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المؤلفون: Tara Mezzasalma Haarlander, Karen Carroll, Sharon L. Burke, Shariff Bayoumy, Ingrid Christa Deckman, Cuifen Huo, Richard Alexander, Monica Singer, Matthew J. Todd, Yue-Mei Zhang, Kristi A. Leonard, Cindy Milligan, Robyn Williams, Kenneth J. Rhodes, Robert H. Scannevin, Keli Dzordzorme, John Spurlino, Brett A. Tounge, Diane M. Maguire, Paul F. Jackson, Celine Schalk-Hihi, Lawrence C. Kuo, Eric Devine, Frank A. Lewandowski
المصدر: The Journal of biological chemistry. 292(43)
مصطلحات موضوعية: 0301 basic medicine, Allosteric regulation, Drug action, Matrix metalloproteinase, Biology, Matrix Metalloproteinase Inhibitors, Biochemistry, 03 medical and health sciences, 0302 clinical medicine, Allosteric Regulation, Protein Domains, Zymogen, Catalytic Domain, Chlorocebus aethiops, medicine, Animals, Humans, Editors' Picks, Molecular Biology, Enzyme Precursors, Drug discovery, Experimental autoimmune encephalomyelitis, Cell Biology, medicine.disease, Matrix Metalloproteinases, Cell biology, 030104 developmental biology, Matrix Metalloproteinase 9, Enzyme inhibitor, Zymogen activation, COS Cells, biology.protein, Editors' Picks Highlights, 030217 neurology & neurosurgery
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef7e2f60e01bada9e1e4fd469d2a6f02
https://pubmed.ncbi.nlm.nih.gov/29079642 -
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المؤلفون: Matthew J. Todd, Marina I. Nelen, Celine Schalk-Hihi, Jose C. Clemente, James K. Kranz, Christopher M. Flores, Lawrence C. Kuo, Diane M. Maguire, Erica L Nulton, Sui-Po Zhang
المصدر: SLAS Discovery. 17:629-640
مصطلحات موضوعية: Cannabinoid receptor, High-throughput screening, Arachidonic Acids, Plasma protein binding, Biochemistry, Glycerides, Substrate Specificity, Analytical Chemistry, Inhibitory Concentration 50, Catalytic Domain, High-Throughput Screening Assays, medicine, Humans, Enzyme Inhibitors, Enzyme Assays, chemistry.chemical_classification, biology, Hydrolysis, Active site, Monoacylglycerol Lipases, Monoacylglycerol lipase, Kinetics, Enzyme, Solubility, chemistry, Mechanism of action, biology.protein, Molecular Medicine, medicine.symptom, Endocannabinoids, Protein Binding, Biotechnology
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05db4e32fcae5283a2c28027f6dc8703
https://doi.org/10.1177/1087057112441012 -
3
المؤلفون: Lawrence C. Kuo, Gee-Hong Kuo, Weimei Sun, Fengbing Song, Zhihua Sui, Amy Xiang, Alan C. Gibbs, Marta C. Abad, Xuqing Zhang
المصدر: Bioorganic & Medicinal Chemistry Letters. 21:4762-4767
مصطلحات موضوعية: Models, Molecular, Indazole, Indazoles, Dose-Response Relationship, Drug, Molecular Structure, Drug discovery, Stereochemistry, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Stereoisomerism, Pyrazole, Crystallography, X-Ray, Biochemistry, Combinatorial chemistry, Fructokinases, Structure-Activity Relationship, chemistry.chemical_compound, chemistry, Drug Discovery, Pyrazoles, Molecular Medicine, Molecular Biology
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المؤلفون: Frank A. Lewandowski, Li Liu, Jose Clemente, Charles H. Reynolds, Bruce L. Grasberger, Renee L. DesJarlais, Mark J. Macielag, Celine Schalk-Hihi, Christopher M. Flores, Mcdonnell Mark E, Richard S. Alexander, Shariff Bayoumy, Hongchang Ma, Ingrid Deckman, Diane M. Maguire, Keli C. Dzordzorme, Robyn L. Miller, Tara Mezzasalma Haarlander, Carsten Schubert, Lawrence C. Kuo, James K. Kranz, Cindy Milligan
