المؤلفون: Arensman, MD, Kovochich, AN, Kulikauskas, RM, Lay, AR, Yang, P-T, Li, X, Donahue, T, Major, MB, Moon, RT, Chien, AJ, Dawson, DW

المصدر: Oncogene. 33(7)

مصطلحات موضوعية: Rare Diseases, Genetics, Cancer, Digestive Diseases, Pancreatic Cancer, Aetiology, 2.1 Biological and endogenous factors, Aged, Autocrine Communication, Carcinoma, Pancreatic Ductal, Cell Adhesion, Cell Line, Tumor, Cell Proliferation, Female, Humans, Kaplan-Meier Estimate, Male, Middle Aged, Pancreatic Neoplasms, Prognosis, Proportional Hazards Models, Transcription, Genetic, Transcriptome, Wnt Proteins, Wnt Signaling Pathway, pancreatic cancer, WNT7B, Wnt/beta-catenin signaling, Clinical Sciences, Oncology and Carcinogenesis, Oncology & Carcinogenesis

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/88p764cn

المؤلفون: Hatziapostolou M; Department of Biosciences, John van Geest Cancer Research Centre, Centre for Systems Health and Integrated Metabolic Research, School of Science and Technology, Nottingham Trent University, Nottingham, UK., Koutsioumpa M; Vatche and Tamar Manoukian Division of Digestive Diseases, Center for Systems Biomedicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California., Zaitoun AM; Department of Cellular Pathology, Nottingham Digestive Diseases Centre and NIHR Nottingham Biomedical Research Centre, Nottingham University Hospitals and University of Nottingham, Queen's Medical Centre, Nottingham, UK., Polytarchou C; Department of Biosciences, John van Geest Cancer Research Centre, Centre for Systems Health and Integrated Metabolic Research, School of Science and Technology, Nottingham Trent University, Nottingham, UK., Edderkaoui M; Departments of Medicine and Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California., Mahurkar-Joshi S; Vatche and Tamar Manoukian Division of Digestive Diseases, Center for Systems Biomedicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California., Vadakekolathu J; Department of Biosciences, John van Geest Cancer Research Centre, Centre for Systems Health and Integrated Metabolic Research, School of Science and Technology, Nottingham Trent University, Nottingham, UK., D'Andrea D; Department of Biosciences, John van Geest Cancer Research Centre, Centre for Systems Health and Integrated Metabolic Research, School of Science and Technology, Nottingham Trent University, Nottingham, UK., Lay AR; Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, California.; Jonsson Comprehensive Cancer Center, David Geffen School of Medicine, University of California, Los Angeles, California., Christodoulou N; Department of Biosciences, John van Geest Cancer Research Centre, Centre for Systems Health and Integrated Metabolic Research, School of Science and Technology, Nottingham Trent University, Nottingham, UK., Pham T; Department of Biosciences, John van Geest Cancer Research Centre, Centre for Systems Health and Integrated Metabolic Research, School of Science and Technology, Nottingham Trent University, Nottingham, UK., Yau TO; Department of Biosciences, John van Geest Cancer Research Centre, Centre for Systems Health and Integrated Metabolic Research, School of Science and Technology, Nottingham Trent University, Nottingham, UK., Vorvis C; Vatche and Tamar Manoukian Division of Digestive Diseases, Center for Systems Biomedicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California., Chatterji S; Department of Biosciences, John van Geest Cancer Research Centre, Centre for Systems Health and Integrated Metabolic Research, School of Science and Technology, Nottingham Trent University, Nottingham, UK., Pandol SJ; Departments of Medicine and Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California., Poultsides GA; Department of Surgery, Stanford University School of Medicine, Stanford, California., Dawson DW; Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, California.; Jonsson Comprehensive Cancer Center, David Geffen School of Medicine, University of California, Los Angeles, California., Lobo DN; Nottingham Digestive Diseases Centre and NIHR Nottingham Biomedical Research Centre, Nottingham University Hospitals and University of Nottingham, Queen's Medical Centre, Nottingham, UK.; MRC Versus Arthritis Centre for Musculoskeletal Ageing Research, School of Life Sciences, Queen's Medical Centre, University of Nottingham, Nottingham, UK., Iliopoulos D; Vatche and Tamar Manoukian Division of Digestive Diseases, Center for Systems Biomedicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California.

