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1دورية أكاديمية
المؤلفون: Ross A Kelly, Joseph Leedale, Andy Harrell, Daniel A Beard, Laura E Randle, Amy E Chadwick, Steven D Webb
المصدر: PLoS ONE, Vol 13, Iss 11, p e0207803 (2018)
وصف الملف: electronic resource
Relation: https://doaj.org/toc/1932-6203
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المؤلفون: Said Alizadeh-Shekalgourabi, Sam P. de Visser, James F. Dunn, Alistair J. Fielding, Michael G. B. Drew, Fyaz M.D. Ismail, Fabián G. Cantú Reinhard, Alessio del Casino, Nicola M. Dempster, Philip G. Evans, Verity Male, Dascombe Mj, Valentina Lukinović, Roger H. Bisby, Lutfun Nahar, Satyajit D. Sarker, Laura E. Randle
المصدر: Fielding, A, Lukinović, V, Evans, P G, Alizadeh-Shekalgourabi, S, Bisby, R H, Drew, M G B, ADel Casino, A, Dunn, J F, Randle, L E, Dempster, N M, Nahar, L, Sarker, S D, Cantu Reinhard, F, De Visser, S, Dascombe, M & Ismail, F M D 2017, ' Modulation of Antimalarial Activity at a Putative Bisquinoline Receptor in vivo Using Fluorinated Bisquinolines ', Chemistry: A European Journal, vol. 23, no. 28, pp. 6811-6828 . https://doi.org/10.1002/chem.201605099
مصطلحات موضوعية: 0301 basic medicine, Steric effects, RM, Magnetic Resonance Spectroscopy, Halogenation, Plasmodium berghei, Stereochemistry, Molecular Conformation, Substituent, Protonation, Crystallography, X-Ray, Ferric Compounds, Catalysis, Antimalarials, Mice, 03 medical and health sciences, chemistry.chemical_compound, Isomerism, Animals, QD, Trifluoromethyl, Hydrogen bond, Organic Chemistry, Quinoline, Electron Spin Resonance Spectroscopy, Hydrogen Bonding, General Chemistry, Malaria, 030104 developmental biology, chemistry, Drug Design, Aminoquinolines, Quinolines, Hemin, Thermodynamics, Amine gas treating, Piperidine, Oxidation-Reduction, Locomotion
وصف الملف: application/pdf
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المؤلفون: John Farrell, Sophie L. Regan, Dominic P. Williams, Neil R. Kitteringham, Alvin J. L. Chia, Laura E. Randle, Abhishek Srivastava, Christopher E. Goldring, Andrew V. Stachulski, Dean J. Naisbitt, Daniel J. Antoine, Thomas A. Baillie, Martin S. Lennard, J. Luis Castrejon, Hayley Callan, B. Kevin Park, Deepak Dalvie, R. Scott Obach
المصدر: Medicinal Research Reviews. 33:985-1080
مصطلحات موضوعية: Pharmacology, Drug, Drug discovery, Chemistry, media_common.quotation_subject, Immune system, Pharmacokinetics, Downregulation and upregulation, Metabolic enzymes, Drug Discovery, Molecular Medicine, Drug metabolism, media_common, Preclinical toxicity
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المؤلفون: Neil R. Kitteringham, Samantha J. Williams, Laura E. Randle, B. Kevin Park, Christopher M. Sanderson, Azman Abdullah, Christopher E. Goldring, Rowena L. Sison, Joanne Walsh, Rosalind E. Jenkins, John D. Hayes, Larry G. Higgins, Helen Powell, Masayuki Yamamoto
المصدر: Journal of Proteomics
مصطلحات موضوعية: Male, Proteomics, NF-E2-Related Factor 2, Transgene, Biophysics, Down-Regulation, Mice, Transgenic, Biology, digestive system, environment and public health, Biochemistry, Antioxidants, Article, Nrf2, Transgenic, Mice, 03 medical and health sciences, 0302 clinical medicine, Animals, Electrophoresis, Gel, Two-Dimensional, Transcription factor, 030304 developmental biology, Gel electrophoresis, 0303 health sciences, Gene Expression Profiling, Lipid metabolism, Metabolism, respiratory system, Lipid Metabolism, Up-Regulation, Gene expression profiling, Liver, iTRAQ, 030220 oncology & carcinogenesis, ATP Citrate (pro-S)-Lyase, Protein expression, Drug metabolism
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المؤلفون: Dominic P. Williams, Neil R. Kitteringham, Laura E. Randle, Jean G. Sathish, B.K. Park, I Macdonald
المصدر: British Journal of Pharmacology. 153:820-830
مصطلحات موضوعية: Pharmacology, medicine.medical_specialty, organic chemicals, digestive, oral, and skin physiology, Analgesic, Glutathione, chemistry.chemical_compound, Terazosin, Glucuronosyltransferase activity, Epinephrine, Endocrinology, chemistry, Internal medicine, Toxicity, medicine, Prazosin, Doxazosin, medicine.drug
