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1
المؤلفون: Ching Kim Tye, Chunhong Yan, Sarah C. Traeger, Wayne Vaccaro, Yingru Zhang, Gerry Everlof, Jianqing Li, Henry Yip, Peng Li, John T. Hunt, Michael A. Poss, Gregory D. Vite, Mussari Christopher P, Steven Sheriff, Asoka Ranasinghe, Haiying Zhang, Richard A. Westhouse, Dharmpal S. Dodd, Richard Rampulla, Zheng Yang, Frank Marsilio, Derek J. Norris, Wen-Ching Han, Tram N. Huynh, Yufen Zhao, Patrice Gill, Nirmala Raghavan, Lalgudi S. Harikrishnan, Ashvinikumar V. Gavai, Susan Wee, John S. Tokarski, Dauh-Rurng Wu, Arvind Mathur, Mei-Li Wen, Huiping Zhang, David R. Tortolani, George V. Delucca, Krista Menard, Francis Y. Lee, Claude A. Quesnelle, Dawn Sun, Vijay T. Ahuja, Daniel O'malley, Christine Huang, Muthoni G. Kamau
المصدر: Journal of Medicinal Chemistry. 64:14247-14265
مصطلحات موضوعية: Drug, Proline, Phenylalanine, media_common.quotation_subject, Carbazoles, Administration, Oral, Antineoplastic Agents, Cell Cycle Proteins, Computational biology, BET inhibitor, Structure-Activity Relationship, Pharmacokinetics, In vivo, Drug Discovery, Transcriptional regulation, Humans, Potency, media_common, Dose-Response Relationship, Drug, Molecular Structure, Chemistry, Tryptophan, Signal transducing adaptor protein, Bromodomain, Molecular Medicine, Transcription Factors
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2
المؤلفون: Zhenqiu Hong, Brian E. Fink, Darpandeep Aulakh, Peng Li, Gregory D. Vite, Xiaoping Hou, Dawn Sun, Aaron Smith, Bei Wang, Amy A. Sarjeant, James Kempson, Arvind Mathur, Lan-Ying Qin, Martins S. Oderinde, Rulin Zhao, Peter K. Park, Lalgudi S. Harikrishnan, Dauh-Rurng Wu, Joseph Pawluczyk, Cornelius Lyndon A M, Huiping Zhang, Janet Caceres-Cortes, Shiuhang Yip, Dharmpal S. Dodd
المصدر: The Journal of organic chemistry. 86(13)
مصطلحات موضوعية: Agonist, 010405 organic chemistry, Stereochemistry, Chemistry, medicine.drug_class, Organic Chemistry, Absolute configuration, Conclusive evidence, 010402 general chemistry, 01 natural sciences, 0104 chemical sciences, Stereospecificity, Reagent, medicine, Chirality (chemistry)
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3
المؤلفون: Ji Jiang, Tammy C. Wang, Alice Ye A. Chen, Xiaohong Yin, Jennifer X. Qiao, Ming Chang, Muthoni G. Kamau, Julia Li, David S. Taylor, Leonard P. Adam, Lalgudi S. Harikrishnan, Xue-Qing Chen, Heather Finlay, R. Michael Lawrence, Richard Rampulla, Paul Levesque, Christine Huang, Paul G. Sleph, Carrie Xu, Ruth R. Wexler, Mark E. Salvati
المصدر: ACS Med Chem Lett
مصطلحات موضوعية: biology, Chemistry, Organic Chemistry, Drug Discovery, Cholesterylester transfer protein, biology.protein, Pharmacology, Lead (electronics), Biochemistry, CETP inhibitor, Coronary heart disease
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4
المؤلفون: Yanling Huang, Jingwu Duan, Carolyn A. Weigelt, Cullen L. Cavallaro, Javed Khan, Brian E. Fink, Muthoni G. Kamau, Zheming Ruan, Lan-Ying Qin, Sylwia Stachura, Cliff Chen, Murali Gururajan, Lalgudi S. Harikrishnan, Tram N. Huynh, John S. Sack, Anwar Murtaza, Daniel O'malley, Zhuyin Li, Melissa Yarde, Max Ruzanov, Virna Borowski, Patrice Gill, Huadong Sun, Zhonghui Lu, Jessica J. Wong
المصدر: Bioorganicmedicinal chemistry letters. 30(12)