المصدر: Gastro hep advances [Gastro Hep Adv] 2024 Apr 24; Vol. 3 (5), pp. 687-702. Date of Electronic Publication: 2024 Apr 24 (Print Publication: 2024).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Inc on behalf of the AGA Institute Country of Publication: Netherlands NLM ID: 9918350485906676 Publication Model: eCollection Cited Medium: Internet ISSN: 2772-5723 (Electronic) Linking ISSN: 27725723 NLM ISO Abbreviation: Gastro Hep Adv Subsets: PubMed not MEDLINE

المؤلفون: Aguilera KY; Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, California., Le T; Department of Molecular and Medical Pharmacology, University of California, Los Angeles, California.; Ahmanson Translational Imaging Division, University of California, Los Angeles, California., Riahi R; Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, California., Lay AR; Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, California., Hinz S; Department of Population Sciences, Beckman Research Institute, City of Hope, Duarte, California., Saadat EA; Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, California., Vashisht AA; Department of Biological Chemistry, University of California, Los Angeles, California., Wohlschlegel J; Department of Biological Chemistry, University of California, Los Angeles, California., Donahue TR; Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, California.; Department of Molecular and Medical Pharmacology, University of California, Los Angeles, California.; Ahmanson Translational Imaging Division, University of California, Los Angeles, California.; Department of Surgery, University of California, Los Angeles, California., Radu CG; Department of Molecular and Medical Pharmacology, University of California, Los Angeles, California.; Ahmanson Translational Imaging Division, University of California, Los Angeles, California., Dawson DW; Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, California.; Jonsson Comprehensive Cancer Center, David Geffen School of Medicine, University of California, Los Angeles, California.

المصدر: Molecular cancer therapeutics [Mol Cancer Ther] 2022 Jun 01; Vol. 21 (6), pp. 936-947.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Association for Cancer Research, Inc Country of Publication: United States NLM ID: 101132535 Publication Model: Print Cited Medium: Internet ISSN: 1538-8514 (Electronic) Linking ISSN: 15357163 NLM ISO Abbreviation: Mol Cancer Ther Subsets: MEDLINE

مواضيع طبية MeSH: Carcinoma, Pancreatic Ductal*/drug therapy , Carcinoma, Pancreatic Ductal*/genetics , Carcinoma, Pancreatic Ductal*/metabolism , Pancreatic Neoplasms*/drug therapy , Pancreatic Neoplasms*/genetics , Pancreatic Neoplasms*/metabolism , Wnt Signaling Pathway*, Acyltransferases/antagonists & inhibitors ; Acyltransferases/genetics ; Acyltransferases/metabolism ; Cell Line, Tumor ; Cell Proliferation ; Homeostasis ; Humans ; Ligands ; Membrane Proteins/antagonists & inhibitors ; Membrane Proteins/genetics ; Membrane Proteins/metabolism ; Mitochondria/metabolism ; Proteomics ; Pancreatic Neoplasms

المؤلفون: Nigenda-Morales SF; Department of Ecology & Evolutionary Biology, University of California, Los Angeles, Los Angeles, CA 90095, USA. Electronic address: snigenda@ucla.edu., Gompper ME; School of Natural Resources, University of Missouri, Columbia, MO 65211, USA., Valenzuela-Galván D; Departamento de Ecología Evolutiva, Centro de Investigación en Biodiversidad y Conservación, Universidad Autónoma del Estado de Morelos, Cuernavaca, Morelos 62209, Mexico., Lay AR; Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA., Kapheim KM; Department of Biology, Utah State University, Logan, UT 84322, USA., Hass C; Wild Mountain Echoes, Vail, AZ 85641, USA., Booth-Binczik SD; New York State Department of Environmental Conservation, Albany, NY 12233, USA., Binczik GA; Amsterdam, New York 12010, USA., Hirsch BT; Zoology and Ecology, College of Science and Engineering, James Cook University, Townsville, QLD 4811, Australia., McColgin M; Department of Biological Sciences, Purdue University, West Lafayette, IN 47907, USA., Koprowski JL; School of Natural Resources and the Environment, The University of Arizona, Tucson, AZ 85721, USA., McFadden K; College of Agriculture, Forestry and Life Sciences, Clemson University, Clemson, SC 29634, USA., Wayne RK; Department of Ecology & Evolutionary Biology, University of California, Los Angeles, Los Angeles, CA 90095, USA., Koepfli KP; Smithsonian Conservation Biology Institute, National Zoological Park, Washington, D.C. 20008, USA; Theodosius Dobzhansky Center for Genome Bioinformatics, Saint Petersburg State University, Saint Petersburg 199034, Russian Federation. Electronic address: koepflik@si.edu.

