المؤلفون: Sergei Timofeevski, Lars D. Engstrom, Mingying He, Michael R. Collins, Martin Paul Edwards, Phuong Le, Graham L. Smith, John Charles Kath, Helen Y. Zou, Deal Judith G, Ya-Li Deng, Robert Steven Kania, Benjamin J. Burke, Cynthia Louise Palmer, Huichun Zhu, A.E. Stewart, Hieu Lam, Dac M. Dinh, Simon Bailey, Jacqui Elizabeth Hoffman, Neal W. Sach, Robert Louis Hoffman, Qinhua Huang, J. Jean Cui, Alexei Brooun, Wei Liu, Laura Lingardo, Tod Smeal, Ted William Johnson, Michele McTigue, Justine L. Lam, Jinjiang Zhu, Paul F. Richardson

المصدر: Journal of Medicinal Chemistry. 57:4720-4744

مصطلحات موضوعية: Models, Molecular, Lactams, Brigatinib, Lactams, Macrocyclic, Aminopyridines, Antineoplastic Agents, Crystallography, X-Ray, Mice, Structure-Activity Relationship, Proto-Oncogene Proteins, hemic and lymphatic diseases, Drug Discovery, medicine, ROS1, Animals, Humans, Anaplastic lymphoma kinase, Anaplastic Lymphoma Kinase, ADME, Crizotinib, Chemistry, Drug discovery, Brain, Receptor Protein-Tyrosine Kinases, Stereoisomerism, Protein-Tyrosine Kinases, Lorlatinib, Rats, Drug Resistance, Neoplasm, Lipophilic efficiency, Mutation, Microsomes, Liver, NIH 3T3 Cells, Cancer research, Pyrazoles, Molecular Medicine, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a88513bc93ec9da81fd3688f6b55fb99
https://doi.org/10.1021/jm500261q

المؤلفون: Tod Smeal, Wei Liu, Huichun Zhu, Simon Bailey, Michael R. Collins, A.E. Stewart, Jacqui Elizabeth Hoffman, Lars D. Engstrom, Graham L. Smith, J. Jean Cui, Ya-Li Deng, Benjamin J. Burke, Laura Lingardo, Phuong Le, Andrew Simon Cook, Konstantinos Tsaparikos, Hieu Lam, Jinjiang Zhu, Ted William Johnson, Neal W. Sach, Dac M. Dinh, Robert Louis Hoffman, Mingying He, Hui Wang, Alexei Brooun, Dack Kevin Neil, Qinhua Huang, Sergei Timofeevski, Deal Judith G, Justine L. Lam, Qiuhua Li, Hong Shen, Melissa West Lu, Michele McTigue, Paul F. Richardson, Kevin D. Bunker, Robert Steven Kania, Martin Paul Edwards, Helen Y. Zou, Cynthia Louise Palmer, Patrick S. Johnson

المصدر: Journal of Medicinal Chemistry. 57:1170-1187

مصطلحات موضوعية: Drug, Pyridines, media_common.quotation_subject, Drug resistance, Pharmacology, Crizotinib, hemic and lymphatic diseases, Drug Discovery, medicine, Humans, Point Mutation, Anaplastic lymphoma kinase, Anaplastic Lymphoma Kinase, Protein Kinase Inhibitors, media_common, Chemistry, Point mutation, Receptor Protein-Tyrosine Kinases, medicine.disease, Protein kinase domain, Drug Resistance, Neoplasm, Cell culture, Cancer research, Pyrazoles, Molecular Medicine, Progressive disease, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f25cdb3a3b4202005c75976a5f6a5ac
https://doi.org/10.1021/jm401805h

المؤلفون: Michelle Kraus, Stephan Grant, Sutton Scott Channing, Ciarán N. Cronin, Alexandra Hofler, John Charles Kath, Scott Gridley, Mike Gehring, Timothy Nichols, Edward A. Esposito, Gordon Alton, Jacques Ermolieff, Laura Lingardo, Murphy Sean T, Zhi Xie

