Department of Pediatrics, University of California, San Diego, San Diego, United States., Tye MA; Center for Systems Biology, Massachusetts General Hospital, Boston, United States.; Harvard Graduate School of Arts and Sciences, Cambridge, United States., Mazitschek R; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, United States.; Center for Systems Biology, Massachusetts General Hospital, Boston, United States., Ottilie S; Division of Host Pathogen Systems and Therapeutics, Department of Pediatrics, University of California, San Diego, San Diego, United States., Winzeler EA; Division of Host Pathogen Systems and Therapeutics, Department of Pediatrics, University of California, San Diego, San Diego, United States.; Skaggs School of Pharmaceutical Sciences, University of California, San Diego, La Jolla, United States., Lafuente-Monasterio MJ; Tres Cantos Medicines Development Campus, Diseases of the Developing World, GlaxoSmithKline, Madrid, Spain., Gamo FJ; Tres Cantos Medicines Development Campus, Diseases of the Developing World, GlaxoSmithKline, Madrid, Spain., Wirth DF; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, United States.; Infectious Disease and Microbiome Program, The Broad Institute, Cambridge, United States., Lukens AK; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, United States.; Infectious Disease and Microbiome Program, The Broad Institute, Cambridge, United States.

المصدر: ELife [Elife] 2023 Sep 22; Vol. 12. Date of Electronic Publication: 2023 Sep 22.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic Cited Medium: Internet ISSN: 2050-084X (Electronic) Linking ISSN: 2050084X NLM ISO Abbreviation: Elife Subsets: MEDLINE

مواضيع طبية MeSH: Malaria, Falciparum*/parasitology , Oxidoreductases Acting on CH-CH Group Donors*/genetics , Oxidoreductases Acting on CH-CH Group Donors*/metabolism , Antimalarials*/pharmacology , Antimalarials*/therapeutic use , Parasites*/metabolism, Animals ; Humans ; Dihydroorotate Dehydrogenase ; Plasmodium falciparum ; DNA Copy Number Variations ; Drug Collateral Sensitivity

المؤلفون: Samayoa-Reyes G; Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, Colorado, United States of America., Flaherty SM; Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, Colorado, United States of America., Wickham KS; Department of Drug Discovery, Experimental Therapeutics Branch, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America., Viera-Morilla S; Diseases of the Developing World, Infectious Diseases-Centre for Excellence in Drug Discovery (ID CEDD), GlaxoSmithKline, Tres Cantos, Madrid, Spain., Strauch PM; Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, Colorado, United States of America., Roth A; Department of Drug Discovery, Experimental Therapeutics Branch, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America., Padrón L; Diseases of the Developing World, Infectious Diseases-Centre for Excellence in Drug Discovery (ID CEDD), GlaxoSmithKline, Tres Cantos, Madrid, Spain., Jackson CM; Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, Colorado, United States of America., Meireles P; Diseases of the Developing World, Infectious Diseases-Centre for Excellence in Drug Discovery (ID CEDD), GlaxoSmithKline, Tres Cantos, Madrid, Spain., Calvo D; Diseases of the Developing World, Infectious Diseases-Centre for Excellence in Drug Discovery (ID CEDD), GlaxoSmithKline, Tres Cantos, Madrid, Spain., Roobsoong W; Faculty of Tropical Medicine, Mahidol Vivax Research Unit, Mahidol University, Bangkok, Thailand., Kangwanrangsan N; Faculty of Science, Pathobiology Department, Mahidol University, Bangkok, Thailand., Sattabongkot J; Faculty of Tropical Medicine, Mahidol Vivax Research Unit, Mahidol University, Bangkok, Thailand., Reichard G; Department of Drug Discovery, Experimental Therapeutics Branch, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America., Lafuente-Monasterio MJ; Diseases of the Developing World, Infectious Diseases-Centre for Excellence in Drug Discovery (ID CEDD), GlaxoSmithKline, Tres Cantos, Madrid, Spain., Rochford R; Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, Colorado, United States of America.

