المؤلفون: Boerth JA; Medicinal Chemistry, Research and Early Development, Oncology R&D, AstraZeneca, Waltham, Massachusetts 02451, United States., Chinn AJ; Medicinal Chemistry, Research and Early Development, Oncology R&D, AstraZeneca, Waltham, Massachusetts 02451, United States., Schimpl M; Discovery Sciences, R&D, The Discovery Centre, AstraZeneca, Cambridge Biomedical Campus, 1 Francis Crick Avenue, Cambridge CB2 0AA, United Kingdom., Bommakanti G; Bioscience, Oncology R&D, AstraZeneca, Waltham, Massachusetts 02451, United States., Chan C; DMPK, Research and Early Development, Oncology R&D, AstraZeneca, Cambridge Biomedical Campus, 1 Francis Crick Avenue, Cambridge CB2 0AA, United Kingdom., Code EL; Discovery Sciences, R&D, AstraZeneca, Waltham, Massachusetts 02451, United States., Giblin KA; Medicinal Chemistry, Research and Early Development, Oncology R&D, AstraZeneca, Cambridge Biomedical Campus, 1 Francis Crick Avenue, Cambridge CB2 0AA, United Kingdom., Gohlke A; Discovery Sciences, R&D, The Discovery Centre, AstraZeneca, Cambridge Biomedical Campus, 1 Francis Crick Avenue, Cambridge CB2 0AA, United Kingdom., Hansel CS; Discovery Sciences, R&D, The Discovery Centre, AstraZeneca, Cambridge Biomedical Campus, 1 Francis Crick Avenue, Cambridge CB2 0AA, United Kingdom., Jin M; Medicinal Chemistry, Research and Early Development, Oncology R&D, AstraZeneca, Waltham, Massachusetts 02451, United States., Kavanagh SL; Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Cambridge CB2 0AA, United Kingdom., Lamb ML; Medicinal Chemistry, Research and Early Development, Oncology R&D, AstraZeneca, Waltham, Massachusetts 02451, United States., Lane JS; Discovery Sciences, R&D, The Discovery Centre, AstraZeneca, Cambridge Biomedical Campus, 1 Francis Crick Avenue, Cambridge CB2 0AA, United Kingdom., Larner CJB; Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Cambridge CB2 0AA, United Kingdom., Mfuh AM; Medicinal Chemistry, Research and Early Development, Oncology R&D, AstraZeneca, Waltham, Massachusetts 02451, United States., Moore RK; High Throughput Screening, Hit Discovery, Discovery Sciences, R&D BioPharmaceuticals, AstraZeneca, Alderley Park, Macclesfield SK10 4TG, United Kingdom., Puri T; Medicinal Chemistry, Research and Early Development, Oncology R&D, AstraZeneca, Waltham, Massachusetts 02451, United States., Quinn TR; Medicinal Chemistry, Research and Early Development, Oncology R&D, AstraZeneca, Waltham, Massachusetts 02451, United States., Ye M; Bioscience, Oncology R&D, AstraZeneca, Waltham, Massachusetts 02451, United States., Robbins KJ; Medicinal Chemistry, Research and Early Development, Oncology R&D, AstraZeneca, Waltham, Massachusetts 02451, United States., Gancedo-Rodrigo M; Discovery Sciences, R&D, The Discovery Centre, AstraZeneca, Cambridge Biomedical Campus, 1 Francis Crick Avenue, Cambridge CB2 0AA, United Kingdom., Tang H; Discovery Sciences, R&D, The Discovery Centre, AstraZeneca, Cambridge Biomedical Campus, 1 Francis Crick Avenue, Cambridge CB2 0AA, United Kingdom., Walsh J; High Throughput Screening, Hit Discovery, Discovery Sciences, R&D BioPharmaceuticals, AstraZeneca, Alderley Park, Macclesfield SK10 4TG, United Kingdom., Ware J; Discovery Sciences, R&D, The Discovery Centre, AstraZeneca, Cambridge Biomedical Campus, 1 Francis Crick Avenue, Cambridge CB2 0AA, United Kingdom., Wrigley GL; Medicinal Chemistry, Research and Early Development, Oncology R&D, AstraZeneca, Cambridge Biomedical Campus, 1 Francis Crick Avenue, Cambridge CB2 0AA, United Kingdom., Reddy IK; Bioscience, Oncology R&D, AstraZeneca, Waltham, Massachusetts 02451, United States., Zhang Y; Medicinal Chemistry, Research and Early Development, Oncology R&D, AstraZeneca, Waltham, Massachusetts 02451, United States., Grimster NP; Medicinal Chemistry, Research and Early Development, Oncology R&D, AstraZeneca, Waltham, Massachusetts 02451, United States.