المصدر: Analytical Biochemistry. 414:179-186

مصطلحات موضوعية: animal structures, Biophysics, AKT1, AKT2, CHO Cells, Protein Serine-Threonine Kinases, Biology, Biochemistry, 3-Phosphoinositide-Dependent Protein Kinases, Cricetulus, Cricetinae, Animals, Humans, Histidine, Phosphorylation, Kinase activity, Protein Kinase Inhibitors, Molecular Biology, Protein kinase B, PI3K/AKT/mTOR pathway, Enzyme Assays, Akt/PKB signaling pathway, Adenine, Cell Biology, Recombinant Proteins, Cell biology, Kinetics, Pyrazines, Signal transduction, Oligopeptides, Proto-Oncogene Proteins c-akt, Signal Transduction

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eafb0ace08d77461f8968b1004b4ec48
https://doi.org/10.1016/j.ab.2011.03.013

المؤلفون: Catherine Hwang, Laura Lingardo, Laura R. Pearce, Dario R. Alessi, Justin Chapman, Daniel Tyler Richter, John Charles Kath, Gordon Alton

المصدر: Biochemical Journal. 431:245-255

مصطلحات موضوعية: P70-S6 Kinase 1, Mechanistic Target of Rapamycin Complex 1, Mitogen-activated protein kinase kinase, Ribosomal Protein S6 Kinases, 90-kDa, Biochemistry, Piperazines, Cell Line, Substrate Specificity, MAP2K7, Ribosomal s6 kinase, Humans, ASK1, Phosphorylation, Protein Kinase Inhibitors, Molecular Biology, biology, MAP kinase kinase kinase, Chemistry, TOR Serine-Threonine Kinases, Cyclin-dependent kinase 2, Imidazoles, Proteins, Ribosomal Protein S6 Kinases, 70-kDa, Cell Biology, Phosphothreonine, Multiprotein Complexes, biology.protein, Cyclin-dependent kinase 9, Transcription Factors

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7ee34aa847291a4b3ad05ffbb213922
https://doi.org/10.1042/bj20101024

المؤلفون: Wade Diehl, Robert A. Love, Peter S. Dragovich, Shella A. Fuhrman, Hans E. Parge, Xiu Yu, Laura Lingardo, Rose Ann Ferre, Karen A. Maegley

المصدر: Structure. 12:1533-1544

مصطلحات موضوعية: Genetics, viruses, Poliovirus, Hepatitis C virus, Picornaviridae, RNA-dependent RNA polymerase, RNA, Biology, medicine.disease_cause, Virology, Virus, chemistry.chemical_compound, chemistry, Structural Biology, RNA polymerase, medicine, Primer (molecular biology), Molecular Biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99154a25b944718ca7a4df93a1110ca6
https://doi.org/10.1016/j.str.2004.05.024

المؤلفون: Ayse Batova, Wade Warren Stanfield, James W. Zapf, Peter Pallai, Gordon Alton, Todd Meyer, Laura Lingardo

المصدر: Cancer Research. 76:2180-2180

مصطلحات موضوعية: 0301 basic medicine, Cancer Research, Gene knockdown, urogenital system, Kinase, medicine.medical_treatment, Biology, Bioinformatics, medicine.disease, Metastasis, Targeted therapy, 03 medical and health sciences, 030104 developmental biology, Oncology, In vivo, Cancer cell, Cancer research, medicine, Phosphorylation, IC50

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::f10a65dfd3287504695302535d3a9596
https://doi.org/10.1158/1538-7445.am2016-2180

المؤلفون: Murphy Sean T, Gordon Alton, Xiao-Hong Yu, Stan Kupchinsky, Steven P. Tanis, Jacques Ermolieff, Tran Khanh Tuan, Min-Jean Yin, Sangita M. Baxi, William F. Vernier, Natasha M. Kablaoui, Michael J. Hickey, Benjamin J. Burke, John Charles Kath, Zhi Xie, Daniel Tyler Richter, John M. Humphrey, Michelle Kraus, RoseAnn Ferre, John Li, Matthew A. Marx, Thomas Allen Chappie, Samantha Elizabeth Greasley, Steven Kazmirski, Simon Bailey, Laura Lingardo