المصدر: PloS one [PLoS One] 2023 Mar 16; Vol. 18 (3), pp. e0279144. Date of Electronic Publication: 2023 Mar 16 (Print Publication: 2023).

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE

مواضيع طبية MeSH: Malaria*/drug therapy , Plasmodium* , Malaria, Falciparum*/parasitology , Liver Diseases* , Malaria, Vivax* , Communicable Diseases*, Mice ; Animals ; Humans ; Liver/parasitology ; Hepatocytes/parasitology ; Plasmodium falciparum ; Sporozoites

المؤلفون: Arendse LB; Drug Discovery and Development Centre (H3D), University of Cape Town, Rondebosch, Cape Town 7701, South Africa.; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, Cape Town 7925, South Africa.; South African Medical Research Council Drug Discovery and Development Research Unit, University of Cape Town, Rondebosch, Cape Town 7701, South Africa., Murithi JM; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY 10032, USA., Qahash T; Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, PA 16802, USA.; Huck Center for Malaria Research, Pennsylvania State University, University Park, PA 16802, USA., Pasaje CFA; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Godoy LC; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Dey S; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Gibhard L; Drug Discovery and Development Centre (H3D), University of Cape Town, Rondebosch, Cape Town 7701, South Africa., Ghidelli-Disse S; Cellzome GmbH, a GSK Company, Heidelberg 69117, Germany., Drewes G; Cellzome GmbH, a GSK Company, Heidelberg 69117, Germany., Bantscheff M; Cellzome GmbH, a GSK Company, Heidelberg 69117, Germany., Lafuente-Monasterio MJ; Tres Cantos Medicines Development Campus-Diseases of the Developing World, GlaxoSmithKline, Tres Cantos, Madrid 28760, Spain., Fienberg S; Drug Discovery and Development Centre (H3D), University of Cape Town, Rondebosch, Cape Town 7701, South Africa.; Department of Chemistry, University of Cape Town, Rondebosch, Cape Town 7701, South Africa., Wambua L; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, Cape Town 7925, South Africa.; Department of Chemistry, University of Cape Town, Rondebosch, Cape Town 7701, South Africa., Gachuhi S; Department of Chemistry, University of Cape Town, Rondebosch, Cape Town 7701, South Africa., Coertzen D; Department of Biochemistry, Genetics and Microbiology, Institute for Sustainable Malaria Control, University of Pretoria, Hatfield 0028, South Africa., van der Watt M; Department of Biochemistry, Genetics and Microbiology, Institute for Sustainable Malaria Control, University of Pretoria, Hatfield 0028, South Africa., Reader J; Department of Biochemistry, Genetics and Microbiology, Institute for Sustainable Malaria Control, University of Pretoria, Hatfield 0028, South Africa., Aswat AS; Wits Research Institute for Malaria, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg 2193, South Africa.; Centre for Emerging Zoonotic and Parasitic Diseases, National Institute for Communicable Diseases of the National Health Laboratory Service, Johannesburg 2193, South Africa., Erlank E; Wits Research Institute for Malaria, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg 2193, South Africa.; Centre for Emerging Zoonotic and Parasitic Diseases, National Institute for Communicable Diseases of the National Health Laboratory Service, Johannesburg 2193, South Africa., Venter N; Wits Research Institute for Malaria, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg 2193, South Africa.; Centre for Emerging Zoonotic and Parasitic Diseases, National Institute for Communicable Diseases of the National Health Laboratory Service, Johannesburg 2193, South Africa., Mittal N; School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA., Luth MR; School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA., Ottilie S; School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA., Winzeler EA; School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA., Koekemoer LL; Wits Research Institute for Malaria, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg 2193, South Africa.; Centre for Emerging Zoonotic and Parasitic Diseases, National Institute for Communicable Diseases of the National Health Laboratory Service, Johannesburg 2193, South Africa., Birkholtz LM; Department of Biochemistry, Genetics and Microbiology, Institute for Sustainable Malaria Control, University of Pretoria, Hatfield 0028, South Africa., Niles JC; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Llinás M; Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, PA 16802, USA.; Huck Center for Malaria Research, Pennsylvania State University, University Park, PA 16802, USA.; Department of Chemistry, Pennsylvania State University, University Park, PA 16802, USA., Fidock DA; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY 10032, USA.; Center for Malaria Therapeutics and Antimicrobial Resistance, Division of Infectious Diseases, Columbia University Irving Medical Center, New York, NY 10032, USA., Chibale K; Drug Discovery and Development Centre (H3D), University of Cape Town, Rondebosch, Cape Town 7701, South Africa.; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, Cape Town 7925, South Africa.; South African Medical Research Council Drug Discovery and Development Research Unit, University of Cape Town, Rondebosch, Cape Town 7701, South Africa.; Department of Chemistry, University of Cape Town, Rondebosch, Cape Town 7701, South Africa.

