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المؤلفون: Dominik Mumberg, Karl Ziegelbauer, Michael Brands, Franz von Nussbaum, Andreas Schlicker, Pascale Lejeune, Bernard Haendler, Simon J. Baumgart, Christoph A. Schatz, Sven Golfier, Uwe Eberspächer, Dieter Moosmayer, Ulf Bömer, Benjamin Bader, Philip Lienau, Lars Wortmann, Julien Lefranc, Ulrich Lücking, Gerhard Siemeister, Antje M. Wengner
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b320e3c23f072f7d98b788ef8e1aa81
https://doi.org/10.1158/1535-7163.22507162 -
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المؤلفون: Dominik Mumberg, Karl Ziegelbauer, Michael Brands, Franz von Nussbaum, Andreas Schlicker, Pascale Lejeune, Bernard Haendler, Simon J. Baumgart, Christoph A. Schatz, Sven Golfier, Uwe Eberspächer, Dieter Moosmayer, Ulf Bömer, Benjamin Bader, Philip Lienau, Lars Wortmann, Julien Lefranc, Ulrich Lücking, Gerhard Siemeister, Antje M. Wengner
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::e71b4129b5b767f4375ccfbccdc80fc9
https://doi.org/10.1158/1535-7163.c.6538606.v1 -
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المؤلفون: Dominik Mumberg, Karl Ziegelbauer, Michael Brands, Franz von Nussbaum, Andreas Schlicker, Pascale Lejeune, Bernard Haendler, Simon J. Baumgart, Christoph A. Schatz, Sven Golfier, Uwe Eberspächer, Dieter Moosmayer, Ulf Bömer, Benjamin Bader, Philip Lienau, Lars Wortmann, Julien Lefranc, Ulrich Lücking, Gerhard Siemeister, Antje M. Wengner
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::110985976c0032596d291c0c9cff1993
https://doi.org/10.1158/1535-7163.22507159 -
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المؤلفون: Dominik Mumberg, Karl Ziegelbauer, Michael Brands, Franz von Nussbaum, Andreas Schlicker, Pascale Lejeune, Bernard Haendler, Simon J. Baumgart, Christoph A. Schatz, Sven Golfier, Uwe Eberspächer, Dieter Moosmayer, Ulf Bömer, Benjamin Bader, Philip Lienau, Lars Wortmann, Julien Lefranc, Ulrich Lücking, Gerhard Siemeister, Antje M. Wengner
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6cecdc7c4b3d24cb9b91927a1753418
https://doi.org/10.1158/1535-7163.22507165 -
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المؤلفون: Benjamin Bader, Sabine Zitzmann-Kolbe, Carl Friedrich Nising, Ulrich Lücking, Qi Wang, Hartmut Rehwinkel, Florian Bartels, Qiuwen Wang, Markus Berger, Antje Margret Wengner, Lars Wortmann, Dieter Moosmayer, Philipp Buchgraber, Hans Briem, Dominik Mumberg, Knut Eis, Uwe Eberspächer, Stefanie Hammer, Christoph A. Schatz, Gerhard Siemeister, Philip Lienau, Ulf Bömer
المصدر: Journal of Medicinal Chemistry. 64:12723-12737
مصطلحات موضوعية: DNA repair, Cell, Antineoplastic Agents, DNA-Activated Protein Kinase, Cell cycle phase, Mice, Phosphatidylinositol 3-Kinases, Structure-Activity Relationship, chemistry.chemical_compound, Cell Line, Tumor, Drug Discovery, medicine, Animals, Humans, Protein kinase A, Cell Proliferation, Molecular Structure, Chemistry, TOR Serine-Threonine Kinases, Drug Synergism, medicine.disease, Xenograft Model Antitumor Assays, In vitro, Rats, medicine.anatomical_structure, Gene Expression Regulation, Ataxia-telangiectasia, Hepatocytes, Cancer research, Molecular Medicine, Drug Therapy, Combination, Homologous recombination, DNA
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المؤلفون: Katrin Juenemann, Ulrike Scheib, Michael Brands, Philipp M. Cromm, Laura M. Luh, Lars Wortmann
المصدر: Angewandte Chemie. 132:15576-15595
مصطلحات موضوعية: Chemistry, General Medicine
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المؤلفون: Katrin Juenemann, Ulrike Scheib, Laura M. Luh, Philipp M. Cromm, Lars Wortmann, Michael Brands
