نتائج البحث - "Laker RC"

المؤلفون: Golubic R; Wellcome-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, UK.; Oxford Centre for Diabetes Endocrinology and Metabolism, University of Oxford, Oxford, UK., Kennet J; Wellcome-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Parker V; Research and Early Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Robertson D; Research and Early Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Luo D; Statistics, Biometrics Oncology, Oncology R&D, AstraZeneca, Gaithersburg, Maryland, USA., Hansen L; Research and Early Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, Maryland, USA., Jermutus L; Research and Early Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Ambery P; Late Clinical Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Ryaboshapkina M; Translational Science and Experimental Medicine, Research and Early Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Surakala M; R&D IT, AstraZeneca, Cambridge, UK., Laker RC; Bioscience Metabolism, Research and Early Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, Maryland, USA., Venables M; MRC Epidemiology Unit, University of Cambridge, Cambridge, UK., Koulman A; MRC Epidemiology Unit, University of Cambridge, Cambridge, UK., Park A; Wellcome-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Evans M; Wellcome-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, UK.

المصدر: Diabetes, obesity & metabolism [Diabetes Obes Metab] 2024 Jul; Vol. 26 (7), pp. 2634-2644. Date of Electronic Publication: 2024 Apr 01.

نوع المنشور: Journal Article; Randomized Controlled Trial; Clinical Trial, Phase II

بيانات الدورية: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 100883645 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1463-1326 (Electronic) Linking ISSN: 14628902 NLM ISO Abbreviation: Diabetes Obes Metab Subsets: MEDLINE

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دورية أكاديمية

Hepatic glucagon action: beyond glucose mobilization.

المؤلفون: Kajani S; Early Cardiovascular, Renal and Metabolism, Biopharmaceuticals R&D, AstraZeneca, Gaithersburg, Maryland, United States., Laker RC; Early Cardiovascular, Renal and Metabolism, Biopharmaceuticals R&D, AstraZeneca, Gaithersburg, Maryland, United States., Ratkova E; Early Cardiovascular, Renal and Metabolism, Biopharmaceuticals R&D, AstraZeneca, Mölndal, Sweden., Will S; Early Cardiovascular, Renal and Metabolism, Biopharmaceuticals R&D, AstraZeneca, Gaithersburg, Maryland, United States., Rhodes CJ; Early Cardiovascular, Renal and Metabolism, Biopharmaceuticals R&D, AstraZeneca, Gaithersburg, Maryland, United States.

المصدر: Physiological reviews [Physiol Rev] 2024 Jul 01; Vol. 104 (3), pp. 1021-1060. Date of Electronic Publication: 2024 Feb 01.

نوع المنشور: Journal Article; Review; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Physiological Society Country of Publication: United States NLM ID: 0231714 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1522-1210 (Electronic) Linking ISSN: 00319333 NLM ISO Abbreviation: Physiol Rev Subsets: MEDLINE

مواضيع طبية MeSH: Glucagon*/metabolism , Liver*/metabolism , Glucose*/metabolism, Humans ; Animals ; Lipid Metabolism/physiology ; Homeostasis/physiology

9

دورية أكاديمية

Peptide-YY 3-36 /glucagon-like peptide-1 combination treatment of obese diabetic mice improves insulin sensitivity associated with recovered pancreatic β-cell function and synergistic activation of discrete hypothalamic and brainstem neuronal circuitries.

المؤلفون: Boland BB; Research and Early Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, USA; Research and Early Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK; Gubra ApS, Horsholm, Denmark; PRECISIONscientia, Yardley, PA, USA., Laker RC; Research and Early Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, USA; Research and Early Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., O'Brien S; Antibody and Protein Engineering, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, USA; Antibody and Protein Engineering, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Sitaula S; Research and Early Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, USA; Research and Early Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Sermadiras I; Antibody and Protein Engineering, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, USA; Antibody and Protein Engineering, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Nielsen JC; Gubra ApS, Horsholm, Denmark., Barkholt P; Gubra ApS, Horsholm, Denmark., Roostalu U; Gubra ApS, Horsholm, Denmark., Hecksher-Sørensen J; Gubra ApS, Horsholm, Denmark., Sejthen SR; Gubra ApS, Horsholm, Denmark., Thorbek DD; Gubra ApS, Horsholm, Denmark., Suckow A; Research and Early Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, USA; Research and Early Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK; DTX Pharma, San Diego, CA, USA., Burmeister N; Antibody and Protein Engineering, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, USA; Antibody and Protein Engineering, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK; Roche, Penzberg, Germany., Oldham S; Research and Early Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, USA; Research and Early Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Will S; Research and Early Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, USA; Research and Early Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Howard VG; Research and Early Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, USA; Research and Early Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Gill BM; Research and Early Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, USA; Research and Early Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Newton P; Antibody and Protein Engineering, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, USA; Antibody and Protein Engineering, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Naylor J; Research and Early Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, USA; Research and Early Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Hornigold DC; Research and Early Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, USA; Research and Early Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Austin J; University of Chicago Advanced Electron Microscopy Core Facility, Chicago, IL, USA., Lantier L; Vanderbilt University Mouse Metabolic Phenotyping Center, Nashville, TN, USA., McGuinness OP; Vanderbilt University Mouse Metabolic Phenotyping Center, Nashville, TN, USA., Trevaskis JL; Research and Early Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, USA; Research and Early Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK; Gilead Sciences, Foster City, CA, USA., Grimsby JS; Research and Early Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, USA; Research and Early Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Rhodes CJ; Research and Early Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, USA; Research and Early Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK. Electronic address: christopher.rhodes@astrazeneca.com.

