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1
المؤلفون: Karen Lundgren, Roy Grecko, Srinivas Rao Kasibhatla, Kevin Hong, Adeela Kamal, Rachel Lough, Gregg Timony, Lawrence C. Fritz, Edgar H. Ulm, Marco A. Biamonte, Patricia Karjian, David J. Busch, Marcus F. Boehm, Robert K. Mansfield, Francis Burrows, John Brekken, Yingqing Ran, John Sensintaffar
المصدر: Journal of Medicinal Chemistry. 50:2767-2778
مصطلحات موضوعية: biology, Chemistry, Hsp90, Hsp90 inhibitor, Transplantation, Biochemistry, Enzyme inhibitor, Heat shock protein, Chaperone (protein), Drug Discovery, biology.protein, Molecular Medicine, Structure–activity relationship, Receptor
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2
المؤلفون: Kevin J. Tomaselli, Julia Herrmann, Robert O. Sayers, Joe C. Wu, Lalitha Kodandapani, Kathy G. Jahangiri, Craig D. Fisher, David T. Winn, Edward D. Robinson, Steven P. Meduna, Robert J. Ternansky, Pauline Yeo, Karen L. Valentino, Jose-Luis Diaz, Vincent J. Kalish, Steven D. Linton, Kristen Sebring, Robert A. Armstrong, Joseph F. Krebs, Niel C. Hoglen, Alfred P. Spada, Brad P. Hirakawa, Ning Chen, Brett R. Ullman, Brett Weylan Ching, Cheng-zhi Zhang, Xu Bai, Xin Gu, Kip Nalley, Long-Shiuh Chen, Patricia L. Gladstone, Jeff McQuiston, Teresa Aja, Todd Groessl, Donald S. Karanewsky, Suzanne Weeks, Lawrence C. Fritz, Patricia C. Contreras
المصدر: Journal of Medicinal Chemistry. 48:6779-6782
مصطلحات موضوعية: Adult, Biological Availability, Phases of clinical research, Apoptosis, Pharmacology, Jurkat Cells, Mice, Structure-Activity Relationship, Liver disease, Pharmacokinetics, In vivo, Drug Discovery, medicine, Animals, Humans, Aspartate Aminotransferases, Pentanoic Acids, Caspase, Liver injury, Cholestasis, Clinical Trials, Phase I as Topic, biology, Caspase 3, Chemistry, Liver Diseases, Alanine Transaminase, Hepatitis C, Chronic, medicine.disease, Caspase Inhibitors, In vitro, Rats, Liver, Biochemistry, Enzyme inhibitor, Hepatocytes, biology.protein, Molecular Medicine, Half-Life
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3
المؤلفون: Lawrence C. Fritz, Lia Thao, Marcus F. Boehm, Francis Burrows, John Sensintaffar, Lin Zhang, Adeela Kamal
المصدر: Nature. 425:407-410
مصطلحات موضوعية: Proteasome Endopeptidase Complex, Protein Conformation, Lactams, Macrocyclic, Ganetespib, Antineoplastic Agents, Cell Line, Substrate Specificity, Hsp90 inhibitor, Inhibitory Concentration 50, Adenosine Triphosphate, Multienzyme Complexes, Neoplasms, Heat shock protein, Benzoquinones, Tumor Cells, Cultured, polycyclic compounds, Humans, HSP90 Heat-Shock Proteins, Adenosine Triphosphatases, Multidisciplinary, biology, Chemistry, Precipitin Tests, Hsp90, In vitro, Cysteine Endopeptidases, Rifabutin, Biochemistry, Cell culture, Chaperone (protein), Cancer cell, biology.protein, Protein Binding
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4دورية أكاديمية
المؤلفون: Adeela Kamal, Lia Thao, John Sensintaffar, Lin Zhang, Marcus F. Boehm, Lawrence C. Fritz, Francis J. Burrows
المصدر: Nature, Nature. 425(6956):407-410
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5
المؤلفون: Anu Srinivasan, Lawrence C. Fritz, Joseph F. Krebs, Kevin J. Tomaselli, Joe C. Wu, Angela M. Wong
المصدر: Biochemistry. 39:16056-16063