المصدر: Angewandte Chemie (International Ed. in English)
مصطلحات موضوعية: Proteasome Endopeptidase Complex, Computer science, Druggability, Chemical biology, Reviews, chemical biology, Context (language use), Review, Computational biology, Protein degradation, 010402 general chemistry, 01 natural sciences, Catalysis, molecular glue, PROTACs, medicinal chemistry, Humans, Targeted Protein Degradation, Protein function, 010405 organic chemistry, Drug discovery, Proteins, General Chemistry, Small molecule, 0104 chemical sciences, Proteasome, Proteolysis
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المؤلفون: Hans Briem, Benjamin Bader, Ulf Boemer, Brice Sautier, N. Bohnke, A. Hilpmann, Nicolas Werbeck, J. Kahmann, Volker Badock, D. Wegener, Knut Eis, J. Schroeder, K. Graham, Dieter Moosmayer, Christian Stegmann, J. Mastouri, K. Petersen, Jörg Weiske, Gerhard Siemeister, Roman C. Hillig, Lars Wortmann, F. von Nussbaum
المصدر: 'Proceedings of the National Academy of Sciences of the USA ', vol: 116, pages: 2551-2560 (2019)
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America 116(7), 2551-2560 (2019). doi:10.1073/pnas.1812963116مصطلحات موضوعية: crystal structure, GTP', Crystallography, X-Ray, medicine.disease_cause, Biochemistry, Cell Line, Proto-Oncogene Proteins p21(ras), Drug Discovery, Fluorescence Resonance Energy Transfer, medicine, Humans, Small GTPase, Mode of action, Multidisciplinary, Chemistry, Drug discovery, fragment screen, SOS, Biological Sciences, High-Throughput Screening Assays, Cell biology, PNAS Plus, SOS1, ddc:500, Guanine nucleotide exchange factor, KRAS, Signal transduction, SOS1 Protein, small-molecule inhibitor, Protein Binding, Signal Transduction, RAS
وصف الملف: application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b81d68c52d5b8e57b984ebab279c8e8
https://doi.org/10.1073/pnas.1812963116 -
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المؤلفون: Hilmar Weinmann, Lisa Candish, Daniel T. Hog, Henriette Lämmermann, Lars Wortmann, Karl D. Collins, R. Meier, Alexander Sudau, Daniel Rackl
المصدر: Synlett. 29:2679-2684
مصطلحات موضوعية: 010405 organic chemistry, Chemistry, Organic Chemistry, Late stage, Photoredox catalysis, 010402 general chemistry, 01 natural sciences, Combinatorial chemistry, 0104 chemical sciences, chemistry.chemical_compound, Functional group, Photocatalysis, Molecular oxygen, Blue light
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::2920b507571cd37ddaf2f96c70987e82
https://doi.org/10.1055/s-0037-1609656 -
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المؤلفون: Reinhard Nubbemeyer, Judith Günther, Federica Morandi, Gernot Langer, Dieter Moosmayer, Peter Muhn, Bernhard Lindenthal, Ulrich Lücking, Marcus Koppitz, Hilmar Weinmann, Martina Schäfer, Ronald Kühne, Dieter Heldmann, Anna K. Schrey, Alexander Walter, Ulrike Röhn, Lothar Sobek, Katrin Nowak-Reppel, Kuhnke Joachim, Lars Wortmann
المصدر: Journal of medicinal chemistry. 62(22)
مصطلحات موضوعية: Male, Ovulation, endocrine system, ERG1 Potassium Channel, Administration, Oral, Biological Availability, Pharmacology, Mice, Structure-Activity Relationship, Sex hormone-binding globulin, In vivo, hemic and lymphatic diseases, Drug Discovery, Animals, Humans, Testosterone, Naphthyridines, Rats, Wistar, Receptor, Progesterone, G protein-coupled receptor, Granulosa Cells, biology, Dose-Response Relationship, Drug, Estradiol, Chemistry, luteinizing hormone/choriogonadotropin receptor, Receptors, LH, Polycystic ovary, High-Throughput Screening Assays, biology.protein, Microsomes, Liver, Molecular Medicine, Receptors, FSH, Female, Luteinizing hormone, Hormone