المصدر: Journal of medicinal chemistry. 54(24)

مصطلحات موضوعية: Models, Molecular, Pyrazine, Stereochemistry, Protein Conformation, Pyridines, Antineoplastic Agents, Protein Serine-Threonine Kinases, Ring (chemistry), Crystallography, X-Ray, 3-Phosphoinositide-Dependent Protein Kinases, chemistry.chemical_compound, Structure-Activity Relationship, Cell Line, Tumor, Drug Discovery, Ethylamines, Structure–activity relationship, Potency, Humans, Pyrroles, Phosphorylation, ADME, Chemistry, Aryl, Lipophilicity, Molecular Medicine, Drug Screening Assays, Antitumor, Selectivity, Proto-Oncogene Proteins c-akt, Signal Transduction

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::101b59a087b116c191559a0cc406942f
https://pubmed.ncbi.nlm.nih.gov/22040023

المؤلفون: Ping Chen, Laura Lingardo, Rose Ann Ferre, John Charles Kath, Qiyue Hu, M. Catherine Johnson, Jiangli Yan, Jacques Ermolieff, Samantha Elizabeth Greasley, Gordon Alton

المصدر: Journal of computer-aided molecular design. 25(7)

مصطلحات موضوعية: Protein-Serine-Threonine Kinases, Ligand efficiency, Binding Sites, Drug discovery, Kinase, Stereochemistry, Fragment-based lead discovery, Drug Evaluation, Preclinical, Pyruvate Dehydrogenase Acetyl-Transferring Kinase, Hydrogen Bonding, Plasma protein binding, Biology, Protein Serine-Threonine Kinases, Crystallography, X-Ray, Ligands, Magnetic Resonance Imaging, Peptide Fragments, Computer Science Applications, High-Throughput Screening Assays, Drug Discovery, Humans, Physical and Theoretical Chemistry, PI3K/AKT/mTOR pathway, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fded407f1bcf345111ac88e74c6f00a
https://pubmed.ncbi.nlm.nih.gov/21779981

المؤلفون: Joseph John Binder, Amy K. Patick, Robert A. Love, Megan Weinshank, Laura Lingardo, Karen A. Maegley, George J. Smith, Selwyna Tetangco, Wade Diehl

المصدر: Antiviral research. 91(2)

مصطلحات موضوعية: Macrocyclic Compounds, Genotype, viruses, Hepatitis C virus, medicine.medical_treatment, Genetic Vectors, Heterologous, Hepacivirus, Microbial Sensitivity Tests, Biology, Viral Nonstructural Proteins, medicine.disease_cause, Virus Replication, Antiviral Agents, Virus, Cell Line, Sequence Analysis, Protein, Virology, medicine, Fluorescence Resonance Energy Transfer, Animals, Humans, Luciferase, Protease Inhibitors, Replicon, Cloning, Molecular, Gene, Phylogeny, Pharmacology, NS3, Protease, Binding Sites, Base Sequence, Genetic Variation, biochemical phenomena, metabolism, and nutrition, Thiazoles, Quinolines, Carbamates, Oligopeptides

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a218ff1df5386c0c6cd1a211dbceb45
https://pubmed.ncbi.nlm.nih.gov/21620899

المؤلفون: Chris A. Buhr, Jim Zapf, Leo R. Fitzpatrick, Jeffrey S. Small, Satheesh B. Ravula, Laura Lingardo, Elizabeth M. Flood, Gordon Alton, Fabio C. Tucci

المصدر: Gastroenterology. 148:S-26

مصطلحات موضوعية: Hepatology, business.industry, Gastroenterology, Cancer research, medicine, Inverse agonist, medicine.disease, business, Inflammatory bowel disease, Small molecule

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::d09b8513964aef63fc9fc96b05390817
https://doi.org/10.1016/s0016-5085(15)30090-1