نتائج البحث - "Lan-Ying Qin"

1

A Stereocontrolled Synthesis of a Phosphorothioate Cyclic Dinucleotide-Based STING Agonist

المصدر: The Journal of organic chemistry. 86(13)

مصطلحات موضوعية: Agonist, 010405 organic chemistry, Stereochemistry, Chemistry, medicine.drug_class, Organic Chemistry, Absolute configuration, Conclusive evidence, 010402 general chemistry, 01 natural sciences, 0104 chemical sciences, Stereospecificity, Reagent, medicine, Chirality (chemistry)

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6369d2614241414c22a55b878cc89a63
https://pubmed.ncbi.nlm.nih.gov/34126006

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2

Substituted benzyloxytricyclic compounds as retinoic acid-related orphan receptor gamma t (RORγt) agonists

المصدر: Bioorganicmedicinal chemistry letters. 30(12)

مصطلحات موضوعية: Agonist, Drug, medicine.drug_class, Receptors, Retinoic Acid, media_common.quotation_subject, Clinical Biochemistry, Retinoic acid, Pharmaceutical Science, Pharmacology, 01 natural sciences, Biochemistry, chemistry.chemical_compound, Mice, Structure-Activity Relationship, Pharmacokinetics, RAR-related orphan receptor gamma, Heterocyclic Compounds, Drug Discovery, Benzyl Compounds, medicine, Animals, Molecular Biology, media_common, Orphan receptor, chemistry.chemical_classification, Dose-Response Relationship, Drug, Molecular Structure, 010405 organic chemistry, Organic Chemistry, 0104 chemical sciences, Mice, Inbred C57BL, 010404 medicinal & biomolecular chemistry, chemistry, Pharmacodynamics, Molecular Medicine, Female, Tricyclic

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d28391368dbe9fe0275182d85ed69ba6
https://pubmed.ncbi.nlm.nih.gov/32334911

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3

Abstract 1140: A novel MTA non-competitive PRMT5 inhibitor

المصدر: Cancer Research. 81:1140-1140

مصطلحات موضوعية: Cancer Research, Gene knockdown, Chemistry, Protein arginine methyltransferase 5, Cancer, medicine.disease, Molecular biology, In vitro, law.invention, Oncology, CDKN2A, In vivo, law, Cancer cell, medicine, Suppressor

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::769a298e5dedd6469a5cf85008a3a619
https://doi.org/10.1158/1538-7445.am2021-1140

4

Discovery of 7-(3-(piperazin-1-yl)phenyl)pyrrolo[2,1-f][1,2,4]triazin-4-amine derivatives as highly potent and selective PI3Kδ inhibitors

المصدر: Bioorganic & Medicinal Chemistry Letters. 27:855-861

مصطلحات موضوعية: 0301 basic medicine, Class I Phosphatidylinositol 3-Kinases, Stereochemistry, Clinical Biochemistry, Drug Evaluation, Preclinical, Pharmaceutical Science, Pharmacology, Crystallography, X-Ray, Biochemistry, Piperazines, Autoimmune Diseases, Mice, Phosphatidylinositol 3-Kinases, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Immune system, In vivo, Drug Discovery, Animals, Humans, Protein Isoforms, Amines, Piperazine, Protein Kinase Inhibitors, Molecular Biology, Phosphoinositide-3 Kinase Inhibitors, Amine derivatives, Binding Sites, Triazines, Organic Chemistry, Alternative treatment, Molecular Docking Simulation, Disease Models, Animal, 030104 developmental biology, chemistry, 030220 oncology & carcinogenesis, Microsomes, Liver, Molecular Medicine, Lead compound

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a62fd58c8612f99a2829596d8b0690e5
https://doi.org/10.1016/j.bmcl.2017.01.016

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5

Discovery and SAR of pyrrolo[2,1-f][1,2,4]triazin-4-amines as potent and selective PI3Kδ inhibitors