المصدر: Science translational medicine [Sci Transl Med] 2022 Oct 19; Vol. 14 (667), pp. eabo7219. Date of Electronic Publication: 2022 Oct 19.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE

مواضيع طبية MeSH: Antimalarials*/pharmacology , Antimalarials*/therapeutic use , Plasmodium*, Animals ; Humans ; Plasmodium falciparum ; MTOR Inhibitors ; 1-Phosphatidylinositol 4-Kinase ; Guanosine Monophosphate ; Life Cycle Stages ; TOR Serine-Threonine Kinases ; Sirolimus ; Mammals

المؤلفون: Zhan W; Department of Microbiology & Immunology, Weill Cornell Medicine, 1300 York Ave, New York, NY, 10065, USA., Zhang H; Department of Microbiology & Immunology, Weill Cornell Medicine, 1300 York Ave, New York, NY, 10065, USA., Ginn J; Tri-Institutional Therapeutics Discovery Institute, 413 E 69th St, New York, NY, 10065, USA., Leung A; Department of Medicine, Division of Infectious Diseases, Weill Cornell Medicine, 1300 York Ave, New York, NY, 10065, USA., Liu YJ; Department of Medicine, Division of Infectious Diseases, Weill Cornell Medicine, 1300 York Ave, New York, NY, 10065, USA., Michino M; Tri-Institutional Therapeutics Discovery Institute, 413 E 69th St, New York, NY, 10065, USA., Toita A; Tri-Institutional Therapeutics Discovery Institute, 413 E 69th St, New York, NY, 10065, USA., Okamoto R; Tri-Institutional Therapeutics Discovery Institute, 413 E 69th St, New York, NY, 10065, USA., Wong TT; Tri-Institutional Therapeutics Discovery Institute, 413 E 69th St, New York, NY, 10065, USA., Imaeda T; Tri-Institutional Therapeutics Discovery Institute, 413 E 69th St, New York, NY, 10065, USA., Hara R; Tri-Institutional Therapeutics Discovery Institute, 413 E 69th St, New York, NY, 10065, USA., Yukawa T; Tri-Institutional Therapeutics Discovery Institute, 413 E 69th St, New York, NY, 10065, USA., Chelebieva S; Department of Natural Sciences and Mathematics, Dominican University of California, San Rafael, CA, 94901, USA., Tumwebaze PK; Infectious Diseases Research Collaboration, Kampala, Uganda., Lafuente-Monasterio MJ; Diseases of the Developing World (DDW), Tres Cantos Medicine Development Campus, GlaxoSmithKline, Severo Ochoa 2, 28760, Tres Cantos, Madrid, Spain., Martinez-Martinez MS; Diseases of the Developing World (DDW), Tres Cantos Medicine Development Campus, GlaxoSmithKline, Severo Ochoa 2, 28760, Tres Cantos, Madrid, Spain., Vendome J; Schrödinger, Inc., New York, NY, 10036, USA., Beuming T; Schrödinger, Inc., New York, NY, 10036, USA., Sato K; Tri-Institutional Therapeutics Discovery Institute, 413 E 69th St, New York, NY, 10065, USA., Aso K; Tri-Institutional Therapeutics Discovery Institute, 413 E 69th St, New York, NY, 10065, USA., Rosenthal PJ; Department of Medicine, University of California, San Francisco, CA, 94143, USA., Cooper RA; Department of Natural Sciences and Mathematics, Dominican University of California, San Rafael, CA, 94901, USA., Meinke PT; Tri-Institutional Therapeutics Discovery Institute, 413 E 69th St, New York, NY, 10065, USA., Nathan CF; Department of Microbiology & Immunology, Weill Cornell Medicine, 1300 York Ave, New York, NY, 10065, USA., Kirkman LA; Department of Medicine, Division of Infectious Diseases, Weill Cornell Medicine, 1300 York Ave, New York, NY, 10065, USA., Lin G; Department of Microbiology & Immunology, Weill Cornell Medicine, 1300 York Ave, New York, NY, 10065, USA.