المصدر: Molecular phylogenetics and evolution [Mol Phylogenet Evol] 2019 Feb; Vol. 131, pp. 149-163. Date of Electronic Publication: 2018 Nov 20.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: Academic Press Country of Publication: United States NLM ID: 9304400 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9513 (Electronic) Linking ISSN: 10557903 NLM ISO Abbreviation: Mol Phylogenet Evol Subsets: MEDLINE

مواضيع طبية MeSH: Genetic Variation* , Phylogeography*, Procyonidae/*classification , Procyonidae/*genetics, Animals ; Base Sequence ; Bayes Theorem ; DNA, Mitochondrial/genetics ; Gene Flow ; Genetics, Population ; Genotype ; Microsatellite Repeats/genetics ; North America ; Phylogeny ; South America ; Time Factors

المؤلفون: Schultz MA; Division of Gastroenterology, Department of Medicine, University of Illinois-Chicago, Chicago IL 60612, USA.; Department of Surgery, Northwestern University Feinberg School of Medicine, Chicago IL 60611, USA., Diaz AM; Division of Gastroenterology, Department of Medicine, University of Illinois-Chicago, Chicago IL 60612, USA., Smite S; Division of Gastroenterology, Department of Medicine, University of Illinois-Chicago, Chicago IL 60612, USA., Lay AR; Department of Pathology and Laboratory Medicine and Jonsson Comprehensive Cancer Center, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA 90095, USA., DeCant B; Division of Gastroenterology, Department of Medicine, University of Illinois-Chicago, Chicago IL 60612, USA., McKinney R; Division of Gastroenterology, Department of Medicine, University of Illinois-Chicago, Chicago IL 60612, USA., Mascarinas WE; Department of Surgery, Northwestern University Feinberg School of Medicine, Chicago IL 60611, USA., Xia Y; Division of Gastroenterology, Department of Medicine, University of Illinois-Chicago, Chicago IL 60612, USA., Neumann C; Department of Pharmacology and Chemical Biology, University of Pittsburgh Medical Center, Pittsburgh PA 15232, USA., Bentrem D; Department of Surgery, Northwestern University Feinberg School of Medicine, Chicago IL 60611, USA., Dawson DW; Department of Pathology and Laboratory Medicine and Jonsson Comprehensive Cancer Center, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA 90095, USA., Grippo PJ; Division of Gastroenterology, Department of Medicine, University of Illinois-Chicago, Chicago IL 60612, USA.; Department of Surgery, Northwestern University Feinberg School of Medicine, Chicago IL 60611, USA.

المصدر: Oncotarget [Oncotarget] 2017 Oct 04; Vol. 8 (54), pp. 92667-92681. Date of Electronic Publication: 2017 Oct 04 (Print Publication: 2017).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Impact Journals Country of Publication: United States NLM ID: 101532965 Publication Model: eCollection Cited Medium: Internet ISSN: 1949-2553 (Electronic) Linking ISSN: 19492553 NLM ISO Abbreviation: Oncotarget Subsets: PubMed not MEDLINE

المؤلفون: Moris M; From the *Department of Gastroenterology and Hepatology, Mayo Clinic, Jacksonville, FL; †Department of Pathology and Laboratory Medicine and Jonsson Comprehensive Cancer Center, David Geffen School of Medicine at UCLA, Los Angeles, CA; Departments of ‡Pathology and Laboratory Medicine, and §Cancer Biology, Mayo Clinic, Jacksonville, FL; ∥Department of Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA; and ¶Department of Bioengineering, School of Engineering and Applied Sciences, and #Robert M. Berne Cardiovasuclar Research Center, School of Medicine, University of Virginia, Charlottesville, VA., Dawson DW, Jiang J, Lewis J, Nassar A, Takeuchi KK, Lay AR, Zhai Q, Donahue TR, Kelly KA, Crawford HC, Wallace M