المصدر: ACS medicinal chemistry letters [ACS Med Chem Lett] 2023 Nov 17; Vol. 14 (12), pp. 1848-1856. Date of Electronic Publication: 2023 Nov 17 (Print Publication: 2023).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101521073 Publication Model: eCollection Cited Medium: Print ISSN: 1948-5875 (Print) Linking ISSN: 19485875 NLM ISO Abbreviation: ACS Med Chem Lett Subsets: PubMed not MEDLINE

المؤلفون: Scott JS; Oncology R&D, AstraZeneca, Cambridge CB4 0WG, United Kingdom., Stead D; Oncology R&D, AstraZeneca, Cambridge CB4 0WG, United Kingdom., Barlaam B; Oncology R&D, AstraZeneca, Cambridge CB4 0WG, United Kingdom., Breed J; Discovery Sciences R&D, AstraZeneca, Cambridge CB4 0WG, United Kingdom., Carbajo RJ; Oncology R&D, AstraZeneca, Cambridge CB4 0WG, United Kingdom., Chiarparin E; Oncology R&D, AstraZeneca, Cambridge CB4 0WG, United Kingdom., Cureton N; Oncology R&D, AstraZeneca, Cambridge CB4 0WG, United Kingdom., Davey PRJ; Oncology R&D, AstraZeneca, Cambridge CB4 0WG, United Kingdom., Fisher DI; Discovery Sciences R&D, AstraZeneca, Cambridge CB4 0WG, United Kingdom., Gangl ET; Oncology R&D, AstraZeneca, R&D Boston, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States., Grebe T; Oncology R&D, AstraZeneca, R&D Boston, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States., Greenwood RD; Oncology R&D, AstraZeneca, Cambridge CB4 0WG, United Kingdom., Hande S; Oncology R&D, AstraZeneca, R&D Boston, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States., Hatoum-Mokdad H; Oncology R&D, AstraZeneca, R&D Boston, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States., Hughes SJ; Oncology R&D, AstraZeneca, Cambridge CB4 0WG, United Kingdom., Hunt TA; Oncology R&D, AstraZeneca, Cambridge CB4 0WG, United Kingdom., Johnson T; Oncology R&D, AstraZeneca, Cambridge CB4 0WG, United Kingdom., Kavanagh SL; Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Cambridge CB2 OAA, United Kingdom., Klinowska TCM; Oncology R&D, AstraZeneca, Cambridge CB4 0WG, United Kingdom., Larner CJB; Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Cambridge CB2 OAA, United Kingdom., Lawson M; Oncology R&D, AstraZeneca, Cambridge CB4 0WG, United Kingdom., Lister AS; Oncology R&D, AstraZeneca, Cambridge CB4 0WG, United Kingdom., Longmire D; Oncology R&D, AstraZeneca, Cambridge CB4 0WG, United Kingdom., Marden S; Advanced Drug Delivery, Pharmaceutical Sciences, R&D, Boston, Massachusetts 02451, United States., McGuire TM; Oncology R&D, AstraZeneca, Cambridge CB4 0WG, United Kingdom., McMillan C; Oncology R&D, AstraZeneca, Cambridge CB4 0WG, United Kingdom., McMurray L; Oncology R&D, AstraZeneca, Cambridge CB4 0WG, United Kingdom., Morrow CJ; Oncology R&D, AstraZeneca, Cambridge CB4 0WG, United Kingdom., Nissink JWM; Oncology R&D, AstraZeneca, Cambridge CB4 0WG, United Kingdom., Moss TA; Oncology R&D, AstraZeneca, Cambridge CB4 0WG, United Kingdom., O'Donovan DH; Oncology R&D, AstraZeneca, Cambridge CB4 0WG, United Kingdom., Polanski R; Discovery Sciences R&D, AstraZeneca, Cambridge CB4 0WG, United Kingdom., Stokes S; Oncology R&D, AstraZeneca, Cambridge CB4 0WG, United Kingdom., Thakur K; Oncology R&D, AstraZeneca, R&D Boston, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States., Trueman D; Oncology R&D, AstraZeneca, Cambridge CB4 0WG, United Kingdom., Truman C; Discovery Sciences R&D, AstraZeneca, Cambridge CB4 0WG, United Kingdom., Tucker MJ; Oncology R&D, AstraZeneca, Cambridge CB4 0WG, United Kingdom., Wang H; Oncology R&D, AstraZeneca, R&D Boston, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States., Whalley N; Oncology R&D, AstraZeneca, Cambridge CB4 0WG, United Kingdom., Wu D; Advanced Drug Delivery, Pharmaceutical Sciences, R&D, Boston, Massachusetts 02451, United States., Wu Y; Oncology R&D, AstraZeneca, R&D Boston, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States., Yang B; Oncology R&D, AstraZeneca, R&D Boston, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States., Yang W; Advanced Drug Delivery, Pharmaceutical Sciences, R&D, Boston, Massachusetts 02451, United States.

المصدر: Journal of medicinal chemistry [J Med Chem] 2023 Feb 23; Vol. 66 (4), pp. 2918-2945. Date of Electronic Publication: 2023 Feb 01.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Receptors, Estrogen*/metabolism , Breast Neoplasms*/drug therapy, Mice ; Humans ; Animals ; Female ; Selective Estrogen Receptor Modulators/pharmacology ; Estrogen Antagonists/therapeutic use ; Estrogen Receptor alpha/metabolism ; Cell Line