المصدر: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2021 Apr 19; Vol. 60 (17), pp. 9279-9283. Date of Electronic Publication: 2021 Mar 11.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 0370543 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-3773 (Electronic) Linking ISSN: 14337851 NLM ISO Abbreviation: Angew Chem Int Ed Engl Subsets: MEDLINE

مواضيع طبية MeSH: Drug Development*, Antimalarials/*pharmacology , Malaria, Falciparum/*drug therapy , Plasmodium falciparum/*drug effects , Proteasome Endopeptidase Complex/*metabolism , Proteasome Inhibitors/*pharmacology, Animals ; Antimalarials/chemical synthesis ; Antimalarials/chemistry ; Malaria, Falciparum/metabolism ; Mice ; Models, Molecular ; Molecular Conformation ; Parasitic Sensitivity Tests ; Plasmodium falciparum/enzymology ; Proteasome Inhibitors/chemical synthesis ; Proteasome Inhibitors/chemistry

المؤلفون: Kokkonda S; Departments of Chemistry and Global Health, University of Washington, Seattle, Washington 98195, United States., Deng X; Departments of Biochemistry, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, Texas 75390-9135, United States., White KL; Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia., El Mazouni F; Departments of Biochemistry, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, Texas 75390-9135, United States., White J; Departments of Chemistry and Global Health, University of Washington, Seattle, Washington 98195, United States., Shackleford DM; Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia., Katneni K; Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia., Chiu FCK; Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia., Barker H; Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia., McLaren J; Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia., Crighton E; Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia., Chen G; Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia., Angulo-Barturen I; GSK, Tres Cantos Medicines Development Campus, Severo Ochoa, Madrid 28760, Spain., Jimenez-Diaz MB; GSK, Tres Cantos Medicines Development Campus, Severo Ochoa, Madrid 28760, Spain., Ferrer S; GSK, Tres Cantos Medicines Development Campus, Severo Ochoa, Madrid 28760, Spain., Huertas-Valentin L; GSK, Tres Cantos Medicines Development Campus, Severo Ochoa, Madrid 28760, Spain., Martinez-Martinez MS; GSK, Tres Cantos Medicines Development Campus, Severo Ochoa, Madrid 28760, Spain., Lafuente-Monasterio MJ; GSK, Tres Cantos Medicines Development Campus, Severo Ochoa, Madrid 28760, Spain., Chittimalla R; Syngene International Ltd, Bangalore 560 099, India., Shahi SP; Syngene International Ltd, Bangalore 560 099, India., Wittlin S; Swiss Tropical and Public Health Institute, Socinstrasse 57, 4002 Basel, Switzerland.; University of Basel, 4002 Basel, Switzerland., Waterson D; Medicines for Malaria Venture, 1215 Geneva, Switzerland., Burrows JN; Medicines for Malaria Venture, 1215 Geneva, Switzerland., Matthews D; Medicines for Malaria Venture, 1215 Geneva, Switzerland., Tomchick D; Department of Biophysics, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, Texas 75390-9135, United States., Rathod PK; Departments of Chemistry and Global Health, University of Washington, Seattle, Washington 98195, United States., Palmer MJ; Medicines for Malaria Venture, 1215 Geneva, Switzerland., Charman SA; Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia., Phillips MA; Departments of Biochemistry, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, Texas 75390-9135, United States.