المصدر: Pancreas [Pancreas] 2016 Oct; Vol. 45 (9), pp. 1353-8.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 8608542 Publication Model: Print Cited Medium: Internet ISSN: 1536-4828 (Electronic) Linking ISSN: 08853177 NLM ISO Abbreviation: Pancreas Subsets: MEDLINE

مواضيع طبية MeSH: Pancreatic Neoplasms*, Adenocarcinoma, Mucinous ; Biomarkers, Tumor ; Carcinoma, Pancreatic Ductal ; Humans ; Plectin

المؤلفون: Arensman MD; Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California., Nguyen P; Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California., Kershaw KM; Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California., Lay AR; Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California., Ostertag-Hill CA; Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California., Sherman MH; Gene Expression Laboratory, Salk Institute, La Jolla, California., Downes M; Gene Expression Laboratory, Salk Institute, La Jolla, California., Liddle C; The Storr Liver Unit, Westmead Millennium Institute and University of Sydney, Westmead Hospital, Westmead, New South Wales, Australia., Evans RM; Gene Expression Laboratory, Salk Institute, La Jolla, California. Howard Hughes Medical Institute, Salk Institute, La Jolla, California., Dawson DW; Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California. Jonsson Comprehensive Cancer Center, David Geffen School of Medicine at UCLA, Los Angeles, California. ddawson@mednet.ucla.edu.

المصدر: Molecular cancer research : MCR [Mol Cancer Res] 2015 Nov; Vol. 13 (11), pp. 1509-19. Date of Electronic Publication: 2015 Jul 29.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 101150042 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1557-3125 (Electronic) Linking ISSN: 15417786 NLM ISO Abbreviation: Mol Cancer Res Subsets: MEDLINE

مواضيع طبية MeSH: Adaptor Proteins, Signal Transducing/*metabolism , Antineoplastic Agents/*pharmacology , Calcitriol/*analogs & derivatives , Carcinoma, Pancreatic Ductal/*metabolism , Low Density Lipoprotein Receptor-Related Protein-6/*metabolism , Wnt Signaling Pathway/*drug effects, Antineoplastic Agents/therapeutic use ; Calcitriol/pharmacology ; Calcitriol/therapeutic use ; Carcinoma, Pancreatic Ductal/pathology ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Humans ; Molecular Targeted Therapy

المؤلفون: Chen R; Department of Medicine, University of Washington, Seattle, WA, USA., Dawson DW; 1] Department of Pathology and Laboratory Medicine, UCLA, Los Angeles, CA, USA [2] Jonsson Comprehensive Cancer Center, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA., Pan S; Department of Medicine, University of Washington, Seattle, WA, USA., Ottenhof NA; Department of Pathology, Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins Medical Institutions, Baltimore, MD, USA., de Wilde RF; Department of Pathology, Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins Medical Institutions, Baltimore, MD, USA., Wolfgang CL; Department of Surgery, Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins Medical Institutions, Baltimore, MD, USA., May DH; Fred Hutchinson Cancer Research Center, Molecular Diagnostics Program, Seattle, WA, USA., Crispin DA; Department of Medicine, University of Washington, Seattle, WA, USA., Lai LA; Department of Medicine, University of Washington, Seattle, WA, USA., Lay AR; Department of Pathology and Laboratory Medicine, UCLA, Los Angeles, CA, USA., Waghray M; Department of Surgery, University of Michigan, Ann Arbor, MI, USA., Wang S; Department of Pathology, Soochow University School of Medicine, Suzhou, China., McIntosh MW; Fred Hutchinson Cancer Research Center, Molecular Diagnostics Program, Seattle, WA, USA., Simeone DM; Department of Surgery, University of Michigan, Ann Arbor, MI, USA., Maitra A; Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Brentnall TA; Department of Medicine, University of Washington, Seattle, WA, USA.