المؤلفون: Carolyn A. Weigelt, Xiaomei Gu, Lan-Ying Qin, Christine B. Goldstine, Sylwia Stachura, Jenny Xie, Zheming Ruan, T. G. Murali Dhar, Donna L. Pedicord, Michael A. Poss, Luisa Salter-Cid, Rajeev S. Bhide, Percy H. Carter, James Neels, John S. Sack, Stefan Ruepp, Kevin Stefanski, Paul Davies, Stacey Skala

المصدر: Bioorganic & Medicinal Chemistry Letters. 26:4256-4260

مصطلحات موضوعية: 0301 basic medicine, Gene isoform, Clinical Biochemistry, Drug Evaluation, Preclinical, Pharmaceutical Science, chemical and pharmacologic phenomena, Phosphatidylinositol 3-Kinases, Biochemistry, PI3K signaling, Inhibitory Concentration 50, Mice, Structure-Activity Relationship, 03 medical and health sciences, 0302 clinical medicine, Drug Discovery, Animals, Protein Isoforms, Structure–activity relationship, Amines, Protein Kinase Inhibitors, Molecular Biology, Phosphoinositide-3 Kinase Inhibitors, Binding Sites, biology, Triazines, Chemistry, Arthritis, Organic Chemistry, Protein Structure, Tertiary, Molecular Docking Simulation, Disease Models, Animal, 030104 developmental biology, 030220 oncology & carcinogenesis, biology.protein, Molecular Medicine, Keyhole limpet hemocyanin, Protein Binding, Collagen-induced arthritis

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdaa3a62c46009198cffe25f36688ef7
https://doi.org/10.1016/j.bmcl.2016.07.047

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6

Identification of a Potent, Selective, and Efficacious Phosphatidylinositol 3-Kinase δ (PI3Kδ) Inhibitor for the Treatment of Immunological Disorders

المؤلفون: Dezhi Xing, Carolyn A. Weigelt, Luisa Salter-Cid, Pirama Nayagam Arunachalam, Rodney B.W. Smith, Ling Li, Melissa Yarde, Jodi K. Muckelbauer, Jonathan Lippy, Mary Ellen Cvijic, Sidney Pitt, John S. Sack, Thatipamula Rp, Michael A. Poss, Paul Levesque, Robert J. Cherney, Ipsit Kundu, David Marcoux, Gary L. Schieven, Arvind Mathur, Qingjie Liu, Zheming Ruan, Rosemary Zhang, R M Fancher, Shweta Padmanabhan, Scott H. Watterson, Qing Shi, Mary T. Obermeier, Anurag S. Srivastava, Anuradha Gupta, Douglas G. Batt, James Neels, Joseph A. Tino, Kevin Stefanski, Percy H. Carter, Macor John E, John Hynes, Myra Beaudoin-Bertrand, Hao Lu, Kim W. McIntyre, Stacey Skala, Aberra Fura, Lan-Ying Qin, Cornelius Lyndon A M, James Hennan, Richard Rampulla, Bogdan Sleczka, Jenny Xie, Kallem Rajareddy, Jie Pan, Christine B. Goldstine, Hua Gong, Qian Ruan, Kathleen M. Gillooly, Donna L. Pedicord, Jingsong Fan, Rajeev S. Bhide, Stefan Ruepp

المصدر: Journal of medicinal chemistry. 60(12)

مصطلحات موضوعية: 0301 basic medicine, Antigens, Differentiation, T-Lymphocyte, Male, ERG1 Potassium Channel, hERG, Drug Evaluation, Preclinical, Phosphatidylinositol 3-Kinases, Pharmacology, Pyrazole, 03 medical and health sciences, chemistry.chemical_compound, Structure-Activity Relationship, Dogs, Antigens, CD, Drug Discovery, Structure–activity relationship, Potency, Animals, Humans, Lectins, C-Type, Phosphatidylinositol, Enzyme Inhibitors, Phosphoinositide-3 Kinase Inhibitors, Mice, Inbred BALB C, biology, Kinase, Arthritis, Experimental, Isoenzymes, 030104 developmental biology, chemistry, Immune System Diseases, biology.protein, Molecular Medicine, Pyrazoles, Female, Efflux, Rabbits, Caco-2 Cells