المصدر: Journal of medicinal chemistry [J Med Chem] 2020 May 14; Vol. 63 (9), pp. 4929-4956. Date of Electronic Publication: 2020 Apr 16.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Antimalarials/*therapeutic use , Enzyme Inhibitors/*therapeutic use , Malaria, Falciparum/*drug therapy , Oxidoreductases Acting on CH-CH Group Donors/*antagonists & inhibitors , Pyrroles/*therapeutic use, Animals ; Antimalarials/chemical synthesis ; Antimalarials/metabolism ; Antimalarials/pharmacokinetics ; Cell Line, Tumor ; Crystallography, X-Ray ; Dihydroorotate Dehydrogenase ; Dogs ; Enzyme Inhibitors/chemical synthesis ; Enzyme Inhibitors/metabolism ; Enzyme Inhibitors/pharmacokinetics ; Female ; Humans ; Male ; Mice, SCID ; Microsomes, Liver/metabolism ; Molecular Structure ; Oxidoreductases Acting on CH-CH Group Donors/metabolism ; Parasitic Sensitivity Tests ; Plasmodium falciparum/drug effects ; Plasmodium falciparum/enzymology ; Plasmodium vivax/drug effects ; Plasmodium vivax/enzymology ; Protein Binding ; Pyrroles/chemical synthesis ; Pyrroles/metabolism ; Pyrroles/pharmacokinetics ; Rats ; Structure-Activity Relationship

المؤلفون: Matthews KA; Department of Pharmacology, The University of Texas Southwestern Medical Center, 6000 Harry Hines Blvd., Dallas, Texas 75390, United States., Senagbe KM; Hamon Center for Therapeutic Oncology Research, The University of Texas Southwestern Medical Center, 6000 Harry Hines Blvd., Dallas, Texas 75390, United States., Nötzel C; Department of Microbiology & Immunology, Weill Cornell Medicine, 1300 York Avenue, W-705, New York, New York 10065, United States.; Biochemistry, Cell & Molecular Biology Graduate Program, Weill Cornell Medicine, 1300 York Avenue, W-705, New York, New York 10065, United States., Gonzales CA; Hamon Center for Therapeutic Oncology Research, The University of Texas Southwestern Medical Center, 6000 Harry Hines Blvd., Dallas, Texas 75390, United States., Tong X; Department of Microbiology & Immunology, Weill Cornell Medicine, 1300 York Avenue, W-705, New York, New York 10065, United States., Rijo-Ferreira F; Department of Neuroscience, The University of Texas Southwestern Medical Center, 6000 Harry Hines Blvd., Dallas, Texas 75390, United States., Bhanu NV; Epigenetics Program, Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, 3400 Civic Center Blvd., Bldg. 421, Philadelphia, Pennsylvania 19104, United States., Miguel-Blanco C; Tres Cantos Medicines Development Campus, GlaxoSmithKline, P.T.M. Severo Ochoa, Tres Cantos, Madrid 28760, Spain., Lafuente-Monasterio MJ; Tres Cantos Medicines Development Campus, GlaxoSmithKline, P.T.M. Severo Ochoa, Tres Cantos, Madrid 28760, Spain., Garcia BA; Epigenetics Program, Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, 3400 Civic Center Blvd., Bldg. 421, Philadelphia, Pennsylvania 19104, United States., Kafsack BFC; Department of Microbiology & Immunology, Weill Cornell Medicine, 1300 York Avenue, W-705, New York, New York 10065, United States.; Biochemistry, Cell & Molecular Biology Graduate Program, Weill Cornell Medicine, 1300 York Avenue, W-705, New York, New York 10065, United States., Martinez ED; Department of Pharmacology, The University of Texas Southwestern Medical Center, 6000 Harry Hines Blvd., Dallas, Texas 75390, United States.; Hamon Center for Therapeutic Oncology Research, The University of Texas Southwestern Medical Center, 6000 Harry Hines Blvd., Dallas, Texas 75390, United States.

