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المؤلفون: Arthur, Pearson, Paul-Armand, Dujardin, Louis, d'Alteroche, Frédéric, Patat, Béatrice, Scotto, Fanny, Dujardin, Cécile, Bastard, Véronique, Miette, Laurent, Sandrin, Jean-Pierre, Remenieras
المصدر: Medical physics. 49(3)
مصطلحات موضوعية: Liver Cirrhosis, Liver, ROC Curve, Non-alcoholic Fatty Liver Disease, Biopsy, Elasticity Imaging Techniques, Humans, Prospective Studies, Vibration
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المؤلفون: Véronique Miette, Stephane Audiere, Sabine F. Bensamoun, Aymeric Labourdette, Fabrice Charleux, Stephen A. Harrison, Philippe Pouletaut, Céline Fournier, Redouane Ternifi, Laurent Sandrin, Salem Boussida
المساهمون: ECHOSENS S.A., Echosens, Biomécanique et Bioingénierie (BMBI), Université de Technologie de Compiègne (UTC)-Centre National de la Recherche Scientifique (CNRS), Radcliffe Department of Medicine [Oxford], University of Oxford [Oxford], Echosens company
المصدر: Ultrasound in Medicine & Biology
Ultrasound in Medicine & Biology, Elsevier, 2021, 47 (11), pp.3181-3195. ⟨10.1016/j.ultrasmedbio.2021.07.007⟩مصطلحات موضوعية: Steatosis, Acoustics and Ultrasonics, Biophysics, Controlled Attenuation Parameter (CAP), 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, Non-alcoholic Fatty Liver Disease, In vivo, Vibration-Controlled Transient Elastography (VCTE), [INFO.INFO-IM]Computer Science [cs]/Medical Imaging, Humans, Medicine, Radiology, Nuclear Medicine and imaging, Ultrasonography, Radiological and Ultrasound Technology, Receiver operating characteristic, medicine.diagnostic_test, FibroScan, business.industry, Attenuation, Ultrasound, Magnetic resonance imaging, [SDV.MHEP.HEG]Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology, medicine.disease, Proton Density Fat Fraction (PDFF), ROC Curve, Liver, Elasticity Imaging Techniques, Ultrasound attenuation, 030211 gastroenterology & hepatology, Elastography, business, [SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing, Ex vivo, Biomedical engineering
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المؤلفون: Arun J. Sanyal, Julie Foucquier, Zobair M. Younossi, Stephen A. Harrison, Philip N. Newsome, Wah-Kheong Chan, Yusuf Yilmaz, Victor De Ledinghen, Charlotte Costentin, Ming-Hua Zheng, Vincent Wai-Sun Wong, Magdy Elkhashab, Ryan S. Huss, Robert P. Myers, Marine Roux, Aymeric Labourdette, Marie Destro, Céline Fournier-Poizat, Véronique Miette, Laurent Sandrin, Jérôme Boursier
المساهمون: RTEÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Yılmaz, Yusuf
المصدر: Journal of hepatology.
مصطلحات موضوعية: Non-Alcoholic Fatty Liver Disease, Cirrhosis, Hepatology, Non-invasive test, Vibration-Controlled transient elastography, Currently available non-invasive tests, including fibrosis-4 index (FIB-4) and liver stiffness measurement (LSM by VCTE), are highly effective at excluding advanced fibrosis (AF) (F ≥3) or cirrhosis in people with non-alcoholic fatty liver disease (NAFLD), but only have moderate ability to rule-in these conditions. Our objective was to develop and validate two new scores (Agile 4 and Agile 3+) to identify cirrhosis or AF, respectively, with optimized positive predictive value and fewer indeterminate results, in individuals with NAFLD attending liver clinics. Methods: This international study included seven adult cohorts with suspected NAFLD who underwent liver biopsy, LSM and blood sampling during routine clinical practice or screening for trials. The population was randomly divided into a training set and an internal validation set, on which the best-fitting logistic regression model was built, and performance and goodness of fit were assessed, respectively. Furthermore, both scores were externally validated on two large cohorts. Cut-offs for high sensitivity and specificity were derived in the training set to rule-out and rule-in cirrhosis or AF and then tested in the validation set and compared to FIB-4 and LSM. Results: Each score combined LSM, AST/ALT ratio, platelets, sex and diabetes status, as well as age for Agile 3+. Calibration plots for Agile 4 and Agile 3+ indicated satisfactory to excellent goodness of fit. Agile 4 and Agile 3+ outperformed FIB-4 and LSM in terms of AUROC, percentage of patients with indeterminate results and positive predictive value to rule-in cirrhosis or AF. Conclusions: The two novel non-invasive scores improve identification of cirrhosis or AF among individuals with NAFLD attending liver clinics and reduce the need for liver biopsy in this population. Impact and implications: Non-invasive tests currently used to identify patients with advanced fibrosis or cirrhosis, such as fibrosis-4 index and liver stiffness measurement by vibration-controlled transient elastography, have high negative predictive values but high false positive rates, while results are indeterminate for a large number of cases. This study provides scores that will help the clinician diagnose advanced fibrosis or cirrhosis. These new easy-to-implement scores will help liver specialists to better identify (1) patients who need more intensive follow-up, (2) patients who should be referred for inclusion in therapeutic trials, and (3) which patients should be treated with pharmacological agents when effective therapies are approved [Background & Aims], VCTE