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e67ea5386a71d40a3c8aca591866f2ab
https://pubmed.ncbi.nlm.nih.gov/28541707

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7

Identification of highly potent and selective PI3Kδ inhibitors

المؤلفون: Rajeev S. Bhide, Carolyn A. Weigelt, David Marcoux, Zheming Ruan, Joseph A. Tino, Lan-Ying Qin, Qian Ruan, John Hynes, Qing Shi, Michael A. Poss, Hongchen Qiu, Gary L. Schieven

المصدر: Bioorganicmedicinal chemistry letters. 27(13)

مصطلحات موضوعية: 0301 basic medicine, Gene isoform, Models, Molecular, Clinical Biochemistry, Pharmaceutical Science, Phosphatidylinositol 3-Kinases, Pharmacology, Biochemistry, 03 medical and health sciences, Mice, Structure-Activity Relationship, 0302 clinical medicine, Drug Discovery, medicine, Structure–activity relationship, Animals, Humans, Kinome, Molecular Biology, Protein Kinase Inhibitors, PI3K/AKT/mTOR pathway, Phosphoinositide-3 Kinase Inhibitors, Dose-Response Relationship, Drug, Molecular Structure, Chemistry, Organic Chemistry, Highly selective, medicine.disease, 030104 developmental biology, 030220 oncology & carcinogenesis, Rheumatoid arthritis, Molecular Medicine, Identification (biology)

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::faa6e633769aca402bfa7c285b9d57d2
https://pubmed.ncbi.nlm.nih.gov/28209465

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8

Synthesis of novel substituted 3,8,11-triazaspiro[5,6]dodecan-7-ones

المؤلفون: Ian R. Henderson, Lan-Ying Qin, Axel Metzger, Kurt W. Saionz, Andrew G. Cole

المصدر: Tetrahedron Letters. 52:849-852

مصطلحات موضوعية: chemistry.chemical_compound, chemistry, Yield (chemistry), Organic Chemistry, Drug Discovery, Piperidine, Biochemistry, Combinatorial chemistry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::f245d43a2ed805654a8e49cd62337ea4
https://doi.org/10.1016/j.tetlet.2010.11.150

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9

A facile synthesis of novel 2-amino-6-arylmethyl-7-carboxamido-7,8-dihydropyrimido[5,4-f][1,4]thiazepin-5-ones

المؤلفون: Lan-Ying Qin, Kurt W. Saionz, Roland E. Dolle, Baldwin John J, Marc-Raleigh Brescia, Joan J. Zhang, James R. Wareing, Ian R. Henderson, Juerg Zimmermann, Axel Metzger, Pascal Rigollier, Hubert Gstach, Andrew G. Cole

المصدر: Tetrahedron Letters. 51:4486-4489

مصطلحات موضوعية: Organic Chemistry, Biochemistry, Combinatorial chemistry, Chloride, Acylation, chemistry.chemical_compound, chemistry, Yield (chemistry), Drug Discovery, medicine, Amine gas treating, Derivative (chemistry), Cysteine, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::612c6229b945ede53f82e56c7f50e463
https://doi.org/10.1016/j.tetlet.2010.06.070

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10

Abstract B198: Targeting CSK kinase activity to enhance antitumor immunity

المؤلفون: Brian E. Fink, Jesse Swanson, Lan-Ying Qin, Rukiye Eraslan, Miguel Sanjuan, Gregory D. Vite, John T. Hunt, Lisa Berman-Booty, Cindy Wang, Susan Wee, Carolyn Cao

المصدر: Molecular Cancer Therapeutics. 17:B198-B198

مصطلحات موضوعية: Cancer Research, Kinase, Chemistry, medicine.medical_treatment, T-cell receptor, Proinflammatory cytokine, Cytokine, Immune system, Oncology, Knockout mouse, Cancer research, medicine, Kinase activity, Proto-oncogene tyrosine-protein kinase Src

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::aeb73cc83e29905b2422701159313ed8
https://doi.org/10.1158/1535-7163.targ-17-b198

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