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1دورية أكاديمية
المؤلفون: Maiju K. Rinne, Lauri Urvas, Ilona Mandrika, Dāvids Fridmanis, Darren M. Riddy, Christopher J. Langmead, Jyrki P. Kukkonen, Henri Xhaard
المصدر: Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)
مصطلحات موضوعية: Orexin, Hypocretin, Calcium, Receptor binding, Ciona intestinalis, Medicine, Science
وصف الملف: electronic resource
Relation: https://doaj.org/toc/2045-2322
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المؤلفون: Teppo O. Leino, Ainoleena Turku, Lauri Urvas, Karuna Adhikari, Jouni Oksanen, Yana Steynen, Jari Yli-Kauhaluoma, Henri Xhaard, Jyrki P. Kukkonen, Erik A.A. Wallén
المساهمون: Divisions of Faculty of Pharmacy, Division of Pharmaceutical Chemistry and Technology, Drug Research Program, Pharmaceutical Design and Discovery group, Veterinary Biosciences, Faculty of Veterinary Medicine, Faculty of Pharmacy, Department of Pharmacology, Jari Yli-Kauhaluoma / Principal Investigator, Computational Adme, Henri Xhaard / Principal Investigator, Division of Pharmaceutical Biosciences, Erik Wallen / Principal Investigator
مصطلحات موضوعية: Orexin receptor, Sulfonamides, azulene, Organic Chemistry, Clinical Biochemistry, Agonist, Pharmaceutical Science, Medicinal chemistry, Biochemistry, lääkekemia, 317 Pharmacy, medicinal chemistry, sulfonamides, Drug Discovery, atsuleeni, Molecular Medicine, 1182 Biochemistry, cell and molecular biology, Azulene, 3111 Biomedicine, agonist, Molecular Biology, orexin receptor
وصف الملف: application/pdf; fulltext
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7df09711b7611d8344b9ac76de0bc4c
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المؤلفون: Jouko Peltonen, Jawad Sarfraz, Sari Tähkä, Tiina Sikanen, Riccardo Provenzani, Susanne K. Wiedmer, Lauri Urvas, Ville Jokinen
المساهمون: University of Helsinki, Åbo Akademi University, Department of Chemistry and Materials Science, Aalto-yliopisto, Aalto University, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, Divisions of Faculty of Pharmacy, Department of Chemistry, Susanne Wiedmer / Principal Investigator, Tiina Sikanen / Chemical Microsystems Lab
المصدر: Analytical and Bioanalytical Chemistry
مصطلحات موضوعية: Models, Molecular, Immobilized enzyme, PROTEINS, Microfluidics, FABRICATION, Metal Nanoparticles, 02 engineering and technology, TRYPSIN, Bradykinin, 01 natural sciences, Biochemistry, Soft lithography, Analytical Chemistry, Hydrolysis, CHEMISTRY, Lab-On-A-Chip Devices, Animals, Chymotrypsin, Enzyme immobilization, Gold nanoparticles, Sulfhydryl Compounds, Thiol-enes, chemistry.chemical_classification, Mass spectrometry, Chemistry, SOFT-LITHOGRAPHY, 010401 analytical chemistry, Proteolytic enzymes, PERFORMANCE, Enzymes, Immobilized, Microreactors, 021001 nanoscience & nanotechnology, 0104 chemical sciences, INTERFACE, Chemical engineering, 317 Pharmacy, Colloidal gold, Thiol, Cattle, MICROCHIP ELECTROPHORESIS, Gold, Microreactor, 0210 nano-technology
وصف الملف: application/pdf
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المؤلفون: Lauri Urvas, Tommi Kilpeläinen, Saara Kivioja, Ulrika Julku, Susanna Norrbacka, Maria Jäntti, Timo T. Myöhänen, Reinis Svarcbahs
المساهمون: Regenerative pharmacology group, PREP in neurodegenerative disorders, Division of Pharmacology and Pharmacotherapy, Drug Research Program, Divisions of Faculty of Pharmacy, University of Helsinki, Faculty of Pharmacy, University Management