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المؤلفون: Andrew V, Stachulski, Thomas A, Baillie, B Kevin, Park, R Scott, Obach, Deepak K, Dalvie, Dominic P, Williams, Abhishek, Srivastava, Sophie L, Regan, Daniel J, Antoine, Christopher E P, Goldring, Alvin J L, Chia, Neil R, Kitteringham, Laura E, Randle, Hayley, Callan, J Luis, Castrejon, John, Farrell, Dean J, Naisbitt, Martin S, Lennard
المصدر: Medicinal research reviews. 33(5)
مصطلحات موضوعية: Biomedical Research, Glucuronides, Cytochrome P-450 Enzyme System, Drug-Related Side Effects and Adverse Reactions, Pharmaceutical Preparations, Drug Design, Animals, Humans
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المؤلفون: Alvin J. L. Chia, John D. Hayes, B. Kevin Park, Christopher E. Goldring, Neil R. Kitteringham, Rosalind E. Jenkins, Laura E. Randle, Ian M. Copple
المصدر: Hepatology (Baltimore, Md.). 48(4)
مصطلحات موضوعية: Carcinoma, Hepatocellular, NAPQI, NF-E2-Related Factor 2, Metabolite, Repressor, Biology, environment and public health, digestive system, Cell Line, chemistry.chemical_compound, Mice, Cell Line, Tumor, medicine, Benzoquinones, Animals, Humans, Buthionine sulfoximine, Acetaminophen, Adaptor Proteins, Signal Transducing, Kelch-Like ECH-Associated Protein 1, Hepatology, Liver Neoplasms, Glutathione, respiratory system, Cytoskeletal Proteins, chemistry, Biochemistry, Liver, Iodoacetamide, RNA Interference, Imines, medicine.drug, Cysteine, Signal Transduction
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المؤلفون: Dominic P. Williams, Christopher E. Goldring, Peter Metcalfe, Craig Benson, B. Kevin Park, Neil R. Kitteringham, Laura E. Randle
المصدر: Toxicology. 243(3)
مصطلحات موضوعية: Male, medicine.medical_specialty, NF-E2-Related Factor 2, Glutamate-Cysteine Ligase, Blotting, Western, CCL4, Toxicology, digestive system, Xenobiotics, chemistry.chemical_compound, Mice, Western blot, Furosemide, Internal medicine, Gene expression, medicine, Animals, RNA, Messenger, Carbon Tetrachloride, Acetaminophen, Adaptor Proteins, Signal Transducing, Cell Nucleus, Analysis of Variance, Kelch-Like ECH-Associated Protein 1, medicine.diagnostic_test, Molecular Structure, Chemistry, Reverse Transcriptase Polymerase Chain Reaction, Hepatotoxin, Alanine Transaminase, Glutathione, Cytoskeletal Proteins, Endocrinology, GCLC, Biochemistry, Liver, Toxicity, Carbon tetrachloride, Heme Oxygenase-1, Injections, Intraperitoneal, Bromobenzenes, Signal Transduction
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المؤلفون: Julian Blagg, Dominic P. Williams, Daniel J. Antoine, Laura E. Randle, Martin Howard, Russell Jones, B. Kevin Park, Iain Gardner, Philip J. Butler, Anthony Payne
المصدر: The Journal of pharmacology and experimental therapeutics. 322(3)
مصطلحات موضوعية: Metabolite, Pharmacology, Acetylcysteine, chemistry.chemical_compound, Mice, Species Specificity, Furosemide, medicine, Animals, Cytochrome P-450 Enzyme Inhibitors, Rats, Wistar, Cells, Cultured, biology, Cytochrome P450, Metabolism, Glutathione, Rats, chemistry, Toxicity, biology.protein, Hepatocytes, Microsomes, Liver, Molecular Medicine, Glucuronide, medicine.drug, Protein Binding
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b022cc78d2c8197af68055c483f191e9
https://pubmed.ncbi.nlm.nih.gov/17556636 -
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المؤلفون: Cerys A. Lovatt, Dominic P. Williams, Andrew Owen, Wolfgang Hillen, Philip J. Butler, Xiao-Ping Liu, Christian Berens, Azman Abdullah, Peter Metcalfe, Rosalind E. Jenkins, B. Kevin Park, Alec W.M. Simpson, Neil R. Kitteringham, Laura E. Randle, Lesley I. McLellan, Christopher E. Goldring, Brian Foster
المصدر: American journal of physiology. Cell physiology. 290(1)
مصطلحات موضوعية: Cell physiology, Carcinoma, Hepatocellular, Physiology, NF-E2-Related Factor 2, Molecular Sequence Data, NF-E2-Related Factor 1, Biology, Protein expression, Xenobiotics, Transactivation, GSTP1, Mice, Phase (matter), Cell Line, Tumor, Animals, Humans, Amino Acid Sequence, Transgenes, Gene, Glutathione Transferase, Protein Synthesis Inhibitors, Liver Neoplasms, NF-kappa B p50 Subunit, Cytochrome P-450 CYP2E1, Cell Biology, CYP2E1, Tetracycline, Molecular biology, Cell biology, Anti-Bacterial Agents, Gene Expression Regulation, Neoplastic, Liver, Doxycycline, Hepatocytes, Chemical defense
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2db496917bfaf8c3918433d7061f1584
https://pubmed.ncbi.nlm.nih.gov/16338979
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