مصطلحات موضوعية: Agonist, Drug, medicine.drug_class, Receptors, Retinoic Acid, media_common.quotation_subject, Clinical Biochemistry, Retinoic acid, Pharmaceutical Science, Pharmacology, 01 natural sciences, Biochemistry, chemistry.chemical_compound, Mice, Structure-Activity Relationship, Pharmacokinetics, RAR-related orphan receptor gamma, Heterocyclic Compounds, Drug Discovery, Benzyl Compounds, medicine, Animals, Molecular Biology, media_common, Orphan receptor, chemistry.chemical_classification, Dose-Response Relationship, Drug, Molecular Structure, 010405 organic chemistry, Organic Chemistry, 0104 chemical sciences, Mice, Inbred C57BL, 010404 medicinal & biomolecular chemistry, chemistry, Pharmacodynamics, Molecular Medicine, Female, Tricyclic
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5
المؤلفون: Barri Wautlet, Lalgudi S. Harikrishnan, Jonathan Lippy, Andrew J. Tebben, Amol G. Dikundwar, P.N. Arunachalam, Raju Mannoori, Max Ruzanov, Yi Fan, Gopikishan Tonukunuru, Vishweshwaraiah Baligar, Mark Fereshteh, Balaji Seshadri, Jayakumar Warrier, Sudhakara R. Madduri, Joseph Fargnoli, Robert M. Borzilleri, Ching-Ping Ho, Brian E. Fink, Steven Sheriff, Hasibur Rahaman
المصدر: Bioorganic & Medicinal Chemistry. 26:1026-1034
مصطلحات موضوعية: 0301 basic medicine, Epithelial-Mesenchymal Transition, T-Lymphocytes, Clinical Biochemistry, Receptor, Transforming Growth Factor-beta Type I, Thiazines, Pharmaceutical Science, Smad Proteins, SMAD, Molecular Dynamics Simulation, Protein Serine-Threonine Kinases, Crystallography, X-Ray, Biochemistry, Bridged Bicyclo Compounds, Structure-Activity Relationship, 03 medical and health sciences, 0302 clinical medicine, In vivo, Drug Discovery, TGF beta signaling pathway, Humans, Pyrroles, Epithelial–mesenchymal transition, Phosphorylation, Molecular Biology, Cells, Cultured, Binding Sites, Chemistry, Organic Chemistry, In vitro, Protein Structure, Tertiary, 030104 developmental biology, Drug Design, 030220 oncology & carcinogenesis, Cancer research, Molecular Medicine, Signal transduction, Receptors, Transforming Growth Factor beta, Protein Binding, Transforming growth factor
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6
المؤلفون: Yanling Huang, Murali Gururajan, Cullen L. Cavallaro, Zhuyin Li, Ashok V. Purandare, Jessica J. Wong, Jenny Xie, Sylwia Stachura, Huadong Sun, Lalgudi S. Harikrishnan, Javed Khan, Brian E. Fink, Carolyn A. Weigelt, Honghe Wan, Peter K. Park, Daniel O'malley, Michele Agler, Cliff Chen, John S. Sack, Donna D. Wei, Zheming Ruan, Melissa Yarde, Heidi L. Perez, Monique Anthony, Virna Borowski, Max Ruzanov
المصدر: Bioorganic & Medicinal Chemistry Letters. 35:127778
مصطلحات موضوعية: Models, Molecular, Agonist, medicine.drug_class, Clinical Biochemistry, Retinoic acid, Pharmaceutical Science, Tretinoin, Pharmacology, Crystallography, X-Ray, 01 natural sciences, Biochemistry, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Pharmacokinetics, RAR-related orphan receptor gamma, Drug Discovery, medicine, Animals, Humans, Potency, Molecular Biology, Orphan receptor, Diaryl ether, Dose-Response Relationship, Drug, Molecular Structure, 010405 organic chemistry, Organic Chemistry, Nuclear Receptor Subfamily 1, Group F, Member 3, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, chemistry, Th17 Cells, Molecular Medicine, Lead compound, Ethers
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المؤلفون: Leonard P. Adam, James A. Johnson, Paul G. Sleph, Ruth R. Wexler, Heather Finlay, Mark E. Salvati, Lalgudi S. Harikrishnan, David S. Taylor, Alice Ye A. Chen, Xiaohong Yin, Richard Yang, Muthoni G. Kamau, Jennifer X. Qiao, Tammy C. Wang, Ji Jiang