المصدر: ACS infectious diseases [ACS Infect Dis] 2020 May 08; Vol. 6 (5), pp. 1058-1075. Date of Electronic Publication: 2020 Apr 24.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: ACS Publications Country of Publication: United States NLM ID: 101654580 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2373-8227 (Electronic) Linking ISSN: 23738227 NLM ISO Abbreviation: ACS Infect Dis Subsets: MEDLINE

مواضيع طبية MeSH: Aminopyridines/*pharmacology , Hydrazones/*pharmacology , Jumonji Domain-Containing Histone Demethylases/*antagonists & inhibitors , Plasmodium falciparum/*drug effects, Animals ; Enzyme Inhibitors/pharmacology ; Histones ; Life Cycle Stages ; Lysine

المؤلفون: De Rycker M; Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery , University of Dundee , Dundee DD1 5EH , United Kingdom., Horn D; Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery , University of Dundee , Dundee DD1 5EH , United Kingdom., Aldridge B; Tufts University School of Medicine , 136 Harrison Avenue , Boston , Massachusetts 02111 , United States., Amewu RK; Department of Chemistry , University of Ghana , P.O. Box LG56, Legon, Accra , Ghana., Barry CE 3rd; National Institute of Allergy and Infectious Diseases , National Institutes of Health , 9000 Rockville Pike , Bethesda , Maryland 20892 , United States., Buckner FS; Center for Emerging and Re-emerging Infectious Diseases (CERID) , University of Washington , MS 358061, 750 Republican Street , Rm E-606, Seattle , Washington 98109-4766 , United States., Cook S; School of Humanities , University of Glasgow , 1 University Gardens , Glasgow G12 8QQ , United Kingdom., Ferguson MAJ; Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery , University of Dundee , Dundee DD1 5EH , United Kingdom., Gobeau N; Medicines for Malaria Venture (MMV) , PO Box 1826, 20 Route de Pré-Bois , 1215 Geneva 15, Switzerland., Herrmann J; Helmholtz Institute for Pharmaceutical Research Saarland, Department Microbial Natural Products , Saarland University , Campus E8.1, 66123 Saarbrücken , Germany.; German Centre for Infection Research , partner site Hannover-Braunschweig , Germany., Herrling P; Independent Consultant, Switzerland., Hope W; Institute of Translational Medicine , University of Liverpool , Liverpool L69 3BX , United Kingdom., Keiser J; Department of Medical Parasitology and Infection Biology , Swiss Tropical and Public Health Institute , Socinstrasse 57 , CH-4051 Basel , Switzerland.; University of Basel , CH-4001 Basel , Switzerland., Lafuente-Monasterio MJ; Tres Cantos Medicines Development Campus, Diseases of the Developing World (DDW) , GlaxoSmithKline , Tres Cantos , Spain., Leeson PD; Paul Leeson Consulting Ltd. , United Kingdom., Leroy D; Medicines for Malaria Venture (MMV) , PO Box 1826, 20 Route de Pré-Bois , 1215 Geneva 15, Switzerland., Manjunatha UH; Novartis Institute for Tropical Diseases (NITD) , Novartis Institutes for BioMedical Research (NIBR) , 5300 Chiron Way , Emeryville , California 94608 , United States., McCarthy J; QIMR Berghofer Medical Research Institute , 300 Herston Road , Hertson , Queensland 4006 , Australia., Miles TJ; Tres Cantos Medicines Development Campus, Diseases of the Developing World (DDW) , GlaxoSmithKline , Tres Cantos , Spain., Mizrahi V; SAMRC/NHLS/UCT Molecular Mycobacteriology Research Unit, Institute of