المصدر: Protein Science. 20:670-683
مصطلحات موضوعية: biology, Chemistry, Stereochemistry, Glyceride, Plasma protein binding, Biochemistry, Monoacylglycerol lipase, chemistry.chemical_compound, Monomer, Membrane, Catalytic cycle, Static electricity, biology.protein, Lipase, Molecular Biology
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المؤلفون: Christopher D. Cox, Donald E. Slaughter, Eileen S. Walsh, Chunze Li, Carmen Fernandez-Metzler, Michael D. Schaber, George D. Hartman, Elizabeth Mahan, Carolyn A. Buser, Marc Abrams, Maricel Torrent, Vicki J. South, Weikang Tao, Paul J. Coleman, Mark E. Fraley, Michael J. Breslin, Robert B. Lobell, Joseph P. Davide, David B. Whitman, Youwei Yan, Nancy E. Kohl, Lawrence C. Kuo, Robert M. Garbaccio, Thomayant Prueksaritanont, Kelly Hamilton, Ronald E. Diehl, Hans E. Huber
المصدر: Journal of Medicinal Chemistry. 51:4239-4252
مصطلحات موضوعية: biology, Chemistry, medicine.drug_class, Stereochemistry, Metabolite, hERG, Carboxamide, Chemical synthesis, chemistry.chemical_compound, In vivo, Enzyme inhibitor, Drug Discovery, medicine, biology.protein, Molecular Medicine, Hydroxymethyl, Piperidine
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المؤلفون: Robert B. Lobell, Carolyn A. Buser, Anthony J. Roecker, Weikang Tao, Thomayant Prueksaritanont, Chunze Li, Elizabeth Mahan, Eileen S. Walsh, Lawrence C. Kuo, George D. Hartman, Ronald E. Diehl, Joseph P. Davide, Nancy E. Kohl, Vicki J. South, Swati P. Mercer, John D. Schreier, Kelly Hamilton, Carmen Fernandez-Metzler, Paul J. Coleman, Youwei Yan
المصدر: Bioorganic & Medicinal Chemistry Letters. 17:5677-5682
مصطلحات موضوعية: Models, Molecular, Tertiary amine, Clinical Biochemistry, Kinesins, Mitosis, Pharmaceutical Science, Crystallography, X-Ray, Biochemistry, Chemical synthesis, Structure-Activity Relationship, Drug Discovery, Humans, Structure–activity relationship, Binding site, Molecular Biology, Binding Sites, Molecular Structure, biology, Chemistry, Organic Chemistry, Spindle apparatus, Enzyme inhibitor, Drug Design, biology.protein, Pyrazoles, Molecular Medicine, Kinesin, Hydrogen
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المؤلفون: Elizabeth Mahan, Joseph J. Salata, Maricel Torrent, Mark E. Fraley, Chunze Li, Robert B. Lobell, Lou Anne Neilson, Joseph P. Davide, Paul J. Coleman, Olson Christy M, Eileen S. Walsh, Youwei Yan, Carolyn A. Buser, George D. Hartman, Thomayant Prueksaritanont, Keith W. Rickert, Weikang Tao, Kelly Hamilton, Donald E. Slaughter, Carmen Fernandez-Metzler, Ronald E. Diehl, Edward S. Tasber, Robert M. Garbaccio, Lawrence C. Kuo, Hans E. Huber, Nancy E. Kohl, Vicki J. South, Jeff Bergman
المصدر: Bioorganic & Medicinal Chemistry Letters. 17:5671-5676
مصطلحات موضوعية: Stereochemistry, medicine.drug_class, Clinical Biochemistry, Kinesins, Mitosis, Pharmaceutical Science, Carboxamide, Biochemistry, Chemical synthesis, Cell Line, Structure-Activity Relationship, Dogs, In vivo, Drug Discovery, medicine, Animals, Humans, Molecular Biology, chemistry.chemical_classification, Molecular Structure, biology, Organic Chemistry, Benzoxazines, Spindle apparatus, Enzyme, chemistry, Enzyme inhibitor, Drug Design, biology.protein, Pyrazoles, Molecular Medicine, Kinesin, Hydrogen