المصدر: Molecular metabolism [Mol Metab] 2022 Jan; Vol. 55, pp. 101392. Date of Electronic Publication: 2021 Nov 12.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: Elsevier GmbH Country of Publication: Germany NLM ID: 101605730 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2212-8778 (Electronic) Linking ISSN: 22128778 NLM ISO Abbreviation: Mol Metab Subsets: MEDLINE

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دورية أكاديمية

Mitochondria-localized AMPK responds to local energetics and contributes to exercise and energetic stress-induced mitophagy.

المؤلفون: Drake JC; Center for Skeletal Muscle Research at Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA 22908; zy3m@virginia.edu joshuacd@vt.edu.; Department of Human Nutrition, Foods, and Exercise, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061., Wilson RJ; Center for Skeletal Muscle Research at Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA 22908.; Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, VA 22908., Laker RC; Center for Skeletal Muscle Research at Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA 22908., Guan Y; Center for Skeletal Muscle Research at Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA 22908.; Department of Pharmacology, University of Virginia School of Medicine, Charlottesville, VA 22908., Spaulding HR; Center for Skeletal Muscle Research at Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA 22908., Nichenko AS; Department of Human Nutrition, Foods, and Exercise, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061., Shen W; Center for Skeletal Muscle Research at Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA 22908., Shang H; Center for Skeletal Muscle Research at Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA 22908., Dorn MV; Center for Skeletal Muscle Research at Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA 22908., Huang K; Center for Skeletal Muscle Research at Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA 22908., Zhang M; Center for Skeletal Muscle Research at Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA 22908.; Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA 22908., Bandara AB; Department of Human Nutrition, Foods, and Exercise, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061., Brisendine MH; Department of Human Nutrition, Foods, and Exercise, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061., Kashatus JA; Department of Microbiology, Immunology and Cancer Biology, University of Virginia School of Medicine, Charlottesville, VA 22908., Sharma PR; Department of Biomedical Engineering, University of Virginia School of Medicine, Charlottesville, VA 22908., Young A; Center for Skeletal Muscle Research at Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA 22908., Gautam J; Department of Nephrology, University of Virginia School of Medicine, Charlottesville, VA 22908., Cao R; W. M. Keck Center for Cellular Imaging, University of Virginia, Charlottesville, VA 22904., Wallrabe H; W. M. Keck Center for Cellular Imaging, University of Virginia, Charlottesville, VA 22904.; Department of Biology, University of Virginia, Charlottesville, VA 22904., Chang PA; Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA 94305., Wong M; Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA 94305., Desjardins EM; Centre for Metabolism, Obesity and Diabetes Research, Department of Medicine, McMaster University, Hamilton ON L8N 3Z5, Canada.; Department of Medicine, McMaster University, Hamilton ON L8N 3Z5, Canada., Hawley SA; Division of Cell Signaling and Immunology, School of Life Sciences, University of Dundee, DD1 5EH Scotland, United Kingdom., Christ GJ; Department of Biomedical Engineering, University of Virginia School of Medicine, Charlottesville, VA 22908.; Department of Orthopaedic Surgery, University of Virginia School of Medicine, Charlottesville, VA 22908., Kashatus DF; Department of Microbiology, Immunology and Cancer Biology, University of Virginia School of Medicine, Charlottesville, VA 22908., Miller CL; Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, VA 22908.; Department of Biomedical Engineering, University of Virginia School of Medicine, Charlottesville, VA 22908.; Department of Public Health Sciences, University of Virginia School of Medicine, Charlottesville, VA 22908.; Center for Public Health Genomics, University of Virginia School of Medicine, Charlottesville, VA 22908., Wolf MJ; Center for Skeletal Muscle Research at Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA 22908.; Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA 22908., Periasamy A; W. M. Keck Center for Cellular Imaging, University of Virginia, Charlottesville, VA 22904.; Department of Biology, University of Virginia, Charlottesville, VA 22904., Steinberg GR; Centre for Metabolism, Obesity and Diabetes Research, Department of Medicine, McMaster University, Hamilton ON L8N 3Z5, Canada.; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton ON L8N 3Z5, Canada., Hardie DG; Division of Cell Signaling and Immunology, School of Life Sciences, University of Dundee, DD1 5EH Scotland, United Kingdom., Yan Z; Center for Skeletal Muscle Research at Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA 22908; zy3m@virginia.edu joshuacd@vt.edu.; Department of Pharmacology, University of Virginia School of Medicine, Charlottesville, VA 22908.; Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA 22908.; Department of Molecular Physiology and Biological Physics, University of Virginia School of Medicine, Charlottesville, VA 22908.

المصدر: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2021 Sep 14; Vol. 118 (37).

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

مواضيع طبية MeSH: Energy Metabolism* , Mitophagy* , Physical Conditioning, Animal*, AMP-Activated Protein Kinases/*metabolism , Mitochondria/*pathology, AMP-Activated Protein Kinases/genetics ; Animals ; Humans ; Male ; Mice ; Mitochondria/metabolism

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