المصدر: Bioorganic & Medicinal Chemistry Letters. 26:3278-3281
مصطلحات موضوعية: Genetically modified mouse, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Mice, Transgenic, 030204 cardiovascular system & hematology, 01 natural sciences, Biochemistry, Mice, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Drug Discovery, Cholesterylester transfer protein, Animals, Humans, Potency, Amines, Molecular Biology, Dose-Response Relationship, Drug, Molecular Structure, biology, 010405 organic chemistry, Cholesterol, Organic Chemistry, In vitro, Cholesterol Ester Transfer Proteins, 0104 chemical sciences, chemistry, biology.protein, Molecular Medicine, lipids (amino acids, peptides, and proteins), Lead compound
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8
المؤلفون: Daniel Smith, Richard Rampulla, Xue-Qing Chen, Bilder Donna M, Xiaohong Yin, Ruth R. Wexler, Hong Shen, Yi-Xin Li, Richard Yang, Tammy C. Wang, Julia P. Li, David A. Gordon, Ming Chang, Leslie Leith, Carrie Xu, Lalgudi S. Harikrishnan, Paul G. Sleph, Dauh-Rurng Wu, R. Michael Lawrence, David S. Taylor, Christine Huang, Heather Finlay, Muthoni G. Kamau, Jianqing Li, Alice Ye A. Chen, Leonard P. Adam, Paul Levesque, Danshi Li, Mark E. Salvati, Shaobin Zhuang, Jennifer X. Qiao, Michael M. Miller, Michael A. Poss
المصدر: Journal of Medicinal Chemistry. 58:9010-9026
مصطلحات موضوعية: Aldosterone synthase, biology, Chemistry, Cholesterol, Stereochemistry, Reverse cholesterol transport, Torcetrapib, chemistry.chemical_compound, Drug Discovery, Cholesterylester transfer protein, biology.protein, Cholesteryl ester, Molecular Medicine, lipids (amino acids, peptides, and proteins), Benzamide, CETP inhibitor
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9
المؤلفون: Heather Finlay, Mark E. Salvati, R. Michael Lawrence, Muthoni G. Kamau, Michael A. Poss, Jennifer X. Qiao, Ji Jiang, Lalgudi S. Harikrishnan, Ruth R. Wexler
المصدر: Tetrahedron. 68:2696-2703
مصطلحات موضوعية: chemistry.chemical_classification, chemistry.chemical_compound, chemistry, Scale (ratio), Organic Chemistry, Drug Discovery, Imine, Enantioselective synthesis, Organic chemistry, Salt (chemistry), Biochemistry
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10
المؤلفون: Dauh-Rurng Wu, Zheng Yang, Steven Sheriff, Muthoni G. Kamau, Lalgudi S. Harikrishnan, Dharmpal S. Dodd, Henry Yip, Christine Huang, Yingru Zhang, Yufen Zhao, Jianqing Li, Richard A. Westhouse, Richard Rampulla, Ashvinikumar V. Gavai, Haiying Zhang, Susan Wee, Dawn Sun, Gerry Everlof, Tram N. Huynh, Ching Su, Derek J. Norris, Arvind Mathur, Wayne Vaccaro, Peng Li, Huiping Zhang, Gregory D. Vite, Mussari Christopher P, John T. Hunt, Asoka Ranasinghe, David R. Tortolani, Nirmala Raghavan, Celia D’Arienzo, Daniel O'malley, Vijay T. Ahuja, Patrice Gill, Lisa Zhang, Claude A. Quesnelle, Tokarski John S, Michael A. Poss
المصدر: Cancer Research. 78:5789-5789
مصطلحات موضوعية: 0301 basic medicine, Cancer Research, Thermal shift assay, BRD4, Oncogene, Chemistry, Cancer, medicine.disease, Bromodomain, BET inhibitor, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Oncology, In vivo, 030220 oncology & carcinogenesis, Cancer cell, Cancer research, medicine
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::ad3948219544cdcb29d5e3baea4000aa
https://doi.org/10.1158/1538-7445.am2018-5789
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