المصدر: Laboratory investigation; a journal of technical methods and pathology [Lab Invest] 2015 Jan; Vol. 95 (1), pp. 43-55. Date of Electronic Publication: 2014 Oct 27.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Inc Country of Publication: United States NLM ID: 0376617 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1530-0307 (Electronic) Linking ISSN: 00236837 NLM ISO Abbreviation: Lab Invest Subsets: MEDLINE

مواضيع طبية MeSH: Survival Analysis*, Adenocarcinoma/*metabolism , Carcinoma, Pancreatic Ductal/*metabolism , Neoplasm Proteins/*metabolism , Pancreatic Neoplasms/*metabolism, Adenocarcinoma/surgery ; Carcinoma, Pancreatic Ductal/surgery ; Cell Line, Tumor ; Female ; Humans ; Male ; Middle Aged ; Neoplasm Proteins/genetics ; Pancreatic Neoplasms/surgery ; Proteomics

المؤلفون: Arensman MD; Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California., Telesca D; Department of Biostatistics, David Geffen School of Medicine at UCLA, Los Angeles, California., Lay AR; Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California., Kershaw KM; Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California., Wu N; Deparment of Surgery, David Geffen School of Medicine at UCLA, Los Angeles, California., Donahue TR; Deparment of Surgery, David Geffen School of Medicine at UCLA, Los Angeles, California., Dawson DW; Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California. Jonsson Comprehensive Cancer Center, David Geffen School of Medicine at UCLA, Los Angeles, California. ddawson@mednet.ucla.edu.

المصدر: Molecular cancer therapeutics [Mol Cancer Ther] 2014 Oct; Vol. 13 (10), pp. 2303-14. Date of Electronic Publication: 2014 Jul 31.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Association for Cancer Research, Inc Country of Publication: United States NLM ID: 101132535 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1538-8514 (Electronic) Linking ISSN: 15357163 NLM ISO Abbreviation: Mol Cancer Ther Subsets: MEDLINE

مواضيع طبية MeSH: Bridged Bicyclo Compounds, Heterocyclic/*pharmacology , CREB-Binding Protein/*antagonists & inhibitors , Carcinoma, Pancreatic Ductal/*drug therapy , Pancreatic Neoplasms/*drug therapy , Pyrimidinones/*pharmacology, Animals ; Apoptosis/drug effects ; CREB-Binding Protein/metabolism ; Carcinoma, Pancreatic Ductal/genetics ; Carcinoma, Pancreatic Ductal/metabolism ; Carcinoma, Pancreatic Ductal/pathology ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Female ; G1 Phase Cell Cycle Checkpoints/drug effects ; Gene Expression/drug effects ; Humans ; Mice ; Mice, Nude ; Pancreatic Neoplasms/metabolism ; Pancreatic Neoplasms/pathology ; Random Allocation ; Tissue Array Analysis ; Xenograft Model Antitumor Assays

المؤلفون: Nguyen Kovochich A; Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095-1732, USA., Arensman M, Lay AR, Rao NP, Donahue T, Li X, French SW, Dawson DW

المصدر: Cancer [Cancer] 2013 Feb 01; Vol. 119 (3), pp. 529-39. Date of Electronic Publication: 2012 Aug 22.

نوع المنشور: Evaluation Study; Journal Article; Research Support, Non-U.S. Gov't; Validation Study

بيانات الدورية: Publisher: Wiley Country of Publication: United States NLM ID: 0374236 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-0142 (Electronic) Linking ISSN: 0008543X NLM ISO Abbreviation: Cancer Subsets: MEDLINE

مواضيع طبية MeSH: Adenocarcinoma/*diagnosis , Adenocarcinoma/*mortality , Adenocarcinoma/*pathology , Homeodomain Proteins/*physiology , Pancreatic Neoplasms/*diagnosis , Pancreatic Neoplasms/*mortality , Pancreatic Neoplasms/*pathology, Adenocarcinoma/genetics ; Adult ; Aged ; Aged, 80 and over ; Biomarkers, Tumor/genetics ; Biomarkers, Tumor/metabolism ; Biomarkers, Tumor/physiology ; Cell Line, Tumor ; Female ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic ; Homeodomain Proteins/genetics ; Homeodomain Proteins/metabolism ; Humans ; Male ; Microarray Analysis ; Middle Aged ; Neoplasm Invasiveness ; Pancreatic Neoplasms/genetics ; Prognosis ; Survival Analysis ; Up-Regulation/genetics ; Up-Regulation/physiology