يعرض 1 - 2 نتائج من 2 نتيجة بحث عن '"Laurence Fabien"', وقت الاستعلام: 0.83s تنقيح النتائج
  1. 1
    Discovery of 6-(2,4-Dichlorophenyl)-5-[4-[(3S)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7H-benzo[7]annulene-2-carboxylic acid (SAR439859), a Potent and Selective Estrogen Receptor Degrader (SERD) for the Treatment of Estrogen-Receptor-Positive Breast Cancer

    المؤلفون: Chrystelle Girardet, Magali Mathieu, François Vallée, Jacques Le-Roux, Fangxian Sun, Laurence Fabien, Corinne Terrier, Celine Ginesty, Bruno Filoche-Romme, Florence Gruss-Leleu, Maysoun Shomali, Monsif Bouaboula, Sylvie Beccari, Pascal Desmazeau, Gilles Lebourg, Tsiala Benard, Victor Certal, Pascale Vicat, Andrew Hebert, Carlos Garcia-Echeverria, Laurent Schio, Youssef El-Ahmad, Gary Mccort, Claire Muller, Maurice Brollo, Mikhail Levit, Luc Bertin, Hong Cheng, Véronique Loyau, Valerie Steier, Fabienne Thompson, Audrey Louboutin, Fabienne Pilorge, Alexey Rak, Frank Halley, Patrick Richepin, Christelle Perrault, Pierre-Yves Abecassis, Michel Tabart, Albane Courjaud

    المصدر: Journal of Medicinal Chemistry. 63:512-528

    مصطلحات موضوعية: 0303 health sciences, biology, Fulvestrant, Chemistry, Estrogen receptor, medicine.disease, 01 natural sciences, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, 03 medical and health sciences, Breast cancer, Hormone receptor, Drug Discovery, biology.protein, medicine, Cancer research, Molecular Medicine, Aromatase, Receptor, Estrogen receptor alpha, Tamoxifen, 030304 developmental biology, medicine.drug

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::eb6b8e31876cd3009f301f509589bd98
    https://doi.org/10.1021/acs.jmedchem.9b01293

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  2. 2
    Optimization and Gram-Scale Preparation of S -Trifluoromethyl Sulfoximines and Sulfilimino Iminiums, Powerful Reagents for the Late Stage Introduction of the CF 3 Group

    المؤلفون: Youssef El-Ahmad, Laurence Fabien, Luc Bertin, Guillaume Dagousset, Christian Poma, Elsa Anselmi, Bruno Salgues, Victor Certal, Philippe Courtes, Anne-Laure Barthelemy, Emmanuel Magnier

    المساهمون: Centre National de la Recherche Scientifique (CNRS), Institut Lavoisier de Versailles (ILV), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)

    المصدر: Organic Process Research and Development
    Organic Process Research and Development, American Chemical Society, 2020, 24 (5), pp.704-712. ⟨10.1021/acs.oprd.9b00403⟩

    مصطلحات موضوعية: Trifluoromethyl, Scale (ratio), 010405 organic chemistry, [CHIM.ORGA]Chemical Sciences/Organic chemistry, Organic Chemistry, Late stage, 010402 general chemistry, 01 natural sciences, 0104 chemical sciences, 3. Good health, chemistry.chemical_compound, chemistry, Group (periodic table), Reagent, Organic chemistry, Physical and Theoretical Chemistry, ComputingMilieux_MISCELLANEOUS, Gram

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d0b114c3d1037db332e87d0c0a92fed
    https://hal.archives-ouvertes.fr/hal-02992781

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