مصطلحات موضوعية: Octoxynol, Detergents, Molecular Sequence Data, Caspase 3, Biochemistry, Chromatography, Affinity, Substrate Specificity, law.invention, Mice, Glucosides, Affinity chromatography, Coumarins, law, Zymogen, Animals, Humans, Amino Acid Sequence, Lymphocytes, Binding selectivity, Caspase, Cell Line, Transformed, chemistry.chemical_classification, Enzyme Precursors, biology, Hydrolysis, Caspase 1, Cell Membrane, Membrane Proteins, Caspase Inhibitors, Molecular biology, Amino acid, Enzyme Activation, Kinetics, Membrane, chemistry, Caspases, biology.protein, Recombinant DNA, Oligopeptides
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6
المؤلفون: Susan C. Nicholson, Carl Nathan, Stephen R. Grobmyer, Lawrence C. Fritz, Maxine Melchior, William P. Arend, Strite Potter, Robert C. Armstrong, Cem Gabay
المصدر: Molecular Medicine. 5:585-594
مصطلحات موضوعية: biology, Septic shock, Caspase 1, Caspase 3, Pharmacology, medicine.disease, Proinflammatory cytokine, Apoptosis, Intensive care, Shock (circulatory), Immunology, Genetics, medicine, biology.protein, Molecular Medicine, medicine.symptom, Molecular Biology, Genetics (clinical), Caspase
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7
المؤلفون: Anu Srinivasan, Gregory J. Gores, Lawrence C. Fritz, Pierre A. Clavien, Markus Selzner, Karen L. Valentino, Shiho Natori
المصدر: Transplantation. 68:89-96
مصطلحات موضوعية: Liver injury, Transplantation, Pathology, medicine.medical_specialty, TUNEL assay, biology, Caspase 3, medicine.disease, Andrology, Endothelial stem cell, medicine, biology.protein, Viaspan, Liver preservation, Caspase
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::d1808645941e8fcfd359ac3d90cd9cae
https://doi.org/10.1097/00007890-199907150-00018 -
8
المؤلفون: Christian Leist, Kim Hoang, Anu Srinivasan, Donald S. Karanewsky, Tam Vu, Lawrence C. Fritz, Robert C. Armstrong, Joe C. Wu, Bryan Pham, Teresa Aja, Rob Sayers, Albert Schmitz, Angela M. Wong, Joseph F. Krebs, Aileen Aboy, Kevin J. Tomaselli
المصدر: The Journal of Cell Biology
مصطلحات موضوعية: caspase, Cytochrome c Group, Caspase 3, Cell Line, Coumarins, Zymogen, Humans, Bcl-2, programmed cell death, Caspase, Enzyme Precursors, biology, Hydrolysis, Cytochrome c, apoptosis, Membrane Proteins, Cell Biology, Caspase Inhibitors, Cell biology, Enzyme Activation, Cytosol, cytochrome c, Membrane, Proto-Oncogene Proteins c-bcl-2, Cytoplasm, Caspases, biology.protein, Oligopeptides, Intracellular, Subcellular Fractions, Regular Articles
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::789f6e636e676d741d6d8f50362f45a9
https://doi.org/10.1083/jcb.144.5.915 -
9
المؤلفون: William A. Horne, Gary Wilson, Tilman Oltersdorf, Steve Chang, Suzanne Weeks, Yan Wang, Julia Chang, Sabine Ottilie, Jose-Luis Diaz, Lawrence C. Fritz
المصدر: Journal of Biological Chemistry. 272:30866-30872
مصطلحات موضوعية: biology, Sequence analysis, cDNA library, Mutant, Wild type, Bcl-xL, Biological activity, Cell Biology, Transfection, Biochemistry, Cell biology, biology.protein, Gene family, Molecular Biology
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::b92481a703d16a50b3767c5974580669
https://doi.org/10.1074/jbc.272.49.30866 -
10
المؤلفون: Yu Wang, Kevin J. Tomaselli, Lawrence C. Fritz, Anu Srinivasan, Robert C. Armstrong, Feng Li
المصدر: Journal of Biological Chemistry. 272:30299-30305
مصطلحات موضوعية: Programmed cell death, biology, Cytochrome, Cytochrome c, Bcl-xL, Caspase 3, Cell Biology, Fas receptor, Biochemistry, Molecular biology, Cell biology, Apoptosis, biology.protein, Apoptosome, Molecular Biology
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::2edd1b824f49b119bc42d02b339a2e78
https://doi.org/10.1074/jbc.272.48.30299