Infectious Disease and Molecular Medicine and Wellcome Centre for Infectious Disease Research in Africa , University of Cape Town , Observatory, Cape Town 7925 , South Africa., Moshynets O; Biofilm Study Group , Institute of Molecular Biology and Genetics of National Academy of Sciences of Ukraine , 150 Zabolotnoho Street , Kiev 03143 , Ukraine., Niles J; School of Engineering , Massachusetts Institute of Technology , Building 1-206, 77 Massachusetts Avenue , Cambridge , Massachusetts 02139-4307 , United States., Overington JP; Medicines Discovery Catapult , Alderley Park, Alderley Edge, Cheshire SK10 4TG , United Kingdom., Pottage J; ViiV Healthcare , 980 Great West Road , Brentford , Middlesex TW8 9GS , United Kingdom., Rao SPS; Novartis Institute for Tropical Diseases (NITD) , Novartis Institutes for BioMedical Research (NIBR) , 5300 Chiron Way , Emeryville , California 94608 , United States., Read KD; Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery , University of Dundee , Dundee DD1 5EH , United Kingdom., Ribeiro I; Drugs for Neglected Diseases Initiative (DNDi) , Chemin Louis-Dunant 15 , 1202 Genève , Switzerland., Silver LL; LL Silver Consulting , New Jersey , United States., Southern J; Lancaster Institute for the Contemporary Arts (LICA), The LICA Building , Lancaster University , Lancaster LA1 4YW , United Kingdom., Spangenberg T; Global Health Institute of Merck, Ares Trading S.A. , a subsidiary of Merck KGaA Darmstadt Germany , Route de Crassier 1 , 1262 Eysins , Switzerland., Sundar S; Department of Medicine, Institute of Medical Sciences , Banaras Hindu University , Varanasi 221005 , India., Taylor C; SAMRC/NHLS/UCT Molecular Mycobacteriology Research Unit, Institute of Infectious Disease and Molecular Medicine and Wellcome Centre for Infectious Disease Research in Africa , University of Cape Town , Observatory, Cape Town 7925 , South Africa., Van Voorhis W; Center for Emerging and Re-emerging Infectious Diseases (CERID) , University of Washington , MS 358061, 750 Republican Street , Rm E-606, Seattle , Washington 98109-4766 , United States., White NJ; Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine , Mahidol University , 3/F, 60th Anniversary Chalermprakiat Building, 420/6 Rajvithi Road , Bangkok 10400, Thailand., Wyllie S; Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery , University of Dundee , Dundee DD1 5EH , United Kingdom., Wyatt PG; Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery , University of Dundee , Dundee DD1 5EH , United Kingdom., Gilbert IH; Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery , University of Dundee , Dundee DD1 5EH , United Kingdom.

المصدر: ACS infectious diseases [ACS Infect Dis] 2020 Jan 10; Vol. 6 (1), pp. 3-13. Date of Electronic Publication: 2019 Dec 06.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: ACS Publications Country of Publication: United States NLM ID: 101654580 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2373-8227 (Electronic) Linking ISSN: 23738227 NLM ISO Abbreviation: ACS Infect Dis Subsets: MEDLINE

مواضيع طبية MeSH: Communicable Disease Control* , Congresses as Topic*, Communicable Diseases/*drug therapy, Combined Modality Therapy ; Communicable Diseases/epidemiology ; Drug Discovery ; Drug Evaluation, Preclinical ; HIV Infections/drug therapy ; Humans ; Poverty ; United Kingdom