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المؤلفون: Keith Lee Spencer, Barbara Hanney, Eileen S. Walsh, George D. Hartman, Stephen C. Beck, Carolyn A. Buser, Weikang Tao, Robert B. Lobell, Youwei Yan, Lawrence C. Kuo, Kenneth L. Arrington, Edward J. Brnardic, Mari Ikuta, Sanjeev Munshi, Mark E. Fraley, Constantine Kreatsoulas, Justin T. Steen, Bob Drakas, Laura Sepp-Lorenzino, Kelly Hamilton, Yuntae Kim, Xianzhi Mao, James Hardwick, Steven M. Stirdivant, Keith W. Rickert
المصدر: Bioorganic & Medicinal Chemistry Letters. 16:6049-6053
مصطلحات موضوعية: Models, Molecular, Indazoles, Stereochemistry, Clinical Biochemistry, Triazole, Pharmaceutical Science, Crystallography, X-Ray, Biochemistry, Structure-Activity Relationship, chemistry.chemical_compound, Cell Line, Tumor, Drug Discovery, Humans, Structure–activity relationship, Moiety, Potency, Hydroxymethyl, Protein Kinase Inhibitors, Molecular Biology, Indazole, Molecular Structure, biology, Cell Cycle, Organic Chemistry, chemistry, Enzyme inhibitor, Checkpoint Kinase 1, biology.protein, Molecular Medicine, Selectivity, Protein Kinases
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المؤلفون: Christopher D. Cox, Vicki J. South, Elizabeth Mahan, Nancy E. Kohl, Kelly Hamilton, David B. Whitman, Thomayant Prueksaritanont, Michael J. Breslin, Robert B. Lobell, Eileen S. Walsh, Chunze Li, George D. Hartman, Maricel Torrent, Brenda J. Mariano, Lawrence C. Kuo, Paul J. Coleman, Youwei Yan, Bing Lu, Donald E. Slaughter, Carolyn A. Buser, Weikang Tao, Michael D. Schaber
المصدر: Bioorganic & Medicinal Chemistry Letters. 16:3175-3179
مصطلحات موضوعية: Models, Molecular, Alkylation, Molecular model, Stereochemistry, Clinical Biochemistry, Allosteric regulation, Substituent, Kinesins, Mitosis, Pharmaceutical Science, Propylamine, Crystallography, X-Ray, Hydroxylation, Biochemistry, Structure-Activity Relationship, chemistry.chemical_compound, Dogs, Drug Discovery, Animals, Structure–activity relationship, Binding site, Molecular Biology, Amination, chemistry.chemical_classification, Molecular Structure, Organic Chemistry, Water, Enzyme, Solubility, chemistry, Drug Design, Pyrazoles, Molecular Medicine, Kinesin, Allosteric Site
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المؤلفون: David C. Heimbrook, Michael D. Schaber, Christine Fernandes, Hans E. Huber, Maricel Torrent, William F. Hoffman, Olson Christy M, Carolyn A. Buser, Weikang Tao, Robert M. Garbaccio, Cathy Shu, Thomayant Prueksaritanont, Eileen S. Walsh, Lawrence C. Kuo, Donald E. Slaughter, Mark E. Fraley, Youwei Yan, George D. Hartman, Robert B. Lobell, Nancy E. Kohl, Vicki J. South, Kenneth L. Arrington, Edward S. Tasber, Kelly Hamilton
المصدر: Bioorganic & Medicinal Chemistry Letters. 16:1780-1783
مصطلحات موضوعية: Stereochemistry, Clinical Biochemistry, hERG, Kinesins, Pharmaceutical Science, Spindle Apparatus, Biochemistry, Chemical synthesis, chemistry.chemical_compound, Dogs, Drug Discovery, Animals, Prodrugs, Pyrroles, Phenols, Molecular Biology, Aqueous solution, biology, Organic Chemistry, Water, Prodrug, Phosphate, Ether-A-Go-Go Potassium Channels, In vitro, Rats, Solubility, chemistry, Area Under Curve, biology.protein, Molecular Medicine, Kinesin, Protein Binding