المصدر: Svarcbahs, R, Jäntti, M, Kilpeläinen, T, Julku, U H, Urvas, L, Kivioja, S, Norrbacka, S & Myöhänen, T T 2020, ' Prolyl oligopeptidase inhibition activates autophagy via protein phosphatase 2A ', Pharmacological Research, vol. 151, 104558, pp. 104558 . https://doi.org/10.1016/j.phrs.2019.104558
مصطلحات موضوعية: 0301 basic medicine, Male, ALPHA-SYNUCLEIN, MODULATING AUTOPHAGY, Parkinson's disease, Oligopeptidase, Inbred C57BL, DISEASE, 107970) [FTY-720 (fingolimod, PubChem CID], Mice, 0302 clinical medicine, Autophagy/drug effects, Protein phosphatase methylesterase 1, Protein Phosphatase 2, Enzyme Inhibitors, PHOSPHORYLATION, Parkinson Disease/drug therapy, PubChem CID: 107970), DAP-KINASE, Mice, Knockout, Enzyme Inhibitors/pharmacology, 5284616) [Rapamycin (sirolimus, PubChem CID], Chemistry, Kinase, FTY-720 (fingolimod, Parkinson Disease, Alzheimer's disease, PP2A, 11198569) [KYP-2047 (PubChem CID], 3. Good health, Cell biology, Protein phosphatase 2 phosphatase activator, Serine protease, 317 Pharmacy, 030220 oncology & carcinogenesis, 446512) [Okadaic acid (PubChem CID], KYP-2047 (PubChem CID: 11198569), Rapamycin (sirolimus, Phosphorylation, Prolyl Oligopeptidases, Protein Phosphatase 2/metabolism, Knockout, Phosphatase, PubChem CID: 5284616), Cell Line, 03 medical and health sciences, SDG 3 - Good Health and Well-being, ENDOPEPTIDASE INHIBITOR, Autophagy, Humans, Animals, BECLIN 1, Neurodegeneration, Protein kinase A, 6436223) [Bafilomycin A1 (PubChem CID], PARKINSONS, Pharmacology, 135565635) [PP242 (PubChem CID], Activator (genetics), Prolyl Oligopeptidases/antagonists & inhibitors, Protein phosphatase 2, Okadaic acid (PubChem CID: 446512), Mice, Inbred C57BL, 030104 developmental biology, PP242 (PubChem CID: 135565635), HEK293 Cells, Bafilomycin A1 (PubChem CID: 6436223), Gene Deletion
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المؤلفون: Lauri Urvas, Tea Pihlaja, Iiro Kiiski, Tiina Sikanen, Ville Jokinen, Joanna Witos, Susanne K. Wiedmer
المساهمون: Preclinical Drug Formulation and Analysis group, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, Drug Research Program, Laboratory for Instruction in Swedish (-2016), Department of Chemistry, Susanne Wiedmer / Principal Investigator, Tiina Sikanen / Chemical Microsystems Lab
المصدر: Advanced Biosystems. 3(1)
مصطلحات موضوعية: Liposome, biology, Immobilized enzyme, Chemistry, ta221, Biomedical Engineering, Active site, Substrate (chemistry), Cytochrome P450, 02 engineering and technology, 010402 general chemistry, 021001 nanoscience & nanotechnology, 01 natural sciences, General Biochemistry, Genetics and Molecular Biology, Enzyme assay, 0104 chemical sciences, Biomaterials, Biochemistry, 317 Pharmacy, Biotinylation, biology.protein, 1182 Biochemistry, cell and molecular biology, 221 Nano-technology, 0210 nano-technology, Lipid bilayer
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المؤلفون: Joanna Witos, Tea Pihlaja, Lauri Urvas, Ville Jokinen, Susanne K. Wiedmer, Tiina Sikanen, Iiro Kiiski
المصدر: Advanced Biosystems. 3:1970012
مصطلحات موضوعية: 0303 health sciences, Liposome, Immobilized enzyme, biology, Chemistry, Biomedical Engineering, Cytochrome P450, Fusogenic liposome, 02 engineering and technology, 021001 nanoscience & nanotechnology, General Biochemistry, Genetics and Molecular Biology, Biomaterials, 03 medical and health sciences, Biochemistry, biology.protein, 0210 nano-technology, Drug metabolism, 030304 developmental biology
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