المؤلفون: Mandt REK; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA., Lafuente-Monasterio MJ; Tres Cantos Medicines Development Campus, Diseases of the Developing World, GlaxoSmithKline, Tres Cantos, 28760, Madrid, Spain., Sakata-Kato T; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA., Luth MR; Division of Host Pathogen Systems and Therapeutics, Department of Pediatrics, University of California San Diego, La Jolla, CA 92093, USA., Segura D; Tres Cantos Medicines Development Campus, Diseases of the Developing World, GlaxoSmithKline, Tres Cantos, 28760, Madrid, Spain., Pablos-Tanarro A; Tres Cantos Medicines Development Campus, Diseases of the Developing World, GlaxoSmithKline, Tres Cantos, 28760, Madrid, Spain., Viera S; Tres Cantos Medicines Development Campus, Diseases of the Developing World, GlaxoSmithKline, Tres Cantos, 28760, Madrid, Spain., Magan N; Tres Cantos Medicines Development Campus, Diseases of the Developing World, GlaxoSmithKline, Tres Cantos, 28760, Madrid, Spain., Ottilie S; Division of Host Pathogen Systems and Therapeutics, Department of Pediatrics, University of California San Diego, La Jolla, CA 92093, USA., Winzeler EA; Division of Host Pathogen Systems and Therapeutics, Department of Pediatrics, University of California San Diego, La Jolla, CA 92093, USA.; Skaggs School of Pharmaceutical Sciences, University of California San Diego, La Jolla, CA 92093, USA., Lukens AK; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.; Infectious Disease and Microbiome Program, Broad Institute, Cambridge, MA 02142, USA., Gamo FJ; Tres Cantos Medicines Development Campus, Diseases of the Developing World, GlaxoSmithKline, Tres Cantos, 28760, Madrid, Spain., Wirth DF; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA. dfwirth@hsph.harvard.edu.; Infectious Disease and Microbiome Program, Broad Institute, Cambridge, MA 02142, USA.

المصدر: Science translational medicine [Sci Transl Med] 2019 Dec 04; Vol. 11 (521).

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE

مواضيع طبية MeSH: Enzyme Inhibitors/*therapeutic use , Malaria, Falciparum/*drug therapy , Malaria, Falciparum/*parasitology , Oxidoreductases Acting on CH-CH Group Donors/*antagonists & inhibitors , Parasites/*enzymology, Animals ; Dihydroorotate Dehydrogenase ; Disease Models, Animal ; Drug Resistance/drug effects ; Enzyme Inhibitors/chemistry ; Enzyme Inhibitors/pharmacology ; Female ; Mice, SCID ; Oxidoreductases Acting on CH-CH Group Donors/genetics ; Oxidoreductases Acting on CH-CH Group Donors/metabolism ; Parasites/drug effects ; Phenotype ; Plasmodium falciparum ; Point Mutation/genetics ; Pyrimidines/chemistry ; Pyrimidines/pharmacology ; Pyrimidines/therapeutic use ; Triazoles/chemistry ; Triazoles/pharmacology ; Triazoles/therapeutic use

المؤلفون: Delves M; Department of Infection Biology, Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, United Kingdom.; Department of Life Sciences, Imperial College London, London, United Kingdom., Lafuente-Monasterio MJ; Diseases of the Developing World (DDW), GlaxoSmithKline, Tres Cantos, Spain., Upton L; Department of Life Sciences, Imperial College London, London, United Kingdom., Ruecker A; Department of Life Sciences, Imperial College London, London, United Kingdom.; Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom., Leroy D; Medicines for Malaria Venture, Geneva, Switzerland., Gamo FJ; Diseases of the Developing World (DDW), GlaxoSmithKline, Tres Cantos, Spain., Sinden R; Department of Life Sciences, Imperial College London, London, United Kingdom.

المصدر: Frontiers in microbiology [Front Microbiol] 2019 Sep 13; Vol. 10, pp. 2134. Date of Electronic Publication: 2019 Sep 13 (Print Publication: 2019).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Frontiers Research Foundation Country of Publication: Switzerland NLM ID: 101548977 Publication Model: eCollection Cited Medium: Print ISSN: 1664-302X (Print) Linking ISSN: 1664302X NLM ISO Abbreviation: Front Microbiol Subsets: PubMed not MEDLINE