وصف الملف: application/pdf
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المؤلفون: Laurent Sandrin
المصدر: Liver Elastography ISBN: 9783030405410
مصطلحات موضوعية: Shear wave elastography, medicine.medical_specialty, medicine.diagnostic_test, business.industry, medicine.disease, Clinical Practice, Liver disease, Liver steatosis, Liver stiffness, medicine, Elastography, Radiology, Transient elastography, business
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::de56f1e36e2cf7c340988459fc39f3c4
https://doi.org/10.1007/978-3-030-40542-7_3 -
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المؤلفون: Sebastian Mueller, Laurent Sandrin, Felix Piecha, Shami Alquzi, Omar Elshaarawy, Cecil Bastard
المصدر: Liver Elastography ISBN: 9783030405410
مصطلحات موضوعية: Pathology, medicine.medical_specialty, Cirrhosis, medicine.diagnostic_test, business.industry, Liver fibrosis, Portal venous pressure, medicine.disease, Liver stiffness, Small animal, medicine, Portal hypertension, Elastography, Transient elastography, business
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::efbdc6d859ac0790144be73e9c93bb37
https://doi.org/10.1007/978-3-030-40542-7_7 -
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المؤلفون: Laurent Sandrin, Magali Sasso
المصدر: Liver Elastography ISBN: 9783030405410
مصطلحات موضوعية: Response rate (survey), medicine.medical_specialty, business.industry, Fatty liver, Context (language use), Disease, medicine.disease, Gastroenterology, Fibrosis, Internal medicine, Hepatocellular carcinoma, medicine, Metabolic syndrome, Steatosis, business
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::ee8898f613f29f6ece4ba93ee9a644d5
https://doi.org/10.1007/978-3-030-40542-7_37 -
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المؤلفون: Véronique Miette, Cécile Bastard, Laurent Sandrin, Hugo Loree
المصدر: Ultrasound in medicinebiology. 46(9)
مصطلحات موضوعية: 0301 basic medicine, Adult, Liver Cirrhosis, Male, Acoustics and Ultrasonics, Computer science, Liver fibrosis, Biophysics, Chronic liver disease, Vibration, 03 medical and health sciences, 0302 clinical medicine, Liver stiffness, medicine, Humans, Radiology, Nuclear Medicine and imaging, Transient (computer programming), Radiological and Ultrasound Technology, business.industry, Ultrasound, Middle Aged, medicine.disease, 030104 developmental biology, Elasticity Imaging Techniques, 030211 gastroenterology & hepatology, Female, Reference device, Transient elastography, business, Biomedical engineering
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المؤلفون: Magali Sasso, Véronique Miette, Laurent Sandrin
المصدر: Alcohol and Alcoholism. 52:i4-i30
مصطلحات موضوعية: medicine.medical_specialty, Liver steatosis, business.industry, Internal medicine, Attenuation, Medicine, General Medicine, business, Gastroenterology
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::a901aa3402729fc6409a8c37707a1821
https://doi.org/10.1093/alcalc/agx075.02 -
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المؤلفون: Véronique Miette, Thomas C. Smyrk, Meng Yin, Laurent Sandrin, Richard L. Ehman, Kevin J. Glaser, Jun Chen, Jennifer Oudry, Jayant A. Talwalkar
المصدر: Radiology. 283:418-428
مصطلحات موضوعية: Liver Cirrhosis, Male, medicine.medical_specialty, Intraclass correlation, Sensitivity and Specificity, Vibration, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, Image Interpretation, Computer-Assisted, Biopsy, Humans, Medicine, Radiology, Nuclear Medicine and imaging, Stage (cooking), Original Research, medicine.diagnostic_test, business.industry, Reproducibility of Results, Magnetic resonance imaging, Middle Aged, Obesity, Morbid, Adipose Tissue, Liver biopsy, Elasticity Imaging Techniques, Female, 030211 gastroenterology & hepatology, Elastography, Radiology, business, Transient elastography, Hepatic fibrosis
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dd24224084c647d90af0b90589714b2
https://doi.org/10.1148/radiol.2016160685 -
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المؤلفون: Philip N Newsome, Michel Clet, Sebastien Czernichow, Peter Eddowes, Michael Allison, Emmanouil Tsochatzis, Quentin Anstee, David Sheridan, Neil Guha, Jeremy Cobbold, Céline Fournier, Véronique Miette, Laurent Sandrin, Stephen Harrison
المصدر: Journal of Hepatology. 73:S430-S431
مصطلحات موضوعية: Hepatology